#setwd('/afs/inf.ed.ac.uk/user/s17/s1725186/Documents/PhD-Models/FirstPUModel/RMarkdowns')

library(tidyverse) ; library(reshape2) ; library(glue) ; library(plotly) ; library(dendextend)
library(RColorBrewer) ; library(viridis) ; require(gridExtra) ; library(GGally)
library(knitr)
library(biomaRt)
library(clusterProfiler) ; library(ReactomePA) ; library(DOSE)

Load preprocessed dataset (preprocessing code in 19_10_14_data_preprocessing.Rmd) and clustering (pipeline in 19_10_21_WGCNA.Rmd)

# Gandal dataset
load('./../Data/preprocessed_data.RData')
datExpr = datExpr %>% data.frame
DE_info = DE_info %>% data.frame


# GO Neuronal annotations: regex 'neuron' in GO functional annotations and label the genes that make a match as neuronal
GO_annotations = read.csv('./../Data/genes_GO_annotations.csv')
GO_neuronal = GO_annotations %>% filter(grepl('neuron', go_term)) %>% 
              mutate('ID'=as.character(ensembl_gene_id)) %>% 
              dplyr::select(-ensembl_gene_id) %>% distinct(ID) %>%
              mutate('Neuronal'=1)


# SFARI Genes
SFARI_genes = read_csv('./../../../SFARI/Data/SFARI_genes_01-03-2020_w_ensembl_IDs.csv')
SFARI_genes = SFARI_genes[!duplicated(SFARI_genes$ID) & !is.na(SFARI_genes$ID),]


# Clusterings
clusterings = read_csv('./../Data/clusters.csv')


# Update DE_info with SFARI and Neuronal information
genes_info = DE_info %>% mutate('ID'=rownames(.)) %>% left_join(SFARI_genes, by='ID') %>% 
  mutate(`gene-score`=ifelse(is.na(`gene-score`), 'None', `gene-score`)) %>%
  left_join(GO_neuronal, by='ID') %>% left_join(clusterings, by='ID') %>%
  mutate(Neuronal=ifelse(is.na(Neuronal), 0, Neuronal)) %>%
  mutate(gene.score=ifelse(`gene-score`=='None' & Neuronal==1, 'Neuronal', `gene-score`), 
         significant=padj<0.05 & !is.na(padj))


clustering_selected = 'DynamicHybrid'
genes_info$Module = genes_info[,clustering_selected]

dataset = read.csv(paste0('./../Data/dataset_', clustering_selected, '.csv'))
dataset$Module = dataset[,clustering_selected]

# Correct SFARI Scores
dataset$gene.score = genes_info$gene.score

# GSEA Results
load('./../Data/GSEA.RData')


SFARI_colour_hue = function(r) {
  pal = c('#FF7631','#FFB100','#E8E328','#8CC83F','#62CCA6','#59B9C9','#b3b3b3','#808080','gray','#d9d9d9')[r]
}

rm(DE_info, GO_annotations, clusterings, getinfo, mart, dds, GO_neuronal)


Module-Diagnosis Correlation

plot_data = dataset %>% dplyr::select(Module, MTcor) %>% distinct

ggplotly(plot_data %>% ggplot(aes(reorder(Module, -MTcor), MTcor)) + geom_bar(stat='identity', fill = plot_data$Module) + theme_minimal() + 
         xlab('Modules')+ ylab('Module-Diagnosis Correlation') + geom_hline(yintercept =c(0.9, -0.9), color = 'gray', linetype = 'dashed') + 
         theme(axis.text.x = element_text(angle = 90, hjust = 1)))
top_modules = plot_data$Module[abs(plot_data$MTcor)>0.9]

cat(paste0('Top modules selected: ', paste(top_modules, collapse=', '),'\n'))
## Top modules selected: #00B9E3, #73B000, #EE8045, #84AD00


GSEA Results


KEGG

for(module in top_modules){
  df = enrichment_KEGG[[module]] %>% dplyr::select(ID, Description, setSize, NES, p.adjust, qvalues) %>% arrange(desc(NES)) %>% filter(NES>0)
  if(nrow(df)>0){
    print(kable(df, caption = paste0('Enriched terms for module ', module, ' (MTcor = ', round(dataset$MTcor[dataset$Module==module][1],2),')')))
    cat('\n') 
  } else cat(paste0('\nNo enrichment found for module ',module,'\n'))
}
Enriched terms for module #00B9E3 (MTcor = -0.93)
ID Description setSize NES p.adjust qvalues
hsa00190 Oxidative phosphorylation 127 2.725585 0.0142895 0.0090437
hsa05016 Huntington disease 289 2.590995 0.0142895 0.0090437
hsa05012 Parkinson disease 235 2.558477 0.0142895 0.0090437
hsa04721 Synaptic vesicle cycle 70 2.390995 0.0142895 0.0090437
hsa04723 Retrograde endocannabinoid signaling 142 2.372331 0.0142895 0.0090437
hsa05010 Alzheimer disease 348 2.329095 0.0142895 0.0090437
hsa04260 Cardiac muscle contraction 79 2.291035 0.0142895 0.0090437
hsa04970 Salivary secretion 72 2.282914 0.0142895 0.0090437
hsa05033 Nicotine addiction 35 2.266381 0.0142895 0.0090437
hsa04720 Long-term potentiation 65 2.227201 0.0142895 0.0090437
hsa00020 Citrate cycle (TCA cycle) 29 2.222275 0.0142895 0.0090437
hsa04114 Oocyte meiosis 108 2.220302 0.0142895 0.0090437
hsa04728 Dopaminergic synapse 125 2.187980 0.0142895 0.0090437
hsa03050 Proteasome 43 2.178270 0.0142895 0.0090437
hsa04727 GABAergic synapse 82 2.167709 0.0142895 0.0090437
hsa05017 Spinocerebellar ataxia 124 2.147446 0.0142895 0.0090437
hsa04932 Non-alcoholic fatty liver disease (NAFLD) 139 2.146858 0.0142895 0.0090437
hsa04714 Thermogenesis 220 2.133993 0.0142895 0.0090437
hsa04713 Circadian entrainment 93 2.128740 0.0142895 0.0090437
hsa04961 Endocrine and other factor-regulated calcium reabsorption 48 2.127776 0.0142895 0.0090437
hsa04724 Glutamatergic synapse 108 2.091530 0.0142895 0.0090437
hsa05031 Amphetamine addiction 63 2.059674 0.0142895 0.0090437
hsa04740 Olfactory transduction 76 2.055744 0.0142895 0.0090437
hsa05032 Morphine addiction 85 2.031618 0.0142895 0.0090437
hsa01210 2-Oxocarboxylic acid metabolism 16 2.003497 0.0185904 0.0117657
hsa04020 Calcium signaling pathway 184 1.966258 0.0142895 0.0090437
hsa04070 Phosphatidylinositol signaling system 95 1.950537 0.0142895 0.0090437
hsa04929 GnRH secretion 60 1.939168 0.0142895 0.0090437
hsa04925 Aldosterone synthesis and secretion 91 1.937756 0.0142895 0.0090437
hsa04261 Adrenergic signaling in cardiomyocytes 141 1.909070 0.0142895 0.0090437
hsa04921 Oxytocin signaling pathway 149 1.894214 0.0142895 0.0090437
hsa04136 Autophagy - other 31 1.881438 0.0182086 0.0115241
hsa04750 Inflammatory mediator regulation of TRP channels 94 1.880734 0.0142895 0.0090437
hsa00430 Taurine and hypotaurine metabolism 10 1.868491 0.0333333 0.0210964
hsa04725 Cholinergic synapse 106 1.867310 0.0142895 0.0090437
hsa04971 Gastric acid secretion 70 1.847689 0.0177466 0.0112316
hsa04911 Insulin secretion 77 1.814558 0.0177466 0.0112316
hsa01230 Biosynthesis of amino acids 68 1.779597 0.0177466 0.0112316
hsa04910 Insulin signaling pathway 130 1.773621 0.0142895 0.0090437
hsa04962 Vasopressin-regulated water reabsorption 40 1.772690 0.0142895 0.0090437
hsa04966 Collecting duct acid secretion 23 1.769597 0.0281783 0.0178338
hsa01200 Carbon metabolism 109 1.762592 0.0142895 0.0090437
hsa04973 Carbohydrate digestion and absorption 34 1.729121 0.0276165 0.0174782
hsa04914 Progesterone-mediated oocyte maturation 82 1.708799 0.0261934 0.0165776
hsa05110 Vibrio cholerae infection 47 1.704891 0.0266368 0.0168582
hsa04930 Type II diabetes mellitus 40 1.693712 0.0275011 0.0174052
hsa04924 Renin secretion 64 1.675302 0.0264688 0.0167518
hsa05214 Glioma 72 1.662962 0.0287805 0.0182149
hsa00650 Butanoate metabolism 23 1.660218 0.0281783 0.0178338
hsa05014 Amyotrophic lateral sclerosis (ALS) 52 1.656965 0.0293698 0.0185879
hsa04912 GnRH signaling pathway 86 1.650970 0.0287805 0.0182149
hsa04972 Pancreatic secretion 72 1.646154 0.0287805 0.0182149
hsa00970 Aminoacyl-tRNA biosynthesis 44 1.644861 0.0231068 0.0146241
hsa04012 ErbB signaling pathway 82 1.640908 0.0287805 0.0182149
hsa04360 Axon guidance 179 1.625791 0.0142895 0.0090437
hsa04024 cAMP signaling pathway 192 1.618113 0.0142895 0.0090437
hsa04922 Glucagon signaling pathway 93 1.614376 0.0215552 0.0136421
hsa00250 Alanine, aspartate and glutamate metabolism 34 1.612569 0.0357580 0.0226309
hsa00620 Pyruvate metabolism 36 1.610817 0.0357514 0.0226267
hsa04960 Aldosterone-regulated sodium reabsorption 32 1.590688 0.0357580 0.0226309
hsa04150 mTOR signaling pathway 147 1.587515 0.0142895 0.0090437
hsa04120 Ubiquitin mediated proteolysis 135 1.578271 0.0177466 0.0112316
hsa04140 Autophagy - animal 131 1.546534 0.0142895 0.0090437
hsa04978 Mineral absorption 48 1.540175 0.0383349 0.0242618
hsa04726 Serotonergic synapse 102 1.532754 0.0215552 0.0136421
hsa04014 Ras signaling pathway 209 1.514586 0.0213190 0.0134926
hsa04371 Apelin signaling pathway 127 1.510024 0.0256672 0.0162445
hsa04660 T cell receptor signaling pathway 87 1.469408 0.0444462 0.0281296
hsa04071 Sphingolipid signaling pathway 113 1.457265 0.0357580 0.0226309
hsa04022 cGMP-PKG signaling pathway 157 1.435193 0.0427310 0.0270440
hsa04080 Neuroactive ligand-receptor interaction 254 1.385600 0.0439353 0.0278062
Enriched terms for module #73B000 (MTcor = 0.94)
ID Description setSize NES p.adjust qvalues
hsa05322 Systemic lupus erythematosus 108 3.169288 0.0117509 0.0072829
hsa05034 Alcoholism 165 2.474094 0.0117509 0.0072829
hsa04061 Viral protein interaction with cytokine and cytokine receptor 52 2.309397 0.0117509 0.0072829
hsa05202 Transcriptional misregulation in cancer 163 2.223024 0.0117509 0.0072829
hsa05144 Malaria 39 2.172061 0.0117509 0.0072829
hsa04392 Hippo signaling pathway - multiple species 26 2.149780 0.0117509 0.0072829
hsa05150 Staphylococcus aureus infection 49 2.132591 0.0117509 0.0072829
hsa05321 Inflammatory bowel disease (IBD) 47 2.125786 0.0117509 0.0072829
hsa04064 NF-kappa B signaling pathway 89 2.090723 0.0117509 0.0072829
hsa04060 Cytokine-cytokine receptor interaction 170 2.053668 0.0117509 0.0072829
hsa05134 Legionellosis 52 1.967451 0.0117509 0.0072829
hsa04612 Antigen processing and presentation 59 1.964714 0.0117509 0.0072829
hsa05203 Viral carcinogenesis 188 1.955215 0.0117509 0.0072829
hsa04977 Vitamin digestion and absorption 18 1.947716 0.0190273 0.0117926
hsa04610 Complement and coagulation cascades 61 1.879219 0.0190273 0.0117926
hsa05416 Viral myocarditis 52 1.858729 0.0117509 0.0072829
hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 19 1.858662 0.0190273 0.0117926
hsa04520 Adherens junction 70 1.853247 0.0117509 0.0072829
hsa05145 Toxoplasmosis 104 1.817225 0.0117509 0.0072829
hsa04330 Notch signaling pathway 51 1.813349 0.0117509 0.0072829
hsa04512 ECM-receptor interaction 80 1.781208 0.0117509 0.0072829
hsa05206 MicroRNAs in cancer 155 1.775663 0.0117509 0.0072829
hsa05205 Proteoglycans in cancer 190 1.775018 0.0117509 0.0072829
hsa05131 Shigellosis 226 1.749792 0.0117509 0.0072829
hsa04510 Focal adhesion 192 1.737613 0.0117509 0.0072829
hsa04350 TGF-beta signaling pathway 86 1.714838 0.0190273 0.0117926
hsa05332 Graft-versus-host disease 26 1.709331 0.0241808 0.0149866
hsa05340 Primary immunodeficiency 25 1.705382 0.0301940 0.0187135
hsa05330 Allograft rejection 24 1.700455 0.0190273 0.0117926
hsa05168 Herpes simplex virus 1 infection 446 1.673237 0.0117509 0.0072829
hsa05320 Autoimmune thyroid disease 28 1.669109 0.0455375 0.0282229
hsa04672 Intestinal immune network for IgA production 32 1.666816 0.0241808 0.0149866
hsa04621 NOD-like receptor signaling pathway 148 1.636858 0.0117509 0.0072829
hsa04514 Cell adhesion molecules (CAMs) 123 1.565910 0.0117509 0.0072829
hsa04659 Th17 cell differentiation 88 1.564444 0.0302873 0.0187713
hsa04670 Leukocyte transendothelial migration 97 1.561877 0.0243206 0.0150733
hsa04810 Regulation of actin cytoskeleton 197 1.561233 0.0190273 0.0117926
hsa04668 TNF signaling pathway 103 1.545790 0.0190273 0.0117926
hsa00514 Other types of O-glycan biosynthesis 46 1.532010 0.0455375 0.0282229
hsa04151 PI3K-Akt signaling pathway 308 1.497327 0.0241808 0.0149866
hsa05222 Small cell lung cancer 89 1.472050 0.0455375 0.0282229
hsa04630 JAK-STAT signaling pathway 113 1.458875 0.0455375 0.0282229
hsa05130 Pathogenic Escherichia coli infection 176 1.454159 0.0245707 0.0152283
hsa04390 Hippo signaling pathway 148 1.444705 0.0359616 0.0222880
hsa04217 Necroptosis 134 1.439714 0.0412331 0.0255552
hsa05200 Pathways in cancer 479 1.417741 0.0117509 0.0072829
hsa05165 Human papillomavirus infection 300 1.416952 0.0348186 0.0215797
hsa05163 Human cytomegalovirus infection 199 1.370276 0.0455375 0.0282229
hsa05166 Human T-cell leukemia virus 1 infection 197 1.344666 0.0496712 0.0307849
Enriched terms for module #EE8045 (MTcor = 0.93)
ID Description setSize NES p.adjust qvalues
hsa05322 Systemic lupus erythematosus 108 3.121824 0.0140101 0.0083156
hsa05168 Herpes simplex virus 1 infection 446 2.543998 0.0140101 0.0083156
hsa05202 Transcriptional misregulation in cancer 163 2.476173 0.0140101 0.0083156
hsa05150 Staphylococcus aureus infection 49 2.471518 0.0140101 0.0083156
hsa05034 Alcoholism 165 2.465300 0.0140101 0.0083156
hsa04064 NF-kappa B signaling pathway 89 2.305115 0.0140101 0.0083156
hsa04610 Complement and coagulation cascades 61 2.192555 0.0140101 0.0083156
hsa05321 Inflammatory bowel disease (IBD) 47 2.156191 0.0140101 0.0083156
hsa04061 Viral protein interaction with cytokine and cytokine receptor 52 2.120471 0.0140101 0.0083156
hsa05320 Autoimmune thyroid disease 28 2.092993 0.0140101 0.0083156
hsa04392 Hippo signaling pathway - multiple species 26 2.086178 0.0140101 0.0083156
hsa05416 Viral myocarditis 52 2.083955 0.0140101 0.0083156
hsa05134 Legionellosis 52 2.079065 0.0140101 0.0083156
hsa05330 Allograft rejection 24 2.036625 0.0140101 0.0083156
hsa05203 Viral carcinogenesis 188 2.002009 0.0140101 0.0083156
hsa05332 Graft-versus-host disease 26 1.983489 0.0140101 0.0083156
hsa04672 Intestinal immune network for IgA production 32 1.982276 0.0140101 0.0083156
hsa04060 Cytokine-cytokine receptor interaction 170 1.974136 0.0140101 0.0083156
hsa04640 Hematopoietic cell lineage 66 1.926270 0.0140101 0.0083156
hsa05140 Leishmaniasis 67 1.923574 0.0140101 0.0083156
hsa05340 Primary immunodeficiency 25 1.902833 0.0140101 0.0083156
hsa04612 Antigen processing and presentation 59 1.873119 0.0140101 0.0083156
hsa05310 Asthma 14 1.863082 0.0140101 0.0083156
hsa04658 Th1 and Th2 cell differentiation 75 1.819414 0.0140101 0.0083156
hsa05144 Malaria 39 1.814599 0.0203551 0.0120816
hsa04621 NOD-like receptor signaling pathway 148 1.808902 0.0140101 0.0083156
hsa04670 Leukocyte transendothelial migration 97 1.807719 0.0140101 0.0083156
hsa05145 Toxoplasmosis 104 1.790727 0.0140101 0.0083156
hsa00310 Lysine degradation 58 1.773076 0.0238857 0.0141771
hsa04611 Platelet activation 114 1.747916 0.0140101 0.0083156
hsa05130 Pathogenic Escherichia coli infection 176 1.688804 0.0140101 0.0083156
hsa04520 Adherens junction 70 1.674426 0.0238857 0.0141771
hsa04380 Osteoclast differentiation 114 1.661062 0.0151515 0.0089930
hsa04659 Th17 cell differentiation 88 1.659774 0.0140101 0.0083156
hsa04512 ECM-receptor interaction 80 1.658362 0.0151594 0.0089977
hsa04350 TGF-beta signaling pathway 86 1.654834 0.0151594 0.0089977
hsa05205 Proteoglycans in cancer 190 1.621493 0.0140101 0.0083156
hsa04510 Focal adhesion 192 1.620985 0.0140101 0.0083156
hsa05206 MicroRNAs in cancer 155 1.603931 0.0140101 0.0083156
hsa05131 Shigellosis 226 1.594731 0.0140101 0.0083156
hsa04810 Regulation of actin cytoskeleton 197 1.572728 0.0140101 0.0083156
hsa04668 TNF signaling pathway 103 1.524116 0.0321654 0.0190915
hsa05167 Kaposi sarcoma-associated herpesvirus infection 166 1.495412 0.0221601 0.0131529
hsa05222 Small cell lung cancer 89 1.478848 0.0497166 0.0295088
hsa04151 PI3K-Akt signaling pathway 308 1.448583 0.0186492 0.0110691
hsa03040 Spliceosome 130 1.447219 0.0360264 0.0213831
hsa05200 Pathways in cancer 479 1.441772 0.0140101 0.0083156
hsa05135 Yersinia infection 114 1.439091 0.0450000 0.0267093
Enriched terms for module #84AD00 (MTcor = -0.93)
ID Description setSize NES p.adjust qvalues
hsa00190 Oxidative phosphorylation 127 2.984700 0.0149748 0.0097229
hsa05016 Huntington disease 289 2.681127 0.0149748 0.0097229
hsa00020 Citrate cycle (TCA cycle) 29 2.617023 0.0149748 0.0097229
hsa05012 Parkinson disease 235 2.586621 0.0149748 0.0097229
hsa04260 Cardiac muscle contraction 79 2.357500 0.0149748 0.0097229
hsa04721 Synaptic vesicle cycle 70 2.315254 0.0149748 0.0097229
hsa05010 Alzheimer disease 348 2.305927 0.0149748 0.0097229
hsa03050 Proteasome 43 2.256555 0.0149748 0.0097229
hsa04714 Thermogenesis 220 2.236098 0.0149748 0.0097229
hsa04932 Non-alcoholic fatty liver disease (NAFLD) 139 2.187360 0.0149748 0.0097229
hsa01200 Carbon metabolism 109 2.162344 0.0149748 0.0097229
hsa01210 2-Oxocarboxylic acid metabolism 16 2.143368 0.0149748 0.0097229
hsa00650 Butanoate metabolism 23 2.105636 0.0149748 0.0097229
hsa04723 Retrograde endocannabinoid signaling 142 2.104901 0.0149748 0.0097229
hsa04728 Dopaminergic synapse 125 2.030861 0.0149748 0.0097229
hsa04961 Endocrine and other factor-regulated calcium reabsorption 48 2.023331 0.0149748 0.0097229
hsa00620 Pyruvate metabolism 36 2.019126 0.0149748 0.0097229
hsa05017 Spinocerebellar ataxia 124 1.993816 0.0149748 0.0097229
hsa01230 Biosynthesis of amino acids 68 1.991617 0.0149748 0.0097229
hsa04929 GnRH secretion 60 1.972337 0.0149748 0.0097229
hsa00970 Aminoacyl-tRNA biosynthesis 44 1.943065 0.0212745 0.0138132
hsa04910 Insulin signaling pathway 130 1.938894 0.0149748 0.0097229
hsa04925 Aldosterone synthesis and secretion 91 1.935218 0.0149748 0.0097229
hsa04740 Olfactory transduction 76 1.931878 0.0212745 0.0138132
hsa04930 Type II diabetes mellitus 40 1.906107 0.0149748 0.0097229
hsa04727 GABAergic synapse 82 1.893952 0.0149748 0.0097229
hsa04261 Adrenergic signaling in cardiomyocytes 141 1.880492 0.0149748 0.0097229
hsa04136 Autophagy - other 31 1.857815 0.0149748 0.0097229
hsa04970 Salivary secretion 72 1.856238 0.0212745 0.0138132
hsa00250 Alanine, aspartate and glutamate metabolism 34 1.849277 0.0149748 0.0097229
hsa00010 Glycolysis / Gluconeogenesis 54 1.848296 0.0149748 0.0097229
hsa05230 Central carbon metabolism in cancer 64 1.817534 0.0212745 0.0138132
hsa04922 Glucagon signaling pathway 93 1.808411 0.0212745 0.0138132
hsa04962 Vasopressin-regulated water reabsorption 40 1.792405 0.0287017 0.0186356
hsa04114 Oocyte meiosis 108 1.784072 0.0149748 0.0097229
hsa04966 Collecting duct acid secretion 23 1.783771 0.0212745 0.0138132
hsa04720 Long-term potentiation 65 1.770606 0.0212745 0.0138132
hsa04070 Phosphatidylinositol signaling system 95 1.754164 0.0212745 0.0138132
hsa04750 Inflammatory mediator regulation of TRP channels 94 1.744438 0.0212745 0.0138132
hsa05032 Morphine addiction 85 1.719339 0.0280815 0.0182330
hsa04020 Calcium signaling pathway 184 1.696421 0.0212745 0.0138132
hsa00640 Propanoate metabolism 32 1.684396 0.0280815 0.0182330
hsa04973 Carbohydrate digestion and absorption 34 1.683316 0.0329560 0.0213979
hsa04971 Gastric acid secretion 70 1.681012 0.0329560 0.0213979
hsa04960 Aldosterone-regulated sodium reabsorption 32 1.676416 0.0280815 0.0182330
hsa04211 Longevity regulating pathway 84 1.668980 0.0280815 0.0182330
hsa04911 Insulin secretion 77 1.654238 0.0329560 0.0213979
hsa05031 Amphetamine addiction 63 1.622657 0.0388357 0.0252155
hsa04912 GnRH signaling pathway 86 1.611412 0.0329560 0.0213979
hsa04725 Cholinergic synapse 106 1.610910 0.0212745 0.0138132
hsa04713 Circadian entrainment 93 1.605346 0.0329560 0.0213979
hsa05214 Glioma 72 1.595373 0.0498834 0.0323887
hsa04152 AMPK signaling pathway 112 1.593264 0.0212745 0.0138132
hsa04921 Oxytocin signaling pathway 149 1.591210 0.0329560 0.0213979
hsa04140 Autophagy - animal 131 1.588714 0.0430699 0.0279647
hsa04724 Glutamatergic synapse 108 1.580104 0.0280815 0.0182330
hsa04137 Mitophagy - animal 66 1.576242 0.0440329 0.0285900
hsa04146 Peroxisome 76 1.547012 0.0440329 0.0285900
hsa04144 Endocytosis 240 1.492803 0.0212745 0.0138132
hsa04150 mTOR signaling pathway 147 1.483418 0.0440329 0.0285900
rm(df)


Reactome

for(module in top_modules){
  df = enrichment_Reactome[[module]] %>% dplyr::select(ID, Description, setSize, NES, p.adjust, qvalues) %>% arrange(desc(NES)) %>% filter(NES>0)
  if(nrow(df)>0){
    print(kable(df, caption = paste0('Enriched terms for module ', module, ' (MTcor = ', round(dataset$MTcor[dataset$Module==module][1],2),')')))
    cat('\n') 
  } else cat(paste0('\nNo enrichment found for module ',module,'\n'))
}
Enriched terms for module #00B9E3 (MTcor = -0.93)
ID Description setSize NES p.adjust qvalues
R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 122 2.776410 0.0178724 0.0120179
R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport 170 2.728433 0.0178724 0.0120179
R-HSA-611105 Respiratory electron transport 100 2.715462 0.0178724 0.0120179
R-HSA-112316 Neuronal System 379 2.651142 0.0178724 0.0120179
R-HSA-112315 Transmission across Chemical Synapses 245 2.574492 0.0178724 0.0120179
R-HSA-5576892 Phase 0 - rapid depolarisation 45 2.562846 0.0178724 0.0120179
R-HSA-1296072 Voltage gated Potassium channels 40 2.562391 0.0178724 0.0120179
R-HSA-180024 DARPP-32 events 25 2.561405 0.0178724 0.0120179
R-HSA-399719 Trafficking of AMPA receptors 30 2.551657 0.0178724 0.0120179
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 30 2.551657 0.0178724 0.0120179
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 184 2.509965 0.0178724 0.0120179
R-HSA-6799198 Complex I biogenesis 55 2.489791 0.0178724 0.0120179
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 84 2.423144 0.0178724 0.0120179
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 22 2.413535 0.0178724 0.0120179
R-HSA-445095 Interaction between L1 and Ankyrins 29 2.408084 0.0178724 0.0120179
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 21 2.381275 0.0178724 0.0120179
R-HSA-9620244 Long-term potentiation 24 2.352041 0.0178724 0.0120179
R-HSA-5682910 LGI-ADAM interactions 14 2.335524 0.0178724 0.0120179
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 22 2.330838 0.0178724 0.0120179
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors 16 2.324380 0.0178724 0.0120179
R-HSA-438064 Post NMDA receptor activation events 73 2.321122 0.0178724 0.0120179
R-HSA-6794362 Protein-protein interactions at synapses 87 2.291878 0.0178724 0.0120179
R-HSA-111933 Calmodulin induced events 35 2.281160 0.0178724 0.0120179
R-HSA-111997 CaM pathway 35 2.281160 0.0178724 0.0120179
R-HSA-1489509 DAG and IP3 signaling 41 2.276476 0.0178724 0.0120179
R-HSA-8849932 Synaptic adhesion-like molecules 21 2.258640 0.0178724 0.0120179
R-HSA-1296071 Potassium Channels 92 2.229322 0.0178724 0.0120179
R-HSA-168799 Neurotoxicity of clostridium toxins 10 2.217107 0.0178724 0.0120179
R-HSA-5339562 Uptake and actions of bacterial toxins 30 2.208915 0.0178724 0.0120179
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 29 2.207101 0.0178724 0.0120179
R-HSA-5576891 Cardiac conduction 131 2.202644 0.0178724 0.0120179
R-HSA-111996 Ca-dependent events 37 2.201295 0.0178724 0.0120179
R-HSA-888590 GABA synthesis, release, reuptake and degradation 19 2.190853 0.0178724 0.0120179
R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 13 2.190629 0.0178724 0.0120179
R-HSA-111885 Opioid Signalling 86 2.187655 0.0178724 0.0120179
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 47 2.171698 0.0178724 0.0120179
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 24 2.165354 0.0178724 0.0120179
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 81 2.165205 0.0178724 0.0120179
R-HSA-163615 PKA activation 18 2.157031 0.0178724 0.0120179
R-HSA-69052 Switching of origins to a post-replicative state 87 2.152307 0.0178724 0.0120179
R-HSA-68867 Assembly of the pre-replicative complex 65 2.151911 0.0178724 0.0120179
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex 57 2.146901 0.0178724 0.0120179
R-HSA-5578775 Ion homeostasis 53 2.141367 0.0178724 0.0120179
R-HSA-5610783 Degradation of GLI2 by the proteasome 57 2.130907 0.0178724 0.0120179
R-HSA-112310 Neurotransmitter release cycle 47 2.128431 0.0178724 0.0120179
R-HSA-71403 Citric acid cycle (TCA cycle) 22 2.124935 0.0178724 0.0120179
R-HSA-379716 Cytosolic tRNA aminoacylation 24 2.122526 0.0178724 0.0120179
R-HSA-8986944 Transcriptional Regulation by MECP2 61 2.114457 0.0178724 0.0120179
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 57 2.098608 0.0178724 0.0120179
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 129 2.094788 0.0178724 0.0120179
R-HSA-5610780 Degradation of GLI1 by the proteasome 57 2.090762 0.0178724 0.0120179
R-HSA-68949 Orc1 removal from chromatin 69 2.087479 0.0178724 0.0120179
R-HSA-5676590 NIK–>noncanonical NF-kB signaling 56 2.078113 0.0178724 0.0120179
R-HSA-451306 Ionotropic activity of kainate receptors 12 2.076721 0.0178724 0.0120179
R-HSA-451308 Activation of Ca-permeable Kainate Receptor 12 2.076721 0.0178724 0.0120179
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 10 2.065971 0.0178724 0.0120179
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 12 2.057352 0.0178724 0.0120179
R-HSA-8949613 Cristae formation 31 2.044059 0.0178724 0.0120179
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 62 2.036369 0.0178724 0.0120179
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 53 2.034984 0.0178724 0.0120179
R-HSA-68689 CDC6 association with the ORC:origin complex 10 2.025660 0.0178724 0.0120179
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 57 2.023513 0.0178724 0.0120179
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 49 2.023146 0.0178724 0.0120179
R-HSA-8939902 Regulation of RUNX2 expression and activity 70 2.021219 0.0178724 0.0120179
R-HSA-6794361 Neurexins and neuroligins 56 2.020335 0.0178724 0.0120179
R-HSA-112043 PLC beta mediated events 50 2.017642 0.0178724 0.0120179
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 13 2.015495 0.0215245 0.0144737
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 76 2.015234 0.0178724 0.0120179
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 22 2.011941 0.0178724 0.0120179
R-HSA-5610787 Hedgehog ‘off’ state 108 2.004448 0.0178724 0.0120179
R-HSA-983705 Signaling by the B Cell Receptor (BCR) 107 2.001362 0.0178724 0.0120179
R-HSA-9604323 Negative regulation of NOTCH4 signaling 54 2.000729 0.0178724 0.0120179
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 69 1.998678 0.0178724 0.0120179
R-HSA-422356 Regulation of insulin secretion 73 1.994300 0.0178724 0.0120179
R-HSA-163210 Formation of ATP by chemiosmotic coupling 18 1.990580 0.0178724 0.0120179
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 52 1.986354 0.0178724 0.0120179
R-HSA-112040 G-protein mediated events 51 1.982836 0.0178724 0.0120179
R-HSA-1268020 Mitochondrial protein import 63 1.982673 0.0178724 0.0120179
R-HSA-5673000 RAF activation 32 1.981718 0.0178724 0.0120179
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 34 1.979062 0.0178724 0.0120179
R-HSA-2025928 Calcineurin activates NFAT 11 1.979021 0.0178724 0.0120179
R-HSA-180534 Vpu mediated degradation of CD4 50 1.976988 0.0178724 0.0120179
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 69 1.975008 0.0178724 0.0120179
R-HSA-177504 Retrograde neurotrophin signalling 14 1.972319 0.0178724 0.0120179
R-HSA-351202 Metabolism of polyamines 83 1.968965 0.0178724 0.0120179
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 64 1.968879 0.0207406 0.0139466
R-HSA-111931 PKA-mediated phosphorylation of CREB 20 1.964091 0.0178724 0.0120179
R-HSA-180585 Vif-mediated degradation of APOBEC3G 52 1.960509 0.0178724 0.0120179
R-HSA-169911 Regulation of Apoptosis 51 1.956624 0.0178724 0.0120179
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 70 1.953644 0.0178724 0.0120179
R-HSA-418359 Reduction of cytosolic Ca++ levels 14 1.953115 0.0214105 0.0143970
R-HSA-5362768 Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD 54 1.950114 0.0178724 0.0120179
R-HSA-373760 L1CAM interactions 111 1.946890 0.0178724 0.0120179
R-HSA-4641258 Degradation of DVL 55 1.945154 0.0178724 0.0120179
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 67 1.944404 0.0207406 0.0139466
R-HSA-425561 Sodium/Calcium exchangers 12 1.942157 0.0218783 0.0147115
R-HSA-451326 Activation of kainate receptors upon glutamate binding 31 1.938252 0.0178724 0.0120179
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 50 1.933145 0.0178724 0.0120179
R-HSA-5658442 Regulation of RAS by GAPs 66 1.931985 0.0207406 0.0139466
R-HSA-5607764 CLEC7A (Dectin-1) signaling 98 1.928237 0.0178724 0.0120179
R-HSA-70326 Glucose metabolism 85 1.927372 0.0178724 0.0120179
R-HSA-69002 DNA Replication Pre-Initiation 82 1.925271 0.0178724 0.0120179
R-HSA-5387390 Hh mutants abrogate ligand secretion 56 1.922631 0.0178724 0.0120179
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 48 1.919536 0.0178724 0.0120179
R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 1.919144 0.0178724 0.0120179
R-HSA-69610 p53-Independent DNA Damage Response 50 1.919144 0.0178724 0.0120179
R-HSA-69613 p53-Independent G1/S DNA damage checkpoint 50 1.919144 0.0178724 0.0120179
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 50 1.918504 0.0178724 0.0120179
R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 81 1.917352 0.0178724 0.0120179
R-HSA-453276 Regulation of mitotic cell cycle 81 1.917352 0.0178724 0.0120179
R-HSA-936837 Ion transport by P-type ATPases 54 1.915884 0.0178724 0.0120179
R-HSA-164378 PKA activation in glucagon signalling 16 1.914764 0.0214105 0.0143970
R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle 52 1.913308 0.0207406 0.0139466
R-HSA-163685 Integration of energy metabolism 101 1.908613 0.0178724 0.0120179
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 72 1.905243 0.0178724 0.0120179
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 72 1.905243 0.0178724 0.0120179
R-HSA-195253 Degradation of beta-catenin by the destruction complex 80 1.900618 0.0178724 0.0120179
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 17 1.900033 0.0178724 0.0120179
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 39 1.899815 0.0178724 0.0120179
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 296 1.891104 0.0178724 0.0120179
R-HSA-5628897 TP53 Regulates Metabolic Genes 84 1.882978 0.0178724 0.0120179
R-HSA-1169091 Activation of NF-kappaB in B cells 65 1.869737 0.0207406 0.0139466
R-HSA-70263 Gluconeogenesis 29 1.869377 0.0178724 0.0120179
R-HSA-977443 GABA receptor activation 51 1.867643 0.0207406 0.0139466
R-HSA-983712 Ion channel transport 168 1.866359 0.0178724 0.0120179
R-HSA-5673001 RAF/MAP kinase cascade 224 1.863324 0.0178724 0.0120179
R-HSA-5218921 VEGFR2 mediated cell proliferation 21 1.863316 0.0178724 0.0120179
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 14 1.861766 0.0214105 0.0143970
R-HSA-917977 Transferrin endocytosis and recycling 29 1.860765 0.0214105 0.0143970
R-HSA-77387 Insulin receptor recycling 23 1.856669 0.0214105 0.0143970
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 45 1.854048 0.0178724 0.0120179
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 38 1.848467 0.0178724 0.0120179
R-HSA-397014 Muscle contraction 187 1.846668 0.0178724 0.0120179
R-HSA-418346 Platelet homeostasis 85 1.840075 0.0178724 0.0120179
R-HSA-5621481 C-type lectin receptors (CLRs) 123 1.836159 0.0178724 0.0120179
R-HSA-3858494 Beta-catenin independent WNT signaling 139 1.832935 0.0178724 0.0120179
R-HSA-8948751 Regulation of PTEN stability and activity 67 1.832842 0.0207406 0.0139466
R-HSA-1592230 Mitochondrial biogenesis 94 1.832590 0.0178724 0.0120179
R-HSA-69541 Stabilization of p53 55 1.823896 0.0207482 0.0139516
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 60 1.821204 0.0207406 0.0139466
R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol 13 1.818648 0.0215245 0.0144737
R-HSA-5099900 WNT5A-dependent internalization of FZD4 15 1.814820 0.0214105 0.0143970
R-HSA-388844 Receptor-type tyrosine-protein phosphatases 20 1.810257 0.0178724 0.0120179
R-HSA-112308 Presynaptic depolarization and calcium channel opening 13 1.809298 0.0215245 0.0144737
R-HSA-5684996 MAPK1/MAPK3 signaling 230 1.808475 0.0178724 0.0120179
R-HSA-418360 Platelet calcium homeostasis 29 1.802779 0.0214105 0.0143970
R-HSA-74752 Signaling by Insulin receptor 66 1.799373 0.0207406 0.0139466
R-HSA-69306 DNA Replication 123 1.795906 0.0178724 0.0120179
R-HSA-69563 p53-Dependent G1 DNA Damage Response 64 1.788087 0.0207406 0.0139466
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 64 1.788087 0.0207406 0.0139466
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 54 1.785273 0.0207406 0.0139466
R-HSA-1483255 PI Metabolism 82 1.783341 0.0178724 0.0120179
R-HSA-69481 G2/M Checkpoints 162 1.779985 0.0178724 0.0120179
R-HSA-70221 Glycogen breakdown (glycogenolysis) 17 1.779805 0.0357691 0.0240521
R-HSA-8949664 Processing of SMDT1 16 1.775758 0.0426610 0.0286864
R-HSA-2871837 FCERI mediated NF-kB activation 78 1.772306 0.0178724 0.0120179
R-HSA-5358346 Hedgehog ligand biogenesis 62 1.768960 0.0207406 0.0139466
R-HSA-8951664 Neddylation 225 1.768298 0.0178724 0.0120179
R-HSA-69239 Synthesis of DNA 116 1.767844 0.0178724 0.0120179
R-HSA-445717 Aquaporin-mediated transport 44 1.767032 0.0178724 0.0120179
R-HSA-1222556 ROS and RNS production in phagocytes 34 1.764762 0.0208719 0.0140349
R-HSA-69615 G1/S DNA Damage Checkpoints 66 1.763056 0.0207406 0.0139466
R-HSA-114508 Effects of PIP2 hydrolysis 26 1.763054 0.0214105 0.0143970
R-HSA-5210891 Uptake and function of anthrax toxins 13 1.757143 0.0436155 0.0293283
R-HSA-1632852 Macroautophagy 91 1.751486 0.0207406 0.0139466
R-HSA-70171 Glycolysis 68 1.746961 0.0207406 0.0139466
R-HSA-163359 Glucagon signaling in metabolic regulation 30 1.742006 0.0212825 0.0143109
R-HSA-4641257 Degradation of AXIN 53 1.740082 0.0207406 0.0139466
R-HSA-5683057 MAPK family signaling cascades 266 1.739771 0.0178724 0.0120179
R-HSA-8856688 Golgi-to-ER retrograde transport 124 1.738128 0.0205499 0.0138183
R-HSA-8949215 Mitochondrial calcium ion transport 23 1.736394 0.0287430 0.0193276
R-HSA-5358351 Signaling by Hedgehog 143 1.735278 0.0178724 0.0120179
R-HSA-4608870 Asymmetric localization of PCP proteins 62 1.734835 0.0207406 0.0139466
R-HSA-4086400 PCP/CE pathway 89 1.733743 0.0178724 0.0120179
R-HSA-8856828 Clathrin-mediated endocytosis 137 1.732979 0.0178724 0.0120179
R-HSA-1852241 Organelle biogenesis and maintenance 286 1.732181 0.0178724 0.0120179
R-HSA-453274 Mitotic G2-G2/M phases 187 1.727232 0.0178724 0.0120179
R-HSA-1483249 Inositol phosphate metabolism 48 1.725305 0.0207916 0.0139809
R-HSA-162909 Host Interactions of HIV factors 125 1.720101 0.0205499 0.0138183
R-HSA-69275 G2/M Transition 185 1.715159 0.0178724 0.0120179
R-HSA-8941858 Regulation of RUNX3 expression and activity 55 1.706189 0.0338234 0.0227438
R-HSA-2132295 MHC class II antigen presentation 110 1.704641 0.0178724 0.0120179
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 97 1.697754 0.0321613 0.0216261
R-HSA-166520 Signaling by NTRKs 97 1.685550 0.0321613 0.0216261
R-HSA-69620 Cell Cycle Checkpoints 279 1.685291 0.0178724 0.0120179
R-HSA-382556 ABC-family proteins mediated transport 100 1.684830 0.0257145 0.0172911
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 27 1.677675 0.0357691 0.0240521
R-HSA-381753 Olfactory Signaling Pathway 49 1.668289 0.0338234 0.0227438
R-HSA-2871809 FCERI mediated Ca+2 mobilization 31 1.663831 0.0344930 0.0231940
R-HSA-379724 tRNA Aminoacylation 42 1.646165 0.0404812 0.0272207
R-HSA-5205647 Mitophagy 29 1.640185 0.0421256 0.0283264
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 69 1.639983 0.0329968 0.0221879
R-HSA-2682334 EPH-Ephrin signaling 92 1.638920 0.0492122 0.0330917
R-HSA-5687128 MAPK6/MAPK4 signaling 84 1.634592 0.0497877 0.0334786
R-HSA-5619084 ABC transporter disorders 75 1.617943 0.0385323 0.0259102
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 79 1.584249 0.0385323 0.0259102
R-HSA-380287 Centrosome maturation 79 1.584249 0.0385323 0.0259102
R-HSA-9006925 Intracellular signaling by second messengers 285 1.581834 0.0201686 0.0135619
R-HSA-187037 Signaling by NTRK1 (TRKA) 77 1.568724 0.0497877 0.0334786
R-HSA-2467813 Separation of Sister Chromatids 175 1.560684 0.0239269 0.0160891
R-HSA-162906 HIV Infection 224 1.540690 0.0201734 0.0135652
R-HSA-983169 Class I MHC mediated antigen processing & presentation 355 1.536145 0.0196709 0.0132272
R-HSA-9007101 Rab regulation of trafficking 122 1.535149 0.0369855 0.0248701
R-HSA-69206 G1/S Transition 131 1.520515 0.0368454 0.0247758
R-HSA-68882 Mitotic Anaphase 186 1.488832 0.0457744 0.0307800
R-HSA-2555396 Mitotic Metaphase and Anaphase 187 1.486601 0.0404812 0.0272207
R-HSA-69242 S Phase 158 1.483756 0.0404812 0.0272207
R-HSA-9609507 Protein localization 158 1.479809 0.0404812 0.0272207
R-HSA-5617833 Cilium Assembly 192 1.474133 0.0456150 0.0306728
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 191 1.414316 0.0497877 0.0334786
R-HSA-195721 Signaling by WNT 309 1.387903 0.0279923 0.0188228
R-HSA-5663205 Infectious disease 368 1.375228 0.0274275 0.0184430
R-HSA-8953897 Cellular responses to external stimuli 498 1.347697 0.0404812 0.0272207
Enriched terms for module #73B000 (MTcor = 0.94)
ID Description setSize NES p.adjust qvalues
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 59 3.468265 0.0117461 0.0078154
R-HSA-5334118 DNA methylation 57 3.422280 0.0117461 0.0078154
R-HSA-2299718 Condensation of Prophase Chromosomes 66 3.384387 0.0117461 0.0078154
R-HSA-73728 RNA Polymerase I Promoter Opening 57 3.382260 0.0117461 0.0078154
R-HSA-427359 SIRT1 negatively regulates rRNA expression 62 3.273416 0.0117461 0.0078154
R-HSA-212300 PRC2 methylates histones and DNA 67 3.260046 0.0117461 0.0078154
R-HSA-912446 Meiotic recombination 77 3.229282 0.0117461 0.0078154
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 70 3.211547 0.0117461 0.0078154
R-HSA-1912408 Pre-NOTCH Transcription and Translation 87 3.192557 0.0117461 0.0078154
R-HSA-1912422 Pre-NOTCH Expression and Processing 103 3.141059 0.0117461 0.0078154
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 87 3.121136 0.0117461 0.0078154
R-HSA-171306 Packaging Of Telomere Ends 45 3.107865 0.0117461 0.0078154
R-HSA-5625740 RHO GTPases activate PKNs 87 3.101239 0.0117461 0.0078154
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 83 3.089756 0.0117461 0.0078154
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine 49 3.083089 0.0117461 0.0078154
R-HSA-110331 Cleavage of the damaged purine 49 3.083089 0.0117461 0.0078154
R-HSA-73927 Depurination 49 3.083089 0.0117461 0.0078154
R-HSA-1500620 Meiosis 106 3.075246 0.0117461 0.0078154
R-HSA-977225 Amyloid fiber formation 92 3.070625 0.0117461 0.0078154
R-HSA-1474165 Reproduction 121 3.065717 0.0117461 0.0078154
R-HSA-3214815 HDACs deacetylate histones 89 3.053304 0.0117461 0.0078154
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 103 3.053189 0.0117461 0.0078154
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 105 3.023189 0.0117461 0.0078154
R-HSA-5619507 Activation of HOX genes during differentiation 105 3.023189 0.0117461 0.0078154
R-HSA-3214842 HDMs demethylate histones 50 3.021979 0.0117461 0.0078154
R-HSA-9018519 Estrogen-dependent gene expression 139 3.014750 0.0117461 0.0078154
R-HSA-1221632 Meiotic synapsis 69 3.002054 0.0117461 0.0078154
R-HSA-73772 RNA Polymerase I Promoter Escape 85 2.999443 0.0117461 0.0078154
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 85 2.972633 0.0117461 0.0078154
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 54 2.961401 0.0117461 0.0078154
R-HSA-110329 Cleavage of the damaged pyrimidine 54 2.961401 0.0117461 0.0078154
R-HSA-73928 Depyrimidination 54 2.961401 0.0117461 0.0078154
R-HSA-73929 Base-Excision Repair, AP Site Formation 56 2.959082 0.0117461 0.0078154
R-HSA-5578749 Transcriptional regulation by small RNAs 100 2.953369 0.0117461 0.0078154
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 67 2.926504 0.0117461 0.0078154
R-HSA-774815 Nucleosome assembly 67 2.926504 0.0117461 0.0078154
R-HSA-3214858 RMTs methylate histone arginines 74 2.896146 0.0117461 0.0078154
R-HSA-427413 NoRC negatively regulates rRNA expression 100 2.842392 0.0117461 0.0078154
R-HSA-68875 Mitotic Prophase 134 2.834253 0.0117461 0.0078154
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 72 2.823211 0.0117461 0.0078154
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 100 2.816024 0.0117461 0.0078154
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 103 2.786659 0.0117461 0.0078154
R-HSA-73864 RNA Polymerase I Transcription 105 2.775882 0.0117461 0.0078154
R-HSA-73854 RNA Polymerase I Promoter Clearance 104 2.753578 0.0117461 0.0078154
R-HSA-3214841 PKMTs methylate histone lysines 68 2.736044 0.0117461 0.0078154
R-HSA-2559580 Oxidative Stress Induced Senescence 116 2.726098 0.0117461 0.0078154
R-HSA-157579 Telomere Maintenance 74 2.707148 0.0117461 0.0078154
R-HSA-211000 Gene Silencing by RNA 128 2.642296 0.0117461 0.0078154
R-HSA-3214847 HATs acetylate histones 134 2.626393 0.0117461 0.0078154
R-HSA-8939211 ESR-mediated signaling 205 2.605186 0.0117461 0.0078154
R-HSA-73884 Base Excision Repair 84 2.554506 0.0117461 0.0078154
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 120 2.552006 0.0117461 0.0078154
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 88 2.512160 0.0117461 0.0078154
R-HSA-73886 Chromosome Maintenance 101 2.511605 0.0117461 0.0078154
R-HSA-2559583 Cellular Senescence 183 2.502976 0.0117461 0.0078154
R-HSA-6783783 Interleukin-10 signaling 34 2.488127 0.0117461 0.0078154
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 66 2.488032 0.0117461 0.0078154
R-HSA-212165 Epigenetic regulation of gene expression 140 2.483332 0.0117461 0.0078154
R-HSA-5693606 DNA Double Strand Break Response 74 2.426852 0.0117461 0.0078154
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 73 2.423707 0.0117461 0.0078154
R-HSA-8941326 RUNX2 regulates bone development 30 2.403258 0.0117461 0.0078154
R-HSA-1566948 Elastic fibre formation 43 2.391125 0.0117461 0.0078154
R-HSA-9006931 Signaling by Nuclear Receptors 244 2.384423 0.0117461 0.0078154
R-HSA-5693607 Processing of DNA double-strand break ends 94 2.371347 0.0117461 0.0078154
R-HSA-1266695 Interleukin-7 signaling 33 2.369369 0.0117461 0.0078154
R-HSA-69473 G2/M DNA damage checkpoint 91 2.348016 0.0117461 0.0078154
R-HSA-1474244 Extracellular matrix organization 263 2.321442 0.0117461 0.0078154
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 126 2.273638 0.0117461 0.0078154
R-HSA-3247509 Chromatin modifying enzymes 259 2.273256 0.0117461 0.0078154
R-HSA-4839726 Chromatin organization 259 2.273256 0.0117461 0.0078154
R-HSA-157118 Signaling by NOTCH 224 2.221206 0.0117461 0.0078154
R-HSA-3000170 Syndecan interactions 27 2.212491 0.0117461 0.0078154
R-HSA-2129379 Molecules associated with elastic fibres 36 2.209138 0.0117461 0.0078154
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 23 2.208080 0.0117461 0.0078154
R-HSA-8878171 Transcriptional regulation by RUNX1 218 2.204695 0.0117461 0.0078154
R-HSA-5693538 Homology Directed Repair 132 2.198307 0.0117461 0.0078154
R-HSA-8875878 MET promotes cell motility 40 2.179348 0.0117461 0.0078154
R-HSA-75205 Dissolution of Fibrin Clot 10 2.112298 0.0117461 0.0078154
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins 175 2.104719 0.0117461 0.0078154
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 56 2.096615 0.0117461 0.0078154
R-HSA-1474290 Collagen formation 84 2.092427 0.0117461 0.0078154
R-HSA-3000171 Non-integrin membrane-ECM interactions 59 2.091970 0.0117461 0.0078154
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 10 2.071611 0.0117461 0.0078154
R-HSA-8874081 MET activates PTK2 signaling 30 2.049986 0.0117461 0.0078154
R-HSA-8941856 RUNX3 regulates NOTCH signaling 14 2.049880 0.0117461 0.0078154
R-HSA-201681 TCF dependent signaling in response to WNT 215 2.041925 0.0117461 0.0078154
R-HSA-209560 NF-kB is activated and signals survival 13 2.031102 0.0202929 0.0135020
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 2.022195 0.0117461 0.0078154
R-HSA-2990846 SUMOylation 181 2.022195 0.0117461 0.0078154
R-HSA-6783589 Interleukin-6 family signaling 23 2.018325 0.0117461 0.0078154
R-HSA-3000480 Scavenging by Class A Receptors 18 2.014909 0.0197925 0.0131691
R-HSA-4551638 SUMOylation of chromatin organization proteins 70 2.014336 0.0117461 0.0078154
R-HSA-1980145 Signaling by NOTCH2 31 2.001981 0.0117461 0.0078154
R-HSA-211976 Endogenous sterols 20 1.996679 0.0198251 0.0131908
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 36 1.996595 0.0117461 0.0078154
R-HSA-216083 Integrin cell surface interactions 75 1.992018 0.0117461 0.0078154
R-HSA-9012852 Signaling by NOTCH3 47 1.991023 0.0117461 0.0078154
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 43 1.984741 0.0117461 0.0078154
R-HSA-2243919 Crosslinking of collagen fibrils 18 1.979909 0.0197925 0.0131691
R-HSA-2028269 Signaling by Hippo 20 1.974711 0.0198251 0.0131908
R-HSA-140342 Apoptosis induced DNA fragmentation 13 1.952558 0.0344850 0.0229448
R-HSA-5693532 DNA Double-Strand Break Repair 160 1.929721 0.0117461 0.0078154
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 13 1.927565 0.0344850 0.0229448
R-HSA-3000178 ECM proteoglycans 70 1.926631 0.0117461 0.0078154
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 17 1.923799 0.0202929 0.0135020
R-HSA-3000157 Laminin interactions 30 1.914379 0.0117461 0.0078154
R-HSA-193639 p75NTR signals via NF-kB 16 1.911000 0.0117461 0.0078154
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 23 1.904380 0.0117461 0.0078154
R-HSA-5260271 Diseases of Immune System 24 1.879596 0.0278870 0.0185548
R-HSA-5602358 Diseases associated with the TLR signaling cascade 24 1.879596 0.0278870 0.0185548
R-HSA-446353 Cell-extracellular matrix interactions 18 1.879476 0.0197925 0.0131691
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 20 1.873682 0.0276905 0.0184241
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 12 1.873360 0.0344850 0.0229448
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 12 1.868562 0.0344850 0.0229448
R-HSA-111461 Cytochrome c-mediated apoptotic response 13 1.868298 0.0407191 0.0270927
R-HSA-5213460 RIPK1-mediated regulated necrosis 19 1.867988 0.0197925 0.0131691
R-HSA-5218859 Regulated Necrosis 19 1.867988 0.0197925 0.0131691
R-HSA-2022870 Chondroitin sulfate biosynthesis 19 1.867393 0.0197925 0.0131691
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 65 1.837174 0.0117461 0.0078154
R-HSA-1474228 Degradation of the extracellular matrix 117 1.836332 0.0117461 0.0078154
R-HSA-195258 RHO GTPase Effectors 304 1.835419 0.0117461 0.0078154
R-HSA-193692 Regulated proteolysis of p75NTR 11 1.831270 0.0283083 0.0188351
R-HSA-449147 Signaling by Interleukins 393 1.805247 0.0117461 0.0078154
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 95 1.803718 0.0117461 0.0078154
R-HSA-1236977 Endosomal/Vacuolar pathway 11 1.798824 0.0414761 0.0275964
R-HSA-6788467 IL-6-type cytokine receptor ligand interactions 16 1.787366 0.0344850 0.0229448
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 1.784984 0.0409849 0.0272696
R-HSA-174490 Membrane binding and targetting of GAG proteins 14 1.783827 0.0479042 0.0318734
R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 14 1.783827 0.0479042 0.0318734
R-HSA-977606 Regulation of Complement cascade 32 1.781757 0.0197925 0.0131691
R-HSA-5689901 Metalloprotease DUBs 33 1.781302 0.0273723 0.0182123
R-HSA-380108 Chemokine receptors bind chemokines 24 1.775479 0.0406867 0.0270712
R-HSA-166658 Complement cascade 38 1.770962 0.0274778 0.0182825
R-HSA-1059683 Interleukin-6 signaling 11 1.770686 0.0414761 0.0275964
R-HSA-4755510 SUMOylation of immune response proteins 11 1.770228 0.0414761 0.0275964
R-HSA-8957275 Post-translational protein phosphorylation 93 1.762486 0.0117461 0.0078154
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 58 1.760725 0.0117461 0.0078154
R-HSA-202733 Cell surface interactions at the vascular wall 110 1.752706 0.0117461 0.0078154
R-HSA-909733 Interferon alpha/beta signaling 56 1.717716 0.0278020 0.0184983
R-HSA-5656169 Termination of translesion DNA synthesis 32 1.710565 0.0388947 0.0258789
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 102 1.696654 0.0117461 0.0078154
R-HSA-195721 Signaling by WNT 309 1.684956 0.0117461 0.0078154
R-HSA-1442490 Collagen degradation 51 1.680047 0.0278696 0.0185433
R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism 40 1.673642 0.0278085 0.0185026
R-HSA-3906995 Diseases associated with O-glycosylation of proteins 55 1.659918 0.0344850 0.0229448
R-HSA-8852135 Protein ubiquitination 77 1.644277 0.0283083 0.0188351
R-HSA-68886 M Phase 370 1.643709 0.0117461 0.0078154
R-HSA-446728 Cell junction organization 78 1.639326 0.0344850 0.0229448
R-HSA-3781865 Diseases of glycosylation 128 1.636125 0.0117461 0.0078154
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 55 1.631757 0.0344850 0.0229448
R-HSA-2262752 Cellular responses to stress 405 1.625530 0.0117461 0.0078154
R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism 49 1.625400 0.0278969 0.0185614
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 78 1.618267 0.0344850 0.0229448
R-HSA-9006936 Signaling by TGF-beta family members 97 1.598987 0.0404981 0.0269457
R-HSA-6806834 Signaling by MET 78 1.591541 0.0344850 0.0229448
R-HSA-194315 Signaling by Rho GTPases 427 1.585235 0.0117461 0.0078154
R-HSA-73894 DNA Repair 322 1.439976 0.0117461 0.0078154
R-HSA-6798695 Neutrophil degranulation 426 1.411085 0.0117461 0.0078154
R-HSA-8953897 Cellular responses to external stimuli 498 1.368646 0.0117461 0.0078154
Enriched terms for module #EE8045 (MTcor = 0.93)
ID Description setSize NES p.adjust qvalues
R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 59 3.423865 0.0147558 0.0095281
R-HSA-5334118 DNA methylation 57 3.408554 0.0147558 0.0095281
R-HSA-73728 RNA Polymerase I Promoter Opening 57 3.357615 0.0147558 0.0095281
R-HSA-2299718 Condensation of Prophase Chromosomes 66 3.273274 0.0147558 0.0095281
R-HSA-427359 SIRT1 negatively regulates rRNA expression 62 3.258986 0.0147558 0.0095281
R-HSA-212300 PRC2 methylates histones and DNA 67 3.187458 0.0147558 0.0095281
R-HSA-3214815 HDACs deacetylate histones 89 3.173601 0.0147558 0.0095281
R-HSA-1912408 Pre-NOTCH Transcription and Translation 87 3.151928 0.0147558 0.0095281
R-HSA-912446 Meiotic recombination 77 3.147819 0.0147558 0.0095281
R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 70 3.136607 0.0147558 0.0095281
R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 87 3.126798 0.0147558 0.0095281
R-HSA-5625740 RHO GTPases activate PKNs 87 3.077224 0.0147558 0.0095281
R-HSA-171306 Packaging Of Telomere Ends 45 3.026010 0.0147558 0.0095281
R-HSA-1500620 Meiosis 106 3.019959 0.0147558 0.0095281
R-HSA-73772 RNA Polymerase I Promoter Escape 85 3.010768 0.0147558 0.0095281
R-HSA-1221632 Meiotic synapsis 69 3.001838 0.0147558 0.0095281
R-HSA-1912422 Pre-NOTCH Expression and Processing 103 2.983569 0.0147558 0.0095281
R-HSA-1474165 Reproduction 121 2.976872 0.0147558 0.0095281
R-HSA-977225 Amyloid fiber formation 92 2.976040 0.0147558 0.0095281
R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine 49 2.945466 0.0147558 0.0095281
R-HSA-110331 Cleavage of the damaged purine 49 2.945466 0.0147558 0.0095281
R-HSA-73927 Depurination 49 2.945466 0.0147558 0.0095281
R-HSA-5250924 B-WICH complex positively regulates rRNA expression 85 2.932192 0.0147558 0.0095281
R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 83 2.915745 0.0147558 0.0095281
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 103 2.908049 0.0147558 0.0095281
R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 54 2.866451 0.0147558 0.0095281
R-HSA-110329 Cleavage of the damaged pyrimidine 54 2.866451 0.0147558 0.0095281
R-HSA-73928 Depyrimidination 54 2.866451 0.0147558 0.0095281
R-HSA-427413 NoRC negatively regulates rRNA expression 100 2.865425 0.0147558 0.0095281
R-HSA-5578749 Transcriptional regulation by small RNAs 100 2.858178 0.0147558 0.0095281
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 105 2.849947 0.0147558 0.0095281
R-HSA-5619507 Activation of HOX genes during differentiation 105 2.849947 0.0147558 0.0095281
R-HSA-73929 Base-Excision Repair, AP Site Formation 56 2.836182 0.0147558 0.0095281
R-HSA-9018519 Estrogen-dependent gene expression 139 2.831378 0.0147558 0.0095281
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 67 2.825716 0.0147558 0.0095281
R-HSA-774815 Nucleosome assembly 67 2.825716 0.0147558 0.0095281
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 72 2.813244 0.0147558 0.0095281
R-HSA-5250941 Negative epigenetic regulation of rRNA expression 103 2.802212 0.0147558 0.0095281
R-HSA-3214842 HDMs demethylate histones 50 2.793935 0.0147558 0.0095281
R-HSA-73864 RNA Polymerase I Transcription 105 2.755552 0.0147558 0.0095281
R-HSA-5250913 Positive epigenetic regulation of rRNA expression 100 2.738779 0.0147558 0.0095281
R-HSA-73854 RNA Polymerase I Promoter Clearance 104 2.737481 0.0147558 0.0095281
R-HSA-3214858 RMTs methylate histone arginines 74 2.725178 0.0147558 0.0095281
R-HSA-3214847 HATs acetylate histones 134 2.666186 0.0147558 0.0095281
R-HSA-68875 Mitotic Prophase 134 2.658509 0.0147558 0.0095281
R-HSA-157579 Telomere Maintenance 74 2.658310 0.0147558 0.0095281
R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 73 2.639181 0.0147558 0.0095281
R-HSA-5693606 DNA Double Strand Break Response 74 2.638258 0.0147558 0.0095281
R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 66 2.638140 0.0147558 0.0095281
R-HSA-211000 Gene Silencing by RNA 128 2.611310 0.0147558 0.0095281
R-HSA-3214841 PKMTs methylate histone lysines 68 2.549697 0.0147558 0.0095281
R-HSA-2559580 Oxidative Stress Induced Senescence 116 2.536816 0.0147558 0.0095281
R-HSA-212165 Epigenetic regulation of gene expression 140 2.528168 0.0147558 0.0095281
R-HSA-73886 Chromosome Maintenance 101 2.477316 0.0147558 0.0095281
R-HSA-73884 Base Excision Repair 84 2.462647 0.0147558 0.0095281
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 120 2.451663 0.0147558 0.0095281
R-HSA-8939211 ESR-mediated signaling 205 2.437913 0.0147558 0.0095281
R-HSA-5693607 Processing of DNA double-strand break ends 94 2.393373 0.0147558 0.0095281
R-HSA-69473 G2/M DNA damage checkpoint 91 2.384414 0.0147558 0.0095281
R-HSA-3247509 Chromatin modifying enzymes 259 2.368614 0.0147558 0.0095281
R-HSA-4839726 Chromatin organization 259 2.368614 0.0147558 0.0095281
R-HSA-1474290 Collagen formation 84 2.319970 0.0147558 0.0095281
R-HSA-2559583 Cellular Senescence 183 2.277798 0.0147558 0.0095281
R-HSA-8878171 Transcriptional regulation by RUNX1 218 2.246526 0.0147558 0.0095281
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 56 2.246405 0.0147558 0.0095281
R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 126 2.217461 0.0147558 0.0095281
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 88 2.213152 0.0147558 0.0095281
R-HSA-1474244 Extracellular matrix organization 263 2.201084 0.0147558 0.0095281
R-HSA-9006931 Signaling by Nuclear Receptors 244 2.195094 0.0147558 0.0095281
R-HSA-1650814 Collagen biosynthesis and modifying enzymes 65 2.193222 0.0147558 0.0095281
R-HSA-6783783 Interleukin-10 signaling 34 2.173643 0.0147558 0.0095281
R-HSA-5260271 Diseases of Immune System 24 2.124050 0.0147558 0.0095281
R-HSA-5602358 Diseases associated with the TLR signaling cascade 24 2.124050 0.0147558 0.0095281
R-HSA-5693538 Homology Directed Repair 132 2.122800 0.0147558 0.0095281
R-HSA-5689901 Metalloprotease DUBs 33 2.118768 0.0147558 0.0095281
R-HSA-216083 Integrin cell surface interactions 75 2.070907 0.0147558 0.0095281
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins 175 2.062557 0.0147558 0.0095281
R-HSA-8875878 MET promotes cell motility 40 2.034390 0.0147558 0.0095281
R-HSA-4551638 SUMOylation of chromatin organization proteins 70 2.026914 0.0147558 0.0095281
R-HSA-977606 Regulation of Complement cascade 32 2.026791 0.0147558 0.0095281
R-HSA-1266695 Interleukin-7 signaling 33 2.021810 0.0147558 0.0095281
R-HSA-166658 Complement cascade 38 2.012917 0.0147558 0.0095281
R-HSA-1566948 Elastic fibre formation 43 2.010537 0.0147558 0.0095281
R-HSA-1442490 Collagen degradation 51 2.009278 0.0147558 0.0095281
R-HSA-5693532 DNA Double-Strand Break Repair 160 1.999490 0.0147558 0.0095281
R-HSA-2028269 Signaling by Hippo 20 1.977259 0.0147558 0.0095281
R-HSA-2990846 SUMOylation 181 1.958994 0.0147558 0.0095281
R-HSA-68884 Mitotic Telophase/Cytokinesis 12 1.944953 0.0147558 0.0095281
R-HSA-157118 Signaling by NOTCH 224 1.939001 0.0147558 0.0095281
R-HSA-4755510 SUMOylation of immune response proteins 11 1.938659 0.0147558 0.0095281
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 95 1.934964 0.0147558 0.0095281
R-HSA-8941856 RUNX3 regulates NOTCH signaling 14 1.925882 0.0147558 0.0095281
R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 11 1.922341 0.0147558 0.0095281
R-HSA-2470946 Cohesin Loading onto Chromatin 10 1.917789 0.0147558 0.0095281
R-HSA-5213460 RIPK1-mediated regulated necrosis 19 1.914879 0.0147558 0.0095281
R-HSA-5218859 Regulated Necrosis 19 1.914879 0.0147558 0.0095281
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 29 1.913908 0.0151148 0.0097599
R-HSA-8874081 MET activates PTK2 signaling 30 1.912836 0.0147558 0.0095281
R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 43 1.910455 0.0147558 0.0095281
R-HSA-166663 Initial triggering of complement 18 1.897928 0.0147558 0.0095281
R-HSA-8940973 RUNX2 regulates osteoblast differentiation 23 1.894360 0.0147558 0.0095281
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 10 1.892793 0.0147558 0.0095281
R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 13 1.891067 0.0154234 0.0099592
R-HSA-2468052 Establishment of Sister Chromatid Cohesion 11 1.890788 0.0220671 0.0142491
R-HSA-1474228 Degradation of the extracellular matrix 117 1.886363 0.0147558 0.0095281
R-HSA-3000178 ECM proteoglycans 70 1.877492 0.0147558 0.0095281
R-HSA-156902 Peptide chain elongation 85 1.875282 0.0147558 0.0095281
R-HSA-2129379 Molecules associated with elastic fibres 36 1.869785 0.0147558 0.0095281
R-HSA-877300 Interferon gamma signaling 83 1.869736 0.0147558 0.0095281
R-HSA-844456 The NLRP3 inflammasome 15 1.869192 0.0147558 0.0095281
R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand 16 1.862439 0.0153052 0.0098828
R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 63 1.861543 0.0147558 0.0095281
R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 31 1.851776 0.0148705 0.0096022
R-HSA-380108 Chemokine receptors bind chemokines 24 1.843850 0.0147558 0.0095281
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 55 1.841317 0.0147558 0.0095281
R-HSA-2871809 FCERI mediated Ca+2 mobilization 31 1.836736 0.0148705 0.0096022
R-HSA-3000171 Non-integrin membrane-ECM interactions 59 1.836485 0.0147558 0.0095281
R-HSA-195258 RHO GTPase Effectors 304 1.820929 0.0147558 0.0095281
R-HSA-194315 Signaling by Rho GTPases 427 1.816330 0.0147558 0.0095281
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 91 1.815893 0.0147558 0.0095281
R-HSA-209560 NF-kB is activated and signals survival 13 1.808667 0.0280512 0.0181132
R-HSA-933542 TRAF6 mediated NF-kB activation 22 1.805904 0.0211187 0.0136367
R-HSA-156842 Eukaryotic Translation Elongation 88 1.803296 0.0147558 0.0095281
R-HSA-2029481 FCGR activation 11 1.798845 0.0336173 0.0217073
R-HSA-8948216 Collagen chain trimerization 42 1.797346 0.0147558 0.0095281
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 23 1.796343 0.0150909 0.0097445
R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 36 1.795118 0.0147558 0.0095281
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 12 1.792613 0.0279866 0.0180715
R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 12 1.791496 0.0279866 0.0180715
R-HSA-5675482 Regulation of necroptotic cell death 17 1.791205 0.0153082 0.0098848
R-HSA-2243919 Crosslinking of collagen fibrils 18 1.784329 0.0333499 0.0215347
R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 12 1.783150 0.0334883 0.0216240
R-HSA-111465 Apoptotic cleavage of cellular proteins 38 1.782761 0.0147558 0.0095281
R-HSA-76009 Platelet Aggregation (Plug Formation) 33 1.776749 0.0147558 0.0095281
R-HSA-72689 Formation of a pool of free 40S subunits 97 1.773328 0.0147558 0.0095281
R-HSA-3000480 Scavenging by Class A Receptors 18 1.770127 0.0333499 0.0215347
R-HSA-192823 Viral mRNA Translation 85 1.768078 0.0147558 0.0095281
R-HSA-193639 p75NTR signals via NF-kB 16 1.763027 0.0216744 0.0139956
R-HSA-202433 Generation of second messenger molecules 26 1.757591 0.0151148 0.0097599
R-HSA-8941326 RUNX2 regulates bone development 30 1.757124 0.0151148 0.0097599
R-HSA-75205 Dissolution of Fibrin Clot 10 1.751658 0.0336173 0.0217073
R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 14 1.739092 0.0439633 0.0283879
R-HSA-75153 Apoptotic execution phase 52 1.738860 0.0200338 0.0129362
R-HSA-5621480 Dectin-2 family 12 1.738387 0.0433056 0.0279633
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 17 1.737595 0.0433056 0.0279633
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 15 1.733083 0.0383197 0.0247437
R-HSA-622312 Inflammasomes 20 1.732823 0.0277998 0.0179509
R-HSA-5655862 Translesion synthesis by POLK 17 1.732333 0.0433056 0.0279633
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 12 1.729172 0.0433056 0.0279633
R-HSA-1980145 Signaling by NOTCH2 31 1.725154 0.0263370 0.0170063
R-HSA-446353 Cell-extracellular matrix interactions 18 1.725146 0.0384807 0.0248477
R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 12 1.724677 0.0433056 0.0279633
R-HSA-3000157 Laminin interactions 30 1.724279 0.0210780 0.0136105
R-HSA-72764 Eukaryotic Translation Termination 89 1.720346 0.0147558 0.0095281
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 12 1.703555 0.0480998 0.0310589
R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 17 1.698662 0.0478871 0.0309216
R-HSA-937041 IKK complex recruitment mediated by RIP1 25 1.682508 0.0325298 0.0210051
R-HSA-350054 Notch-HLH transcription pathway 28 1.681517 0.0325298 0.0210051
R-HSA-73887 Death Receptor Signalling 134 1.671640 0.0147558 0.0095281
R-HSA-201681 TCF dependent signaling in response to WNT 215 1.671581 0.0147558 0.0095281
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 23 1.671287 0.0460137 0.0297119
R-HSA-909733 Interferon alpha/beta signaling 56 1.659692 0.0147558 0.0095281
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS) 35 1.659660 0.0315379 0.0203646
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 20 1.659234 0.0432009 0.0278956
R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex 31 1.647604 0.0412447 0.0266325
R-HSA-202733 Cell surface interactions at the vascular wall 110 1.642448 0.0147558 0.0095281
R-HSA-449147 Signaling by Interleukins 393 1.642303 0.0147558 0.0095281
R-HSA-168898 Toll-like Receptor Cascades 146 1.640740 0.0147558 0.0095281
R-HSA-114604 GPVI-mediated activation cascade 31 1.639668 0.0498069 0.0321613
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins 36 1.628517 0.0498069 0.0321613
R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 58 1.628071 0.0354229 0.0228732
R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 43 1.617457 0.0406272 0.0262337
R-HSA-9012852 Signaling by NOTCH3 47 1.605728 0.0366911 0.0236921
R-HSA-68886 M Phase 370 1.602841 0.0147558 0.0095281
R-HSA-2408557 Selenocysteine synthesis 89 1.600130 0.0147558 0.0095281
R-HSA-170834 Signaling by TGF-beta Receptor Complex 72 1.598184 0.0360057 0.0232496
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 124 1.596183 0.0147558 0.0095281
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 107 1.587028 0.0147558 0.0095281
R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 47 1.580947 0.0457982 0.0295727
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 102 1.580331 0.0147558 0.0095281
R-HSA-194840 Rho GTPase cycle 133 1.552178 0.0147558 0.0095281
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 108 1.550432 0.0147558 0.0095281
R-HSA-913531 Interferon Signaling 176 1.548906 0.0147558 0.0095281
R-HSA-9006936 Signaling by TGF-beta family members 97 1.537075 0.0147558 0.0095281
R-HSA-927802 Nonsense-Mediated Decay (NMD) 110 1.535218 0.0147558 0.0095281
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 110 1.535218 0.0147558 0.0095281
R-HSA-8957275 Post-translational protein phosphorylation 93 1.508154 0.0250671 0.0161863
R-HSA-72613 Eukaryotic Translation Initiation 115 1.501685 0.0389742 0.0251664
R-HSA-72737 Cap-dependent Translation Initiation 115 1.501685 0.0389742 0.0251664
R-HSA-6806834 Signaling by MET 78 1.500242 0.0498069 0.0321613
R-HSA-193704 p75 NTR receptor-mediated signalling 93 1.477552 0.0350586 0.0226380
R-HSA-73894 DNA Repair 322 1.453064 0.0147558 0.0095281
R-HSA-195721 Signaling by WNT 309 1.448673 0.0147558 0.0095281
R-HSA-2262752 Cellular responses to stress 405 1.436950 0.0147558 0.0095281
Enriched terms for module #84AD00 (MTcor = -0.93)
ID Description setSize NES p.adjust qvalues
R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport 170 3.041814 0.0163383 0.0108580
R-HSA-611105 Respiratory electron transport 100 3.001511 0.0163383 0.0108580
R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 122 2.963208 0.0163383 0.0108580
R-HSA-6799198 Complex I biogenesis 55 2.687405 0.0163383 0.0108580
R-HSA-5576892 Phase 0 - rapid depolarisation 45 2.672837 0.0163383 0.0108580
R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle 52 2.566007 0.0163383 0.0108580
R-HSA-888590 GABA synthesis, release, reuptake and degradation 19 2.531036 0.0163383 0.0108580
R-HSA-1268020 Mitochondrial protein import 63 2.472878 0.0163383 0.0108580
R-HSA-112316 Neuronal System 379 2.463509 0.0163383 0.0108580
R-HSA-1296072 Voltage gated Potassium channels 40 2.462057 0.0163383 0.0108580
R-HSA-71403 Citric acid cycle (TCA cycle) 22 2.459002 0.0163383 0.0108580
R-HSA-399719 Trafficking of AMPA receptors 30 2.431389 0.0163383 0.0108580
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 30 2.431389 0.0163383 0.0108580
R-HSA-112315 Transmission across Chemical Synapses 245 2.428739 0.0163383 0.0108580
R-HSA-180024 DARPP-32 events 25 2.387230 0.0163383 0.0108580
R-HSA-5682910 LGI-ADAM interactions 14 2.375936 0.0163383 0.0108580
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 21 2.369297 0.0163383 0.0108580
R-HSA-112310 Neurotransmitter release cycle 47 2.337743 0.0163383 0.0108580
R-HSA-5339562 Uptake and actions of bacterial toxins 30 2.313288 0.0163383 0.0108580
R-HSA-442755 Activation of NMDA receptors and postsynaptic events 84 2.289119 0.0163383 0.0108580
R-HSA-5389840 Mitochondrial translation elongation 86 2.273528 0.0163383 0.0108580
R-HSA-445095 Interaction between L1 and Ankyrins 29 2.272928 0.0163383 0.0108580
R-HSA-5368287 Mitochondrial translation 92 2.245909 0.0163383 0.0108580
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission 184 2.245515 0.0163383 0.0108580
R-HSA-111933 Calmodulin induced events 35 2.242523 0.0163383 0.0108580
R-HSA-111997 CaM pathway 35 2.242523 0.0163383 0.0108580
R-HSA-168799 Neurotoxicity of clostridium toxins 10 2.212582 0.0163383 0.0108580
R-HSA-5368286 Mitochondrial translation initiation 86 2.207501 0.0163383 0.0108580
R-HSA-111996 Ca-dependent events 37 2.207053 0.0163383 0.0108580
R-HSA-5419276 Mitochondrial translation termination 86 2.203616 0.0163383 0.0108580
R-HSA-351202 Metabolism of polyamines 83 2.190904 0.0163383 0.0108580
R-HSA-1489509 DAG and IP3 signaling 41 2.189185 0.0163383 0.0108580
R-HSA-111885 Opioid Signalling 86 2.172653 0.0163383 0.0108580
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 22 2.157266 0.0163383 0.0108580
R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 49 2.153131 0.0163383 0.0108580
R-HSA-438064 Post NMDA receptor activation events 73 2.150059 0.0163383 0.0108580
R-HSA-1296071 Potassium Channels 92 2.126784 0.0163383 0.0108580
R-HSA-379716 Cytosolic tRNA aminoacylation 24 2.120236 0.0163383 0.0108580
R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 47 2.084574 0.0163383 0.0108580
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 12 2.084286 0.0163383 0.0108580
R-HSA-416993 Trafficking of GluR2-containing AMPA receptors 16 2.075714 0.0163383 0.0108580
R-HSA-8949613 Cristae formation 31 2.075215 0.0163383 0.0108580
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 22 2.046009 0.0245170 0.0162933
R-HSA-9604323 Negative regulation of NOTCH4 signaling 54 2.042919 0.0163383 0.0108580
R-HSA-9620244 Long-term potentiation 24 2.035952 0.0163383 0.0108580
R-HSA-5673000 RAF activation 32 2.019711 0.0163383 0.0108580
R-HSA-9609507 Protein localization 158 2.018606 0.0163383 0.0108580
R-HSA-70221 Glycogen breakdown (glycogenolysis) 17 2.016710 0.0163383 0.0108580
R-HSA-5628897 TP53 Regulates Metabolic Genes 84 2.011609 0.0163383 0.0108580
R-HSA-442729 CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde 10 2.011388 0.0163383 0.0108580
R-HSA-4641258 Degradation of DVL 55 2.006998 0.0163383 0.0108580
R-HSA-163615 PKA activation 18 2.002056 0.0163383 0.0108580
R-HSA-112043 PLC beta mediated events 50 2.001917 0.0163383 0.0108580
R-HSA-212676 Dopamine Neurotransmitter Release Cycle 22 1.998753 0.0319771 0.0212511
R-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis 12 1.997021 0.0163383 0.0108580
R-HSA-210500 Glutamate Neurotransmitter Release Cycle 24 1.992552 0.0245170 0.0162933
R-HSA-5610783 Degradation of GLI2 by the proteasome 57 1.979908 0.0163383 0.0108580
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 29 1.978334 0.0245170 0.0162933
R-HSA-8951664 Neddylation 225 1.976975 0.0163383 0.0108580
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 34 1.976486 0.0245170 0.0162933
R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 13 1.975404 0.0163383 0.0108580
R-HSA-5610780 Degradation of GLI1 by the proteasome 57 1.971102 0.0163383 0.0108580
R-HSA-5578775 Ion homeostasis 53 1.970579 0.0163383 0.0108580
R-HSA-112040 G-protein mediated events 51 1.967535 0.0163383 0.0108580
R-HSA-5576891 Cardiac conduction 131 1.954009 0.0163383 0.0108580
R-HSA-5099900 WNT5A-dependent internalization of FZD4 15 1.945404 0.0245170 0.0162933
R-HSA-169911 Regulation of Apoptosis 51 1.941266 0.0163383 0.0108580
R-HSA-8939902 Regulation of RUNX2 expression and activity 70 1.938164 0.0163383 0.0108580
R-HSA-5676590 NIK–>noncanonical NF-kB signaling 56 1.936767 0.0163383 0.0108580
R-HSA-163685 Integration of energy metabolism 101 1.933458 0.0163383 0.0108580
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 62 1.927796 0.0163383 0.0108580
R-HSA-68867 Assembly of the pre-replicative complex 65 1.926250 0.0163383 0.0108580
R-HSA-5210891 Uptake and function of anthrax toxins 13 1.926208 0.0245170 0.0162933
R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 57 1.922772 0.0163383 0.0108580
R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex 57 1.921878 0.0163383 0.0108580
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 45 1.915043 0.0163383 0.0108580
R-HSA-180585 Vif-mediated degradation of APOBEC3G 52 1.913775 0.0245170 0.0162933
R-HSA-379724 tRNA Aminoacylation 42 1.913478 0.0248666 0.0165257
R-HSA-451306 Ionotropic activity of kainate receptors 12 1.906336 0.0245170 0.0162933
R-HSA-451308 Activation of Ca-permeable Kainate Receptor 12 1.906336 0.0245170 0.0162933
R-HSA-181429 Serotonin Neurotransmitter Release Cycle 17 1.903568 0.0163383 0.0108580
R-HSA-1592230 Mitochondrial biogenesis 94 1.903230 0.0163383 0.0108580
R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 50 1.900190 0.0163383 0.0108580
R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 48 1.899298 0.0163383 0.0108580
R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 50 1.897284 0.0163383 0.0108580
R-HSA-69610 p53-Independent DNA Damage Response 50 1.897284 0.0163383 0.0108580
R-HSA-69613 p53-Independent G1/S DNA damage checkpoint 50 1.897284 0.0163383 0.0108580
R-HSA-163210 Formation of ATP by chemiosmotic coupling 18 1.896052 0.0319771 0.0212511
R-HSA-177504 Retrograde neurotrophin signalling 14 1.894044 0.0245170 0.0162933
R-HSA-5610787 Hedgehog ‘off’ state 108 1.890758 0.0163383 0.0108580
R-HSA-8856688 Golgi-to-ER retrograde transport 124 1.890283 0.0163383 0.0108580
R-HSA-8948751 Regulation of PTEN stability and activity 67 1.888547 0.0163383 0.0108580
R-HSA-5362768 Hh mutants that don’t undergo autocatalytic processing are degraded by ERAD 54 1.883881 0.0245170 0.0162933
R-HSA-8949215 Mitochondrial calcium ion transport 23 1.881357 0.0245170 0.0162933
R-HSA-70263 Gluconeogenesis 29 1.878854 0.0245170 0.0162933
R-HSA-422356 Regulation of insulin secretion 73 1.875978 0.0163383 0.0108580
R-HSA-6794362 Protein-protein interactions at synapses 87 1.870723 0.0163383 0.0108580
R-HSA-8849932 Synaptic adhesion-like molecules 21 1.869932 0.0383797 0.0255061
R-HSA-8949664 Processing of SMDT1 16 1.869291 0.0245170 0.0162933
R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 52 1.867612 0.0245170 0.0162933
R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 14 1.859296 0.0245170 0.0162933
R-HSA-77387 Insulin receptor recycling 23 1.858300 0.0319771 0.0212511
R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 57 1.857786 0.0163383 0.0108580
R-HSA-180534 Vpu mediated degradation of CD4 50 1.853985 0.0163383 0.0108580
R-HSA-4086400 PCP/CE pathway 89 1.836665 0.0163383 0.0108580
R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 50 1.832836 0.0245170 0.0162933
R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 53 1.831612 0.0245170 0.0162933
R-HSA-5387390 Hh mutants abrogate ligand secretion 56 1.826422 0.0245170 0.0162933
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 81 1.816836 0.0245170 0.0162933
R-HSA-1222556 ROS and RNS production in phagocytes 34 1.813762 0.0245170 0.0162933
R-HSA-111931 PKA-mediated phosphorylation of CREB 20 1.812149 0.0440225 0.0292561
R-HSA-4641257 Degradation of AXIN 53 1.807226 0.0245170 0.0162933
R-HSA-917977 Transferrin endocytosis and recycling 29 1.805510 0.0319771 0.0212511
R-HSA-5658442 Regulation of RAS by GAPs 66 1.805475 0.0163383 0.0108580
R-HSA-8854214 TBC/RABGAPs 44 1.791965 0.0163383 0.0108580
R-HSA-3858494 Beta-catenin independent WNT signaling 139 1.791632 0.0163383 0.0108580
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 64 1.790568 0.0245170 0.0162933
R-HSA-1632852 Macroautophagy 91 1.789106 0.0163383 0.0108580
R-HSA-112308 Presynaptic depolarization and calcium channel opening 13 1.777247 0.0383797 0.0255061
R-HSA-164378 PKA activation in glucagon signalling 16 1.770856 0.0440225 0.0292561
R-HSA-373760 L1CAM interactions 111 1.764163 0.0163383 0.0108580
R-HSA-70326 Glucose metabolism 85 1.761742 0.0245170 0.0162933
R-HSA-2132295 MHC class II antigen presentation 110 1.755864 0.0163383 0.0108580
R-HSA-69052 Switching of origins to a post-replicative state 87 1.750889 0.0245170 0.0162933
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 69 1.750688 0.0163383 0.0108580
R-HSA-68949 Orc1 removal from chromatin 69 1.746567 0.0163383 0.0108580
R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 18 1.746453 0.0381679 0.0253653
R-HSA-8941858 Regulation of RUNX3 expression and activity 55 1.741963 0.0319771 0.0212511
R-HSA-195253 Degradation of beta-catenin by the destruction complex 80 1.741499 0.0245170 0.0162933
R-HSA-69541 Stabilization of p53 55 1.737300 0.0319771 0.0212511
R-HSA-451326 Activation of kainate receptors upon glutamate binding 31 1.736232 0.0441783 0.0293597
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 67 1.734365 0.0319771 0.0212511
R-HSA-1852241 Organelle biogenesis and maintenance 286 1.730745 0.0163383 0.0108580
R-HSA-70268 Pyruvate metabolism 28 1.728660 0.0440225 0.0292561
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 28 1.727284 0.0440225 0.0292561
R-HSA-74752 Signaling by Insulin receptor 66 1.726672 0.0383797 0.0255061
R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 70 1.711435 0.0245170 0.0162933
R-HSA-9007101 Rab regulation of trafficking 122 1.711344 0.0163383 0.0108580
R-HSA-9005891 Loss of function of MECP2 in Rett syndrome 14 1.710397 0.0495196 0.0329093
R-HSA-9005895 Pervasive developmental disorders 14 1.710397 0.0495196 0.0329093
R-HSA-418359 Reduction of cytosolic Ca++ levels 14 1.708907 0.0495196 0.0329093
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 69 1.707665 0.0245170 0.0162933
R-HSA-6807878 COPI-mediated anterograde transport 92 1.706563 0.0163383 0.0108580
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 13 1.705175 0.0440225 0.0292561
R-HSA-69002 DNA Replication Pre-Initiation 82 1.700688 0.0245170 0.0162933
R-HSA-8856828 Clathrin-mediated endocytosis 137 1.696411 0.0163383 0.0108580
R-HSA-5607764 CLEC7A (Dectin-1) signaling 98 1.694394 0.0319771 0.0212511
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 72 1.693267 0.0163383 0.0108580
R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 72 1.693267 0.0163383 0.0108580
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 69 1.690602 0.0319771 0.0212511
R-HSA-382556 ABC-family proteins mediated transport 100 1.689007 0.0319771 0.0212511
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 97 1.676854 0.0319771 0.0212511
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 129 1.676732 0.0163383 0.0108580
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 76 1.676132 0.0245170 0.0162933
R-HSA-445717 Aquaporin-mediated transport 44 1.674538 0.0387468 0.0257500
R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 60 1.666134 0.0319771 0.0212511
R-HSA-5358346 Hedgehog ligand biogenesis 62 1.662053 0.0383797 0.0255061
R-HSA-5673001 RAF/MAP kinase cascade 224 1.661475 0.0163383 0.0108580
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 38 1.655159 0.0383797 0.0255061
R-HSA-9006925 Intracellular signaling by second messengers 285 1.654087 0.0163383 0.0108580
R-HSA-4608870 Asymmetric localization of PCP proteins 62 1.645004 0.0383797 0.0255061
R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 39 1.640102 0.0387468 0.0257500
R-HSA-69563 p53-Dependent G1 DNA Damage Response 64 1.639945 0.0442887 0.0294330
R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 64 1.639945 0.0442887 0.0294330
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 91 1.638914 0.0319771 0.0212511
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 79 1.636608 0.0319771 0.0212511
R-HSA-380287 Centrosome maturation 79 1.636608 0.0319771 0.0212511
R-HSA-453274 Mitotic G2-G2/M phases 187 1.630348 0.0163383 0.0108580
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 296 1.630228 0.0163383 0.0108580
R-HSA-5621481 C-type lectin receptors (CLRs) 123 1.629426 0.0163383 0.0108580
R-HSA-1483255 PI Metabolism 82 1.628843 0.0319771 0.0212511
R-HSA-936837 Ion transport by P-type ATPases 54 1.617549 0.0384958 0.0255832
R-HSA-5619084 ABC transporter disorders 75 1.615030 0.0319771 0.0212511
R-HSA-69615 G1/S DNA Damage Checkpoints 66 1.613393 0.0383797 0.0255061
R-HSA-69275 G2/M Transition 185 1.605572 0.0163383 0.0108580
R-HSA-5684996 MAPK1/MAPK3 signaling 230 1.597186 0.0163383 0.0108580
R-HSA-5358351 Signaling by Hedgehog 143 1.596534 0.0163383 0.0108580
R-HSA-2871837 FCERI mediated NF-kB activation 78 1.593279 0.0383797 0.0255061
R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 54 1.591723 0.0496247 0.0329792
R-HSA-5678895 Defective CFTR causes cystic fibrosis 59 1.580100 0.0319771 0.0212511
R-HSA-70171 Glycolysis 68 1.577632 0.0440225 0.0292561
R-HSA-162909 Host Interactions of HIV factors 125 1.575720 0.0245170 0.0162933
R-HSA-6794361 Neurexins and neuroligins 56 1.574817 0.0440225 0.0292561
R-HSA-8986944 Transcriptional Regulation by MECP2 61 1.563358 0.0441783 0.0293597
R-HSA-69202 Cyclin E associated events during G1/S transition 83 1.562412 0.0495196 0.0329093
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 86 1.552969 0.0495196 0.0329093
R-HSA-983712 Ion channel transport 168 1.520687 0.0163383 0.0108580
R-HSA-397014 Muscle contraction 187 1.513686 0.0163383 0.0108580
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 191 1.490328 0.0319413 0.0212273
R-HSA-199977 ER to Golgi Anterograde Transport 142 1.478753 0.0319771 0.0212511
R-HSA-162906 HIV Infection 224 1.450722 0.0245170 0.0162933
R-HSA-5683057 MAPK family signaling cascades 266 1.433513 0.0163383 0.0108580
R-HSA-69481 G2/M Checkpoints 162 1.433334 0.0434028 0.0288443
R-HSA-195721 Signaling by WNT 309 1.385512 0.0319771 0.0212511
rm(df)


Gene Ontology

for(module in top_modules){
  df = enrichment_GO[[module]] %>% dplyr::select(ID, Description, setSize, NES, p.adjust, qvalues) %>% arrange(desc(NES)) %>% filter(NES>0)
  if(nrow(df)>0){
    print(kable(df, caption = paste0('Enriched terms for module ', module, ' (MTcor = ', round(dataset$MTcor[dataset$Module==module][1],2),')')))
    cat('\n') 
  } else cat(paste0('\nNo enrichment found for module ',module,'\n'))
}
Enriched terms for module #00B9E3 (MTcor = -0.93)
ID Description setSize NES p.adjust qvalues
GO:0042775 mitochondrial ATP synthesis coupled electron transport 87 2.752686 0.0329885 0.0231737
GO:0042773 ATP synthesis coupled electron transport 88 2.726014 0.0329885 0.0231737
GO:0098693 regulation of synaptic vesicle cycle 105 2.684098 0.0329885 0.0231737
GO:1900449 regulation of glutamate receptor signaling pathway 54 2.666107 0.0329885 0.0231737
GO:0099504 synaptic vesicle cycle 158 2.665682 0.0329885 0.0231737
GO:0022904 respiratory electron transport chain 104 2.661921 0.0329885 0.0231737
GO:0007269 neurotransmitter secretion 142 2.655961 0.0329885 0.0231737
GO:0099643 signal release from synapse 143 2.645728 0.0329885 0.0231737
GO:0099003 vesicle-mediated transport in synapse 171 2.630220 0.0329885 0.0231737
GO:2000310 regulation of NMDA receptor activity 33 2.616300 0.0329885 0.0231737
GO:0016079 synaptic vesicle exocytosis 99 2.597362 0.0329885 0.0231737
GO:1902803 regulation of synaptic vesicle transport 75 2.562522 0.0329885 0.0231737
GO:0048489 synaptic vesicle transport 125 2.552998 0.0329885 0.0231737
GO:0097480 establishment of synaptic vesicle localization 125 2.552998 0.0329885 0.0231737
GO:0017156 calcium ion regulated exocytosis 124 2.551871 0.0329885 0.0231737
GO:0097479 synaptic vesicle localization 135 2.549518 0.0329885 0.0231737
GO:0099601 regulation of neurotransmitter receptor activity 62 2.546387 0.0329885 0.0231737
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 54 2.543747 0.0329885 0.0231737
GO:0046928 regulation of neurotransmitter secretion 93 2.537430 0.0329885 0.0231737
GO:2001257 regulation of cation channel activity 150 2.525697 0.0329885 0.0231737
GO:0036465 synaptic vesicle recycling 49 2.514152 0.0329885 0.0231737
GO:0017158 regulation of calcium ion-dependent exocytosis 90 2.499577 0.0329885 0.0231737
GO:2000300 regulation of synaptic vesicle exocytosis 70 2.488736 0.0329885 0.0231737
GO:0007215 glutamate receptor signaling pathway 81 2.478794 0.0329885 0.0231737
GO:0045333 cellular respiration 171 2.466633 0.0329885 0.0231737
GO:0006119 oxidative phosphorylation 128 2.447293 0.0329885 0.0231737
GO:0032412 regulation of ion transmembrane transporter activity 213 2.443186 0.0329885 0.0231737
GO:0048168 regulation of neuronal synaptic plasticity 46 2.436418 0.0329885 0.0231737
GO:0051588 regulation of neurotransmitter transport 124 2.428839 0.0329885 0.0231737
GO:0006836 neurotransmitter transport 222 2.425062 0.0329885 0.0231737
GO:0048167 regulation of synaptic plasticity 163 2.421073 0.0329885 0.0231737
GO:0010257 NADH dehydrogenase complex assembly 64 2.415002 0.0329885 0.0231737
GO:0032981 mitochondrial respiratory chain complex I assembly 64 2.415002 0.0329885 0.0231737
GO:0022898 regulation of transmembrane transporter activity 220 2.403669 0.0329885 0.0231737
GO:0032594 protein transport within lipid bilayer 20 2.403186 0.0329885 0.0231737
GO:1903421 regulation of synaptic vesicle recycling 24 2.383206 0.0329885 0.0231737
GO:0032409 regulation of transporter activity 231 2.362543 0.0329885 0.0231737
GO:0098877 neurotransmitter receptor transport to plasma membrane 12 2.357005 0.0329885 0.0231737
GO:0098969 neurotransmitter receptor transport to postsynaptic membrane 12 2.357005 0.0329885 0.0231737
GO:0106027 neuron projection organization 83 2.356722 0.0329885 0.0231737
GO:0099177 regulation of trans-synaptic signaling 375 2.356608 0.0329885 0.0231737
GO:0050804 modulation of chemical synaptic transmission 374 2.355858 0.0329885 0.0231737
GO:1903540 establishment of protein localization to postsynaptic membrane 13 2.354112 0.0329885 0.0231737
GO:0060997 dendritic spine morphogenesis 55 2.344730 0.0329885 0.0231737
GO:0061001 regulation of dendritic spine morphogenesis 42 2.339339 0.0329885 0.0231737
GO:0048169 regulation of long-term neuronal synaptic plasticity 25 2.312561 0.0329885 0.0231737
GO:0048488 synaptic vesicle endocytosis 37 2.306396 0.0329885 0.0231737
GO:0140238 presynaptic endocytosis 37 2.306396 0.0329885 0.0231737
GO:0061003 positive regulation of dendritic spine morphogenesis 20 2.302480 0.0329885 0.0231737
GO:0051650 establishment of vesicle localization 245 2.300951 0.0329885 0.0231737
GO:0051648 vesicle localization 261 2.295127 0.0329885 0.0231737
GO:0099632 protein transport within plasma membrane 13 2.281090 0.0329885 0.0231737
GO:0099637 neurotransmitter receptor transport 13 2.281090 0.0329885 0.0231737
GO:0014047 glutamate secretion 41 2.253292 0.0329885 0.0231737
GO:0097061 dendritic spine organization 75 2.231333 0.0329885 0.0231737
GO:0015672 monovalent inorganic cation transport 407 2.231038 0.0329885 0.0231737
GO:0034765 regulation of ion transmembrane transport 408 2.228250 0.0329885 0.0231737
GO:1902600 proton transmembrane transport 128 2.224872 0.0329885 0.0231737
GO:0060078 regulation of postsynaptic membrane potential 119 2.216082 0.0329885 0.0231737
GO:1904062 regulation of cation transmembrane transport 283 2.205013 0.0329885 0.0231737
GO:0022900 electron transport chain 162 2.198388 0.0329885 0.0231737
GO:1903008 organelle disassembly 78 2.195911 0.0329885 0.0231737
GO:0006101 citrate metabolic process 28 2.194922 0.0329885 0.0231737
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 67 2.184075 0.0329885 0.0231737
GO:2001259 positive regulation of cation channel activity 63 2.178469 0.0329885 0.0231737
GO:0006813 potassium ion transport 169 2.177620 0.0329885 0.0231737
GO:0000422 autophagy of mitochondrion 55 2.159412 0.0329885 0.0231737
GO:0061726 mitochondrion disassembly 55 2.159412 0.0329885 0.0231737
GO:0009060 aerobic respiration 66 2.158508 0.0329885 0.0231737
GO:0071804 cellular potassium ion transport 121 2.155527 0.0329885 0.0231737
GO:0071805 potassium ion transmembrane transport 121 2.155527 0.0329885 0.0231737
GO:0023061 signal release 380 2.154357 0.0329885 0.0231737
GO:0098814 spontaneous synaptic transmission 11 2.149657 0.0329885 0.0231737
GO:0007612 learning 137 2.143456 0.0329885 0.0231737
GO:0008306 associative learning 73 2.138620 0.0329885 0.0231737
GO:0050808 synapse organization 378 2.136757 0.0329885 0.0231737
GO:0072384 organelle transport along microtubule 71 2.132737 0.0329885 0.0231737
GO:0016082 synaptic vesicle priming 12 2.132542 0.0329885 0.0231737
GO:0001963 synaptic transmission, dopaminergic 24 2.131702 0.0329885 0.0231737
GO:0033108 mitochondrial respiratory chain complex assembly 87 2.128374 0.0329885 0.0231737
GO:0015980 energy derivation by oxidation of organic compounds 251 2.124345 0.0329885 0.0231737
GO:1901524 regulation of mitophagy 17 2.117759 0.0329885 0.0231737
GO:0007611 learning or memory 229 2.114837 0.0329885 0.0231737
GO:0034762 regulation of transmembrane transport 475 2.113879 0.0329885 0.0231737
GO:0006099 tricarboxylic acid cycle 26 2.113357 0.0329885 0.0231737
GO:0031111 negative regulation of microtubule polymerization or depolymerization 32 2.105158 0.0329885 0.0231737
GO:0035637 multicellular organismal signaling 176 2.104921 0.0329885 0.0231737
GO:0033238 regulation of cellular amine metabolic process 74 2.103478 0.0329885 0.0231737
GO:0017157 regulation of exocytosis 181 2.100406 0.0329885 0.0231737
GO:0060996 dendritic spine development 93 2.098832 0.0329885 0.0231737
GO:0050775 positive regulation of dendrite morphogenesis 35 2.095214 0.0329885 0.0231737
GO:0099132 ATP hydrolysis coupled cation transmembrane transport 52 2.090769 0.0329885 0.0231737
GO:0045653 negative regulation of megakaryocyte differentiation 17 2.088769 0.0329885 0.0231737
GO:0097484 dendrite extension 32 2.088652 0.0329885 0.0231737
GO:0046034 ATP metabolic process 274 2.085203 0.0329885 0.0231737
GO:0009126 purine nucleoside monophosphate metabolic process 304 2.080307 0.0329885 0.0231737
GO:0048172 regulation of short-term neuronal synaptic plasticity 12 2.079671 0.0329885 0.0231737
GO:0038095 Fc-epsilon receptor signaling pathway 106 2.079635 0.0329885 0.0231737
GO:0035418 protein localization to synapse 55 2.079553 0.0329885 0.0231737
GO:0042391 regulation of membrane potential 338 2.079527 0.0329885 0.0231737
GO:0007007 inner mitochondrial membrane organization 37 2.078651 0.0329885 0.0231737
GO:0007005 mitochondrion organization 452 2.075925 0.0329885 0.0231737
GO:0042407 cristae formation 30 2.075763 0.0329885 0.0231737
GO:0009205 purine ribonucleoside triphosphate metabolic process 300 2.074523 0.0329885 0.0231737
GO:0035641 locomotory exploration behavior 12 2.074474 0.0329885 0.0231737
GO:0009167 purine ribonucleoside monophosphate metabolic process 303 2.073122 0.0329885 0.0231737
GO:0050905 neuromuscular process 87 2.072795 0.0329885 0.0231737
GO:1903305 regulation of regulated secretory pathway 134 2.070448 0.0329885 0.0231737
GO:0009199 ribonucleoside triphosphate metabolic process 305 2.065402 0.0329885 0.0231737
GO:0048813 dendrite morphogenesis 130 2.062597 0.0329885 0.0231737
GO:0009161 ribonucleoside monophosphate metabolic process 316 2.062330 0.0329885 0.0231737
GO:0060998 regulation of dendritic spine development 70 2.056195 0.0329885 0.0231737
GO:0051952 regulation of amine transport 63 2.055964 0.0329885 0.0231737
GO:0009144 purine nucleoside triphosphate metabolic process 307 2.054471 0.0329885 0.0231737
GO:0007006 mitochondrial membrane organization 115 2.053742 0.0329885 0.0231737
GO:1901021 positive regulation of calcium ion transmembrane transporter activity 37 2.053205 0.0329885 0.0231737
GO:0032414 positive regulation of ion transmembrane transporter activity 94 2.050044 0.0329885 0.0231737
GO:0035773 insulin secretion involved in cellular response to glucose stimulus 57 2.050026 0.0329885 0.0231737
GO:1903539 protein localization to postsynaptic membrane 27 2.049038 0.0329885 0.0231737
GO:0035640 exploration behavior 23 2.047852 0.0329885 0.0231737
GO:0045956 positive regulation of calcium ion-dependent exocytosis 22 2.044626 0.0329885 0.0231737
GO:0001505 regulation of neurotransmitter levels 289 2.044403 0.0329885 0.0231737
GO:0048667 cell morphogenesis involved in neuron differentiation 469 2.041336 0.0329885 0.0231737
GO:0060999 positive regulation of dendritic spine development 41 2.037936 0.0329885 0.0231737
GO:0048814 regulation of dendrite morphogenesis 81 2.037870 0.0329885 0.0231737
GO:0009123 nucleoside monophosphate metabolic process 332 2.034644 0.0329885 0.0231737
GO:0010765 positive regulation of sodium ion transport 29 2.033345 0.0329885 0.0231737
GO:0051965 positive regulation of synapse assembly 62 2.032590 0.0329885 0.0231737
GO:1903146 regulation of autophagy of mitochondrion 41 2.032109 0.0329885 0.0231737
GO:0000266 mitochondrial fission 30 2.029498 0.0329885 0.0231737
GO:1903533 regulation of protein targeting 79 2.026574 0.0329885 0.0231737
GO:0015837 amine transport 66 2.025659 0.0329885 0.0231737
GO:0051705 multi-organism behavior 60 2.022718 0.0329885 0.0231737
GO:1903859 regulation of dendrite extension 23 2.019414 0.0329885 0.0231737
GO:0009141 nucleoside triphosphate metabolic process 323 2.017744 0.0329885 0.0231737
GO:0015800 acidic amino acid transport 60 2.017187 0.0329885 0.0231737
GO:1990138 neuron projection extension 141 2.016415 0.0329885 0.0231737
GO:1903779 regulation of cardiac conduction 65 2.015895 0.0329885 0.0231737
GO:0000423 mitophagy 21 2.011547 0.0329885 0.0231737
GO:0061337 cardiac conduction 135 2.011043 0.0329885 0.0231737
GO:0050803 regulation of synapse structure or activity 211 2.008698 0.0329885 0.0231737
GO:0051932 synaptic transmission, GABAergic 36 2.008470 0.0329885 0.0231737
GO:0010976 positive regulation of neuron projection development 249 2.007464 0.0329885 0.0231737
GO:0050806 positive regulation of synaptic transmission 138 2.005569 0.0329885 0.0231737
GO:0097120 receptor localization to synapse 35 2.003388 0.0329885 0.0231737
GO:0070050 neuron cellular homeostasis 30 2.001539 0.0329885 0.0231737
GO:0050432 catecholamine secretion 36 1.999757 0.0329885 0.0231737
GO:0006626 protein targeting to mitochondrion 84 1.995634 0.0329885 0.0231737
GO:0051646 mitochondrion localization 41 1.995059 0.0329885 0.0231737
GO:0042551 neuron maturation 42 1.995024 0.0329885 0.0231737
GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 47 1.994632 0.0329885 0.0231737
GO:0007626 locomotory behavior 171 1.990999 0.0329885 0.0231737
GO:0070585 protein localization to mitochondrion 123 1.990260 0.0329885 0.0231737
GO:0035249 synaptic transmission, glutamatergic 60 1.989865 0.0329885 0.0231737
GO:0007409 axonogenesis 364 1.989650 0.0329885 0.0231737
GO:0051937 catecholamine transport 48 1.989540 0.0329885 0.0231737
GO:0072350 tricarboxylic acid metabolic process 31 1.987657 0.0329885 0.0231737
GO:0072583 clathrin-dependent endocytosis 37 1.983597 0.0329885 0.0231737
GO:0050770 regulation of axonogenesis 143 1.983039 0.0329885 0.0231737
GO:0034643 establishment of mitochondrion localization, microtubule-mediated 18 1.982571 0.0329885 0.0231737
GO:0047497 mitochondrion transport along microtubule 18 1.982571 0.0329885 0.0231737
GO:0043950 positive regulation of cAMP-mediated signaling 19 1.982362 0.0329885 0.0231737
GO:0051963 regulation of synapse assembly 99 1.982270 0.0329885 0.0231737
GO:0051656 establishment of organelle localization 426 1.981614 0.0329885 0.0231737
GO:0032411 positive regulation of transporter activity 102 1.980314 0.0329885 0.0231737
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 17 1.977501 0.0329885 0.0231737
GO:0010970 transport along microtubule 141 1.976551 0.0329885 0.0231737
GO:0099111 microtubule-based transport 141 1.976551 0.0329885 0.0231737
GO:0072655 establishment of protein localization to mitochondrion 120 1.975209 0.0329885 0.0231737
GO:0007416 synapse assembly 163 1.974775 0.0329885 0.0231737
GO:0030705 cytoskeleton-dependent intracellular transport 152 1.969909 0.0329885 0.0231737
GO:0050890 cognition 261 1.967167 0.0329885 0.0231737
GO:0016241 regulation of macroautophagy 161 1.964031 0.0329885 0.0231737
GO:1900242 regulation of synaptic vesicle endocytosis 16 1.963537 0.0329885 0.0231737
GO:0051654 establishment of mitochondrion localization 21 1.960714 0.0329885 0.0231737
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 17 1.959332 0.0329885 0.0231737
GO:0019646 aerobic electron transport chain 17 1.959332 0.0329885 0.0231737
GO:0061564 axon development 403 1.956203 0.0329885 0.0231737
GO:0032402 melanosome transport 19 1.955188 0.0372897 0.0261952
GO:0045161 neuronal ion channel clustering 11 1.953780 0.0329885 0.0231737
GO:0050433 regulation of catecholamine secretion 34 1.952564 0.0361638 0.0254042
GO:0050807 regulation of synapse organization 207 1.951989 0.0329885 0.0231737
GO:0010822 positive regulation of mitochondrion organization 113 1.951196 0.0329885 0.0231737
GO:2000649 regulation of sodium ion transmembrane transporter activity 38 1.951137 0.0329885 0.0231737
GO:0035725 sodium ion transmembrane transport 92 1.942098 0.0329885 0.0231737
GO:0010975 regulation of neuron projection development 433 1.936125 0.0329885 0.0231737
GO:0009150 purine ribonucleotide metabolic process 471 1.935344 0.0329885 0.0231737
GO:0048308 organelle inheritance 13 1.932428 0.0329885 0.0231737
GO:0048313 Golgi inheritance 13 1.932428 0.0329885 0.0231737
GO:0009259 ribonucleotide metabolic process 485 1.929754 0.0329885 0.0231737
GO:0006734 NADH metabolic process 34 1.926405 0.0361638 0.0254042
GO:0019226 transmission of nerve impulse 46 1.925135 0.0361638 0.0254042
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 12 1.924772 0.0329885 0.0231737
GO:0018210 peptidyl-threonine modification 103 1.923904 0.0329885 0.0231737
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 50 1.922104 0.0361638 0.0254042
GO:0000338 protein deneddylation 10 1.920473 0.0332231 0.0233385
GO:0032225 regulation of synaptic transmission, dopaminergic 15 1.919432 0.0372328 0.0261552
GO:0015991 ATP hydrolysis coupled proton transport 24 1.917065 0.0365558 0.0256796
GO:0060079 excitatory postsynaptic potential 88 1.916596 0.0329885 0.0231737
GO:0033173 calcineurin-NFAT signaling cascade 35 1.915508 0.0361638 0.0254042
GO:0097720 calcineurin-mediated signaling 35 1.915508 0.0361638 0.0254042
GO:0006091 generation of precursor metabolites and energy 464 1.915246 0.0329885 0.0231737
GO:0015985 energy coupled proton transport, down electrochemical gradient 22 1.915053 0.0370308 0.0260133
GO:0015986 ATP synthesis coupled proton transport 22 1.915053 0.0370308 0.0260133
GO:0099173 postsynapse organization 154 1.915023 0.0329885 0.0231737
GO:0099188 postsynaptic cytoskeleton organization 10 1.913675 0.0332231 0.0233385
GO:0042537 benzene-containing compound metabolic process 18 1.913102 0.0329885 0.0231737
GO:0010644 cell communication by electrical coupling 29 1.912673 0.0329885 0.0231737
GO:0006883 cellular sodium ion homeostasis 12 1.912650 0.0329885 0.0231737
GO:0045666 positive regulation of neuron differentiation 321 1.911493 0.0329885 0.0231737
GO:0090140 regulation of mitochondrial fission 23 1.910528 0.0418253 0.0293813
GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient 25 1.910508 0.0364581 0.0256110
GO:0051954 positive regulation of amine transport 30 1.910092 0.0364581 0.0256110
GO:0099131 ATP hydrolysis coupled ion transmembrane transport 26 1.908546 0.0329885 0.0231737
GO:0007026 negative regulation of microtubule depolymerization 21 1.902486 0.0418288 0.0293838
GO:0035235 ionotropic glutamate receptor signaling pathway 23 1.902453 0.0418253 0.0293813
GO:0006163 purine nucleotide metabolic process 493 1.901963 0.0329885 0.0231737
GO:0006839 mitochondrial transport 215 1.901035 0.0329885 0.0231737
GO:0071322 cellular response to carbohydrate stimulus 122 1.900792 0.0329885 0.0231737
GO:0007632 visual behavior 47 1.899945 0.0361638 0.0254042
GO:0043266 regulation of potassium ion transport 83 1.898484 0.0329885 0.0231737
GO:0006007 glucose catabolic process 33 1.893309 0.0361638 0.0254042
GO:0032400 melanosome localization 23 1.891257 0.0418253 0.0293813
GO:0018107 peptidyl-threonine phosphorylation 95 1.891067 0.0329885 0.0231737
GO:0051904 pigment granule transport 20 1.889613 0.0371078 0.0260674
GO:0001508 action potential 108 1.883125 0.0329885 0.0231737
GO:0099565 chemical synaptic transmission, postsynaptic 96 1.882913 0.0329885 0.0231737
GO:0098930 axonal transport 50 1.882348 0.0361638 0.0254042
GO:0099518 vesicle cytoskeletal trafficking 43 1.882010 0.0329885 0.0231737
GO:0032401 establishment of melanosome localization 20 1.880900 0.0371078 0.0260674
GO:1903861 positive regulation of dendrite extension 21 1.879665 0.0418288 0.0293838
GO:0047496 vesicle transport along microtubule 38 1.879176 0.0361638 0.0254042
GO:0008542 visual learning 43 1.878617 0.0329885 0.0231737
GO:0007018 microtubule-based movement 215 1.877469 0.0329885 0.0231737
GO:0048588 developmental cell growth 194 1.877176 0.0329885 0.0231737
GO:0035306 positive regulation of dephosphorylation 51 1.875293 0.0361638 0.0254042
GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation 14 1.874695 0.0422693 0.0296932
GO:0086010 membrane depolarization during action potential 24 1.873622 0.0365558 0.0256796
GO:0016358 dendrite development 212 1.872788 0.0329885 0.0231737
GO:0032252 secretory granule localization 12 1.870949 0.0372897 0.0261952
GO:0045773 positive regulation of axon extension 40 1.865765 0.0364733 0.0256217
GO:0045760 positive regulation of action potential 10 1.862002 0.0332231 0.0233385
GO:0043524 negative regulation of neuron apoptotic process 129 1.861224 0.0329885 0.0231737
GO:0031338 regulation of vesicle fusion 24 1.858766 0.0365558 0.0256796
GO:1901016 regulation of potassium ion transmembrane transporter activity 48 1.856563 0.0361638 0.0254042
GO:0051966 regulation of synaptic transmission, glutamatergic 48 1.856446 0.0361638 0.0254042
GO:1901379 regulation of potassium ion transmembrane transport 70 1.854265 0.0329885 0.0231737
GO:0021955 central nervous system neuron axonogenesis 33 1.853617 0.0361638 0.0254042
GO:0042776 mitochondrial ATP synthesis coupled proton transport 21 1.853299 0.0493475 0.0346655
GO:0005513 detection of calcium ion 11 1.851566 0.0329885 0.0231737
GO:0015872 dopamine transport 29 1.851506 0.0414464 0.0291152
GO:0031115 negative regulation of microtubule polymerization 12 1.850001 0.0372897 0.0261952
GO:1902305 regulation of sodium ion transmembrane transport 47 1.848530 0.0361638 0.0254042
GO:0051875 pigment granule localization 24 1.848487 0.0365558 0.0256796
GO:0051905 establishment of pigment granule localization 21 1.846098 0.0493475 0.0346655
GO:0014046 dopamine secretion 19 1.844211 0.0372897 0.0261952
GO:0014059 regulation of dopamine secretion 19 1.844211 0.0372897 0.0261952
GO:0006335 DNA replication-dependent nucleosome assembly 32 1.843980 0.0412551 0.0289807
GO:0034723 DNA replication-dependent nucleosome organization 32 1.843980 0.0412551 0.0289807
GO:0090662 ATP hydrolysis coupled transmembrane transport 27 1.842097 0.0414183 0.0290954
GO:0014075 response to amine 43 1.840971 0.0361638 0.0254042
GO:0050884 neuromuscular process controlling posture 12 1.840520 0.0372897 0.0261952
GO:0043039 tRNA aminoacylation 45 1.840516 0.0361638 0.0254042
GO:0046785 microtubule polymerization 65 1.838624 0.0329885 0.0231737
GO:2000311 regulation of AMPA receptor activity 18 1.838282 0.0373115 0.0262105
GO:0099500 vesicle fusion to plasma membrane 10 1.837430 0.0332231 0.0233385
GO:0043038 amino acid activation 46 1.835369 0.0361638 0.0254042
GO:0008344 adult locomotory behavior 66 1.832419 0.0329885 0.0231737
GO:0031110 regulation of microtubule polymerization or depolymerization 68 1.832100 0.0329885 0.0231737
GO:0099560 synaptic membrane adhesion 25 1.831498 0.0364581 0.0256110
GO:0071333 cellular response to glucose stimulus 112 1.830380 0.0329885 0.0231737
GO:0016236 macroautophagy 267 1.830115 0.0329885 0.0231737
GO:0007631 feeding behavior 70 1.829381 0.0329885 0.0231737
GO:0030516 regulation of axon extension 73 1.829230 0.0329885 0.0231737
GO:0006521 regulation of cellular amino acid metabolic process 56 1.828062 0.0329885 0.0231737
GO:1903818 positive regulation of voltage-gated potassium channel activity 13 1.827941 0.0424425 0.0298149
GO:0031346 positive regulation of cell projection organization 334 1.826776 0.0329885 0.0231737
GO:0071326 cellular response to monosaccharide stimulus 114 1.826581 0.0329885 0.0231737
GO:0071331 cellular response to hexose stimulus 114 1.826581 0.0329885 0.0231737
GO:0086064 cell communication by electrical coupling involved in cardiac conduction 24 1.826574 0.0365558 0.0256796
GO:1902259 regulation of delayed rectifier potassium channel activity 15 1.826100 0.0495117 0.0347808
GO:0001967 suckling behavior 10 1.825988 0.0332231 0.0233385
GO:0008038 neuron recognition 36 1.824314 0.0361638 0.0254042
GO:0030534 adult behavior 120 1.823954 0.0329885 0.0231737
GO:0035864 response to potassium ion 12 1.823571 0.0372897 0.0261952
GO:0031114 regulation of microtubule depolymerization 23 1.823571 0.0418253 0.0293813
GO:0021954 central nervous system neuron development 73 1.822958 0.0329885 0.0231737
GO:0008088 axo-dendritic transport 60 1.822731 0.0399769 0.0280829
GO:0035307 positive regulation of protein dephosphorylation 39 1.820643 0.0364581 0.0256110
GO:0006814 sodium ion transport 160 1.820127 0.0329885 0.0231737
GO:0006103 2-oxoglutarate metabolic process 14 1.819521 0.0497435 0.0349437
GO:0043267 negative regulation of potassium ion transport 26 1.818268 0.0413027 0.0290142
GO:0031145 anaphase-promoting complex-dependent catabolic process 76 1.817985 0.0329885 0.0231737
GO:0006865 amino acid transport 122 1.817086 0.0329885 0.0231737
GO:0046717 acid secretion 91 1.817077 0.0329885 0.0231737
GO:0060627 regulation of vesicle-mediated transport 443 1.816982 0.0329885 0.0231737
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 78 1.816556 0.0329885 0.0231737
GO:1903747 regulation of establishment of protein localization to mitochondrion 70 1.815295 0.0329885 0.0231737
GO:0044106 cellular amine metabolic process 111 1.814096 0.0329885 0.0231737
GO:0099175 regulation of postsynapse organization 95 1.813649 0.0329885 0.0231737
GO:1903214 regulation of protein targeting to mitochondrion 44 1.812415 0.0361638 0.0254042
GO:0061615 glycolytic process through fructose-6-phosphate 27 1.810486 0.0470662 0.0330630
GO:0061620 glycolytic process through glucose-6-phosphate 27 1.810486 0.0470662 0.0330630
GO:0016242 negative regulation of macroautophagy 32 1.809182 0.0412551 0.0289807
GO:0006735 NADH regeneration 26 1.808499 0.0413027 0.0290142
GO:0061621 canonical glycolysis 26 1.808499 0.0413027 0.0290142
GO:0061718 glucose catabolic process to pyruvate 26 1.808499 0.0413027 0.0290142
GO:0006089 lactate metabolic process 11 1.808210 0.0424097 0.0297918
GO:0030073 insulin secretion 173 1.807628 0.0329885 0.0231737
GO:0007020 microtubule nucleation 20 1.806025 0.0371078 0.0260674
GO:1904064 positive regulation of cation transmembrane transport 126 1.803541 0.0329885 0.0231737
GO:0006851 mitochondrial calcium ion transmembrane transport 25 1.799711 0.0414464 0.0291152
GO:0045921 positive regulation of exocytosis 77 1.797803 0.0329885 0.0231737
GO:0014850 response to muscle activity 22 1.795749 0.0418253 0.0293813
GO:0015682 ferric iron transport 34 1.794657 0.0361638 0.0254042
GO:0033572 transferrin transport 34 1.794657 0.0361638 0.0254042
GO:0072512 trivalent inorganic cation transport 34 1.794657 0.0361638 0.0254042
GO:1901019 regulation of calcium ion transmembrane transporter activity 80 1.793652 0.0329885 0.0231737
GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 23 1.791149 0.0418253 0.0293813
GO:0031109 microtubule polymerization or depolymerization 92 1.789393 0.0329885 0.0231737
GO:0008637 apoptotic mitochondrial changes 110 1.788843 0.0329885 0.0231737
GO:0030072 peptide hormone secretion 204 1.788405 0.0329885 0.0231737
GO:0007019 microtubule depolymerization 33 1.785194 0.0361638 0.0254042
GO:0010769 regulation of cell morphogenesis involved in differentiation 250 1.784852 0.0329885 0.0231737
GO:0007613 memory 105 1.784290 0.0329885 0.0231737
GO:0071871 response to epinephrine 15 1.784180 0.0495117 0.0347808
GO:1903307 positive regulation of regulated secretory pathway 47 1.783901 0.0361638 0.0254042
GO:0060359 response to ammonium ion 115 1.783650 0.0329885 0.0231737
GO:0002028 regulation of sodium ion transport 67 1.779401 0.0329885 0.0231737
GO:0015844 monoamine transport 59 1.779024 0.0399769 0.0280829
GO:0008016 regulation of heart contraction 215 1.777692 0.0329885 0.0231737
GO:0006835 dicarboxylic acid transport 85 1.776517 0.0329885 0.0231737
GO:0048675 axon extension 97 1.773955 0.0329885 0.0231737
GO:1901526 positive regulation of mitophagy 10 1.772817 0.0377405 0.0265118
GO:0071242 cellular response to ammonium ion 59 1.771362 0.0399769 0.0280829
GO:0009583 detection of light stimulus 54 1.770242 0.0452588 0.0317933
GO:1904427 positive regulation of calcium ion transmembrane transport 62 1.770031 0.0399769 0.0280829
GO:1901215 negative regulation of neuron death 181 1.768385 0.0329885 0.0231737
GO:0006418 tRNA aminoacylation for protein translation 42 1.767853 0.0361638 0.0254042
GO:0007413 axonal fasciculation 23 1.767492 0.0418253 0.0293813
GO:0106030 neuron projection fasciculation 23 1.767492 0.0418253 0.0293813
GO:0090313 regulation of protein targeting to membrane 34 1.766085 0.0361638 0.0254042
GO:0007616 long-term memory 32 1.764279 0.0412551 0.0289807
GO:0038093 Fc receptor signaling pathway 169 1.762124 0.0329885 0.0231737
GO:0021544 subpallium development 25 1.760856 0.0414464 0.0291152
GO:0098876 vesicle-mediated transport to the plasma membrane 67 1.760633 0.0361638 0.0254042
GO:0140029 exocytic process 61 1.758505 0.0399769 0.0280829
GO:0034767 positive regulation of ion transmembrane transport 137 1.757556 0.0329885 0.0231737
GO:0061050 regulation of cell growth involved in cardiac muscle cell development 17 1.756141 0.0496223 0.0348585
GO:0010821 regulation of mitochondrion organization 170 1.755546 0.0329885 0.0231737
GO:0070588 calcium ion transmembrane transport 265 1.755267 0.0329885 0.0231737
GO:0042053 regulation of dopamine metabolic process 19 1.752472 0.0496223 0.0348585
GO:0042069 regulation of catecholamine metabolic process 19 1.752472 0.0496223 0.0348585
GO:0002223 stimulatory C-type lectin receptor signaling pathway 93 1.750958 0.0329885 0.0231737
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 90 1.749373 0.0329885 0.0231737
GO:0001678 cellular glucose homeostasis 122 1.746522 0.0329885 0.0231737
GO:0007212 dopamine receptor signaling pathway 32 1.744495 0.0412551 0.0289807
GO:0009582 detection of abiotic stimulus 103 1.742630 0.0329885 0.0231737
GO:0050773 regulation of dendrite development 137 1.740372 0.0329885 0.0231737
GO:1900006 positive regulation of dendrite development 68 1.738244 0.0398385 0.0279856
GO:0060047 heart contraction 239 1.729889 0.0329885 0.0231737
GO:0050805 negative regulation of synaptic transmission 65 1.727945 0.0361638 0.0254042
GO:1902750 negative regulation of cell cycle G2/M phase transition 89 1.726677 0.0329885 0.0231737
GO:0050772 positive regulation of axonogenesis 68 1.726340 0.0398385 0.0279856
GO:0086065 cell communication involved in cardiac conduction 53 1.721109 0.0451615 0.0317249
GO:0010922 positive regulation of phosphatase activity 29 1.720764 0.0472546 0.0331953
GO:0008089 anterograde axonal transport 42 1.719498 0.0468024 0.0328776
GO:0009308 amine metabolic process 118 1.718747 0.0329885 0.0231737
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process 57 1.716750 0.0400578 0.0281397
GO:0051258 protein polymerization 212 1.716319 0.0329885 0.0231737
GO:0002220 innate immune response activating cell surface receptor signaling pathway 95 1.714947 0.0329885 0.0231737
GO:0043624 cellular protein complex disassembly 189 1.712157 0.0329885 0.0231737
GO:0061387 regulation of extent of cell growth 87 1.707442 0.0329885 0.0231737
GO:0032386 regulation of intracellular transport 384 1.702326 0.0329885 0.0231737
GO:0021756 striatum development 19 1.700471 0.0496223 0.0348585
GO:0097485 neuron projection guidance 190 1.697753 0.0329885 0.0231737
GO:0050796 regulation of insulin secretion 147 1.695784 0.0329885 0.0231737
GO:0050850 positive regulation of calcium-mediated signaling 37 1.694157 0.0468024 0.0328776
GO:0000209 protein polyubiquitination 279 1.692666 0.0329885 0.0231737
GO:0010389 regulation of G2/M transition of mitotic cell cycle 175 1.691840 0.0329885 0.0231737
GO:0043270 positive regulation of ion transport 237 1.691439 0.0329885 0.0231737
GO:0001504 neurotransmitter uptake 35 1.688373 0.0468177 0.0328884
GO:0048639 positive regulation of developmental growth 148 1.686601 0.0329885 0.0231737
GO:0098815 modulation of excitatory postsynaptic potential 40 1.686033 0.0414641 0.0291276
GO:0007411 axon guidance 188 1.684894 0.0329885 0.0231737
GO:0009156 ribonucleoside monophosphate biosynthetic process 178 1.684870 0.0329885 0.0231737
GO:0048016 inositol phosphate-mediated signaling 44 1.683970 0.0411452 0.0289035
GO:0000086 G2/M transition of mitotic cell cycle 227 1.679335 0.0329885 0.0231737
GO:0009581 detection of external stimulus 100 1.676362 0.0329885 0.0231737
GO:0090276 regulation of peptide hormone secretion 167 1.673736 0.0329885 0.0231737
GO:1903169 regulation of calcium ion transmembrane transport 131 1.672211 0.0329885 0.0231737
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 93 1.671856 0.0329885 0.0231737
GO:0009152 purine ribonucleotide biosynthetic process 253 1.670815 0.0329885 0.0231737
GO:0046390 ribose phosphate biosynthetic process 270 1.670552 0.0329885 0.0231737
GO:0043523 regulation of neuron apoptotic process 185 1.670277 0.0329885 0.0231737
GO:0032410 negative regulation of transporter activity 64 1.667364 0.0399769 0.0280829
GO:0051962 positive regulation of nervous system development 472 1.664464 0.0329885 0.0231737
GO:0019722 calcium-mediated signaling 163 1.663989 0.0329885 0.0231737
GO:0010959 regulation of metal ion transport 321 1.662330 0.0329885 0.0231737
GO:1905037 autophagosome organization 72 1.662293 0.0398370 0.0279846
GO:0006164 purine nucleotide biosynthetic process 263 1.662232 0.0329885 0.0231737
GO:0019884 antigen processing and presentation of exogenous antigen 164 1.659401 0.0329885 0.0231737
GO:0009127 purine nucleoside monophosphate biosynthetic process 165 1.658463 0.0329885 0.0231737
GO:0009168 purine ribonucleoside monophosphate biosynthetic process 165 1.658463 0.0329885 0.0231737
GO:0086001 cardiac muscle cell action potential 65 1.657872 0.0399769 0.0280829
GO:0009124 nucleoside monophosphate biosynthetic process 185 1.657065 0.0329885 0.0231737
GO:0051402 neuron apoptotic process 211 1.651694 0.0329885 0.0231737
GO:0002478 antigen processing and presentation of exogenous peptide antigen 162 1.650379 0.0329885 0.0231737
GO:1903522 regulation of blood circulation 251 1.650151 0.0329885 0.0231737
GO:1990778 protein localization to cell periphery 260 1.649874 0.0329885 0.0231737
GO:0035304 regulation of protein dephosphorylation 125 1.649792 0.0329885 0.0231737
GO:0003015 heart process 248 1.649419 0.0329885 0.0231737
GO:1904063 negative regulation of cation transmembrane transport 70 1.646627 0.0398385 0.0279856
GO:0097553 calcium ion transmembrane import into cytosol 111 1.646449 0.0329885 0.0231737
GO:0051279 regulation of release of sequestered calcium ion into cytosol 68 1.643922 0.0398385 0.0279856
GO:0009260 ribonucleotide biosynthetic process 266 1.643206 0.0329885 0.0231737
GO:0035303 regulation of dephosphorylation 189 1.642118 0.0329885 0.0231737
GO:0043648 dicarboxylic acid metabolic process 81 1.640228 0.0361638 0.0254042
GO:0009584 detection of visible light 44 1.636438 0.0463643 0.0325699
GO:0009206 purine ribonucleoside triphosphate biosynthetic process 150 1.636214 0.0329885 0.0231737
GO:0006754 ATP biosynthetic process 142 1.635834 0.0329885 0.0231737
GO:0000045 autophagosome assembly 69 1.635262 0.0398385 0.0279856
GO:0032886 regulation of microtubule-based process 195 1.634997 0.0329885 0.0231737
GO:0072347 response to anesthetic 67 1.633743 0.0399769 0.0280829
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 94 1.630325 0.0329885 0.0231737
GO:0072522 purine-containing compound biosynthetic process 273 1.627893 0.0329885 0.0231737
GO:0048013 ephrin receptor signaling pathway 86 1.626647 0.0359985 0.0252881
GO:0034764 positive regulation of transmembrane transport 173 1.625043 0.0329885 0.0231737
GO:0018105 peptidyl-serine phosphorylation 213 1.624816 0.0329885 0.0231737
GO:0044839 cell cycle G2/M phase transition 246 1.622401 0.0329885 0.0231737
GO:0030004 cellular monovalent inorganic cation homeostasis 73 1.618903 0.0393800 0.0276636
GO:0009145 purine nucleoside triphosphate biosynthetic process 151 1.616011 0.0329885 0.0231737
GO:0010921 regulation of phosphatase activity 157 1.613414 0.0329885 0.0231737
GO:0032535 regulation of cellular component size 292 1.613411 0.0329885 0.0231737
GO:0010770 positive regulation of cell morphogenesis involved in differentiation 130 1.611952 0.0351659 0.0247032
GO:0010771 negative regulation of cell morphogenesis involved in differentiation 77 1.608511 0.0438865 0.0308293
GO:0018209 peptidyl-serine modification 232 1.608387 0.0329885 0.0231737
GO:0051592 response to calcium ion 115 1.602920 0.0351670 0.0247040
GO:0006094 gluconeogenesis 74 1.601187 0.0393800 0.0276636
GO:0009749 response to glucose 165 1.600291 0.0329885 0.0231737
GO:0050769 positive regulation of neurogenesis 413 1.599805 0.0329885 0.0231737
GO:1902749 regulation of cell cycle G2/M phase transition 192 1.598032 0.0329885 0.0231737
GO:0009743 response to carbohydrate 196 1.596119 0.0329885 0.0231737
GO:0031333 negative regulation of protein complex assembly 115 1.595746 0.0351670 0.0247040
GO:0034763 negative regulation of transmembrane transport 100 1.591549 0.0422654 0.0296905
GO:0031345 negative regulation of cell projection organization 151 1.586870 0.0329885 0.0231737
GO:0009201 ribonucleoside triphosphate biosynthetic process 155 1.583576 0.0350660 0.0246330
GO:0034766 negative regulation of ion transmembrane transport 81 1.579244 0.0498255 0.0350013
GO:0032271 regulation of protein polymerization 165 1.578958 0.0329885 0.0231737
GO:1905477 positive regulation of protein localization to membrane 111 1.574253 0.0358382 0.0251755
GO:0050848 regulation of calcium-mediated signaling 87 1.571969 0.0496734 0.0348945
GO:0048284 organelle fusion 92 1.571128 0.0393800 0.0276636
GO:0060560 developmental growth involved in morphogenesis 202 1.570183 0.0329885 0.0231737
GO:0051668 localization within membrane 120 1.568688 0.0487162 0.0342220
GO:0033157 regulation of intracellular protein transport 210 1.566313 0.0329885 0.0231737
GO:1901800 positive regulation of proteasomal protein catabolic process 90 1.566068 0.0392689 0.0275855
GO:0043666 regulation of phosphoprotein phosphatase activity 104 1.561188 0.0486938 0.0342063
GO:0009746 response to hexose 170 1.559169 0.0329885 0.0231737
GO:0048193 Golgi vesicle transport 290 1.550247 0.0329885 0.0231737
GO:0072659 protein localization to plasma membrane 223 1.549284 0.0329885 0.0231737
GO:0061136 regulation of proteasomal protein catabolic process 162 1.545539 0.0350660 0.0246330
GO:0046879 hormone secretion 254 1.543492 0.0329885 0.0231737
GO:0019319 hexose biosynthetic process 77 1.542174 0.0497992 0.0349828
GO:0009914 hormone transport 263 1.538192 0.0329885 0.0231737
GO:0048638 regulation of developmental growth 275 1.538192 0.0329885 0.0231737
GO:0070507 regulation of microtubule cytoskeleton organization 167 1.533430 0.0350660 0.0246330
GO:0009142 nucleoside triphosphate biosynthetic process 166 1.532739 0.0378730 0.0266049
GO:0002027 regulation of heart rate 84 1.530637 0.0495946 0.0348391
GO:0010506 regulation of autophagy 301 1.528084 0.0329885 0.0231737
GO:0034284 response to monosaccharide 174 1.525524 0.0329885 0.0231737
GO:0019932 second-messenger-mediated signaling 305 1.519423 0.0329885 0.0231737
GO:0022604 regulation of cell morphogenesis 411 1.515354 0.0329885 0.0231737
GO:0050906 detection of stimulus involved in sensory perception 108 1.514434 0.0424097 0.0297918
GO:0070997 neuron death 311 1.511110 0.0329885 0.0231737
GO:0006914 autophagy 455 1.511034 0.0329885 0.0231737
GO:0061919 process utilizing autophagic mechanism 455 1.511034 0.0329885 0.0231737
GO:0006470 protein dephosphorylation 288 1.510004 0.0329885 0.0231737
GO:0070838 divalent metal ion transport 401 1.509694 0.0329885 0.0231737
GO:1901293 nucleoside phosphate biosynthetic process 343 1.502273 0.0329885 0.0231737
GO:0072511 divalent inorganic cation transport 403 1.501848 0.0329885 0.0231737
GO:0006520 cellular amino acid metabolic process 323 1.501355 0.0329885 0.0231737
GO:0032984 protein-containing complex disassembly 286 1.499978 0.0329885 0.0231737
GO:0010256 endomembrane system organization 344 1.498688 0.0329885 0.0231737
GO:0048002 antigen processing and presentation of peptide antigen 174 1.496180 0.0377405 0.0265118
GO:0009165 nucleotide biosynthetic process 340 1.496154 0.0329885 0.0231737
GO:0006816 calcium ion transport 364 1.493733 0.0329885 0.0231737
GO:0046883 regulation of hormone secretion 215 1.493640 0.0343030 0.0240971
GO:0090150 establishment of protein localization to membrane 267 1.493224 0.0329885 0.0231737
GO:0022411 cellular component disassembly 454 1.491968 0.0329885 0.0231737
GO:0010720 positive regulation of cell development 468 1.491403 0.0329885 0.0231737
GO:0010498 proteasomal protein catabolic process 369 1.490679 0.0329885 0.0231737
GO:1903827 regulation of cellular protein localization 478 1.490491 0.0329885 0.0231737
GO:1901214 regulation of neuron death 279 1.490443 0.0329885 0.0231737
GO:1905475 regulation of protein localization to membrane 167 1.485561 0.0480538 0.0337567
GO:0016311 dephosphorylation 418 1.483413 0.0329885 0.0231737
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 316 1.482798 0.0329885 0.0231737
GO:0070646 protein modification by small protein removal 263 1.468921 0.0370498 0.0260266
GO:0060271 cilium assembly 319 1.462095 0.0329885 0.0231737
GO:0019882 antigen processing and presentation 202 1.449168 0.0414718 0.0291330
GO:0046434 organophosphate catabolic process 211 1.440211 0.0414641 0.0291276
GO:0000226 microtubule cytoskeleton organization 433 1.426885 0.0332928 0.0233874
GO:0044782 cilium organization 328 1.423031 0.0403803 0.0283662
GO:0090066 regulation of anatomical structure size 396 1.416338 0.0329885 0.0231737
GO:0002768 immune response-regulating cell surface receptor signaling pathway 312 1.415533 0.0496734 0.0348945
GO:0051051 negative regulation of transport 412 1.406800 0.0329885 0.0231737
GO:0019941 modification-dependent protein catabolic process 472 1.402441 0.0329885 0.0231737
GO:0006873 cellular ion homeostasis 459 1.398508 0.0329885 0.0231737
GO:0006511 ubiquitin-dependent protein catabolic process 467 1.396923 0.0361638 0.0254042
GO:0030003 cellular cation homeostasis 450 1.380773 0.0332231 0.0233385
GO:0043632 modification-dependent macromolecule catabolic process 479 1.379019 0.0361638 0.0254042
GO:0042176 regulation of protein catabolic process 335 1.377503 0.0498414 0.0350125
GO:0010817 regulation of hormone levels 412 1.354427 0.0490027 0.0344233
GO:0006875 cellular metal ion homeostasis 403 1.351955 0.0488689 0.0343293
Enriched terms for module #73B000 (MTcor = 0.94)
ID Description setSize NES p.adjust qvalues
GO:0006335 DNA replication-dependent nucleosome assembly 32 3.281963 0.0163009 0.0113833
GO:0034723 DNA replication-dependent nucleosome organization 32 3.281963 0.0163009 0.0113833
GO:0000183 chromatin silencing at rDNA 39 3.015703 0.0163009 0.0113833
GO:0051290 protein heterotetramerization 51 2.920453 0.0163009 0.0113833
GO:0045653 negative regulation of megakaryocyte differentiation 17 2.823607 0.0163009 0.0113833
GO:0006334 nucleosome assembly 119 2.804989 0.0163009 0.0113833
GO:0045652 regulation of megakaryocyte differentiation 74 2.724017 0.0163009 0.0113833
GO:0030219 megakaryocyte differentiation 90 2.682767 0.0163009 0.0113833
GO:0031497 chromatin assembly 135 2.634938 0.0163009 0.0113833
GO:0034728 nucleosome organization 144 2.572696 0.0163009 0.0113833
GO:0034080 CENP-A containing nucleosome assembly 41 2.502281 0.0163009 0.0113833
GO:0061641 CENP-A containing chromatin organization 41 2.502281 0.0163009 0.0113833
GO:0006333 chromatin assembly or disassembly 159 2.494888 0.0163009 0.0113833
GO:0006323 DNA packaging 168 2.476166 0.0163009 0.0113833
GO:0048514 blood vessel morphogenesis 495 2.414044 0.0163009 0.0113833
GO:0006342 chromatin silencing 76 2.403177 0.0163009 0.0113833
GO:0031055 chromatin remodeling at centromere 45 2.353854 0.0163009 0.0113833
GO:1903707 negative regulation of hemopoiesis 129 2.333940 0.0163009 0.0113833
GO:0003158 endothelium development 106 2.333436 0.0163009 0.0113833
GO:0038111 interleukin-7-mediated signaling pathway 29 2.326228 0.0163009 0.0113833
GO:0060964 regulation of gene silencing by miRNA 110 2.318738 0.0163009 0.0113833
GO:0010718 positive regulation of epithelial to mesenchymal transition 45 2.314219 0.0163009 0.0113833
GO:0043486 histone exchange 50 2.313078 0.0163009 0.0113833
GO:0006336 DNA replication-independent nucleosome assembly 52 2.313018 0.0163009 0.0113833
GO:0034724 DNA replication-independent nucleosome organization 52 2.313018 0.0163009 0.0113833
GO:0060147 regulation of posttranscriptional gene silencing 112 2.300594 0.0163009 0.0113833
GO:0060966 regulation of gene silencing by RNA 112 2.300594 0.0163009 0.0113833
GO:0001525 angiogenesis 418 2.298458 0.0163009 0.0113833
GO:0045814 negative regulation of gene expression, epigenetic 94 2.288462 0.0163009 0.0113833
GO:0065004 protein-DNA complex assembly 191 2.260830 0.0163009 0.0113833
GO:1904018 positive regulation of vasculature development 161 2.253925 0.0163009 0.0113833
GO:0030856 regulation of epithelial cell differentiation 112 2.248593 0.0163009 0.0113833
GO:0001704 formation of primary germ layer 95 2.241676 0.0163009 0.0113833
GO:0007492 endoderm development 60 2.232370 0.0163009 0.0113833
GO:0046637 regulation of alpha-beta T cell differentiation 51 2.231238 0.0163009 0.0113833
GO:0045637 regulation of myeloid cell differentiation 214 2.230233 0.0163009 0.0113833
GO:0045446 endothelial cell differentiation 88 2.218811 0.0163009 0.0113833
GO:0061614 pri-miRNA transcription by RNA polymerase II 43 2.218749 0.0163009 0.0113833
GO:0030198 extracellular matrix organization 286 2.192768 0.0163009 0.0113833
GO:0045766 positive regulation of angiogenesis 143 2.191895 0.0163009 0.0113833
GO:0046632 alpha-beta T cell differentiation 78 2.189461 0.0163009 0.0113833
GO:0046638 positive regulation of alpha-beta T cell differentiation 40 2.185307 0.0163009 0.0113833
GO:1901342 regulation of vasculature development 274 2.184894 0.0163009 0.0113833
GO:0034508 centromere complex assembly 53 2.182849 0.0163009 0.0113833
GO:0046636 negative regulation of alpha-beta T cell activation 31 2.181756 0.0163009 0.0113833
GO:0046631 alpha-beta T cell activation 107 2.163636 0.0163009 0.0113833
GO:0046634 regulation of alpha-beta T cell activation 74 2.156328 0.0163009 0.0113833
GO:0045765 regulation of angiogenesis 246 2.155318 0.0163009 0.0113833
GO:0035195 gene silencing by miRNA 150 2.153835 0.0163009 0.0113833
GO:0045638 negative regulation of myeloid cell differentiation 79 2.147018 0.0163009 0.0113833
GO:0043062 extracellular structure organization 330 2.142770 0.0163009 0.0113833
GO:0001706 endoderm formation 42 2.139188 0.0163009 0.0113833
GO:0050866 negative regulation of cell activation 162 2.138813 0.0163009 0.0113833
GO:0030260 entry into host cell 118 2.134275 0.0163009 0.0113833
GO:0044409 entry into host 118 2.134275 0.0163009 0.0113833
GO:0051806 entry into cell of other organism involved in symbiotic interaction 118 2.134275 0.0163009 0.0113833
GO:0051828 entry into other organism involved in symbiotic interaction 118 2.134275 0.0163009 0.0113833
GO:1904035 regulation of epithelial cell apoptotic process 61 2.128339 0.0163009 0.0113833
GO:0014745 negative regulation of muscle adaptation 11 2.127725 0.0163009 0.0113833
GO:0030855 epithelial cell differentiation 481 2.126033 0.0163009 0.0113833
GO:0002286 T cell activation involved in immune response 70 2.125011 0.0163009 0.0113833
GO:0030099 myeloid cell differentiation 357 2.124192 0.0163009 0.0113833
GO:0045667 regulation of osteoblast differentiation 107 2.124127 0.0163009 0.0113833
GO:0032200 telomere organization 158 2.124006 0.0163009 0.0113833
GO:0061180 mammary gland epithelium development 59 2.120205 0.0163009 0.0113833
GO:0016233 telomere capping 49 2.111809 0.0163009 0.0113833
GO:0071824 protein-DNA complex subunit organization 216 2.107134 0.0163009 0.0113833
GO:0071103 DNA conformation change 253 2.106475 0.0163009 0.0113833
GO:0061138 morphogenesis of a branching epithelium 154 2.106262 0.0163009 0.0113833
GO:0060968 regulation of gene silencing 132 2.104981 0.0163009 0.0113833
GO:0034446 substrate adhesion-dependent cell spreading 82 2.102304 0.0163009 0.0113833
GO:0016441 posttranscriptional gene silencing 155 2.102180 0.0163009 0.0113833
GO:0031047 gene silencing by RNA 174 2.100760 0.0163009 0.0113833
GO:0035194 posttranscriptional gene silencing by RNA 154 2.100144 0.0163009 0.0113833
GO:0042110 T cell activation 376 2.098991 0.0163009 0.0113833
GO:0002064 epithelial cell development 175 2.098650 0.0163009 0.0113833
GO:0035987 endodermal cell differentiation 38 2.098008 0.0163009 0.0113833
GO:0048754 branching morphogenesis of an epithelial tube 126 2.095619 0.0163009 0.0113833
GO:0042307 positive regulation of protein import into nucleus 34 2.095381 0.0163009 0.0113833
GO:0007369 gastrulation 146 2.095188 0.0163009 0.0113833
GO:0002683 negative regulation of immune system process 376 2.094643 0.0163009 0.0113833
GO:0042060 wound healing 458 2.093919 0.0163009 0.0113833
GO:0110110 positive regulation of animal organ morphogenesis 69 2.093698 0.0163009 0.0113833
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 22 2.093155 0.0163009 0.0113833
GO:0051291 protein heterooligomerization 120 2.088588 0.0163009 0.0113833
GO:0033002 muscle cell proliferation 175 2.084705 0.0163009 0.0113833
GO:0030199 collagen fibril organization 40 2.079294 0.0163009 0.0113833
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 13 2.077650 0.0163009 0.0113833
GO:1903708 positive regulation of hemopoiesis 155 2.075687 0.0163009 0.0113833
GO:0035329 hippo signaling 38 2.071621 0.0163009 0.0113833
GO:0032496 response to lipopolysaccharide 248 2.071391 0.0163009 0.0113833
GO:0009617 response to bacterium 413 2.070860 0.0163009 0.0113833
GO:0002237 response to molecule of bacterial origin 260 2.069487 0.0163009 0.0113833
GO:0002819 regulation of adaptive immune response 128 2.068829 0.0163009 0.0113833
GO:0098760 response to interleukin-7 40 2.067516 0.0163009 0.0113833
GO:0098761 cellular response to interleukin-7 40 2.067516 0.0163009 0.0113833
GO:0022612 gland morphogenesis 101 2.064871 0.0163009 0.0113833
GO:0048333 mesodermal cell differentiation 27 2.062396 0.0163009 0.0113833
GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 46 2.055948 0.0163009 0.0113833
GO:0002227 innate immune response in mucosa 11 2.052684 0.0163009 0.0113833
GO:0032677 regulation of interleukin-8 production 53 2.051840 0.0163009 0.0113833
GO:0060326 cell chemotaxis 201 2.050613 0.0163009 0.0113833
GO:0003151 outflow tract morphogenesis 70 2.045981 0.0163009 0.0113833
GO:0071216 cellular response to biotic stimulus 178 2.044258 0.0163009 0.0113833
GO:1904036 negative regulation of epithelial cell apoptotic process 30 2.041644 0.0163009 0.0113833
GO:0014741 negative regulation of muscle hypertrophy 25 2.039269 0.0163009 0.0113833
GO:0048368 lateral mesoderm development 13 2.037636 0.0163009 0.0113833
GO:1904894 positive regulation of STAT cascade 61 2.037606 0.0163009 0.0113833
GO:0001570 vasculogenesis 68 2.037259 0.0163009 0.0113833
GO:0072006 nephron development 121 2.037143 0.0163009 0.0113833
GO:0022408 negative regulation of cell-cell adhesion 138 2.034252 0.0163009 0.0113833
GO:0030217 T cell differentiation 193 2.031911 0.0163009 0.0113833
GO:0046718 viral entry into host cell 106 2.031748 0.0163009 0.0113833
GO:0048332 mesoderm morphogenesis 57 2.026901 0.0163009 0.0113833
GO:1902107 positive regulation of leukocyte differentiation 122 2.023687 0.0163009 0.0113833
GO:0002695 negative regulation of leukocyte activation 143 2.023093 0.0163009 0.0113833
GO:0072028 nephron morphogenesis 66 2.021569 0.0163009 0.0113833
GO:0002507 tolerance induction 18 2.019637 0.0163009 0.0113833
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 23 2.017153 0.0163009 0.0113833
GO:0046427 positive regulation of JAK-STAT cascade 59 2.015126 0.0163009 0.0113833
GO:2001236 regulation of extrinsic apoptotic signaling pathway 137 2.014815 0.0163009 0.0113833
GO:0002577 regulation of antigen processing and presentation 15 2.013972 0.0163009 0.0113833
GO:0030278 regulation of ossification 169 2.011543 0.0163009 0.0113833
GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 37 2.011033 0.0163009 0.0113833
GO:1903053 regulation of extracellular matrix organization 36 2.009104 0.0163009 0.0113833
GO:0071222 cellular response to lipopolysaccharide 148 2.007952 0.0163009 0.0113833
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 39 2.005453 0.0256950 0.0179433
GO:0045616 regulation of keratinocyte differentiation 30 2.004612 0.0163009 0.0113833
GO:0090183 regulation of kidney development 46 2.004535 0.0256950 0.0179433
GO:0072073 kidney epithelium development 120 2.002833 0.0163009 0.0113833
GO:0007566 embryo implantation 43 2.002232 0.0258183 0.0180295
GO:0001890 placenta development 131 2.000883 0.0163009 0.0113833
GO:0045621 positive regulation of lymphocyte differentiation 81 2.000118 0.0163009 0.0113833
GO:0050868 negative regulation of T cell activation 89 1.998171 0.0163009 0.0113833
GO:0003181 atrioventricular valve morphogenesis 22 1.997860 0.0163009 0.0113833
GO:0001763 morphogenesis of a branching structure 167 1.997080 0.0163009 0.0113833
GO:0051250 negative regulation of lymphocyte activation 117 1.996758 0.0163009 0.0113833
GO:2000482 regulation of interleukin-8 secretion 20 1.994918 0.0163009 0.0113833
GO:0060479 lung cell differentiation 15 1.990732 0.0256950 0.0179433
GO:0071219 cellular response to molecule of bacterial origin 155 1.990147 0.0163009 0.0113833
GO:2000179 positive regulation of neural precursor cell proliferation 44 1.989036 0.0256950 0.0179433
GO:1904019 epithelial cell apoptotic process 81 1.987989 0.0163009 0.0113833
GO:0002285 lymphocyte activation involved in immune response 128 1.986501 0.0163009 0.0113833
GO:0032060 bleb assembly 11 1.985604 0.0163009 0.0113833
GO:0045669 positive regulation of osteoblast differentiation 61 1.985265 0.0163009 0.0113833
GO:0061005 cell differentiation involved in kidney development 48 1.984123 0.0257133 0.0179562
GO:1901626 regulation of postsynaptic membrane organization 14 1.982813 0.0163009 0.0113833
GO:2000826 regulation of heart morphogenesis 32 1.982671 0.0163009 0.0113833
GO:0042129 regulation of T cell proliferation 123 1.980702 0.0163009 0.0113833
GO:2000351 regulation of endothelial cell apoptotic process 36 1.978509 0.0163009 0.0113833
GO:0048708 astrocyte differentiation 71 1.978094 0.0163009 0.0113833
GO:0030206 chondroitin sulfate biosynthetic process 25 1.976975 0.0163009 0.0113833
GO:0002821 positive regulation of adaptive immune response 78 1.976761 0.0163009 0.0113833
GO:0009595 detection of biotic stimulus 17 1.975224 0.0163009 0.0113833
GO:0001655 urogenital system development 286 1.975188 0.0163009 0.0113833
GO:0045604 regulation of epidermal cell differentiation 45 1.974814 0.0256950 0.0179433
GO:0002287 alpha-beta T cell activation involved in immune response 47 1.974340 0.0256950 0.0179433
GO:0002293 alpha-beta T cell differentiation involved in immune response 47 1.974340 0.0256950 0.0179433
GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 47 1.974340 0.0256950 0.0179433
GO:0045582 positive regulation of T cell differentiation 71 1.974294 0.0163009 0.0113833
GO:0035710 CD4-positive, alpha-beta T cell activation 71 1.973952 0.0163009 0.0113833
GO:0046635 positive regulation of alpha-beta T cell activation 51 1.971458 0.0163009 0.0113833
GO:0046639 negative regulation of alpha-beta T cell differentiation 21 1.971344 0.0163009 0.0113833
GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 73 1.971195 0.0163009 0.0113833
GO:0072207 metanephric epithelium development 23 1.970801 0.0163009 0.0113833
GO:0003183 mitral valve morphogenesis 10 1.970504 0.0163009 0.0113833
GO:2000147 positive regulation of cell motility 442 1.969086 0.0163009 0.0113833
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 197 1.966630 0.0163009 0.0113833
GO:0030335 positive regulation of cell migration 427 1.966054 0.0163009 0.0113833
GO:0072132 mesenchyme morphogenesis 47 1.964821 0.0256950 0.0179433
GO:0072001 renal system development 260 1.963360 0.0163009 0.0113833
GO:0072009 nephron epithelium development 90 1.963098 0.0163009 0.0113833
GO:0001822 kidney development 245 1.962898 0.0163009 0.0113833
GO:0060411 cardiac septum morphogenesis 67 1.961579 0.0163009 0.0113833
GO:0030858 positive regulation of epithelial cell differentiation 49 1.960627 0.0256950 0.0179433
GO:0001707 mesoderm formation 55 1.960582 0.0163009 0.0113833
GO:0032637 interleukin-8 production 58 1.959157 0.0163009 0.0113833
GO:0097150 neuronal stem cell population maintenance 22 1.958891 0.0163009 0.0113833
GO:0060561 apoptotic process involved in morphogenesis 21 1.958723 0.0163009 0.0113833
GO:0061326 renal tubule development 79 1.955483 0.0163009 0.0113833
GO:0003007 heart morphogenesis 213 1.954472 0.0163009 0.0113833
GO:0002250 adaptive immune response 290 1.951776 0.0163009 0.0113833
GO:2000811 negative regulation of anoikis 15 1.951105 0.0256950 0.0179433
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 114 1.948942 0.0163009 0.0113833
GO:0072080 nephron tubule development 77 1.948245 0.0163009 0.0113833
GO:0072088 nephron epithelium morphogenesis 64 1.947935 0.0163009 0.0113833
GO:0042742 defense response to bacterium 120 1.946931 0.0163009 0.0113833
GO:0042093 T-helper cell differentiation 46 1.945784 0.0256950 0.0179433
GO:0003382 epithelial cell morphogenesis 25 1.944556 0.0163009 0.0113833
GO:0002088 lens development in camera-type eye 58 1.943813 0.0163009 0.0113833
GO:2000036 regulation of stem cell population maintenance 25 1.940979 0.0163009 0.0113833
GO:0006968 cellular defense response 40 1.940089 0.0256950 0.0179433
GO:1905332 positive regulation of morphogenesis of an epithelium 31 1.939865 0.0163009 0.0113833
GO:0003171 atrioventricular valve development 23 1.939460 0.0163009 0.0113833
GO:0010463 mesenchymal cell proliferation 41 1.938546 0.0256950 0.0179433
GO:0048844 artery morphogenesis 58 1.938415 0.0163009 0.0113833
GO:0043297 apical junction assembly 55 1.938197 0.0163009 0.0113833
GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 23 1.936605 0.0163009 0.0113833
GO:0001656 metanephros development 74 1.936547 0.0163009 0.0113833
GO:0072243 metanephric nephron epithelium development 20 1.934631 0.0163009 0.0113833
GO:1904591 positive regulation of protein import 36 1.934484 0.0163009 0.0113833
GO:0006509 membrane protein ectodomain proteolysis 37 1.933582 0.0163009 0.0113833
GO:0002292 T cell differentiation involved in immune response 49 1.933045 0.0256950 0.0179433
GO:0035635 entry of bacterium into host cell 14 1.931106 0.0256950 0.0179433
GO:0050900 leukocyte migration 335 1.929425 0.0163009 0.0113833
GO:0001885 endothelial cell development 53 1.928683 0.0163009 0.0113833
GO:0072170 metanephric tubule development 22 1.927899 0.0163009 0.0113833
GO:0043367 CD4-positive, alpha-beta T cell differentiation 58 1.927700 0.0163009 0.0113833
GO:0050777 negative regulation of immune response 116 1.926393 0.0163009 0.0113833
GO:0050673 epithelial cell proliferation 326 1.925842 0.0163009 0.0113833
GO:0072577 endothelial cell apoptotic process 42 1.925825 0.0256950 0.0179433
GO:0001503 ossification 339 1.925490 0.0163009 0.0113833
GO:0060993 kidney morphogenesis 81 1.922369 0.0163009 0.0113833
GO:0051568 histone H3-K4 methylation 46 1.921827 0.0256950 0.0179433
GO:0002385 mucosal immune response 14 1.920873 0.0325638 0.0227400
GO:0001892 embryonic placenta development 78 1.920229 0.0163009 0.0113833
GO:0050830 defense response to Gram-positive bacterium 45 1.919976 0.0256950 0.0179433
GO:0000768 syncytium formation by plasma membrane fusion 41 1.919721 0.0256950 0.0179433
GO:0140253 cell-cell fusion 41 1.919721 0.0256950 0.0179433
GO:1902807 negative regulation of cell cycle G1/S phase transition 102 1.918019 0.0163009 0.0113833
GO:0072078 nephron tubule morphogenesis 62 1.918014 0.0163009 0.0113833
GO:0042102 positive regulation of T cell proliferation 69 1.917452 0.0163009 0.0113833
GO:0042267 natural killer cell mediated cytotoxicity 43 1.916163 0.0327718 0.0228853
GO:0010759 positive regulation of macrophage chemotaxis 14 1.915875 0.0325638 0.0227400
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 100 1.915439 0.0163009 0.0113833
GO:0002825 regulation of T-helper 1 type immune response 18 1.915277 0.0163009 0.0113833
GO:0051272 positive regulation of cellular component movement 455 1.914921 0.0163009 0.0113833
GO:1903038 negative regulation of leukocyte cell-cell adhesion 98 1.914414 0.0163009 0.0113833
GO:0036119 response to platelet-derived growth factor 21 1.910974 0.0163009 0.0113833
GO:1903706 regulation of hemopoiesis 409 1.910713 0.0163009 0.0113833
GO:0046697 decidualization 22 1.909212 0.0163009 0.0113833
GO:0045655 regulation of monocyte differentiation 16 1.908668 0.0256950 0.0179433
GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 37 1.907452 0.0163009 0.0113833
GO:0061053 somite development 65 1.907433 0.0163009 0.0113833
GO:0042269 regulation of natural killer cell mediated cytotoxicity 29 1.907006 0.0163009 0.0113833
GO:0003170 heart valve development 54 1.906001 0.0163009 0.0113833
GO:0010614 negative regulation of cardiac muscle hypertrophy 23 1.905537 0.0163009 0.0113833
GO:1905523 positive regulation of macrophage migration 19 1.904808 0.0256950 0.0179433
GO:0042098 T cell proliferation 151 1.903371 0.0163009 0.0113833
GO:0048661 positive regulation of smooth muscle cell proliferation 81 1.902375 0.0163009 0.0113833
GO:0030323 respiratory tube development 156 1.902275 0.0163009 0.0113833
GO:1900101 regulation of endoplasmic reticulum unfolded protein response 24 1.900477 0.0163009 0.0113833
GO:0072171 mesonephric tubule morphogenesis 57 1.900140 0.0163009 0.0113833
GO:0007498 mesoderm development 100 1.899509 0.0163009 0.0113833
GO:0030324 lung development 152 1.898808 0.0163009 0.0113833
GO:0031589 cell-substrate adhesion 295 1.896323 0.0163009 0.0113833
GO:0060487 lung epithelial cell differentiation 14 1.895789 0.0325638 0.0227400
GO:0001773 myeloid dendritic cell activation 21 1.894269 0.0163009 0.0113833
GO:0010631 epithelial cell migration 256 1.893528 0.0163009 0.0113833
GO:0002827 positive regulation of T-helper 1 type immune response 12 1.893490 0.0163009 0.0113833
GO:0014015 positive regulation of gliogenesis 69 1.892174 0.0163009 0.0113833
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 87 1.891388 0.0163009 0.0113833
GO:0043044 ATP-dependent chromatin remodeling 72 1.891105 0.0163009 0.0113833
GO:1901213 regulation of transcription from RNA polymerase II promoter involved in heart development 12 1.890390 0.0163009 0.0113833
GO:0002715 regulation of natural killer cell mediated immunity 31 1.887702 0.0163009 0.0113833
GO:0060135 maternal process involved in female pregnancy 56 1.887460 0.0163009 0.0113833
GO:0045601 regulation of endothelial cell differentiation 26 1.887459 0.0163009 0.0113833
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 27 1.886344 0.0163009 0.0113833
GO:0090594 inflammatory response to wounding 12 1.885613 0.0163009 0.0113833
GO:0001667 ameboidal-type cell migration 333 1.885574 0.0163009 0.0113833
GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 28 1.885434 0.0163009 0.0113833
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 204 1.884494 0.0163009 0.0113833
GO:0016458 gene silencing 227 1.882284 0.0163009 0.0113833
GO:0007249 I-kappaB kinase/NF-kappaB signaling 231 1.882138 0.0163009 0.0113833
GO:0014855 striated muscle cell proliferation 58 1.878940 0.0163009 0.0113833
GO:0045581 negative regulation of T cell differentiation 38 1.877032 0.0256950 0.0179433
GO:0032757 positive regulation of interleukin-8 production 36 1.876516 0.0256950 0.0179433
GO:0090132 epithelium migration 257 1.875151 0.0163009 0.0113833
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 27 1.874601 0.0163009 0.0113833
GO:0061333 renal tubule morphogenesis 66 1.874248 0.0163009 0.0113833
GO:0002040 sprouting angiogenesis 100 1.872913 0.0163009 0.0113833
GO:0060675 ureteric bud morphogenesis 56 1.871069 0.0163009 0.0113833
GO:0043542 endothelial cell migration 187 1.869551 0.0163009 0.0113833
GO:0001658 branching involved in ureteric bud morphogenesis 51 1.869461 0.0259198 0.0181004
GO:2000737 negative regulation of stem cell differentiation 19 1.869447 0.0256950 0.0179433
GO:0040017 positive regulation of locomotion 470 1.868969 0.0163009 0.0113833
GO:0030098 lymphocyte differentiation 272 1.868650 0.0163009 0.0113833
GO:0001837 epithelial to mesenchymal transition 121 1.867779 0.0163009 0.0113833
GO:0071674 mononuclear cell migration 54 1.867547 0.0163009 0.0113833
GO:0036120 cellular response to platelet-derived growth factor stimulus 20 1.866624 0.0256950 0.0179433
GO:0070663 regulation of leukocyte proliferation 177 1.866292 0.0163009 0.0113833
GO:0002697 regulation of immune effector process 310 1.864815 0.0163009 0.0113833
GO:0007159 leukocyte cell-cell adhesion 272 1.864264 0.0163009 0.0113833
GO:0001756 somitogenesis 49 1.864114 0.0256950 0.0179433
GO:0006949 syncytium formation 42 1.863773 0.0256950 0.0179433
GO:0007596 blood coagulation 276 1.863759 0.0163009 0.0113833
GO:0050817 coagulation 278 1.862314 0.0163009 0.0113833
GO:0060541 respiratory system development 174 1.862072 0.0163009 0.0113833
GO:0072234 metanephric nephron tubule development 19 1.861117 0.0256950 0.0179433
GO:0090130 tissue migration 262 1.859746 0.0163009 0.0113833
GO:0007221 positive regulation of transcription of Notch receptor target 17 1.859224 0.0325638 0.0227400
GO:1990868 response to chemokine 47 1.859103 0.0256950 0.0179433
GO:1990869 cellular response to chemokine 47 1.859103 0.0256950 0.0179433
GO:0048762 mesenchymal cell differentiation 171 1.858978 0.0163009 0.0113833
GO:0001657 ureteric bud development 87 1.858747 0.0163009 0.0113833
GO:0002714 positive regulation of B cell mediated immunity 28 1.857075 0.0163009 0.0113833
GO:0002891 positive regulation of immunoglobulin mediated immune response 28 1.857075 0.0163009 0.0113833
GO:0003174 mitral valve development 11 1.855191 0.0256950 0.0179433
GO:0002228 natural killer cell mediated immunity 47 1.854758 0.0256950 0.0179433
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 10 1.853873 0.0163009 0.0113833
GO:0032611 interleukin-1 beta production 71 1.853723 0.0163009 0.0113833
GO:0046640 regulation of alpha-beta T cell proliferation 23 1.852490 0.0163009 0.0113833
GO:0072163 mesonephric epithelium development 88 1.851483 0.0163009 0.0113833
GO:0072164 mesonephric tubule development 88 1.851483 0.0163009 0.0113833
GO:0032963 collagen metabolic process 79 1.851348 0.0163009 0.0113833
GO:0002521 leukocyte differentiation 407 1.849519 0.0163009 0.0113833
GO:0050678 regulation of epithelial cell proliferation 276 1.847584 0.0163009 0.0113833
GO:0002920 regulation of humoral immune response 46 1.846352 0.0256950 0.0179433
GO:0010594 regulation of endothelial cell migration 145 1.846086 0.0163009 0.0113833
GO:0045778 positive regulation of ossification 85 1.845822 0.0163009 0.0113833
GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 59 1.845744 0.0163009 0.0113833
GO:0061045 negative regulation of wound healing 58 1.845279 0.0163009 0.0113833
GO:1903670 regulation of sprouting angiogenesis 63 1.844496 0.0163009 0.0113833
GO:0060713 labyrinthine layer morphogenesis 18 1.844154 0.0468647 0.0327267
GO:0032944 regulation of mononuclear cell proliferation 169 1.843834 0.0163009 0.0113833
GO:0061041 regulation of wound healing 113 1.843206 0.0163009 0.0113833
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 24 1.842983 0.0256950 0.0179433
GO:0019915 lipid storage 57 1.841538 0.0163009 0.0113833
GO:0002703 regulation of leukocyte mediated immunity 155 1.840757 0.0163009 0.0113833
GO:0060317 cardiac epithelial to mesenchymal transition 32 1.840155 0.0163009 0.0113833
GO:0033687 osteoblast proliferation 22 1.840090 0.0163009 0.0113833
GO:0055092 sterol homeostasis 59 1.839947 0.0163009 0.0113833
GO:0061383 trabecula morphogenesis 44 1.839812 0.0325638 0.0227400
GO:1901890 positive regulation of cell junction assembly 31 1.839795 0.0163009 0.0113833
GO:0060485 mesenchyme development 210 1.839608 0.0163009 0.0113833
GO:0048660 regulation of smooth muscle cell proliferation 125 1.837426 0.0163009 0.0113833
GO:0033631 cell-cell adhesion mediated by integrin 14 1.837265 0.0325638 0.0227400
GO:0046633 alpha-beta T cell proliferation 26 1.836904 0.0163009 0.0113833
GO:0007565 female pregnancy 159 1.835430 0.0163009 0.0113833
GO:0040029 regulation of gene expression, epigenetic 283 1.833592 0.0163009 0.0113833
GO:0098581 detection of external biotic stimulus 13 1.833551 0.0399030 0.0278651
GO:0060562 epithelial tube morphogenesis 274 1.833518 0.0163009 0.0113833
GO:0050670 regulation of lymphocyte proliferation 168 1.832897 0.0163009 0.0113833
GO:0060009 Sertoli cell development 14 1.832823 0.0325638 0.0227400
GO:0001710 mesodermal cell fate commitment 15 1.832544 0.0397381 0.0277500
GO:0001823 mesonephros development 90 1.832539 0.0163009 0.0113833
GO:0060425 lung morphogenesis 45 1.832494 0.0325638 0.0227400
GO:0030224 monocyte differentiation 31 1.832143 0.0163009 0.0113833
GO:1903131 mononuclear cell differentiation 31 1.832143 0.0163009 0.0113833
GO:1903037 regulation of leukocyte cell-cell adhesion 244 1.830181 0.0163009 0.0113833
GO:0002532 production of molecular mediator involved in inflammatory response 56 1.829235 0.0163009 0.0113833
GO:0048260 positive regulation of receptor-mediated endocytosis 43 1.825883 0.0327718 0.0228853
GO:0072111 cell proliferation involved in kidney development 16 1.825036 0.0467758 0.0326645
GO:0050679 positive regulation of epithelial cell proliferation 159 1.824577 0.0163009 0.0113833
GO:0001649 osteoblast differentiation 193 1.823856 0.0163009 0.0113833
GO:0050702 interleukin-1 beta secretion 42 1.823766 0.0325638 0.0227400
GO:0010811 positive regulation of cell-substrate adhesion 98 1.823616 0.0163009 0.0113833
GO:0002706 regulation of lymphocyte mediated immunity 109 1.823408 0.0163009 0.0113833
GO:0046641 positive regulation of alpha-beta T cell proliferation 14 1.823202 0.0325638 0.0227400
GO:0045620 negative regulation of lymphocyte differentiation 44 1.822794 0.0325638 0.0227400
GO:0034121 regulation of toll-like receptor signaling pathway 59 1.821114 0.0163009 0.0113833
GO:0007599 hemostasis 280 1.819826 0.0163009 0.0113833
GO:0050863 regulation of T cell activation 259 1.818125 0.0163009 0.0113833
GO:0003179 heart valve morphogenesis 46 1.818028 0.0256950 0.0179433
GO:0007507 heart development 479 1.817890 0.0163009 0.0113833
GO:0022407 regulation of cell-cell adhesion 321 1.816402 0.0163009 0.0113833
GO:0007179 transforming growth factor beta receptor signaling pathway 162 1.816087 0.0163009 0.0113833
GO:0048659 smooth muscle cell proliferation 127 1.815300 0.0163009 0.0113833
GO:0060669 embryonic placenta morphogenesis 23 1.814344 0.0256950 0.0179433
GO:0060008 Sertoli cell differentiation 18 1.813795 0.0468647 0.0327267
GO:0045785 positive regulation of cell adhesion 334 1.813704 0.0163009 0.0113833
GO:0002449 lymphocyte mediated immunity 187 1.813407 0.0163009 0.0113833
GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress 12 1.813050 0.0327126 0.0228439
GO:0050650 chondroitin sulfate proteoglycan biosynthetic process 28 1.812344 0.0256950 0.0179433
GO:0003206 cardiac chamber morphogenesis 108 1.811903 0.0163009 0.0113833
GO:1903039 positive regulation of leukocyte cell-cell adhesion 178 1.811751 0.0163009 0.0113833
GO:0034329 cell junction assembly 201 1.811580 0.0163009 0.0113833
GO:0003215 cardiac right ventricle morphogenesis 11 1.811505 0.0325638 0.0227400
GO:0043484 regulation of RNA splicing 106 1.809896 0.0163009 0.0113833
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 44 1.808973 0.0325638 0.0227400
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 32 1.808237 0.0163009 0.0113833
GO:0002712 regulation of B cell mediated immunity 40 1.808092 0.0325638 0.0227400
GO:0002889 regulation of immunoglobulin mediated immune response 40 1.808092 0.0325638 0.0227400
GO:0002221 pattern recognition receptor signaling pathway 168 1.807998 0.0163009 0.0113833
GO:1903671 negative regulation of sprouting angiogenesis 23 1.807662 0.0256950 0.0179433
GO:1905953 negative regulation of lipid localization 33 1.804654 0.0163009 0.0113833
GO:2000050 regulation of non-canonical Wnt signaling pathway 22 1.804380 0.0325638 0.0227400
GO:0001893 maternal placenta development 33 1.803910 0.0163009 0.0113833
GO:0032612 interleukin-1 production 80 1.803802 0.0163009 0.0113833
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 24 1.802113 0.0256950 0.0179433
GO:0002548 monocyte chemotaxis 33 1.801957 0.0163009 0.0113833
GO:0033619 membrane protein proteolysis 52 1.800198 0.0259198 0.0181004
GO:0060142 regulation of syncytium formation by plasma membrane fusion 21 1.799761 0.0256950 0.0179433
GO:0085029 extracellular matrix assembly 25 1.799709 0.0325638 0.0227400
GO:0048644 muscle organ morphogenesis 62 1.799307 0.0163009 0.0113833
GO:0043535 regulation of blood vessel endothelial cell migration 83 1.798916 0.0163009 0.0113833
GO:0032675 regulation of interleukin-6 production 106 1.798374 0.0163009 0.0113833
GO:0010632 regulation of epithelial cell migration 201 1.797881 0.0163009 0.0113833
GO:0019731 antibacterial humoral response 20 1.796163 0.0397381 0.0277500
GO:1900016 negative regulation of cytokine production involved in inflammatory response 15 1.795767 0.0397381 0.0277500
GO:0002251 organ or tissue specific immune response 17 1.794706 0.0467808 0.0326681
GO:2000177 regulation of neural precursor cell proliferation 78 1.794394 0.0163009 0.0113833
GO:1901343 negative regulation of vasculature development 100 1.794285 0.0163009 0.0113833
GO:0006023 aminoglycan biosynthetic process 103 1.792814 0.0163009 0.0113833
GO:0060412 ventricular septum morphogenesis 41 1.792802 0.0397381 0.0277500
GO:0006352 DNA-templated transcription, initiation 215 1.792801 0.0163009 0.0113833
GO:1903909 regulation of receptor clustering 12 1.791603 0.0327126 0.0228439
GO:0071560 cellular response to transforming growth factor beta stimulus 207 1.790781 0.0163009 0.0113833
GO:0051262 protein tetramerization 157 1.790668 0.0163009 0.0113833
GO:1902337 regulation of apoptotic process involved in morphogenesis 11 1.790413 0.0464540 0.0324398
GO:1904748 regulation of apoptotic process involved in development 11 1.790413 0.0464540 0.0324398
GO:0050870 positive regulation of T cell activation 165 1.790322 0.0163009 0.0113833
GO:0042632 cholesterol homeostasis 58 1.789960 0.0259198 0.0181004
GO:0019724 B cell mediated immunity 88 1.789203 0.0163009 0.0113833
GO:0006024 glycosaminoglycan biosynthetic process 102 1.788838 0.0163009 0.0113833
GO:0048339 paraxial mesoderm development 15 1.788537 0.0397381 0.0277500
GO:1902105 regulation of leukocyte differentiation 223 1.788017 0.0163009 0.0113833
GO:0030879 mammary gland development 118 1.787845 0.0163009 0.0113833
GO:0003272 endocardial cushion formation 23 1.785965 0.0325638 0.0227400
GO:2000696 regulation of epithelial cell differentiation involved in kidney development 16 1.785645 0.0467758 0.0326645
GO:0045639 positive regulation of myeloid cell differentiation 71 1.784747 0.0163009 0.0113833
GO:0071559 response to transforming growth factor beta 213 1.781451 0.0163009 0.0113833
GO:0035909 aorta morphogenesis 28 1.781122 0.0325638 0.0227400
GO:0036499 PERK-mediated unfolded protein response 20 1.780651 0.0397381 0.0277500
GO:0048732 gland development 355 1.779743 0.0163009 0.0113833
GO:0016064 immunoglobulin mediated immune response 86 1.779681 0.0163009 0.0113833
GO:0034505 tooth mineralization 16 1.778963 0.0467758 0.0326645
GO:0046209 nitric oxide metabolic process 66 1.778213 0.0163009 0.0113833
GO:0045685 regulation of glial cell differentiation 71 1.777066 0.0163009 0.0113833
GO:0010742 macrophage derived foam cell differentiation 28 1.776461 0.0325638 0.0227400
GO:0090077 foam cell differentiation 28 1.776461 0.0325638 0.0227400
GO:2000352 negative regulation of endothelial cell apoptotic process 20 1.775820 0.0397381 0.0277500
GO:0060977 coronary vasculature morphogenesis 14 1.774879 0.0399030 0.0278651
GO:0010470 regulation of gastrulation 32 1.773164 0.0163009 0.0113833
GO:0030166 proteoglycan biosynthetic process 52 1.772613 0.0336977 0.0235318
GO:0001954 positive regulation of cell-matrix adhesion 44 1.772239 0.0325638 0.0227400
GO:0045622 regulation of T-helper cell differentiation 27 1.771855 0.0256950 0.0179433
GO:0001654 eye development 303 1.771519 0.0163009 0.0113833
GO:0050878 regulation of body fluid levels 413 1.770007 0.0163009 0.0113833
GO:2000136 regulation of cell proliferation involved in heart morphogenesis 12 1.768370 0.0399030 0.0278651
GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 18 1.768002 0.0468647 0.0327267
GO:0032835 glomerulus development 52 1.767365 0.0336977 0.0235318
GO:0051249 regulation of lymphocyte activation 345 1.764462 0.0163009 0.0113833
GO:0072202 cell differentiation involved in metanephros development 23 1.764297 0.0325638 0.0227400
GO:0043534 blood vessel endothelial cell migration 107 1.763994 0.0163009 0.0113833
GO:0010888 negative regulation of lipid storage 15 1.762937 0.0467808 0.0326681
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 48 1.762073 0.0399030 0.0278651
GO:0003229 ventricular cardiac muscle tissue development 45 1.761894 0.0399030 0.0278651
GO:0042306 regulation of protein import into nucleus 51 1.761182 0.0404520 0.0282485
GO:0050865 regulation of cell activation 453 1.761097 0.0163009 0.0113833
GO:0150063 visual system development 307 1.761070 0.0163009 0.0113833
GO:0002708 positive regulation of lymphocyte mediated immunity 72 1.760566 0.0163009 0.0113833
GO:0007160 cell-matrix adhesion 192 1.760495 0.0163009 0.0113833
GO:0050921 positive regulation of chemotaxis 114 1.760388 0.0163009 0.0113833
GO:0042304 regulation of fatty acid biosynthetic process 36 1.759831 0.0256950 0.0179433
GO:0045682 regulation of epidermis development 63 1.759361 0.0163009 0.0113833
GO:0045619 regulation of lymphocyte differentiation 139 1.758581 0.0163009 0.0113833
GO:0010575 positive regulation of vascular endothelial growth factor production 24 1.758009 0.0397381 0.0277500
GO:0060428 lung epithelium development 28 1.757250 0.0325638 0.0227400
GO:0007162 negative regulation of cell adhesion 223 1.756730 0.0163009 0.0113833
GO:0051251 positive regulation of lymphocyte activation 218 1.756096 0.0163009 0.0113833
GO:0032964 collagen biosynthetic process 40 1.755332 0.0325638 0.0227400
GO:0043010 camera-type eye development 263 1.755043 0.0163009 0.0113833
GO:0010831 positive regulation of myotube differentiation 23 1.754484 0.0325638 0.0227400
GO:0035850 epithelial cell differentiation involved in kidney development 39 1.754133 0.0325638 0.0227400
GO:0043277 apoptotic cell clearance 35 1.751872 0.0325638 0.0227400
GO:0061448 connective tissue development 202 1.751458 0.0163009 0.0113833
GO:0003281 ventricular septum development 68 1.751388 0.0259198 0.0181004
GO:0003279 cardiac septum development 101 1.750747 0.0163009 0.0113833
GO:2001057 reactive nitrogen species metabolic process 69 1.749285 0.0163009 0.0113833
GO:0042089 cytokine biosynthetic process 89 1.748636 0.0163009 0.0113833
GO:0048880 sensory system development 308 1.748489 0.0163009 0.0113833
GO:0051147 regulation of muscle cell differentiation 138 1.748004 0.0163009 0.0113833
GO:0044706 multi-multicellular organism process 186 1.747020 0.0163009 0.0113833
GO:0042692 muscle cell differentiation 289 1.746236 0.0163009 0.0113833
GO:0043536 positive regulation of blood vessel endothelial cell migration 53 1.745795 0.0404520 0.0282485
GO:0050728 negative regulation of inflammatory response 110 1.745551 0.0163009 0.0113833
GO:0045687 positive regulation of glial cell differentiation 45 1.745505 0.0399030 0.0278651
GO:0044319 wound healing, spreading of cells 28 1.745239 0.0325638 0.0227400
GO:0090505 epiboly involved in wound healing 28 1.745239 0.0325638 0.0227400
GO:0001825 blastocyst formation 32 1.745151 0.0163009 0.0113833
GO:1902106 negative regulation of leukocyte differentiation 84 1.745144 0.0163009 0.0113833
GO:0051894 positive regulation of focal adhesion assembly 23 1.744498 0.0395251 0.0276012
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 14 1.744128 0.0468647 0.0327267
GO:0042789 mRNA transcription by RNA polymerase II 16 1.743970 0.0467758 0.0326645
GO:0018022 peptidyl-lysine methylation 112 1.743645 0.0163009 0.0113833
GO:0060333 interferon-gamma-mediated signaling pathway 83 1.743626 0.0163009 0.0113833
GO:0048608 reproductive structure development 354 1.742536 0.0163009 0.0113833
GO:0018126 protein hydroxylation 22 1.741543 0.0397381 0.0277500
GO:0061311 cell surface receptor signaling pathway involved in heart development 27 1.741464 0.0325926 0.0227601
GO:0072574 hepatocyte proliferation 16 1.741105 0.0467758 0.0326645
GO:0072575 epithelial cell proliferation involved in liver morphogenesis 16 1.741105 0.0467758 0.0326645
GO:0050864 regulation of B cell activation 97 1.740461 0.0259198 0.0181004
GO:0010595 positive regulation of endothelial cell migration 95 1.740267 0.0259198 0.0181004
GO:2000379 positive regulation of reactive oxygen species metabolic process 83 1.740147 0.0163009 0.0113833
GO:0034330 cell junction organization 259 1.739877 0.0163009 0.0113833
GO:0033688 regulation of osteoblast proliferation 21 1.738387 0.0399030 0.0278651
GO:0034968 histone lysine methylation 100 1.738066 0.0163009 0.0113833
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 32 1.737712 0.0163009 0.0113833
GO:1903035 negative regulation of response to wounding 71 1.737445 0.0163009 0.0113833
GO:0019058 viral life cycle 292 1.737349 0.0163009 0.0113833
GO:0071604 transforming growth factor beta production 32 1.737176 0.0163009 0.0113833
GO:0070935 3’-UTR-mediated mRNA stabilization 14 1.736828 0.0468647 0.0327267
GO:0003203 endocardial cushion morphogenesis 32 1.736728 0.0163009 0.0113833
GO:2000778 positive regulation of interleukin-6 secretion 23 1.736182 0.0465001 0.0324720
GO:0010717 regulation of epithelial to mesenchymal transition 77 1.735835 0.0163009 0.0113833
GO:0070661 leukocyte proliferation 227 1.735540 0.0163009 0.0113833
GO:0045580 regulation of T cell differentiation 117 1.733667 0.0163009 0.0113833
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 35 1.733401 0.0325638 0.0227400
GO:0032103 positive regulation of response to external stimulus 251 1.733346 0.0163009 0.0113833
GO:0048598 embryonic morphogenesis 462 1.732915 0.0163009 0.0113833
GO:1903034 regulation of response to wounding 140 1.731253 0.0163009 0.0113833
GO:0001569 branching involved in blood vessel morphogenesis 26 1.730460 0.0399030 0.0278651
GO:0035313 wound healing, spreading of epidermal cells 14 1.730444 0.0468647 0.0327267
GO:0003231 cardiac ventricle development 112 1.730000 0.0163009 0.0113833
GO:0002262 myeloid cell homeostasis 130 1.728983 0.0163009 0.0113833
GO:0002694 regulation of leukocyte activation 420 1.728955 0.0163009 0.0113833
GO:0045598 regulation of fat cell differentiation 108 1.728722 0.0163009 0.0113833
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 159 1.728286 0.0163009 0.0113833
GO:0035886 vascular smooth muscle cell differentiation 24 1.727656 0.0397381 0.0277500
GO:1901222 regulation of NIK/NF-kappaB signaling 93 1.727335 0.0259198 0.0181004
GO:0016577 histone demethylation 24 1.726554 0.0397381 0.0277500
GO:0034341 response to interferon-gamma 159 1.726475 0.0163009 0.0113833
GO:0060563 neuroepithelial cell differentiation 45 1.725731 0.0468647 0.0327267
GO:0014031 mesenchymal cell development 56 1.725517 0.0399424 0.0278926
GO:0014013 regulation of gliogenesis 111 1.725452 0.0163009 0.0113833
GO:0070664 negative regulation of leukocyte proliferation 63 1.723531 0.0163009 0.0113833
GO:0035767 endothelial cell chemotaxis 24 1.723053 0.0397381 0.0277500
GO:0060840 artery development 81 1.722713 0.0163009 0.0113833
GO:0008360 regulation of cell shape 118 1.722624 0.0163009 0.0113833
GO:0042107 cytokine metabolic process 90 1.722333 0.0163009 0.0113833
GO:0007044 cell-substrate junction assembly 93 1.722018 0.0259198 0.0181004
GO:0032922 circadian regulation of gene expression 57 1.722014 0.0399030 0.0278651
GO:0010634 positive regulation of epithelial cell migration 134 1.721574 0.0163009 0.0113833
GO:0070665 positive regulation of leukocyte proliferation 103 1.721500 0.0163009 0.0113833
GO:0032943 mononuclear cell proliferation 210 1.721224 0.0163009 0.0113833
GO:0030595 leukocyte chemotaxis 149 1.719725 0.0163009 0.0113833
GO:0010837 regulation of keratinocyte proliferation 28 1.717783 0.0325638 0.0227400
GO:0046651 lymphocyte proliferation 208 1.715920 0.0163009 0.0113833
GO:0009952 anterior/posterior pattern specification 136 1.714609 0.0163009 0.0113833
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 51 1.714336 0.0479310 0.0334712
GO:0034101 erythrocyte homeostasis 105 1.714278 0.0163009 0.0113833
GO:0071634 regulation of transforming growth factor beta production 30 1.713948 0.0325638 0.0227400
GO:0002673 regulation of acute inflammatory response 69 1.713691 0.0163009 0.0113833
GO:0098542 defense response to other organism 314 1.713686 0.0163009 0.0113833
GO:0045066 regulatory T cell differentiation 29 1.713231 0.0325638 0.0227400
GO:0035282 segmentation 70 1.712278 0.0163009 0.0113833
GO:0030449 regulation of complement activation 36 1.712009 0.0399030 0.0278651
GO:2000353 positive regulation of endothelial cell apoptotic process 16 1.711954 0.0467758 0.0326645
GO:0097191 extrinsic apoptotic signaling pathway 192 1.711116 0.0163009 0.0113833
GO:0002699 positive regulation of immune effector process 164 1.709659 0.0163009 0.0113833
GO:0032635 interleukin-6 production 114 1.708735 0.0163009 0.0113833
GO:0060976 coronary vasculature development 43 1.708733 0.0399459 0.0278951
GO:0048593 camera-type eye morphogenesis 99 1.708604 0.0259198 0.0181004
GO:1905314 semi-lunar valve development 33 1.707667 0.0394902 0.0275769
GO:0002224 toll-like receptor signaling pathway 126 1.706628 0.0163009 0.0113833
GO:0002526 acute inflammatory response 111 1.705466 0.0163009 0.0113833
GO:1903426 regulation of reactive oxygen species biosynthetic process 76 1.705132 0.0163009 0.0113833
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 36 1.704823 0.0399030 0.0278651
GO:1903427 negative regulation of reactive oxygen species biosynthetic process 27 1.704792 0.0399030 0.0278651
GO:0032755 positive regulation of interleukin-6 production 67 1.704175 0.0259198 0.0181004
GO:2000181 negative regulation of blood vessel morphogenesis 90 1.703702 0.0163009 0.0113833
GO:0060795 cell fate commitment involved in formation of primary germ layer 25 1.701599 0.0467587 0.0326526
GO:0030857 negative regulation of epithelial cell differentiation 28 1.701021 0.0325638 0.0227400
GO:0071675 regulation of mononuclear cell migration 41 1.700848 0.0468268 0.0327001
GO:0010464 regulation of mesenchymal cell proliferation 32 1.700782 0.0256950 0.0179433
GO:0006606 protein import into nucleus 96 1.700140 0.0259198 0.0181004
GO:0097581 lamellipodium organization 71 1.699903 0.0163009 0.0113833
GO:0007259 JAK-STAT cascade 102 1.699291 0.0163009 0.0113833
GO:0061458 reproductive system development 357 1.698398 0.0163009 0.0113833
GO:0051053 negative regulation of DNA metabolic process 119 1.697216 0.0163009 0.0113833
GO:0048592 eye morphogenesis 126 1.697189 0.0163009 0.0113833
GO:0022409 positive regulation of cell-cell adhesion 206 1.696118 0.0163009 0.0113833
GO:0006956 complement activation 43 1.696047 0.0399459 0.0278951
GO:0003205 cardiac chamber development 148 1.695877 0.0163009 0.0113833
GO:0042088 T-helper 1 type immune response 34 1.695840 0.0468647 0.0327267
GO:0007043 cell-cell junction assembly 88 1.694962 0.0163009 0.0113833
GO:1900015 regulation of cytokine production involved in inflammatory response 34 1.693597 0.0468647 0.0327267
GO:0060537 muscle tissue development 323 1.692796 0.0163009 0.0113833
GO:0071260 cellular response to mechanical stimulus 69 1.692460 0.0259198 0.0181004
GO:0048565 digestive tract development 106 1.692063 0.0163009 0.0113833
GO:0002696 positive regulation of leukocyte activation 255 1.692010 0.0163009 0.0113833
GO:0032946 positive regulation of mononuclear cell proliferation 100 1.691647 0.0163009 0.0113833
GO:0050727 regulation of inflammatory response 299 1.691469 0.0163009 0.0113833
GO:0007435 salivary gland morphogenesis 32 1.691318 0.0394902 0.0275769
GO:0060759 regulation of response to cytokine stimulus 154 1.687517 0.0163009 0.0113833
GO:0060415 muscle tissue morphogenesis 58 1.686603 0.0481798 0.0336450
GO:0007431 salivary gland development 36 1.686508 0.0399030 0.0278651
GO:0048536 spleen development 26 1.686255 0.0399030 0.0278651
GO:0001701 in utero embryonic development 307 1.685789 0.0163009 0.0113833
GO:0050867 positive regulation of cell activation 265 1.684700 0.0163009 0.0113833
GO:0048144 fibroblast proliferation 76 1.684354 0.0163009 0.0113833
GO:0072273 metanephric nephron morphogenesis 25 1.683234 0.0467587 0.0326526
GO:0045668 negative regulation of osteoblast differentiation 36 1.683213 0.0469681 0.0327988
GO:0030279 negative regulation of ossification 57 1.682032 0.0399030 0.0278651
GO:0007423 sensory organ development 449 1.681285 0.0163009 0.0113833
GO:0045216 cell-cell junction organization 116 1.681215 0.0163009 0.0113833
GO:0032945 negative regulation of mononuclear cell proliferation 58 1.681199 0.0481798 0.0336450
GO:0050672 negative regulation of lymphocyte proliferation 58 1.681199 0.0481798 0.0336450
GO:0035270 endocrine system development 93 1.681029 0.0259198 0.0181004
GO:0001959 regulation of cytokine-mediated signaling pathway 143 1.681008 0.0163009 0.0113833
GO:0001501 skeletal system development 394 1.680399 0.0163009 0.0113833
GO:0071354 cellular response to interleukin-6 33 1.677193 0.0464565 0.0324416
GO:0097696 STAT cascade 106 1.676635 0.0163009 0.0113833
GO:0048568 embryonic organ development 338 1.675988 0.0163009 0.0113833
GO:0060348 bone development 163 1.675805 0.0163009 0.0113833
GO:0007517 muscle organ development 327 1.673995 0.0163009 0.0113833
GO:0042035 regulation of cytokine biosynthetic process 83 1.673547 0.0163009 0.0113833
GO:0032570 response to progesterone 40 1.672925 0.0469124 0.0327599
GO:0050871 positive regulation of B cell activation 59 1.672629 0.0408088 0.0284976
GO:0090184 positive regulation of kidney development 32 1.672472 0.0464565 0.0324416
GO:0030218 erythrocyte differentiation 99 1.672314 0.0259198 0.0181004
GO:0070741 response to interleukin-6 36 1.671636 0.0469681 0.0327988
GO:0006303 double-strand break repair via nonhomologous end joining 77 1.671189 0.0163009 0.0113833
GO:0002573 myeloid leukocyte differentiation 166 1.670663 0.0163009 0.0113833
GO:0050671 positive regulation of lymphocyte proliferation 99 1.669844 0.0259198 0.0181004
GO:0090504 epiboly 29 1.668664 0.0397381 0.0277500
GO:0016525 negative regulation of angiogenesis 89 1.666168 0.0259198 0.0181004
GO:0045165 cell fate commitment 173 1.665609 0.0163009 0.0113833
GO:0048710 regulation of astrocyte differentiation 31 1.665507 0.0467758 0.0326645
GO:0070613 regulation of protein processing 83 1.664982 0.0163009 0.0113833
GO:0097421 liver regeneration 29 1.664737 0.0397381 0.0277500
GO:1902532 negative regulation of intracellular signal transduction 461 1.664042 0.0163009 0.0113833
GO:0031348 negative regulation of defense response 170 1.663617 0.0163009 0.0113833
GO:0000726 non-recombinational repair 83 1.663509 0.0163009 0.0113833
GO:0009913 epidermal cell differentiation 153 1.660987 0.0163009 0.0113833
GO:0043433 negative regulation of DNA-binding transcription factor activity 144 1.658615 0.0163009 0.0113833
GO:0050818 regulation of coagulation 64 1.658435 0.0163009 0.0113833
GO:0043409 negative regulation of MAPK cascade 146 1.658242 0.0163009 0.0113833
GO:0031532 actin cytoskeleton reorganization 82 1.657939 0.0259198 0.0181004
GO:0048771 tissue remodeling 133 1.656716 0.0163009 0.0113833
GO:0031099 regeneration 163 1.656489 0.0163009 0.0113833
GO:0031100 animal organ regeneration 67 1.656231 0.0259198 0.0181004
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 276 1.655423 0.0163009 0.0113833
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 204 1.655252 0.0163009 0.0113833
GO:0051384 response to glucocorticoid 119 1.654085 0.0259198 0.0181004
GO:0032651 regulation of interleukin-1 beta production 61 1.654041 0.0334693 0.0233723
GO:0120162 positive regulation of cold-induced thermogenesis 84 1.653133 0.0163009 0.0113833
GO:0030216 keratinocyte differentiation 112 1.653075 0.0259198 0.0181004
GO:2000146 negative regulation of cell motility 238 1.651712 0.0163009 0.0113833
GO:0007173 epidermal growth factor receptor signaling pathway 104 1.646665 0.0163009 0.0113833
GO:0034332 adherens junction organization 129 1.644699 0.0163009 0.0113833
GO:0050663 cytokine secretion 178 1.644155 0.0163009 0.0113833
GO:0071901 negative regulation of protein serine/threonine kinase activity 114 1.643109 0.0259198 0.0181004
GO:0014706 striated muscle tissue development 310 1.641667 0.0163009 0.0113833
GO:0070373 negative regulation of ERK1 and ERK2 cascade 64 1.640789 0.0338318 0.0236255
GO:0031960 response to corticosteroid 135 1.640053 0.0163009 0.0113833
GO:0010810 regulation of cell-substrate adhesion 178 1.639850 0.0163009 0.0113833
GO:0030336 negative regulation of cell migration 227 1.638925 0.0163009 0.0113833
GO:0050920 regulation of chemotaxis 157 1.638685 0.0163009 0.0113833
GO:0001935 endothelial cell proliferation 119 1.638411 0.0259198 0.0181004
GO:0001818 negative regulation of cytokine production 225 1.637597 0.0163009 0.0113833
GO:0030183 B cell differentiation 98 1.636794 0.0259198 0.0181004
GO:0048145 regulation of fibroblast proliferation 75 1.635742 0.0163009 0.0113833
GO:0055123 digestive system development 115 1.635506 0.0259198 0.0181004
GO:0032102 negative regulation of response to external stimulus 258 1.633242 0.0163009 0.0113833
GO:0030522 intracellular receptor signaling pathway 253 1.631735 0.0163009 0.0113833
GO:0002698 negative regulation of immune effector process 99 1.630417 0.0259198 0.0181004
GO:0048705 skeletal system morphogenesis 160 1.630014 0.0163009 0.0113833
GO:0002685 regulation of leukocyte migration 157 1.629967 0.0163009 0.0113833
GO:0019827 stem cell population maintenance 140 1.629590 0.0163009 0.0113833
GO:0000723 telomere maintenance 145 1.628975 0.0163009 0.0113833
GO:0050729 positive regulation of inflammatory response 114 1.628065 0.0259198 0.0181004
GO:0098727 maintenance of cell number 142 1.627375 0.0163009 0.0113833
GO:0030203 glycosaminoglycan metabolic process 143 1.625647 0.0163009 0.0113833
GO:0042326 negative regulation of phosphorylation 396 1.623966 0.0163009 0.0113833
GO:0042113 B cell activation 186 1.623769 0.0163009 0.0113833
GO:1903317 regulation of protein maturation 85 1.623546 0.0163009 0.0113833
GO:0035051 cardiocyte differentiation 112 1.623116 0.0341122 0.0238213
GO:0006909 phagocytosis 219 1.622168 0.0163009 0.0113833
GO:0048738 cardiac muscle tissue development 173 1.621893 0.0163009 0.0113833
GO:0071346 cellular response to interferon-gamma 142 1.618006 0.0163009 0.0113833
GO:0051216 cartilage development 151 1.617303 0.0259198 0.0181004
GO:0051271 negative regulation of cellular component movement 254 1.616671 0.0163009 0.0113833
GO:0016485 protein processing 184 1.615846 0.0163009 0.0113833
GO:0006022 aminoglycan metabolic process 146 1.614960 0.0163009 0.0113833
GO:1901888 regulation of cell junction assembly 86 1.612291 0.0163009 0.0113833
GO:0006986 response to unfolded protein 156 1.611920 0.0259198 0.0181004
GO:0007229 integrin-mediated signaling pathway 90 1.611530 0.0259198 0.0181004
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 120 1.610275 0.0338658 0.0236492
GO:0042542 response to hydrogen peroxide 129 1.609989 0.0336977 0.0235318
GO:0071887 leukocyte apoptotic process 83 1.609179 0.0487739 0.0340598
GO:0001936 regulation of endothelial cell proliferation 104 1.608784 0.0259198 0.0181004
GO:0001819 positive regulation of cytokine production 364 1.606572 0.0163009 0.0113833
GO:0032680 regulation of tumor necrosis factor production 117 1.604140 0.0163009 0.0113833
GO:0002761 regulation of myeloid leukocyte differentiation 93 1.603591 0.0341052 0.0238164
GO:2000045 regulation of G1/S transition of mitotic cell cycle 139 1.603339 0.0332441 0.0232151
GO:0008544 epidermis development 242 1.602838 0.0163009 0.0113833
GO:0046425 regulation of JAK-STAT cascade 87 1.601873 0.0259198 0.0181004
GO:0048545 response to steroid hormone 337 1.601295 0.0163009 0.0113833
GO:0032609 interferon-gamma production 78 1.598320 0.0163009 0.0113833
GO:0097529 myeloid leukocyte migration 136 1.598172 0.0259198 0.0181004
GO:0051701 interaction with host 187 1.597637 0.0163009 0.0113833
GO:0009101 glycoprotein biosynthetic process 265 1.597310 0.0163009 0.0113833
GO:0071706 tumor necrosis factor superfamily cytokine production 125 1.596908 0.0337309 0.0235550
GO:0002688 regulation of leukocyte chemotaxis 89 1.596103 0.0259198 0.0181004
GO:0050707 regulation of cytokine secretion 153 1.595940 0.0259198 0.0181004
GO:0048872 homeostasis of number of cells 212 1.595358 0.0163009 0.0113833
GO:0040013 negative regulation of locomotion 265 1.595025 0.0163009 0.0113833
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 119 1.592729 0.0259198 0.0181004
GO:0001659 temperature homeostasis 152 1.592354 0.0259198 0.0181004
GO:0048010 vascular endothelial growth factor receptor signaling pathway 87 1.591525 0.0259198 0.0181004
GO:0007569 cell aging 99 1.590731 0.0341052 0.0238164
GO:0001776 leukocyte homeostasis 74 1.589042 0.0336977 0.0235318
GO:0045444 fat cell differentiation 192 1.587415 0.0163009 0.0113833
GO:0001933 negative regulation of protein phosphorylation 363 1.585326 0.0163009 0.0113833
GO:0043588 skin development 214 1.585202 0.0163009 0.0113833
GO:1905952 regulation of lipid localization 115 1.583176 0.0259198 0.0181004
GO:1904892 regulation of STAT cascade 90 1.579647 0.0341122 0.0238213
GO:0070371 ERK1 and ERK2 cascade 241 1.579013 0.0163009 0.0113833
GO:0034333 adherens junction assembly 88 1.578991 0.0420626 0.0293732
GO:0032526 response to retinoic acid 93 1.577909 0.0341052 0.0238164
GO:0106106 cold-induced thermogenesis 129 1.573761 0.0486648 0.0339837
GO:0120161 regulation of cold-induced thermogenesis 129 1.573761 0.0486648 0.0339837
GO:0010001 glial cell differentiation 200 1.571772 0.0163009 0.0113833
GO:0006959 humoral immune response 119 1.569872 0.0337643 0.0235784
GO:0007265 Ras protein signal transduction 314 1.568428 0.0163009 0.0113833
GO:0035265 organ growth 138 1.566270 0.0479310 0.0334712
GO:1901184 regulation of ERBB signaling pathway 83 1.565565 0.0487739 0.0340598
GO:0032640 tumor necrosis factor production 121 1.565178 0.0414987 0.0289794
GO:0002009 morphogenesis of an epithelium 461 1.564542 0.0163009 0.0113833
GO:0007266 Rho protein signal transduction 151 1.563486 0.0259198 0.0181004
GO:0043009 chordate embryonic development 496 1.560149 0.0163009 0.0113833
GO:0051090 regulation of DNA-binding transcription factor activity 377 1.559297 0.0163009 0.0113833
GO:0006493 protein O-linked glycosylation 87 1.558964 0.0493729 0.0344781
GO:0001906 cell killing 94 1.552809 0.0341096 0.0238195
GO:0033673 negative regulation of kinase activity 214 1.549712 0.0163009 0.0113833
GO:0051170 import into nucleus 117 1.549609 0.0259198 0.0181004
GO:0006469 negative regulation of protein kinase activity 197 1.548833 0.0163009 0.0113833
GO:0019216 regulation of lipid metabolic process 339 1.543705 0.0163009 0.0113833
GO:0001101 response to acid chemical 298 1.543320 0.0163009 0.0113833
GO:0042063 gliogenesis 262 1.541951 0.0163009 0.0113833
GO:1902806 regulation of cell cycle G1/S phase transition 152 1.539691 0.0259198 0.0181004
GO:1903409 reactive oxygen species biosynthetic process 96 1.538200 0.0419599 0.0293015
GO:0062014 negative regulation of small molecule metabolic process 84 1.533317 0.0494299 0.0345180
GO:2000377 regulation of reactive oxygen species metabolic process 161 1.527025 0.0259198 0.0181004
GO:0045936 negative regulation of phosphate metabolic process 498 1.522672 0.0163009 0.0113833
GO:0051146 striated muscle cell differentiation 212 1.518334 0.0163009 0.0113833
GO:2001020 regulation of response to DNA damage stimulus 194 1.517527 0.0256950 0.0179433
GO:0070372 regulation of ERK1 and ERK2 cascade 226 1.513326 0.0163009 0.0113833
GO:0090596 sensory organ morphogenesis 207 1.509917 0.0163009 0.0113833
GO:0010563 negative regulation of phosphorus metabolic process 499 1.509790 0.0163009 0.0113833
GO:0007219 Notch signaling pathway 157 1.504911 0.0259198 0.0181004
GO:0035966 response to topologically incorrect protein 170 1.500023 0.0163009 0.0113833
GO:1901652 response to peptide 433 1.497208 0.0163009 0.0113833
GO:0071407 cellular response to organic cyclic compound 489 1.495282 0.0163009 0.0113833
GO:0042330 taxis 461 1.489261 0.0163009 0.0113833
GO:0006302 double-strand break repair 200 1.477868 0.0256950 0.0179433
GO:0006935 chemotaxis 459 1.475953 0.0163009 0.0113833
GO:0009612 response to mechanical stimulus 180 1.475874 0.0259198 0.0181004
GO:0007568 aging 276 1.472302 0.0259198 0.0181004
GO:0043583 ear development 180 1.465610 0.0259198 0.0181004
GO:0043405 regulation of MAP kinase activity 293 1.462833 0.0256950 0.0179433
GO:2001234 negative regulation of apoptotic signaling pathway 199 1.460054 0.0325638 0.0227400
GO:0009100 glycoprotein metabolic process 321 1.459553 0.0163009 0.0113833
GO:0043434 response to peptide hormone 359 1.454162 0.0163009 0.0113833
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 176 1.453980 0.0163009 0.0113833
GO:2000116 regulation of cysteine-type endopeptidase activity 200 1.451070 0.0325638 0.0227400
GO:0000302 response to reactive oxygen species 204 1.448319 0.0256950 0.0179433
GO:0071214 cellular response to abiotic stimulus 277 1.438212 0.0258183 0.0180295
GO:0104004 cellular response to environmental stimulus 277 1.438212 0.0258183 0.0180295
GO:0045088 regulation of innate immune response 367 1.436410 0.0163009 0.0113833
GO:0051604 protein maturation 238 1.432332 0.0163009 0.0113833
GO:2001233 regulation of apoptotic signaling pathway 360 1.425854 0.0163009 0.0113833
GO:0042119 neutrophil activation 442 1.425386 0.0163009 0.0113833
GO:0052547 regulation of peptidase activity 311 1.424759 0.0256950 0.0179433
GO:0007548 sex differentiation 219 1.423387 0.0325638 0.0227400
GO:0002446 neutrophil mediated immunity 442 1.420592 0.0163009 0.0113833
GO:0043410 positive regulation of MAPK cascade 430 1.420062 0.0163009 0.0113833
GO:0002253 activation of immune response 482 1.418634 0.0163009 0.0113833
GO:0097193 intrinsic apoptotic signaling pathway 252 1.413788 0.0325638 0.0227400
GO:0071383 cellular response to steroid hormone stimulus 224 1.413623 0.0325638 0.0227400
GO:0046578 regulation of Ras protein signal transduction 208 1.407638 0.0399857 0.0279229
GO:0048562 embryonic organ morphogenesis 217 1.404412 0.0399030 0.0278651
GO:1901653 cellular response to peptide 322 1.402946 0.0391379 0.0273308
GO:0036230 granulocyte activation 449 1.392785 0.0163009 0.0113833
GO:0043312 neutrophil degranulation 431 1.389726 0.0163009 0.0113833
GO:0002283 neutrophil activation involved in immune response 433 1.388856 0.0163009 0.0113833
GO:0000082 G1/S transition of mitotic cell cycle 229 1.388597 0.0468647 0.0327267
GO:0072593 reactive oxygen species metabolic process 229 1.387864 0.0468647 0.0327267
GO:0045926 negative regulation of growth 211 1.386956 0.0399030 0.0278651
GO:0052548 regulation of endopeptidase activity 287 1.384939 0.0468647 0.0327267
GO:0007264 small GTPase mediated signal transduction 449 1.383349 0.0163009 0.0113833
GO:0071900 regulation of protein serine/threonine kinase activity 433 1.378355 0.0163009 0.0113833
GO:0044843 cell cycle G1/S phase transition 243 1.376693 0.0399030 0.0278651
GO:0090287 regulation of cellular response to growth factor stimulus 225 1.372181 0.0473740 0.0330823
GO:0051348 negative regulation of transferase activity 241 1.367540 0.0469681 0.0327988
GO:0048871 multicellular organismal homeostasis 393 1.362653 0.0384836 0.0268740
GO:0043299 leukocyte degranulation 475 1.355314 0.0256950 0.0179433
GO:0031349 positive regulation of defense response 415 1.352573 0.0325638 0.0227400
GO:0002444 myeloid leukocyte mediated immunity 490 1.342794 0.0256950 0.0179433
GO:0002275 myeloid cell activation involved in immune response 483 1.338694 0.0256950 0.0179433
Enriched terms for module #EE8045 (MTcor = 0.93)
ID Description setSize NES p.adjust qvalues
GO:0006335 DNA replication-dependent nucleosome assembly 32 2.996751 0.0159016 0.0102626
GO:0034723 DNA replication-dependent nucleosome organization 32 2.996751 0.0159016 0.0102626
GO:0000183 chromatin silencing at rDNA 39 2.777755 0.0159016 0.0102626
GO:0030219 megakaryocyte differentiation 90 2.673639 0.0159016 0.0102626
GO:0045652 regulation of megakaryocyte differentiation 74 2.668044 0.0159016 0.0102626
GO:0045653 negative regulation of megakaryocyte differentiation 17 2.640593 0.0159016 0.0102626
GO:0046637 regulation of alpha-beta T cell differentiation 51 2.599135 0.0159016 0.0102626
GO:0002250 adaptive immune response 290 2.578289 0.0159016 0.0102626
GO:0051290 protein heterotetramerization 51 2.569952 0.0159016 0.0102626
GO:1902107 positive regulation of leukocyte differentiation 122 2.565363 0.0159016 0.0102626
GO:0002819 regulation of adaptive immune response 128 2.547999 0.0159016 0.0102626
GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 37 2.545056 0.0159016 0.0102626
GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 46 2.521920 0.0159016 0.0102626
GO:0045621 positive regulation of lymphocyte differentiation 81 2.519959 0.0159016 0.0102626
GO:0046634 regulation of alpha-beta T cell activation 74 2.495200 0.0159016 0.0102626
GO:0006334 nucleosome assembly 119 2.491964 0.0159016 0.0102626
GO:1903708 positive regulation of hemopoiesis 155 2.475645 0.0159016 0.0102626
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 197 2.468648 0.0159016 0.0102626
GO:0046638 positive regulation of alpha-beta T cell differentiation 40 2.468390 0.0159016 0.0102626
GO:1903707 negative regulation of hemopoiesis 129 2.465092 0.0159016 0.0102626
GO:0045582 positive regulation of T cell differentiation 71 2.462210 0.0159016 0.0102626
GO:0042129 regulation of T cell proliferation 123 2.446160 0.0159016 0.0102626
GO:0070663 regulation of leukocyte proliferation 177 2.437859 0.0159016 0.0102626
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 114 2.437506 0.0159016 0.0102626
GO:0046631 alpha-beta T cell activation 107 2.428381 0.0159016 0.0102626
GO:0042098 T cell proliferation 151 2.424494 0.0159016 0.0102626
GO:0032944 regulation of mononuclear cell proliferation 169 2.420905 0.0159016 0.0102626
GO:0051250 negative regulation of lymphocyte activation 117 2.413892 0.0159016 0.0102626
GO:0046635 positive regulation of alpha-beta T cell activation 51 2.413465 0.0159016 0.0102626
GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 23 2.410038 0.0159016 0.0102626
GO:0045622 regulation of T-helper cell differentiation 27 2.404610 0.0159016 0.0102626
GO:0050670 regulation of lymphocyte proliferation 168 2.400951 0.0159016 0.0102626
GO:1902105 regulation of leukocyte differentiation 223 2.391644 0.0159016 0.0102626
GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation 18 2.387865 0.0159016 0.0102626
GO:0002821 positive regulation of adaptive immune response 78 2.387704 0.0159016 0.0102626
GO:0042110 T cell activation 376 2.385384 0.0159016 0.0102626
GO:0034728 nucleosome organization 144 2.382611 0.0159016 0.0102626
GO:0031497 chromatin assembly 135 2.382550 0.0159016 0.0102626
GO:0045580 regulation of T cell differentiation 117 2.363514 0.0159016 0.0102626
GO:0046632 alpha-beta T cell differentiation 78 2.363269 0.0159016 0.0102626
GO:0002385 mucosal immune response 14 2.360574 0.0159016 0.0102626
GO:0045619 regulation of lymphocyte differentiation 139 2.357851 0.0159016 0.0102626
GO:0046639 negative regulation of alpha-beta T cell differentiation 21 2.355658 0.0159016 0.0102626
GO:0043367 CD4-positive, alpha-beta T cell differentiation 58 2.353200 0.0159016 0.0102626
GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 73 2.352232 0.0159016 0.0102626
GO:0070661 leukocyte proliferation 227 2.347786 0.0159016 0.0102626
GO:0045637 regulation of myeloid cell differentiation 214 2.342380 0.0159016 0.0102626
GO:0030217 T cell differentiation 193 2.336414 0.0159016 0.0102626
GO:0002695 negative regulation of leukocyte activation 143 2.335048 0.0159016 0.0102626
GO:0050863 regulation of T cell activation 259 2.334270 0.0159016 0.0102626
GO:0002285 lymphocyte activation involved in immune response 128 2.329127 0.0159016 0.0102626
GO:0032943 mononuclear cell proliferation 210 2.328515 0.0159016 0.0102626
GO:0050866 negative regulation of cell activation 162 2.325771 0.0159016 0.0102626
GO:0050853 B cell receptor signaling pathway 43 2.324354 0.0159016 0.0102626
GO:0030199 collagen fibril organization 40 2.319824 0.0159016 0.0102626
GO:0046651 lymphocyte proliferation 208 2.315219 0.0159016 0.0102626
GO:0006342 chromatin silencing 76 2.311585 0.0159016 0.0102626
GO:0007159 leukocyte cell-cell adhesion 272 2.310113 0.0159016 0.0102626
GO:0046636 negative regulation of alpha-beta T cell activation 31 2.307623 0.0159016 0.0102626
GO:0002286 T cell activation involved in immune response 70 2.303469 0.0159016 0.0102626
GO:0035710 CD4-positive, alpha-beta T cell activation 71 2.301925 0.0159016 0.0102626
GO:0006333 chromatin assembly or disassembly 159 2.301213 0.0159016 0.0102626
GO:0051249 regulation of lymphocyte activation 345 2.296515 0.0159016 0.0102626
GO:0050868 negative regulation of T cell activation 89 2.294916 0.0159016 0.0102626
GO:0022408 negative regulation of cell-cell adhesion 138 2.292432 0.0159016 0.0102626
GO:1903037 regulation of leukocyte cell-cell adhesion 244 2.285001 0.0159016 0.0102626
GO:0030098 lymphocyte differentiation 272 2.282246 0.0159016 0.0102626
GO:1903038 negative regulation of leukocyte cell-cell adhesion 98 2.280447 0.0159016 0.0102626
GO:0002227 innate immune response in mucosa 11 2.268398 0.0162534 0.0104897
GO:1903039 positive regulation of leukocyte cell-cell adhesion 178 2.268072 0.0159016 0.0102626
GO:0060964 regulation of gene silencing by miRNA 110 2.265707 0.0159016 0.0102626
GO:0002449 lymphocyte mediated immunity 187 2.264338 0.0159016 0.0102626
GO:0002467 germinal center formation 14 2.264219 0.0159016 0.0102626
GO:0002694 regulation of leukocyte activation 420 2.263749 0.0159016 0.0102626
GO:0070664 negative regulation of leukocyte proliferation 63 2.263131 0.0159016 0.0102626
GO:0007492 endoderm development 60 2.260271 0.0159016 0.0102626
GO:0060333 interferon-gamma-mediated signaling pathway 83 2.258355 0.0159016 0.0102626
GO:0002683 negative regulation of immune system process 376 2.255517 0.0159016 0.0102626
GO:1902106 negative regulation of leukocyte differentiation 84 2.252447 0.0159016 0.0102626
GO:0002251 organ or tissue specific immune response 17 2.251300 0.0159016 0.0102626
GO:0034508 centromere complex assembly 53 2.243692 0.0159016 0.0102626
GO:0050870 positive regulation of T cell activation 165 2.241986 0.0159016 0.0102626
GO:0060326 cell chemotaxis 201 2.238333 0.0159016 0.0102626
GO:0042102 positive regulation of T cell proliferation 69 2.237726 0.0159016 0.0102626
GO:0045581 negative regulation of T cell differentiation 38 2.233343 0.0159016 0.0102626
GO:0050865 regulation of cell activation 453 2.231562 0.0159016 0.0102626
GO:0002521 leukocyte differentiation 407 2.231494 0.0159016 0.0102626
GO:0060147 regulation of posttranscriptional gene silencing 112 2.229272 0.0159016 0.0102626
GO:0060966 regulation of gene silencing by RNA 112 2.229272 0.0159016 0.0102626
GO:0002577 regulation of antigen processing and presentation 15 2.227794 0.0159016 0.0102626
GO:0048514 blood vessel morphogenesis 495 2.224973 0.0159016 0.0102626
GO:0045624 positive regulation of T-helper cell differentiation 17 2.224029 0.0159016 0.0102626
GO:0032677 regulation of interleukin-8 production 53 2.217004 0.0159016 0.0102626
GO:0016064 immunoglobulin mediated immune response 86 2.214410 0.0159016 0.0102626
GO:0032945 negative regulation of mononuclear cell proliferation 58 2.211020 0.0159016 0.0102626
GO:0050672 negative regulation of lymphocyte proliferation 58 2.211020 0.0159016 0.0102626
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation 24 2.209178 0.0159016 0.0102626
GO:0006323 DNA packaging 168 2.206612 0.0159016 0.0102626
GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 28 2.206398 0.0159016 0.0102626
GO:0019731 antibacterial humoral response 20 2.205999 0.0159016 0.0102626
GO:0045066 regulatory T cell differentiation 29 2.203715 0.0159016 0.0102626
GO:0002703 regulation of leukocyte mediated immunity 155 2.201637 0.0159016 0.0102626
GO:0019724 B cell mediated immunity 88 2.201544 0.0159016 0.0102626
GO:0045616 regulation of keratinocyte differentiation 30 2.198550 0.0159016 0.0102626
GO:0002696 positive regulation of leukocyte activation 255 2.197440 0.0159016 0.0102626
GO:0050867 positive regulation of cell activation 265 2.196000 0.0159016 0.0102626
GO:0045814 negative regulation of gene expression, epigenetic 94 2.195384 0.0159016 0.0102626
GO:0010718 positive regulation of epithelial to mesenchymal transition 45 2.192845 0.0159016 0.0102626
GO:0022407 regulation of cell-cell adhesion 321 2.192025 0.0159016 0.0102626
GO:0001710 mesodermal cell fate commitment 15 2.191462 0.0159016 0.0102626
GO:0002706 regulation of lymphocyte mediated immunity 109 2.186002 0.0159016 0.0102626
GO:0006968 cellular defense response 40 2.185394 0.0159016 0.0102626
GO:0045638 negative regulation of myeloid cell differentiation 79 2.183768 0.0159016 0.0102626
GO:0051251 positive regulation of lymphocyte activation 218 2.180389 0.0159016 0.0102626
GO:0030099 myeloid cell differentiation 357 2.180262 0.0159016 0.0102626
GO:0002287 alpha-beta T cell activation involved in immune response 47 2.177864 0.0159016 0.0102626
GO:0002293 alpha-beta T cell differentiation involved in immune response 47 2.177864 0.0159016 0.0102626
GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 47 2.177864 0.0159016 0.0102626
GO:0002697 regulation of immune effector process 310 2.176051 0.0159016 0.0102626
GO:0002292 T cell differentiation involved in immune response 49 2.174498 0.0159016 0.0102626
GO:0042113 B cell activation 186 2.172635 0.0159016 0.0102626
GO:0001704 formation of primary germ layer 95 2.165954 0.0159016 0.0102626
GO:0009617 response to bacterium 413 2.162041 0.0159016 0.0102626
GO:0022409 positive regulation of cell-cell adhesion 206 2.159242 0.0159016 0.0102626
GO:1903706 regulation of hemopoiesis 409 2.155280 0.0159016 0.0102626
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway 13 2.154887 0.0159016 0.0102626
GO:0003272 endocardial cushion formation 23 2.152902 0.0159016 0.0102626
GO:0031055 chromatin remodeling at centromere 45 2.151889 0.0159016 0.0102626
GO:0042093 T-helper cell differentiation 46 2.151698 0.0159016 0.0102626
GO:0001773 myeloid dendritic cell activation 21 2.151516 0.0159016 0.0102626
GO:0048333 mesodermal cell differentiation 27 2.148310 0.0159016 0.0102626
GO:0045589 regulation of regulatory T cell differentiation 28 2.147716 0.0159016 0.0102626
GO:0032060 bleb assembly 11 2.146013 0.0162534 0.0104897
GO:0070665 positive regulation of leukocyte proliferation 103 2.145809 0.0159016 0.0102626
GO:2000482 regulation of interleukin-8 secretion 20 2.144121 0.0159016 0.0102626
GO:0050864 regulation of B cell activation 97 2.140673 0.0159016 0.0102626
GO:0046633 alpha-beta T cell proliferation 26 2.136271 0.0159016 0.0102626
GO:0045620 negative regulation of lymphocyte differentiation 44 2.134582 0.0159016 0.0102626
GO:2000036 regulation of stem cell population maintenance 25 2.132358 0.0159016 0.0102626
GO:0038111 interleukin-7-mediated signaling pathway 29 2.129577 0.0159016 0.0102626
GO:0001525 angiogenesis 418 2.124523 0.0159016 0.0102626
GO:0035329 hippo signaling 38 2.122046 0.0159016 0.0102626
GO:0045623 negative regulation of T-helper cell differentiation 14 2.121473 0.0159016 0.0102626
GO:2000319 regulation of T-helper 17 cell differentiation 13 2.120336 0.0159016 0.0102626
GO:0034341 response to interferon-gamma 159 2.112033 0.0159016 0.0102626
GO:0032729 positive regulation of interferon-gamma production 46 2.111243 0.0159016 0.0102626
GO:0032946 positive regulation of mononuclear cell proliferation 100 2.110927 0.0159016 0.0102626
GO:0043486 histone exchange 50 2.110727 0.0159016 0.0102626
GO:0009595 detection of biotic stimulus 17 2.107029 0.0159016 0.0102626
GO:0007162 negative regulation of cell adhesion 223 2.105805 0.0159016 0.0102626
GO:0051291 protein heterooligomerization 120 2.103920 0.0159016 0.0102626
GO:0002064 epithelial cell development 175 2.102489 0.0159016 0.0102626
GO:0045785 positive regulation of cell adhesion 334 2.098971 0.0159016 0.0102626
GO:1904018 positive regulation of vasculature development 161 2.096105 0.0159016 0.0102626
GO:0003158 endothelium development 106 2.096033 0.0159016 0.0102626
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 23 2.092080 0.0159016 0.0102626
GO:0006911 phagocytosis, engulfment 40 2.091847 0.0159016 0.0102626
GO:0050671 positive regulation of lymphocyte proliferation 99 2.088629 0.0159016 0.0102626
GO:0060968 regulation of gene silencing 132 2.088293 0.0159016 0.0102626
GO:0002237 response to molecule of bacterial origin 260 2.086782 0.0159016 0.0102626
GO:0002507 tolerance induction 18 2.083241 0.0159016 0.0102626
GO:0032637 interleukin-8 production 58 2.082901 0.0159016 0.0102626
GO:0034080 CENP-A containing nucleosome assembly 41 2.080170 0.0159016 0.0102626
GO:0061641 CENP-A containing chromatin organization 41 2.080170 0.0159016 0.0102626
GO:0032757 positive regulation of interleukin-8 production 36 2.079433 0.0159016 0.0102626
GO:2001026 regulation of endothelial cell chemotaxis 17 2.077567 0.0159016 0.0102626
GO:2000050 regulation of non-canonical Wnt signaling pathway 22 2.076022 0.0159016 0.0102626
GO:0065004 protein-DNA complex assembly 191 2.073912 0.0159016 0.0102626
GO:0030183 B cell differentiation 98 2.073187 0.0159016 0.0102626
GO:0008360 regulation of cell shape 118 2.073166 0.0159016 0.0102626
GO:0030856 regulation of epithelial cell differentiation 112 2.071347 0.0159016 0.0102626
GO:0002708 positive regulation of lymphocyte mediated immunity 72 2.071081 0.0159016 0.0102626
GO:0072160 nephron tubule epithelial cell differentiation 13 2.070807 0.0159016 0.0102626
GO:0072574 hepatocyte proliferation 16 2.069090 0.0159016 0.0102626
GO:0072575 epithelial cell proliferation involved in liver morphogenesis 16 2.069090 0.0159016 0.0102626
GO:0090049 regulation of cell migration involved in sprouting angiogenesis 37 2.068410 0.0159016 0.0102626
GO:0060795 cell fate commitment involved in formation of primary germ layer 25 2.067592 0.0159016 0.0102626
GO:0016233 telomere capping 49 2.067202 0.0159016 0.0102626
GO:0035767 endothelial cell chemotaxis 24 2.067169 0.0159016 0.0102626
GO:2000316 regulation of T-helper 17 type immune response 15 2.066747 0.0159016 0.0102626
GO:0002755 MyD88-dependent toll-like receptor signaling pathway 34 2.066536 0.0159016 0.0102626
GO:0043484 regulation of RNA splicing 106 2.061311 0.0159016 0.0102626
GO:0050854 regulation of antigen receptor-mediated signaling pathway 50 2.058590 0.0159016 0.0102626
GO:0071216 cellular response to biotic stimulus 178 2.056995 0.0159016 0.0102626
GO:0006336 DNA replication-independent nucleosome assembly 52 2.052734 0.0159016 0.0102626
GO:0034724 DNA replication-independent nucleosome organization 52 2.052734 0.0159016 0.0102626
GO:0033622 integrin activation 19 2.051575 0.0159016 0.0102626
GO:0014855 striated muscle cell proliferation 58 2.049696 0.0159016 0.0102626
GO:0071346 cellular response to interferon-gamma 142 2.047801 0.0159016 0.0102626
GO:2000826 regulation of heart morphogenesis 32 2.045632 0.0159016 0.0102626
GO:0010452 histone H3-K36 methylation 12 2.043796 0.0159016 0.0102626
GO:0002699 positive regulation of immune effector process 164 2.040104 0.0159016 0.0102626
GO:0003151 outflow tract morphogenesis 70 2.038889 0.0159016 0.0102626
GO:0061053 somite development 65 2.036500 0.0159016 0.0102626
GO:0001756 somitogenesis 49 2.035314 0.0159016 0.0102626
GO:2000737 negative regulation of stem cell differentiation 19 2.034768 0.0159016 0.0102626
GO:0097150 neuronal stem cell population maintenance 22 2.033552 0.0159016 0.0102626
GO:0032496 response to lipopolysaccharide 248 2.033551 0.0159016 0.0102626
GO:0007498 mesoderm development 100 2.033095 0.0159016 0.0102626
GO:0030449 regulation of complement activation 36 2.033087 0.0159016 0.0102626
GO:0050777 negative regulation of immune response 116 2.031395 0.0159016 0.0102626
GO:0030198 extracellular matrix organization 286 2.031014 0.0159016 0.0102626
GO:2000257 regulation of protein activation cascade 37 2.030388 0.0159016 0.0102626
GO:0034968 histone lysine methylation 100 2.028889 0.0159016 0.0102626
GO:0050830 defense response to Gram-positive bacterium 45 2.023377 0.0159016 0.0102626
GO:0071675 regulation of mononuclear cell migration 41 2.020780 0.0159016 0.0102626
GO:0016441 posttranscriptional gene silencing 155 2.020633 0.0159016 0.0102626
GO:0046640 regulation of alpha-beta T cell proliferation 23 2.020561 0.0159016 0.0102626
GO:0035195 gene silencing by miRNA 150 2.020028 0.0159016 0.0102626
GO:0043044 ATP-dependent chromatin remodeling 72 2.018077 0.0159016 0.0102626
GO:1904036 negative regulation of epithelial cell apoptotic process 30 2.017284 0.0159016 0.0102626
GO:0045446 endothelial cell differentiation 88 2.015375 0.0159016 0.0102626
GO:0045649 regulation of macrophage differentiation 19 2.013752 0.0159016 0.0102626
GO:0002761 regulation of myeloid leukocyte differentiation 93 2.010662 0.0159016 0.0102626
GO:0007369 gastrulation 146 2.009882 0.0159016 0.0102626
GO:0045579 positive regulation of B cell differentiation 11 2.007057 0.0162534 0.0104897
GO:0072132 mesenchyme morphogenesis 47 2.006785 0.0159016 0.0102626
GO:0071824 protein-DNA complex subunit organization 216 2.006527 0.0159016 0.0102626
GO:0006956 complement activation 43 2.005610 0.0159016 0.0102626
GO:0008340 determination of adult lifespan 14 2.003847 0.0159016 0.0102626
GO:1904035 regulation of epithelial cell apoptotic process 61 2.002353 0.0159016 0.0102626
GO:0016577 histone demethylation 24 2.001585 0.0159016 0.0102626
GO:0098581 detection of external biotic stimulus 13 2.000402 0.0159016 0.0102626
GO:0045778 positive regulation of ossification 85 2.000043 0.0159016 0.0102626
GO:0045639 positive regulation of myeloid cell differentiation 71 2.000001 0.0159016 0.0102626
GO:0050900 leukocyte migration 335 1.998014 0.0159016 0.0102626
GO:0045766 positive regulation of angiogenesis 143 1.997812 0.0159016 0.0102626
GO:0007229 integrin-mediated signaling pathway 90 1.996853 0.0159016 0.0102626
GO:0002920 regulation of humoral immune response 46 1.996339 0.0159016 0.0102626
GO:0035194 posttranscriptional gene silencing by RNA 154 1.996125 0.0159016 0.0102626
GO:0045604 regulation of epidermal cell differentiation 45 1.994987 0.0159016 0.0102626
GO:1905523 positive regulation of macrophage migration 19 1.993109 0.0159016 0.0102626
GO:0043011 myeloid dendritic cell differentiation 14 1.992992 0.0159016 0.0102626
GO:0003382 epithelial cell morphogenesis 25 1.991944 0.0159016 0.0102626
GO:0042089 cytokine biosynthetic process 89 1.991620 0.0159016 0.0102626
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 65 1.990390 0.0159016 0.0102626
GO:0071219 cellular response to molecule of bacterial origin 155 1.990373 0.0159016 0.0102626
GO:0042060 wound healing 458 1.990057 0.0159016 0.0102626
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 39 1.990055 0.0159016 0.0102626
GO:0072576 liver morphogenesis 17 1.989076 0.0159016 0.0102626
GO:0030225 macrophage differentiation 38 1.988708 0.0159016 0.0102626
GO:0003229 ventricular cardiac muscle tissue development 45 1.988014 0.0159016 0.0102626
GO:0060411 cardiac septum morphogenesis 67 1.988007 0.0159016 0.0102626
GO:0042107 cytokine metabolic process 90 1.987084 0.0159016 0.0102626
GO:0042130 negative regulation of T cell proliferation 47 1.986294 0.0159016 0.0102626
GO:0002714 positive regulation of B cell mediated immunity 28 1.985472 0.0159016 0.0102626
GO:0002891 positive regulation of immunoglobulin mediated immune response 28 1.985472 0.0159016 0.0102626
GO:0002673 regulation of acute inflammatory response 69 1.985236 0.0159016 0.0102626
GO:2000677 regulation of transcription regulatory region DNA binding 42 1.983749 0.0159016 0.0102626
GO:0002712 regulation of B cell mediated immunity 40 1.983496 0.0159016 0.0102626
GO:0002889 regulation of immunoglobulin mediated immune response 40 1.983496 0.0159016 0.0102626
GO:0110110 positive regulation of animal organ morphogenesis 69 1.983304 0.0159016 0.0102626
GO:0010575 positive regulation of vascular endothelial growth factor production 24 1.982622 0.0159016 0.0102626
GO:0048332 mesoderm morphogenesis 57 1.981666 0.0159016 0.0102626
GO:0045628 regulation of T-helper 2 cell differentiation 11 1.981046 0.0162534 0.0104897
GO:1901342 regulation of vasculature development 274 1.980583 0.0159016 0.0102626
GO:0042116 macrophage activation 78 1.980234 0.0159016 0.0102626
GO:0006959 humoral immune response 119 1.979436 0.0159016 0.0102626
GO:2000679 positive regulation of transcription regulatory region DNA binding 19 1.979197 0.0159016 0.0102626
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation 17 1.979054 0.0159016 0.0102626
GO:0014842 regulation of skeletal muscle satellite cell proliferation 12 1.978968 0.0159016 0.0102626
GO:0071222 cellular response to lipopolysaccharide 148 1.976056 0.0159016 0.0102626
GO:0042742 defense response to bacterium 120 1.975638 0.0159016 0.0102626
GO:0002763 positive regulation of myeloid leukocyte differentiation 41 1.975124 0.0159016 0.0102626
GO:0032623 interleukin-2 production 54 1.974236 0.0159016 0.0102626
GO:0099024 plasma membrane invagination 48 1.972812 0.0159016 0.0102626
GO:0050798 activated T cell proliferation 31 1.972576 0.0159016 0.0102626
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 36 1.971354 0.0159016 0.0102626
GO:0072606 interleukin-8 secretion 23 1.970205 0.0159016 0.0102626
GO:0061614 pri-miRNA transcription by RNA polymerase II 43 1.969405 0.0159016 0.0102626
GO:0035666 TRIF-dependent toll-like receptor signaling pathway 29 1.967972 0.0159016 0.0102626
GO:0048644 muscle organ morphogenesis 62 1.967900 0.0159016 0.0102626
GO:2001236 regulation of extrinsic apoptotic signaling pathway 137 1.967410 0.0159016 0.0102626
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 35 1.967118 0.0159016 0.0102626
GO:0050702 interleukin-1 beta secretion 42 1.963622 0.0159016 0.0102626
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 22 1.961361 0.0159016 0.0102626
GO:0030855 epithelial cell differentiation 481 1.957537 0.0159016 0.0102626
GO:0022612 gland morphogenesis 101 1.957471 0.0159016 0.0102626
GO:0050920 regulation of chemotaxis 157 1.956884 0.0159016 0.0102626
GO:0003279 cardiac septum development 101 1.956674 0.0159016 0.0102626
GO:0035987 endodermal cell differentiation 38 1.956129 0.0159016 0.0102626
GO:0032663 regulation of interleukin-2 production 46 1.954072 0.0159016 0.0102626
GO:0001706 endoderm formation 42 1.953888 0.0159016 0.0102626
GO:0060142 regulation of syncytium formation by plasma membrane fusion 21 1.953618 0.0159016 0.0102626
GO:0050869 negative regulation of B cell activation 28 1.951449 0.0159016 0.0102626
GO:0030595 leukocyte chemotaxis 149 1.950895 0.0159016 0.0102626
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 10 1.950753 0.0204307 0.0131856
GO:0045682 regulation of epidermis development 63 1.950337 0.0159016 0.0102626
GO:1990776 response to angiotensin 25 1.949864 0.0159016 0.0102626
GO:0035282 segmentation 70 1.949668 0.0159016 0.0102626
GO:0003170 heart valve development 54 1.949245 0.0159016 0.0102626
GO:0002705 positive regulation of leukocyte mediated immunity 97 1.948220 0.0159016 0.0102626
GO:0002573 myeloid leukocyte differentiation 166 1.947939 0.0159016 0.0102626
GO:0050713 negative regulation of interleukin-1 beta secretion 10 1.945093 0.0204307 0.0131856
GO:0045064 T-helper 2 cell differentiation 12 1.944399 0.0159016 0.0102626
GO:0001707 mesoderm formation 55 1.943634 0.0159016 0.0102626
GO:0098760 response to interleukin-7 40 1.943011 0.0159016 0.0102626
GO:0098761 cellular response to interleukin-7 40 1.943011 0.0159016 0.0102626
GO:0072182 regulation of nephron tubule epithelial cell differentiation 11 1.941712 0.0162534 0.0104897
GO:0046641 positive regulation of alpha-beta T cell proliferation 14 1.941564 0.0159016 0.0102626
GO:0018022 peptidyl-lysine methylation 112 1.941119 0.0159016 0.0102626
GO:0032609 interferon-gamma production 78 1.940796 0.0159016 0.0102626
GO:0002548 monocyte chemotaxis 33 1.940102 0.0159016 0.0102626
GO:0043062 extracellular structure organization 330 1.939101 0.0159016 0.0102626
GO:0070076 histone lysine demethylation 23 1.938599 0.0159016 0.0102626
GO:0046831 regulation of RNA export from nucleus 11 1.937940 0.0162534 0.0104897
GO:0042035 regulation of cytokine biosynthetic process 83 1.936657 0.0159016 0.0102626
GO:0014857 regulation of skeletal muscle cell proliferation 13 1.935150 0.0159016 0.0102626
GO:0031047 gene silencing by RNA 174 1.934478 0.0159016 0.0102626
GO:0060977 coronary vasculature morphogenesis 14 1.932245 0.0159016 0.0102626
GO:0090195 chemokine secretion 16 1.932141 0.0159016 0.0102626
GO:0051101 regulation of DNA binding 106 1.931130 0.0159016 0.0102626
GO:0051567 histone H3-K9 methylation 35 1.930734 0.0159016 0.0102626
GO:0045655 regulation of monocyte differentiation 16 1.930230 0.0159016 0.0102626
GO:0032743 positive regulation of interleukin-2 production 27 1.929536 0.0159016 0.0102626
GO:1901213 regulation of transcription from RNA polymerase II promoter involved in heart development 12 1.929135 0.0159016 0.0102626
GO:0030216 keratinocyte differentiation 112 1.927246 0.0159016 0.0102626
GO:0150076 neuroinflammatory response 54 1.926403 0.0159016 0.0102626
GO:0010528 regulation of transposition 18 1.926016 0.0159016 0.0102626
GO:0010529 negative regulation of transposition 18 1.926016 0.0159016 0.0102626
GO:0032760 positive regulation of tumor necrosis factor production 63 1.925842 0.0159016 0.0102626
GO:0045577 regulation of B cell differentiation 24 1.925295 0.0159016 0.0102626
GO:0045651 positive regulation of macrophage differentiation 13 1.922123 0.0159016 0.0102626
GO:0050855 regulation of B cell receptor signaling pathway 20 1.921984 0.0159016 0.0102626
GO:0042088 T-helper 1 type immune response 34 1.920935 0.0159016 0.0102626
GO:0003231 cardiac ventricle development 112 1.919741 0.0159016 0.0102626
GO:2000052 positive regulation of non-canonical Wnt signaling pathway 12 1.919267 0.0159016 0.0102626
GO:0032722 positive regulation of chemokine production 46 1.919169 0.0159016 0.0102626
GO:0060759 regulation of response to cytokine stimulus 154 1.918880 0.0159016 0.0102626
GO:0061900 glial cell activation 44 1.918561 0.0159016 0.0102626
GO:0000768 syncytium formation by plasma membrane fusion 41 1.918345 0.0159016 0.0102626
GO:0140253 cell-cell fusion 41 1.918345 0.0159016 0.0102626
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 87 1.914418 0.0159016 0.0102626
GO:1901222 regulation of NIK/NF-kappaB signaling 93 1.912684 0.0159016 0.0102626
GO:0030278 regulation of ossification 169 1.911704 0.0159016 0.0102626
GO:0001959 regulation of cytokine-mediated signaling pathway 143 1.909492 0.0159016 0.0102626
GO:0002688 regulation of leukocyte chemotaxis 89 1.908966 0.0159016 0.0102626
GO:0001771 immunological synapse formation 11 1.908597 0.0162534 0.0104897
GO:0006338 chromatin remodeling 145 1.907939 0.0159016 0.0102626
GO:1990868 response to chemokine 47 1.907536 0.0159016 0.0102626
GO:1990869 cellular response to chemokine 47 1.907536 0.0159016 0.0102626
GO:0003281 ventricular septum development 68 1.906723 0.0159016 0.0102626
GO:0030335 positive regulation of cell migration 427 1.906160 0.0159016 0.0102626
GO:0098727 maintenance of cell number 142 1.904374 0.0159016 0.0102626
GO:0060395 SMAD protein signal transduction 47 1.904358 0.0159016 0.0102626
GO:0001503 ossification 339 1.904357 0.0159016 0.0102626
GO:0042108 positive regulation of cytokine biosynthetic process 51 1.904243 0.0159016 0.0102626
GO:2000147 positive regulation of cell motility 442 1.902984 0.0159016 0.0102626
GO:0040029 regulation of gene expression, epigenetic 283 1.902963 0.0159016 0.0102626
GO:0006949 syncytium formation 42 1.902869 0.0159016 0.0102626
GO:0045591 positive regulation of regulatory T cell differentiation 12 1.902219 0.0159016 0.0102626
GO:0045576 mast cell activation 52 1.900166 0.0159016 0.0102626
GO:0033627 cell adhesion mediated by integrin 57 1.898605 0.0159016 0.0102626
GO:0002825 regulation of T-helper 1 type immune response 18 1.897308 0.0159016 0.0102626
GO:0002685 regulation of leukocyte migration 157 1.895378 0.0159016 0.0102626
GO:0002709 regulation of T cell mediated immunity 53 1.895353 0.0159016 0.0102626
GO:0032494 response to peptidoglycan 11 1.894001 0.0203686 0.0131455
GO:0072539 T-helper 17 cell differentiation 18 1.893888 0.0159016 0.0102626
GO:0010463 mesenchymal cell proliferation 41 1.893831 0.0159016 0.0102626
GO:0090197 positive regulation of chemokine secretion 13 1.891444 0.0159016 0.0102626
GO:0014841 skeletal muscle satellite cell proliferation 13 1.891213 0.0159016 0.0102626
GO:0032611 interleukin-1 beta production 71 1.889475 0.0159016 0.0102626
GO:0071103 DNA conformation change 253 1.889396 0.0159016 0.0102626
GO:2000696 regulation of epithelial cell differentiation involved in kidney development 16 1.888025 0.0159016 0.0102626
GO:0043297 apical junction assembly 55 1.885889 0.0159016 0.0102626
GO:2001028 positive regulation of endothelial cell chemotaxis 14 1.885876 0.0159016 0.0102626
GO:0036499 PERK-mediated unfolded protein response 20 1.885593 0.0159016 0.0102626
GO:0061647 histone H3-K9 modification 45 1.884986 0.0159016 0.0102626
GO:0032732 positive regulation of interleukin-1 production 40 1.884932 0.0159016 0.0102626
GO:2000351 regulation of endothelial cell apoptotic process 36 1.884912 0.0159016 0.0102626
GO:0001782 B cell homeostasis 26 1.884167 0.0159016 0.0102626
GO:0019827 stem cell population maintenance 140 1.883757 0.0159016 0.0102626
GO:0034446 substrate adhesion-dependent cell spreading 82 1.882150 0.0159016 0.0102626
GO:0071677 positive regulation of mononuclear cell migration 19 1.882003 0.0159016 0.0102626
GO:0032200 telomere organization 158 1.879343 0.0159016 0.0102626
GO:0033003 regulation of mast cell activation 36 1.877610 0.0159016 0.0102626
GO:0045667 regulation of osteoblast differentiation 107 1.876388 0.0159016 0.0102626
GO:0050871 positive regulation of B cell activation 59 1.876015 0.0159016 0.0102626
GO:0033002 muscle cell proliferation 175 1.875741 0.0159016 0.0102626
GO:0032612 interleukin-1 production 80 1.874850 0.0159016 0.0102626
GO:0002711 positive regulation of T cell mediated immunity 33 1.874776 0.0159016 0.0102626
GO:0045765 regulation of angiogenesis 246 1.874682 0.0159016 0.0102626
GO:0002526 acute inflammatory response 111 1.873877 0.0159016 0.0102626
GO:0002820 negative regulation of adaptive immune response 38 1.872689 0.0159016 0.0102626
GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 14 1.871924 0.0159016 0.0102626
GO:0032196 transposition 21 1.868497 0.0159016 0.0102626
GO:0043535 regulation of blood vessel endothelial cell migration 83 1.868467 0.0159016 0.0102626
GO:0045669 positive regulation of osteoblast differentiation 61 1.868142 0.0159016 0.0102626
GO:0050706 regulation of interleukin-1 beta secretion 35 1.867738 0.0159016 0.0102626
GO:0003401 axis elongation 25 1.866647 0.0159016 0.0102626
GO:0007249 I-kappaB kinase/NF-kappaB signaling 231 1.865616 0.0159016 0.0102626
GO:0002224 toll-like receptor signaling pathway 126 1.864033 0.0159016 0.0102626
GO:0048844 artery morphogenesis 58 1.863530 0.0159016 0.0102626
GO:0001819 positive regulation of cytokine production 364 1.863384 0.0159016 0.0102626
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis 20 1.862362 0.0159016 0.0102626
GO:0032490 detection of molecule of bacterial origin 10 1.862120 0.0204307 0.0131856
GO:0032633 interleukin-4 production 25 1.862024 0.0159016 0.0102626
GO:0060561 apoptotic process involved in morphogenesis 21 1.861257 0.0159016 0.0102626
GO:0072376 protein activation cascade 58 1.860262 0.0159016 0.0102626
GO:0001776 leukocyte homeostasis 74 1.859524 0.0159016 0.0102626
GO:0072073 kidney epithelium development 120 1.858270 0.0159016 0.0102626
GO:0002643 regulation of tolerance induction 12 1.858143 0.0197595 0.0127525
GO:0032835 glomerulus development 52 1.858010 0.0159016 0.0102626
GO:0032103 positive regulation of response to external stimulus 251 1.856278 0.0159016 0.0102626
GO:0045342 MHC class II biosynthetic process 11 1.855797 0.0273893 0.0176766
GO:2000778 positive regulation of interleukin-6 secretion 23 1.855353 0.0159016 0.0102626
GO:0030888 regulation of B cell proliferation 49 1.854950 0.0159016 0.0102626
GO:0003179 heart valve morphogenesis 46 1.854925 0.0159016 0.0102626
GO:0060415 muscle tissue morphogenesis 58 1.854238 0.0159016 0.0102626
GO:0050921 positive regulation of chemotaxis 114 1.853568 0.0159016 0.0102626
GO:0002221 pattern recognition receptor signaling pathway 168 1.852932 0.0159016 0.0102626
GO:0032239 regulation of nucleobase-containing compound transport 13 1.852647 0.0265576 0.0171398
GO:0071674 mononuclear cell migration 54 1.848777 0.0159016 0.0102626
GO:0042100 B cell proliferation 57 1.848374 0.0159016 0.0102626
GO:0001892 embryonic placenta development 78 1.846747 0.0159016 0.0102626
GO:0045600 positive regulation of fat cell differentiation 55 1.846010 0.0159016 0.0102626
GO:0032731 positive regulation of interleukin-1 beta production 36 1.845689 0.0159016 0.0102626
GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response 44 1.845314 0.0159016 0.0102626
GO:0060602 branch elongation of an epithelium 17 1.844510 0.0159016 0.0102626
GO:0072538 T-helper 17 type immune response 20 1.844498 0.0159016 0.0102626
GO:1903209 positive regulation of oxidative stress-induced cell death 13 1.844202 0.0320996 0.0207165
GO:0043534 blood vessel endothelial cell migration 107 1.843567 0.0159016 0.0102626
GO:0055008 cardiac muscle tissue morphogenesis 50 1.842807 0.0159016 0.0102626
GO:0051272 positive regulation of cellular component movement 455 1.842325 0.0159016 0.0102626
GO:0032635 interleukin-6 production 114 1.842206 0.0159016 0.0102626
GO:0002827 positive regulation of T-helper 1 type immune response 12 1.841313 0.0265900 0.0171607
GO:0097028 dendritic cell differentiation 34 1.840625 0.0159016 0.0102626
GO:2000345 regulation of hepatocyte proliferation 12 1.840346 0.0265900 0.0171607
GO:1900409 positive regulation of cellular response to oxidative stress 14 1.839527 0.0197048 0.0127172
GO:0090025 regulation of monocyte chemotaxis 22 1.838861 0.0159016 0.0102626
GO:0062033 positive regulation of mitotic sister chromatid segregation 12 1.838753 0.0265900 0.0171607
GO:0003203 endocardial cushion morphogenesis 32 1.838738 0.0159016 0.0102626
GO:0048745 smooth muscle tissue development 17 1.838502 0.0159016 0.0102626
GO:0035850 epithelial cell differentiation involved in kidney development 39 1.838298 0.0159016 0.0102626
GO:0050856 regulation of T cell receptor signaling pathway 33 1.837707 0.0159016 0.0102626
GO:0050701 interleukin-1 secretion 46 1.837602 0.0159016 0.0102626
GO:0043536 positive regulation of blood vessel endothelial cell migration 53 1.837136 0.0159016 0.0102626
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 204 1.837084 0.0159016 0.0102626
GO:0014856 skeletal muscle cell proliferation 14 1.836477 0.0197048 0.0127172
GO:0032642 regulation of chemokine production 65 1.836350 0.0159016 0.0102626
GO:1901798 positive regulation of signal transduction by p53 class mediator 19 1.834798 0.0159016 0.0102626
GO:0007501 mesodermal cell fate specification 11 1.834673 0.0273893 0.0176766
GO:0010324 membrane invagination 56 1.834297 0.0159016 0.0102626
GO:0072006 nephron development 121 1.834188 0.0159016 0.0102626
GO:0007517 muscle organ development 327 1.832733 0.0159016 0.0102626
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 32 1.832515 0.0159016 0.0102626
GO:0001885 endothelial cell development 53 1.831371 0.0159016 0.0102626
GO:0055010 ventricular cardiac muscle tissue morphogenesis 39 1.829912 0.0159016 0.0102626
GO:0030224 monocyte differentiation 31 1.829335 0.0159016 0.0102626
GO:1903131 mononuclear cell differentiation 31 1.829335 0.0159016 0.0102626
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 14 1.829280 0.0197048 0.0127172
GO:0046006 regulation of activated T cell proliferation 27 1.829036 0.0159016 0.0102626
GO:0043392 negative regulation of DNA binding 43 1.828329 0.0159016 0.0102626
GO:0033628 regulation of cell adhesion mediated by integrin 41 1.828047 0.0159016 0.0102626
GO:0003205 cardiac chamber development 148 1.826673 0.0159016 0.0102626
GO:0051570 regulation of histone H3-K9 methylation 22 1.826448 0.0197048 0.0127172
GO:0090594 inflammatory response to wounding 12 1.826228 0.0321942 0.0207776
GO:0050727 regulation of inflammatory response 299 1.825642 0.0159016 0.0102626
GO:0045165 cell fate commitment 173 1.825579 0.0159016 0.0102626
GO:0070613 regulation of protein processing 83 1.824910 0.0159016 0.0102626
GO:0001774 microglial cell activation 37 1.824135 0.0159016 0.0102626
GO:0002269 leukocyte activation involved in inflammatory response 37 1.824135 0.0159016 0.0102626
GO:0031060 regulation of histone methylation 58 1.824079 0.0159016 0.0102626
GO:0045063 T-helper 1 cell differentiation 16 1.823253 0.0159016 0.0102626
GO:0002456 T cell mediated immunity 79 1.821986 0.0159016 0.0102626
GO:0010837 regulation of keratinocyte proliferation 28 1.821786 0.0159016 0.0102626
GO:0045618 positive regulation of keratinocyte differentiation 13 1.821416 0.0375938 0.0242624
GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 37 1.819091 0.0159016 0.0102626
GO:0032755 positive regulation of interleukin-6 production 67 1.816677 0.0159016 0.0102626
GO:0043032 positive regulation of macrophage activation 24 1.815363 0.0264554 0.0170738
GO:0032373 positive regulation of sterol transport 20 1.815061 0.0159016 0.0102626
GO:0032376 positive regulation of cholesterol transport 20 1.815061 0.0159016 0.0102626
GO:0016571 histone methylation 119 1.814959 0.0159016 0.0102626
GO:0008544 epidermis development 242 1.814736 0.0159016 0.0102626
GO:0035313 wound healing, spreading of epidermal cells 14 1.814266 0.0265576 0.0171398
GO:0036037 CD8-positive, alpha-beta T cell activation 17 1.813591 0.0159016 0.0102626
GO:0034086 maintenance of sister chromatid cohesion 12 1.812161 0.0434232 0.0280246
GO:0034088 maintenance of mitotic sister chromatid cohesion 12 1.812161 0.0434232 0.0280246
GO:0072009 nephron epithelium development 90 1.810670 0.0159016 0.0102626
GO:0016458 gene silencing 227 1.809978 0.0159016 0.0102626
GO:1905521 regulation of macrophage migration 31 1.809713 0.0159016 0.0102626
GO:0097581 lamellipodium organization 71 1.808668 0.0159016 0.0102626
GO:0003206 cardiac chamber morphogenesis 108 1.808651 0.0159016 0.0102626
GO:0042226 interleukin-6 biosynthetic process 18 1.808337 0.0198333 0.0128001
GO:0034329 cell junction assembly 201 1.808048 0.0159016 0.0102626
GO:1901888 regulation of cell junction assembly 86 1.807964 0.0159016 0.0102626
GO:1904019 epithelial cell apoptotic process 81 1.807663 0.0159016 0.0102626
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 51 1.807237 0.0159016 0.0102626
GO:0032675 regulation of interleukin-6 production 106 1.806698 0.0159016 0.0102626
GO:0040017 positive regulation of locomotion 470 1.806416 0.0159016 0.0102626
GO:1903317 regulation of protein maturation 85 1.806376 0.0159016 0.0102626
GO:0070266 necroptotic process 33 1.805738 0.0159016 0.0102626
GO:0036119 response to platelet-derived growth factor 21 1.802855 0.0159016 0.0102626
GO:0061448 connective tissue development 202 1.801726 0.0159016 0.0102626
GO:0002756 MyD88-independent toll-like receptor signaling pathway 33 1.801717 0.0159016 0.0102626
GO:0042554 superoxide anion generation 29 1.801536 0.0159016 0.0102626
GO:0006909 phagocytosis 219 1.800905 0.0159016 0.0102626
GO:0033631 cell-cell adhesion mediated by integrin 14 1.800522 0.0320996 0.0207165
GO:0002260 lymphocyte homeostasis 52 1.799426 0.0159016 0.0102626
GO:0090169 regulation of spindle assembly 26 1.798345 0.0159016 0.0102626
GO:0030858 positive regulation of epithelial cell differentiation 49 1.798153 0.0159016 0.0102626
GO:0060537 muscle tissue development 323 1.795333 0.0159016 0.0102626
GO:0036342 post-anal tail morphogenesis 15 1.794048 0.0159016 0.0102626
GO:0060038 cardiac muscle cell proliferation 45 1.793642 0.0159016 0.0102626
GO:0072678 T cell migration 47 1.792363 0.0197048 0.0127172
GO:0043922 negative regulation by host of viral transcription 10 1.792066 0.0274543 0.0177185
GO:0090196 regulation of chemokine secretion 14 1.791961 0.0320996 0.0207165
GO:2000117 negative regulation of cysteine-type endopeptidase activity 76 1.791895 0.0159016 0.0102626
GO:0032649 regulation of interferon-gamma production 69 1.791683 0.0159016 0.0102626
GO:0051092 positive regulation of NF-kappaB transcription factor activity 138 1.791230 0.0159016 0.0102626
GO:0050718 positive regulation of interleukin-1 beta secretion 25 1.791179 0.0159016 0.0102626
GO:0061005 cell differentiation involved in kidney development 48 1.790834 0.0197048 0.0127172
GO:0097300 programmed necrotic cell death 37 1.790489 0.0159016 0.0102626
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity 11 1.790206 0.0273893 0.0176766
GO:0001570 vasculogenesis 68 1.790056 0.0159016 0.0102626
GO:0003197 endocardial cushion development 39 1.789537 0.0197048 0.0127172
GO:0006957 complement activation, alternative pathway 10 1.788942 0.0274543 0.0177185
GO:0002228 natural killer cell mediated immunity 47 1.787778 0.0197048 0.0127172
GO:0009913 epidermal cell differentiation 153 1.786766 0.0159016 0.0102626
GO:0050663 cytokine secretion 178 1.786763 0.0159016 0.0102626
GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 19 1.786232 0.0197048 0.0127172
GO:0009048 dosage compensation by inactivation of X chromosome 14 1.784684 0.0375938 0.0242624
GO:0030889 negative regulation of B cell proliferation 14 1.783965 0.0375938 0.0242624
GO:0001906 cell killing 94 1.783955 0.0159016 0.0102626
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 31 1.782842 0.0197048 0.0127172
GO:1904738 vascular associated smooth muscle cell migration 21 1.782671 0.0159016 0.0102626
GO:1904752 regulation of vascular associated smooth muscle cell migration 21 1.782671 0.0159016 0.0102626
GO:0010759 positive regulation of macrophage chemotaxis 14 1.782527 0.0375938 0.0242624
GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 51 1.782434 0.0159016 0.0102626
GO:0016444 somatic cell DNA recombination 51 1.782434 0.0159016 0.0102626
GO:0031663 lipopolysaccharide-mediated signaling pathway 50 1.782364 0.0159016 0.0102626
GO:0001910 regulation of leukocyte mediated cytotoxicity 48 1.782318 0.0197048 0.0127172
GO:0042267 natural killer cell mediated cytotoxicity 43 1.782111 0.0159016 0.0102626
GO:0001818 negative regulation of cytokine production 225 1.781499 0.0159016 0.0102626
GO:1904385 cellular response to angiotensin 22 1.781400 0.0197048 0.0127172
GO:0050673 epithelial cell proliferation 326 1.781044 0.0159016 0.0102626
GO:0002312 B cell activation involved in immune response 58 1.779864 0.0159016 0.0102626
GO:0014015 positive regulation of gliogenesis 69 1.779598 0.0159016 0.0102626
GO:0002687 positive regulation of leukocyte migration 104 1.779018 0.0159016 0.0102626
GO:0060043 regulation of cardiac muscle cell proliferation 35 1.778492 0.0159016 0.0102626
GO:0060993 kidney morphogenesis 81 1.778479 0.0159016 0.0102626
GO:0048339 paraxial mesoderm development 15 1.778448 0.0159016 0.0102626
GO:0048872 homeostasis of number of cells 212 1.777820 0.0159016 0.0102626
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 12 1.776545 0.0483532 0.0312063
GO:0048565 digestive tract development 106 1.776344 0.0159016 0.0102626
GO:0060669 embryonic placenta morphogenesis 23 1.775885 0.0197048 0.0127172
GO:0001780 neutrophil homeostasis 16 1.775843 0.0159016 0.0102626
GO:0002040 sprouting angiogenesis 100 1.774975 0.0159016 0.0102626
GO:0032652 regulation of interleukin-1 production 69 1.774452 0.0159016 0.0102626
GO:0060099 regulation of phagocytosis, engulfment 13 1.771086 0.0375938 0.0242624
GO:0050817 coagulation 278 1.770573 0.0159016 0.0102626
GO:0010464 regulation of mesenchymal cell proliferation 32 1.770290 0.0197048 0.0127172
GO:0051053 negative regulation of DNA metabolic process 119 1.770101 0.0159016 0.0102626
GO:0050729 positive regulation of inflammatory response 114 1.769475 0.0159016 0.0102626
GO:0090026 positive regulation of monocyte chemotaxis 15 1.769075 0.0264462 0.0170679
GO:0072001 renal system development 260 1.768404 0.0159016 0.0102626
GO:0061323 cell proliferation involved in heart morphogenesis 11 1.767924 0.0273893 0.0176766
GO:0061180 mammary gland epithelium development 59 1.767544 0.0159016 0.0102626
GO:0072028 nephron morphogenesis 66 1.767270 0.0159016 0.0102626
GO:0050716 positive regulation of interleukin-1 secretion 27 1.767115 0.0197048 0.0127172
GO:0071599 otic vesicle development 14 1.766572 0.0433215 0.0279589
GO:0045824 negative regulation of innate immune response 46 1.765943 0.0159016 0.0102626
GO:0050711 negative regulation of interleukin-1 secretion 12 1.765659 0.0483532 0.0312063
GO:0055123 digestive system development 115 1.765231 0.0159016 0.0102626
GO:2001198 regulation of dendritic cell differentiation 11 1.764433 0.0273893 0.0176766
GO:0001822 kidney development 245 1.764288 0.0159016 0.0102626
GO:0097529 myeloid leukocyte migration 136 1.764026 0.0159016 0.0102626
GO:2000106 regulation of leukocyte apoptotic process 65 1.763899 0.0159016 0.0102626
GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 34 1.763889 0.0159016 0.0102626
GO:0002088 lens development in camera-type eye 58 1.763267 0.0159016 0.0102626
GO:0007596 blood coagulation 276 1.763032 0.0159016 0.0102626
GO:0002690 positive regulation of leukocyte chemotaxis 69 1.762997 0.0159016 0.0102626
GO:0002042 cell migration involved in sprouting angiogenesis 53 1.762668 0.0159016 0.0102626
GO:0045685 regulation of glial cell differentiation 71 1.762664 0.0159016 0.0102626
GO:0070231 T cell apoptotic process 36 1.762107 0.0197048 0.0127172
GO:0072080 nephron tubule development 77 1.761785 0.0159016 0.0102626
GO:0032963 collagen metabolic process 79 1.761651 0.0159016 0.0102626
GO:0036005 response to macrophage colony-stimulating factor 11 1.761452 0.0273893 0.0176766
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus 11 1.761452 0.0273893 0.0176766
GO:0001501 skeletal system development 394 1.760832 0.0159016 0.0102626
GO:0018023 peptidyl-lysine trimethylation 40 1.760697 0.0197048 0.0127172
GO:0090084 negative regulation of inclusion body assembly 10 1.759677 0.0274543 0.0177185
GO:0072643 interferon-gamma secretion 13 1.759566 0.0375938 0.0242624
GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 59 1.759054 0.0159016 0.0102626
GO:0043542 endothelial cell migration 187 1.758009 0.0159016 0.0102626
GO:0035855 megakaryocyte development 16 1.757791 0.0159016 0.0102626
GO:0001655 urogenital system development 286 1.757291 0.0159016 0.0102626
GO:0071385 cellular response to glucocorticoid stimulus 50 1.757098 0.0159016 0.0102626
GO:1900101 regulation of endoplasmic reticulum unfolded protein response 24 1.756906 0.0264554 0.0170738
GO:0002377 immunoglobulin production 81 1.755560 0.0159016 0.0102626
GO:0002700 regulation of production of molecular mediator of immune response 113 1.755499 0.0159016 0.0102626
GO:0001657 ureteric bud development 87 1.755266 0.0159016 0.0102626
GO:0051984 positive regulation of chromosome segregation 23 1.755042 0.0264462 0.0170679
GO:0045346 regulation of MHC class II biosynthetic process 10 1.754483 0.0333001 0.0214913
GO:0060348 bone development 163 1.753287 0.0159016 0.0102626
GO:0034340 response to type I interferon 79 1.751717 0.0159016 0.0102626
GO:0045687 positive regulation of glial cell differentiation 45 1.751650 0.0159016 0.0102626
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 100 1.750987 0.0159016 0.0102626
GO:0071887 leukocyte apoptotic process 83 1.750973 0.0159016 0.0102626
GO:0007520 myoblast fusion 30 1.749631 0.0197048 0.0127172
GO:0071157 negative regulation of cell cycle arrest 20 1.749398 0.0197048 0.0127172
GO:0061326 renal tubule development 79 1.748423 0.0159016 0.0102626
GO:0061842 microtubule organizing center localization 24 1.748174 0.0264554 0.0170738
GO:0031589 cell-substrate adhesion 295 1.748047 0.0159016 0.0102626
GO:1901224 positive regulation of NIK/NF-kappaB signaling 65 1.746970 0.0159016 0.0102626
GO:0050704 regulation of interleukin-1 secretion 38 1.746791 0.0263057 0.0169772
GO:0007173 epidermal growth factor receptor signaling pathway 104 1.746629 0.0159016 0.0102626
GO:0098542 defense response to other organism 314 1.746327 0.0159016 0.0102626
GO:2000136 regulation of cell proliferation involved in heart morphogenesis 12 1.746302 0.0483532 0.0312063
GO:0072088 nephron epithelium morphogenesis 64 1.746195 0.0159016 0.0102626
GO:0045598 regulation of fat cell differentiation 108 1.745709 0.0159016 0.0102626
GO:2000484 positive regulation of interleukin-8 secretion 12 1.744731 0.0483532 0.0312063
GO:0043409 negative regulation of MAPK cascade 146 1.744633 0.0159016 0.0102626
GO:0033077 T cell differentiation in thymus 60 1.744315 0.0159016 0.0102626
GO:0071559 response to transforming growth factor beta 213 1.743084 0.0159016 0.0102626
GO:0050678 regulation of epithelial cell proliferation 276 1.743006 0.0159016 0.0102626
GO:0032735 positive regulation of interleukin-12 production 23 1.742468 0.0264462 0.0170679
GO:0051216 cartilage development 151 1.742406 0.0159016 0.0102626
GO:0048010 vascular endothelial growth factor receptor signaling pathway 87 1.742333 0.0159016 0.0102626
GO:0045932 negative regulation of muscle contraction 21 1.741989 0.0264462 0.0170679
GO:0034770 histone H4-K20 methylation 10 1.741871 0.0391612 0.0252740
GO:0032651 regulation of interleukin-1 beta production 61 1.741727 0.0159016 0.0102626
GO:0019730 antimicrobial humoral response 44 1.741602 0.0197048 0.0127172
GO:0010573 vascular endothelial growth factor production 30 1.741538 0.0197048 0.0127172
GO:0014812 muscle cell migration 78 1.741504 0.0159016 0.0102626
GO:0002279 mast cell activation involved in immune response 43 1.741022 0.0197048 0.0127172
GO:1901739 regulation of myoblast fusion 15 1.740615 0.0319261 0.0206045
GO:0060412 ventricular septum morphogenesis 41 1.740595 0.0264462 0.0170679
GO:0043405 regulation of MAP kinase activity 293 1.738556 0.0159016 0.0102626
GO:0001823 mesonephros development 90 1.738153 0.0159016 0.0102626
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II 13 1.737840 0.0375938 0.0242624
GO:0050679 positive regulation of epithelial cell proliferation 159 1.736970 0.0159016 0.0102626
GO:1902884 positive regulation of response to oxidative stress 16 1.736459 0.0159016 0.0102626
GO:0032615 interleukin-12 production 41 1.736317 0.0264462 0.0170679
GO:0001649 osteoblast differentiation 193 1.735343 0.0159016 0.0102626
GO:0006482 protein demethylation 26 1.734219 0.0197048 0.0127172
GO:0008214 protein dealkylation 26 1.734219 0.0197048 0.0127172
GO:0051894 positive regulation of focal adhesion assembly 23 1.734171 0.0319261 0.0206045
GO:0010631 epithelial cell migration 256 1.733934 0.0159016 0.0102626
GO:0001909 leukocyte mediated cytotoxicity 74 1.733642 0.0194000 0.0125204
GO:0048738 cardiac muscle tissue development 173 1.733347 0.0159016 0.0102626
GO:0002828 regulation of type 2 immune response 24 1.732897 0.0264554 0.0170738
GO:0060485 mesenchyme development 210 1.732241 0.0159016 0.0102626
GO:0072163 mesonephric epithelium development 88 1.731744 0.0159016 0.0102626
GO:0072164 mesonephric tubule development 88 1.731744 0.0159016 0.0102626
GO:0007549 dosage compensation 16 1.731523 0.0159016 0.0102626
GO:0061333 renal tubule morphogenesis 66 1.731275 0.0159016 0.0102626
GO:0010574 regulation of vascular endothelial growth factor production 28 1.730542 0.0159016 0.0102626
GO:0009299 mRNA transcription 22 1.730517 0.0374799 0.0241889
GO:0032753 positive regulation of interleukin-4 production 19 1.729985 0.0197048 0.0127172
GO:0010818 T cell chemotaxis 17 1.729262 0.0197048 0.0127172
GO:0032964 collagen biosynthetic process 40 1.729016 0.0319128 0.0205960
GO:0097530 granulocyte migration 76 1.728509 0.0159016 0.0102626
GO:0090132 epithelium migration 257 1.728302 0.0159016 0.0102626
GO:0060479 lung cell differentiation 15 1.727852 0.0319261 0.0206045
GO:0072078 nephron tubule morphogenesis 62 1.727813 0.0159016 0.0102626
GO:0048705 skeletal system morphogenesis 160 1.727186 0.0159016 0.0102626
GO:0032655 regulation of interleukin-12 production 40 1.726788 0.0319128 0.0205960
GO:0043616 keratinocyte proliferation 36 1.726787 0.0263057 0.0169772
GO:0010819 regulation of T cell chemotaxis 11 1.725942 0.0331329 0.0213834
GO:0007599 hemostasis 280 1.725723 0.0159016 0.0102626
GO:2000810 regulation of bicellular tight junction assembly 20 1.725523 0.0263057 0.0169772
GO:0036120 cellular response to platelet-derived growth factor stimulus 20 1.724955 0.0263057 0.0169772
GO:0007252 I-kappaB phosphorylation 17 1.724637 0.0197048 0.0127172
GO:0030866 cortical actin cytoskeleton organization 29 1.724197 0.0319128 0.0205960
GO:0071900 regulation of protein serine/threonine kinase activity 433 1.723793 0.0159016 0.0102626
GO:0048024 regulation of mRNA splicing, via spliceosome 68 1.722403 0.0159016 0.0102626
GO:0032602 chemokine production 72 1.721751 0.0159016 0.0102626
GO:0002262 myeloid cell homeostasis 130 1.721577 0.0159016 0.0102626
GO:0007043 cell-cell junction assembly 88 1.721402 0.0159016 0.0102626
GO:0031341 regulation of cell killing 56 1.720943 0.0159016 0.0102626
GO:0032673 regulation of interleukin-4 production 22 1.720471 0.0374799 0.0241889
GO:0014706 striated muscle tissue development 310 1.720435 0.0159016 0.0102626
GO:0045058 T cell selection 33 1.720380 0.0197048 0.0127172
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 53 1.720286 0.0159016 0.0102626
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 17 1.720223 0.0197048 0.0127172
GO:0051409 response to nitrosative stress 10 1.720201 0.0448092 0.0289191
GO:0002369 T cell cytokine production 33 1.719814 0.0197048 0.0127172
GO:0090322 regulation of superoxide metabolic process 31 1.719692 0.0319128 0.0205960
GO:1903670 regulation of sprouting angiogenesis 63 1.719486 0.0159016 0.0102626
GO:0032495 response to muramyl dipeptide 19 1.719439 0.0197048 0.0127172
GO:0045408 regulation of interleukin-6 biosynthetic process 17 1.719167 0.0197048 0.0127172
GO:0007507 heart development 479 1.719142 0.0159016 0.0102626
GO:0007099 centriole replication 31 1.717945 0.0319128 0.0205960
GO:0035456 response to interferon-beta 23 1.717023 0.0319261 0.0206045
GO:0048598 embryonic morphogenesis 462 1.716917 0.0159016 0.0102626
GO:1903036 positive regulation of response to wounding 55 1.716504 0.0159016 0.0102626
GO:0090083 regulation of inclusion body assembly 15 1.716475 0.0319261 0.0206045
GO:0002724 regulation of T cell cytokine production 26 1.716460 0.0263057 0.0169772
GO:0071901 negative regulation of protein serine/threonine kinase activity 114 1.715957 0.0159016 0.0102626
GO:0002062 chondrocyte differentiation 86 1.715530 0.0159016 0.0102626
GO:0070988 demethylation 51 1.714830 0.0159016 0.0102626
GO:2001185 regulation of CD8-positive, alpha-beta T cell activation 14 1.714713 0.0433215 0.0279589
GO:0043583 ear development 180 1.713264 0.0159016 0.0102626
GO:0030852 regulation of granulocyte differentiation 13 1.712574 0.0375938 0.0242624
GO:0061041 regulation of wound healing 113 1.712218 0.0159016 0.0102626
GO:1900402 regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter 11 1.710765 0.0331329 0.0213834
GO:0071706 tumor necrosis factor superfamily cytokine production 125 1.710714 0.0159016 0.0102626
GO:0050707 regulation of cytokine secretion 153 1.710422 0.0159016 0.0102626
GO:0010742 macrophage derived foam cell differentiation 28 1.710096 0.0197048 0.0127172
GO:0090077 foam cell differentiation 28 1.710096 0.0197048 0.0127172
GO:0030903 notochord development 15 1.710025 0.0319261 0.0206045
GO:0060713 labyrinthine layer morphogenesis 18 1.709459 0.0322532 0.0208156
GO:0150077 regulation of neuroinflammatory response 31 1.709284 0.0319128 0.0205960
GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 39 1.708885 0.0319261 0.0206045
GO:0002208 somatic diversification of immunoglobulins involved in immune response 39 1.708885 0.0319261 0.0206045
GO:0045190 isotype switching 39 1.708885 0.0319261 0.0206045
GO:0003007 heart morphogenesis 213 1.708862 0.0159016 0.0102626
GO:0008156 negative regulation of DNA replication 31 1.708773 0.0319128 0.0205960
GO:0033006 regulation of mast cell activation involved in immune response 28 1.708755 0.0197048 0.0127172
GO:1902807 negative regulation of cell cycle G1/S phase transition 102 1.708707 0.0159016 0.0102626
GO:0035886 vascular smooth muscle cell differentiation 24 1.708602 0.0375938 0.0242624
GO:0002347 response to tumor cell 19 1.708432 0.0197048 0.0127172
GO:0003176 aortic valve development 28 1.707419 0.0197048 0.0127172
GO:0043407 negative regulation of MAP kinase activity 59 1.706592 0.0159016 0.0102626
GO:0072171 mesonephric tubule morphogenesis 57 1.706170 0.0159016 0.0102626
GO:0061138 morphogenesis of a branching epithelium 154 1.705484 0.0159016 0.0102626
GO:0002253 activation of immune response 482 1.705183 0.0159016 0.0102626
GO:0070373 negative regulation of ERK1 and ERK2 cascade 64 1.703926 0.0159016 0.0102626
GO:0034101 erythrocyte homeostasis 105 1.703652 0.0194000 0.0125204
GO:0071560 cellular response to transforming growth factor beta stimulus 207 1.703601 0.0159016 0.0102626
GO:0090130 tissue migration 262 1.703279 0.0159016 0.0102626
GO:0060065 uterus development 17 1.702878 0.0197048 0.0127172
GO:0042246 tissue regeneration 59 1.702226 0.0159016 0.0102626
GO:0002440 production of molecular mediator of immune response 159 1.702047 0.0159016 0.0102626
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis 15 1.701218 0.0319261 0.0206045
GO:0003208 cardiac ventricle morphogenesis 57 1.700933 0.0159016 0.0102626
GO:0097067 cellular response to thyroid hormone stimulus 14 1.700658 0.0433215 0.0279589
GO:0042692 muscle cell differentiation 289 1.700639 0.0159016 0.0102626
GO:0070102 interleukin-6-mediated signaling pathway 19 1.699888 0.0197048 0.0127172
GO:0048762 mesenchymal cell differentiation 171 1.699817 0.0159016 0.0102626
GO:0001763 morphogenesis of a branching structure 167 1.699520 0.0159016 0.0102626
GO:0002455 humoral immune response mediated by circulating immunoglobulin 32 1.699296 0.0260810 0.0168322
GO:1901673 regulation of mitotic spindle assembly 19 1.699292 0.0197048 0.0127172
GO:0003180 aortic valve morphogenesis 24 1.699038 0.0375938 0.0242624
GO:0051225 spindle assembly 85 1.698416 0.0159016 0.0102626
GO:0060544 regulation of necroptotic process 17 1.697964 0.0197048 0.0127172
GO:2001251 negative regulation of chromosome organization 115 1.697737 0.0159016 0.0102626
GO:0033004 negative regulation of mast cell activation 11 1.697672 0.0389629 0.0251460
GO:0001656 metanephros development 74 1.697086 0.0194000 0.0125204
GO:1901186 positive regulation of ERBB signaling pathway 30 1.697002 0.0263057 0.0169772
GO:0007063 regulation of sister chromatid cohesion 21 1.696877 0.0319261 0.0206045
GO:0003230 cardiac atrium development 27 1.695940 0.0374799 0.0241889
GO:0010165 response to X-ray 26 1.695241 0.0319261 0.0206045
GO:0060562 epithelial tube morphogenesis 274 1.694943 0.0159016 0.0102626
GO:0007044 cell-substrate junction assembly 93 1.694481 0.0159016 0.0102626
GO:0016447 somatic recombination of immunoglobulin gene segments 41 1.693616 0.0319261 0.0206045
GO:0051148 negative regulation of muscle cell differentiation 52 1.693158 0.0159016 0.0102626
GO:0071354 cellular response to interleukin-6 33 1.692290 0.0197048 0.0127172
GO:0010594 regulation of endothelial cell migration 145 1.691870 0.0159016 0.0102626
GO:0030218 erythrocyte differentiation 99 1.691794 0.0159016 0.0102626
GO:0048771 tissue remodeling 133 1.691614 0.0193893 0.0125135
GO:0010656 negative regulation of muscle cell apoptotic process 33 1.691224 0.0197048 0.0127172
GO:0002834 regulation of response to tumor cell 11 1.690939 0.0496855 0.0320662
GO:0002837 regulation of immune response to tumor cell 11 1.690939 0.0496855 0.0320662
GO:0048708 astrocyte differentiation 71 1.690388 0.0193760 0.0125049
GO:0035924 cellular response to vascular endothelial growth factor stimulus 48 1.690231 0.0197048 0.0127172
GO:0043303 mast cell degranulation 41 1.690198 0.0319261 0.0206045
GO:0070265 necrotic cell death 45 1.689783 0.0197048 0.0127172
GO:0043433 negative regulation of DNA-binding transcription factor activity 144 1.689639 0.0193760 0.0125049
GO:0060390 regulation of SMAD protein signal transduction 22 1.689180 0.0374799 0.0241889
GO:0010259 multicellular organism aging 28 1.689171 0.0197048 0.0127172
GO:0033119 negative regulation of RNA splicing 24 1.688955 0.0375938 0.0242624
GO:2001224 positive regulation of neuron migration 14 1.688781 0.0433215 0.0279589
GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell 17 1.688635 0.0197048 0.0127172
GO:0043030 regulation of macrophage activation 51 1.687092 0.0159016 0.0102626
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 120 1.686601 0.0193760 0.0125049
GO:0043588 skin development 214 1.686000 0.0159016 0.0102626
GO:0045601 regulation of endothelial cell differentiation 26 1.685928 0.0319261 0.0206045
GO:0002532 production of molecular mediator involved in inflammatory response 56 1.685889 0.0159016 0.0102626
GO:0035729 cellular response to hepatocyte growth factor stimulus 15 1.685665 0.0375213 0.0242156
GO:2000178 negative regulation of neural precursor cell proliferation 23 1.684850 0.0375402 0.0242278
GO:1901223 negative regulation of NIK/NF-kappaB signaling 22 1.684626 0.0374799 0.0241889
GO:0060487 lung epithelial cell differentiation 14 1.684471 0.0433215 0.0279589
GO:0001569 branching involved in blood vessel morphogenesis 26 1.684022 0.0319261 0.0206045
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 28 1.683940 0.0197048 0.0127172
GO:0061383 trabecula morphogenesis 44 1.683233 0.0197048 0.0127172
GO:2000352 negative regulation of endothelial cell apoptotic process 20 1.683192 0.0319261 0.0206045
GO:0002698 negative regulation of immune effector process 99 1.682919 0.0159016 0.0102626
GO:0007266 Rho protein signal transduction 151 1.680327 0.0159016 0.0102626
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 176 1.679771 0.0159016 0.0102626
GO:0051090 regulation of DNA-binding transcription factor activity 377 1.679371 0.0159016 0.0102626
GO:0051642 centrosome localization 23 1.678593 0.0375402 0.0242278
GO:0042330 taxis 461 1.678522 0.0159016 0.0102626
GO:0003159 morphogenesis of an endothelium 18 1.676972 0.0322532 0.0208156
GO:0061154 endothelial tube morphogenesis 18 1.676972 0.0322532 0.0208156
GO:0007221 positive regulation of transcription of Notch receptor target 17 1.676867 0.0320537 0.0206869
GO:0007423 sensory organ development 449 1.676590 0.0159016 0.0102626
GO:0048839 inner ear development 158 1.676317 0.0159016 0.0102626
GO:2000116 regulation of cysteine-type endopeptidase activity 200 1.676160 0.0159016 0.0102626
GO:0060675 ureteric bud morphogenesis 56 1.674972 0.0197048 0.0127172
GO:0072089 stem cell proliferation 102 1.674636 0.0193760 0.0125049
GO:0006935 chemotaxis 459 1.674622 0.0159016 0.0102626
GO:0010667 negative regulation of cardiac muscle cell apoptotic process 20 1.674356 0.0319261 0.0206045
GO:0030330 DNA damage response, signal transduction by p53 class mediator 101 1.674300 0.0193760 0.0125049
GO:0060443 mammary gland morphogenesis 39 1.673613 0.0374799 0.0241889
GO:1905314 semi-lunar valve development 33 1.673501 0.0319128 0.0205960
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 48 1.673466 0.0197048 0.0127172
GO:0021983 pituitary gland development 31 1.672560 0.0319128 0.0205960
GO:0010758 regulation of macrophage chemotaxis 20 1.672143 0.0319261 0.0206045
GO:0072577 endothelial cell apoptotic process 42 1.671673 0.0375402 0.0242278
GO:0007566 embryo implantation 43 1.670773 0.0263057 0.0169772
GO:0072673 lamellipodium morphogenesis 16 1.669202 0.0264462 0.0170679
GO:0045686 negative regulation of glial cell differentiation 22 1.668482 0.0431083 0.0278214
GO:0072111 cell proliferation involved in kidney development 16 1.667810 0.0264462 0.0170679
GO:0007160 cell-matrix adhesion 192 1.666823 0.0188136 0.0121420
GO:0010664 negative regulation of striated muscle cell apoptotic process 23 1.666762 0.0432170 0.0278915
GO:0002726 positive regulation of T cell cytokine production 17 1.665782 0.0320537 0.0206869
GO:0032928 regulation of superoxide anion generation 20 1.665736 0.0319261 0.0206045
GO:0034109 homotypic cell-cell adhesion 68 1.665514 0.0193760 0.0125049
GO:2000648 positive regulation of stem cell proliferation 33 1.664710 0.0319128 0.0205960
GO:0060541 respiratory system development 174 1.664124 0.0188683 0.0121773
GO:0043304 regulation of mast cell degranulation 26 1.663605 0.0374229 0.0241521
GO:0043300 regulation of leukocyte degranulation 42 1.662125 0.0375402 0.0242278
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 159 1.661090 0.0159016 0.0102626
GO:0014911 positive regulation of smooth muscle cell migration 37 1.660726 0.0372315 0.0240286
GO:0060008 Sertoli cell differentiation 18 1.660621 0.0378372 0.0244195
GO:0009952 anterior/posterior pattern specification 136 1.660144 0.0193760 0.0125049
GO:0042533 tumor necrosis factor biosynthetic process 21 1.659768 0.0319261 0.0206045
GO:0042534 regulation of tumor necrosis factor biosynthetic process 21 1.659768 0.0319261 0.0206045
GO:0098534 centriole assembly 33 1.659250 0.0319128 0.0205960
GO:0030323 respiratory tube development 156 1.658955 0.0159016 0.0102626
GO:0034405 response to fluid shear stress 33 1.658654 0.0319128 0.0205960
GO:0030316 osteoclast differentiation 78 1.657688 0.0193760 0.0125049
GO:0006303 double-strand break repair via nonhomologous end joining 77 1.657018 0.0193760 0.0125049
GO:0014910 regulation of smooth muscle cell migration 60 1.656277 0.0159016 0.0102626
GO:0060009 Sertoli cell development 14 1.656253 0.0433215 0.0279589
GO:0002448 mast cell mediated immunity 43 1.656121 0.0374229 0.0241521
GO:0061045 negative regulation of wound healing 58 1.655519 0.0159016 0.0102626
GO:0060216 definitive hemopoiesis 16 1.655259 0.0264462 0.0170679
GO:0061028 establishment of endothelial barrier 39 1.655028 0.0430890 0.0278089
GO:0043388 positive regulation of DNA binding 50 1.654902 0.0197048 0.0127172
GO:0048568 embryonic organ development 338 1.654659 0.0159016 0.0102626
GO:0051147 regulation of muscle cell differentiation 138 1.654647 0.0193760 0.0125049
GO:0032680 regulation of tumor necrosis factor production 117 1.654443 0.0193760 0.0125049
GO:0010717 regulation of epithelial to mesenchymal transition 77 1.653435 0.0193760 0.0125049
GO:0090303 positive regulation of wound healing 45 1.653093 0.0319261 0.0206045
GO:0032691 negative regulation of interleukin-1 beta production 21 1.652860 0.0319261 0.0206045
GO:0034330 cell junction organization 259 1.652797 0.0159016 0.0102626
GO:1902275 regulation of chromatin organization 154 1.652574 0.0193760 0.0125049
GO:0071800 podosome assembly 15 1.652446 0.0478749 0.0308976
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 70 1.652334 0.0306432 0.0197766
GO:0048525 negative regulation of viral process 80 1.652208 0.0193760 0.0125049
GO:0060914 heart formation 19 1.650946 0.0482102 0.0311141
GO:0032640 tumor necrosis factor production 121 1.650859 0.0193760 0.0125049
GO:0001837 epithelial to mesenchymal transition 121 1.649856 0.0193760 0.0125049
GO:0042276 error-prone translesion synthesis 18 1.649016 0.0378372 0.0244195
GO:0071621 granulocyte chemotaxis 64 1.648357 0.0159016 0.0102626
GO:0070098 chemokine-mediated signaling pathway 39 1.648338 0.0430890 0.0278089
GO:0046330 positive regulation of JNK cascade 107 1.648305 0.0193760 0.0125049
GO:0003209 cardiac atrium morphogenesis 22 1.647890 0.0478191 0.0308616
GO:2000142 regulation of DNA-templated transcription, initiation 26 1.647430 0.0429443 0.0277155
GO:0031532 actin cytoskeleton reorganization 82 1.647379 0.0193760 0.0125049
GO:0032570 response to progesterone 40 1.647047 0.0473358 0.0305497
GO:0010470 regulation of gastrulation 32 1.645978 0.0370796 0.0239305
GO:0010595 positive regulation of endothelial cell migration 95 1.645432 0.0193760 0.0125049
GO:0072012 glomerulus vasculature development 19 1.644769 0.0482102 0.0311141
GO:0071384 cellular response to corticosteroid stimulus 54 1.643561 0.0260810 0.0168322
GO:0034121 regulation of toll-like receptor signaling pathway 59 1.643399 0.0159016 0.0102626
GO:0045071 negative regulation of viral genome replication 50 1.641648 0.0264462 0.0170679
GO:0007179 transforming growth factor beta receptor signaling pathway 162 1.641158 0.0159016 0.0102626
GO:0002637 regulation of immunoglobulin production 50 1.639619 0.0264462 0.0170679
GO:0048754 branching morphogenesis of an epithelial tube 126 1.639309 0.0193760 0.0125049
GO:0031062 positive regulation of histone methylation 36 1.638810 0.0429443 0.0277155
GO:0060428 lung epithelium development 28 1.638555 0.0476773 0.0307701
GO:0120193 tight junction organization 51 1.637827 0.0263057 0.0169772
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 92 1.636756 0.0159016 0.0102626
GO:0045445 myoblast differentiation 70 1.636026 0.0306432 0.0197766
GO:1903034 regulation of response to wounding 140 1.634943 0.0193760 0.0125049
GO:0045830 positive regulation of isotype switching 21 1.634767 0.0375402 0.0242278
GO:0035728 response to hepatocyte growth factor 17 1.634492 0.0482102 0.0311141
GO:1904706 negative regulation of vascular smooth muscle cell proliferation 17 1.633855 0.0482102 0.0311141
GO:0150063 visual system development 307 1.633458 0.0159016 0.0102626
GO:0048880 sensory system development 308 1.633448 0.0159016 0.0102626
GO:1904888 cranial skeletal system development 56 1.633236 0.0261757 0.0168934
GO:0050878 regulation of body fluid levels 413 1.633143 0.0159016 0.0102626
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 24 1.633131 0.0482102 0.0311141
GO:0001667 ameboidal-type cell migration 333 1.633123 0.0159016 0.0102626
GO:0070371 ERK1 and ERK2 cascade 241 1.632785 0.0159016 0.0102626
GO:0045606 positive regulation of epidermal cell differentiation 19 1.632305 0.0482102 0.0311141
GO:0001658 branching involved in ureteric bud morphogenesis 51 1.631431 0.0263057 0.0169772
GO:0070830 bicellular tight junction assembly 47 1.630710 0.0197048 0.0127172
GO:0060337 type I interferon signaling pathway 75 1.630452 0.0193760 0.0125049
GO:0071357 cellular response to type I interferon 75 1.630452 0.0193760 0.0125049
GO:0060840 artery development 81 1.630166 0.0193760 0.0125049
GO:0002715 regulation of natural killer cell mediated immunity 31 1.628855 0.0372354 0.0240311
GO:0050715 positive regulation of cytokine secretion 103 1.628801 0.0193760 0.0125049
GO:0051146 striated muscle cell differentiation 212 1.628567 0.0159016 0.0102626
GO:0042789 mRNA transcription by RNA polymerase II 16 1.628472 0.0319261 0.0206045
GO:0001890 placenta development 131 1.627659 0.0193760 0.0125049
GO:0002886 regulation of myeloid leukocyte mediated immunity 49 1.626735 0.0319128 0.0205960
GO:2000177 regulation of neural precursor cell proliferation 78 1.624597 0.0193760 0.0125049
GO:0033673 negative regulation of kinase activity 214 1.624591 0.0159016 0.0102626
GO:0097191 extrinsic apoptotic signaling pathway 192 1.623581 0.0188136 0.0121420
GO:0038127 ERBB signaling pathway 125 1.622297 0.0193760 0.0125049
GO:1904894 positive regulation of STAT cascade 61 1.622054 0.0256715 0.0165680
GO:0030324 lung development 152 1.621762 0.0193760 0.0125049
GO:0002718 regulation of cytokine production involved in immune response 69 1.621591 0.0307259 0.0198300
GO:2000404 regulation of T cell migration 34 1.619174 0.0372354 0.0240311
GO:0042094 interleukin-2 biosynthetic process 19 1.618605 0.0482102 0.0311141
GO:0042307 positive regulation of protein import into nucleus 34 1.617661 0.0372354 0.0240311
GO:0014909 smooth muscle cell migration 66 1.616343 0.0194000 0.0125204
GO:0071902 positive regulation of protein serine/threonine kinase activity 297 1.615329 0.0159016 0.0102626
GO:2000353 positive regulation of endothelial cell apoptotic process 16 1.615307 0.0432170 0.0278915
GO:0042026 protein refolding 18 1.614373 0.0378372 0.0244195
GO:0030206 chondroitin sulfate biosynthetic process 25 1.614203 0.0480182 0.0309901
GO:0061437 renal system vasculature development 21 1.614113 0.0431968 0.0278785
GO:0061440 kidney vasculature development 21 1.614113 0.0431968 0.0278785
GO:0010001 glial cell differentiation 200 1.612794 0.0188136 0.0121420
GO:0051893 regulation of focal adhesion assembly 59 1.612649 0.0197048 0.0127172
GO:0090109 regulation of cell-substrate junction assembly 59 1.612649 0.0197048 0.0127172
GO:1903053 regulation of extracellular matrix organization 36 1.612020 0.0475746 0.0307038
GO:0060317 cardiac epithelial to mesenchymal transition 32 1.610616 0.0424757 0.0274131
GO:0002757 immune response-activating signal transduction 427 1.608768 0.0159016 0.0102626
GO:0060760 positive regulation of response to cytokine stimulus 53 1.608257 0.0197048 0.0127172
GO:0002702 positive regulation of production of molecular mediator of immune response 77 1.607586 0.0193760 0.0125049
GO:1901184 regulation of ERBB signaling pathway 83 1.606535 0.0193760 0.0125049
GO:0007140 male meiotic nuclear division 32 1.606502 0.0424757 0.0274131
GO:0014013 regulation of gliogenesis 111 1.605840 0.0193760 0.0125049
GO:0051568 histone H3-K4 methylation 46 1.604962 0.0476773 0.0307701
GO:0072091 regulation of stem cell proliferation 57 1.604658 0.0159016 0.0102626
GO:0006469 negative regulation of protein kinase activity 197 1.604334 0.0188136 0.0121420
GO:0010830 regulation of myotube differentiation 44 1.604328 0.0319261 0.0206045
GO:0032088 negative regulation of NF-kappaB transcription factor activity 76 1.604119 0.0193760 0.0125049
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 71 1.602707 0.0306432 0.0197766
GO:0045005 DNA-dependent DNA replication maintenance of fidelity 33 1.602378 0.0472826 0.0305154
GO:0031214 biomineral tissue development 127 1.601758 0.0193760 0.0125049
GO:0043406 positive regulation of MAP kinase activity 231 1.600961 0.0159016 0.0102626
GO:2000379 positive regulation of reactive oxygen species metabolic process 83 1.599147 0.0193760 0.0125049
GO:0010811 positive regulation of cell-substrate adhesion 98 1.598895 0.0247948 0.0160021
GO:0002764 immune response-regulating signaling pathway 456 1.598504 0.0159016 0.0102626
GO:0070372 regulation of ERK1 and ERK2 cascade 226 1.597478 0.0159016 0.0102626
GO:0048713 regulation of oligodendrocyte differentiation 38 1.596679 0.0474352 0.0306138
GO:0007062 sister chromatid cohesion 45 1.596322 0.0430890 0.0278089
GO:0002200 somatic diversification of immune receptors 58 1.594089 0.0197048 0.0127172
GO:0051154 negative regulation of striated muscle cell differentiation 34 1.593661 0.0473813 0.0305791
GO:0050684 regulation of mRNA processing 101 1.593209 0.0247948 0.0160021
GO:0014902 myotube differentiation 87 1.591942 0.0159016 0.0102626
GO:0043410 positive regulation of MAPK cascade 430 1.591917 0.0159016 0.0102626
GO:0090183 regulation of kidney development 46 1.589529 0.0476773 0.0307701
GO:0046427 positive regulation of JAK-STAT cascade 59 1.589181 0.0261514 0.0168776
GO:0060761 negative regulation of response to cytokine stimulus 53 1.588439 0.0370676 0.0239228
GO:0001654 eye development 303 1.588298 0.0159016 0.0102626
GO:0050922 negative regulation of chemotaxis 33 1.587057 0.0472826 0.0305154
GO:0070206 protein trimerization 47 1.586973 0.0429443 0.0277155
GO:0061035 regulation of cartilage development 57 1.586969 0.0197048 0.0127172
GO:0000018 regulation of DNA recombination 77 1.586472 0.0193760 0.0125049
GO:0120192 tight junction assembly 48 1.585657 0.0319128 0.0205960
GO:0051153 regulation of striated muscle cell differentiation 87 1.585066 0.0159016 0.0102626
GO:0032922 circadian regulation of gene expression 57 1.584912 0.0197048 0.0127172
GO:2000146 negative regulation of cell motility 238 1.584632 0.0159016 0.0102626
GO:0030336 negative regulation of cell migration 227 1.583821 0.0159016 0.0102626
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 32 1.582697 0.0472169 0.0304730
GO:0050710 negative regulation of cytokine secretion 53 1.582509 0.0424757 0.0274131
GO:0002639 positive regulation of immunoglobulin production 32 1.582412 0.0472169 0.0304730
GO:0045444 fat cell differentiation 192 1.581299 0.0188136 0.0121420
GO:0042058 regulation of epidermal growth factor receptor signaling pathway 77 1.580286 0.0193760 0.0125049
GO:0045995 regulation of embryonic development 110 1.579517 0.0193760 0.0125049
GO:0018205 peptidyl-lysine modification 350 1.578856 0.0159016 0.0102626
GO:0006613 cotranslational protein targeting to membrane 95 1.578639 0.0247948 0.0160021
GO:0035148 tube formation 130 1.578060 0.0248321 0.0160262
GO:0045047 protein targeting to ER 97 1.578037 0.0306432 0.0197766
GO:0048661 positive regulation of smooth muscle cell proliferation 81 1.577414 0.0193760 0.0125049
GO:0034333 adherens junction assembly 88 1.577320 0.0159016 0.0102626
GO:0030859 polarized epithelial cell differentiation 18 1.577243 0.0378372 0.0244195
GO:0050918 positive chemotaxis 55 1.576506 0.0371184 0.0239556
GO:0033044 regulation of chromosome organization 290 1.576322 0.0159016 0.0102626
GO:1900024 regulation of substrate adhesion-dependent cell spreading 47 1.576038 0.0429443 0.0277155
GO:0090307 mitotic spindle assembly 49 1.574693 0.0426607 0.0275325
GO:0001961 positive regulation of cytokine-mediated signaling pathway 46 1.574445 0.0476773 0.0307701
GO:1905954 positive regulation of lipid localization 71 1.574266 0.0355565 0.0229475
GO:0007405 neuroblast proliferation 53 1.572657 0.0472169 0.0304730
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 276 1.571713 0.0159016 0.0102626
GO:0051271 negative regulation of cellular component movement 254 1.571128 0.0159016 0.0102626
GO:0030032 lamellipodium assembly 54 1.570900 0.0424757 0.0274131
GO:0001960 negative regulation of cytokine-mediated signaling pathway 49 1.570795 0.0426607 0.0275325
GO:1905952 regulation of lipid localization 115 1.570432 0.0193760 0.0125049
GO:0042770 signal transduction in response to DNA damage 124 1.569165 0.0247948 0.0160021
GO:0032970 regulation of actin filament-based process 307 1.566530 0.0159016 0.0102626
GO:0046718 viral entry into host cell 106 1.566444 0.0249569 0.0161068
GO:0048706 embryonic skeletal system development 86 1.563905 0.0247948 0.0160021
GO:0001708 cell fate specification 53 1.563160 0.0472169 0.0304730
GO:0030522 intracellular receptor signaling pathway 253 1.562617 0.0159016 0.0102626
GO:0042303 molting cycle 86 1.561371 0.0247948 0.0160021
GO:0042633 hair cycle 86 1.561371 0.0247948 0.0160021
GO:0051145 smooth muscle cell differentiation 54 1.560849 0.0472169 0.0304730
GO:0006801 superoxide metabolic process 57 1.560493 0.0370796 0.0239305
GO:0007264 small GTPase mediated signal transduction 449 1.560206 0.0159016 0.0102626
GO:0060021 roof of mouth development 80 1.560045 0.0247948 0.0160021
GO:0071622 regulation of granulocyte chemotaxis 34 1.559391 0.0473813 0.0305791
GO:0002367 cytokine production involved in immune response 85 1.558968 0.0247948 0.0160021
GO:0000726 non-recombinational repair 83 1.558966 0.0247249 0.0159570
GO:0007045 cell-substrate adherens junction assembly 79 1.557622 0.0247601 0.0159798
GO:0048041 focal adhesion assembly 79 1.557622 0.0247601 0.0159798
GO:0016569 covalent chromatin modification 403 1.555151 0.0159016 0.0102626
GO:0042063 gliogenesis 262 1.554680 0.0159016 0.0102626
GO:0045216 cell-cell junction organization 116 1.553463 0.0248321 0.0160262
GO:0060349 bone morphogenesis 75 1.552902 0.0248321 0.0160262
GO:0048704 embryonic skeletal system morphogenesis 62 1.552842 0.0368442 0.0237786
GO:0051983 regulation of chromosome segregation 85 1.552341 0.0247948 0.0160021
GO:0035023 regulation of Rho protein signal transduction 118 1.550478 0.0306432 0.0197766
GO:0061008 hepaticobiliary system development 120 1.549316 0.0247948 0.0160021
GO:0010632 regulation of epithelial cell migration 201 1.546296 0.0188226 0.0121478
GO:0051781 positive regulation of cell division 68 1.545734 0.0451956 0.0291685
GO:0042326 negative regulation of phosphorylation 396 1.545011 0.0159016 0.0102626
GO:0090288 negative regulation of cellular response to growth factor stimulus 123 1.543845 0.0193760 0.0125049
GO:1903035 negative regulation of response to wounding 71 1.542021 0.0355565 0.0229475
GO:0051056 regulation of small GTPase mediated signal transduction 305 1.540444 0.0159016 0.0102626
GO:0043507 positive regulation of JUN kinase activity 62 1.539523 0.0467119 0.0301470
GO:0016570 histone modification 392 1.538633 0.0159016 0.0102626
GO:0050818 regulation of coagulation 64 1.537981 0.0464996 0.0300100
GO:1902532 negative regulation of intracellular signal transduction 461 1.537920 0.0159016 0.0102626
GO:0048660 regulation of smooth muscle cell proliferation 125 1.537857 0.0352673 0.0227609
GO:0002431 Fc receptor mediated stimulatory signaling pathway 78 1.537543 0.0350445 0.0226171
GO:0050764 regulation of phagocytosis 75 1.534482 0.0248321 0.0160262
GO:0048545 response to steroid hormone 337 1.533894 0.0159016 0.0102626
GO:0040013 negative regulation of locomotion 265 1.533721 0.0188136 0.0121420
GO:0031056 regulation of histone modification 129 1.532957 0.0306432 0.0197766
GO:2001234 negative regulation of apoptotic signaling pathway 199 1.531848 0.0188136 0.0121420
GO:0045088 regulation of innate immune response 367 1.530379 0.0159016 0.0102626
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 103 1.528565 0.0248321 0.0160262
GO:0051091 positive regulation of DNA-binding transcription factor activity 233 1.528187 0.0159016 0.0102626
GO:0052548 regulation of endopeptidase activity 287 1.528158 0.0159016 0.0102626
GO:0007015 actin filament organization 299 1.528005 0.0159016 0.0102626
GO:0033045 regulation of sister chromatid segregation 65 1.527800 0.0456122 0.0294374
GO:0042476 odontogenesis 105 1.525454 0.0307538 0.0198480
GO:0043506 regulation of JUN kinase activity 75 1.525270 0.0355565 0.0229475
GO:0031099 regeneration 163 1.525078 0.0240307 0.0155090
GO:0030838 positive regulation of actin filament polymerization 73 1.524823 0.0450884 0.0290993
GO:0048659 smooth muscle cell proliferation 127 1.524026 0.0353581 0.0228195
GO:0052547 regulation of peptidase activity 311 1.523719 0.0185164 0.0119502
GO:0051384 response to glucocorticoid 119 1.523049 0.0306432 0.0197766
GO:0001889 liver development 117 1.520731 0.0306432 0.0197766
GO:0051262 protein tetramerization 157 1.519759 0.0300692 0.0194062
GO:0010951 negative regulation of endopeptidase activity 145 1.519574 0.0248321 0.0160262
GO:0042475 odontogenesis of dentin-containing tooth 69 1.517813 0.0453344 0.0292581
GO:0048608 reproductive structure development 354 1.516569 0.0159016 0.0102626
GO:0071260 cellular response to mechanical stimulus 69 1.514274 0.0453344 0.0292581
GO:0043901 negative regulation of multi-organism process 143 1.511554 0.0306432 0.0197766
GO:0001933 negative regulation of protein phosphorylation 363 1.510792 0.0159016 0.0102626
GO:0006606 protein import into nucleus 96 1.510361 0.0352673 0.0227609
GO:0048732 gland development 355 1.510302 0.0159016 0.0102626
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 116 1.509756 0.0355157 0.0229212
GO:0051302 regulation of cell division 140 1.508449 0.0306432 0.0197766
GO:0010810 regulation of cell-substrate adhesion 178 1.506937 0.0291339 0.0188025
GO:0048144 fibroblast proliferation 76 1.505964 0.0306432 0.0197766
GO:0007265 Ras protein signal transduction 314 1.503164 0.0185994 0.0120037
GO:0051052 regulation of DNA metabolic process 361 1.502831 0.0159016 0.0102626
GO:0072599 establishment of protein localization to endoplasmic reticulum 101 1.502448 0.0306432 0.0197766
GO:0006352 DNA-templated transcription, initiation 215 1.502219 0.0188136 0.0121420
GO:0001942 hair follicle development 72 1.501251 0.0495485 0.0319778
GO:0032102 negative regulation of response to external stimulus 258 1.499971 0.0188136 0.0121420
GO:0030260 entry into host cell 118 1.499378 0.0352673 0.0227609
GO:0044409 entry into host 118 1.499378 0.0352673 0.0227609
GO:0051806 entry into cell of other organism involved in symbiotic interaction 118 1.499378 0.0352673 0.0227609
GO:0051828 entry into other organism involved in symbiotic interaction 118 1.499378 0.0352673 0.0227609
GO:0032956 regulation of actin cytoskeleton organization 267 1.499080 0.0231200 0.0149212
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 130 1.498967 0.0404474 0.0261040
GO:0009612 response to mechanical stimulus 180 1.496244 0.0336129 0.0216932
GO:0046849 bone remodeling 71 1.494655 0.0495485 0.0319778
GO:0006479 protein methylation 156 1.494622 0.0301179 0.0194376
GO:0008213 protein alkylation 156 1.494622 0.0301179 0.0194376
GO:0000723 telomere maintenance 145 1.494499 0.0306432 0.0197766
GO:0007569 cell aging 99 1.493633 0.0401798 0.0259313
GO:0043010 camera-type eye development 263 1.493101 0.0187720 0.0121151
GO:0051348 negative regulation of transferase activity 241 1.492540 0.0233030 0.0150394
GO:0031334 positive regulation of protein complex assembly 212 1.492490 0.0188136 0.0121420
GO:2000045 regulation of G1/S transition of mitotic cell cycle 139 1.491819 0.0306432 0.0197766
GO:0070302 regulation of stress-activated protein kinase signaling cascade 188 1.491710 0.0289365 0.0186751
GO:0045860 positive regulation of protein kinase activity 456 1.490393 0.0159016 0.0102626
GO:0022404 molting cycle process 74 1.489680 0.0499031 0.0322066
GO:0022405 hair cycle process 74 1.489680 0.0499031 0.0322066
GO:0018108 peptidyl-tyrosine phosphorylation 297 1.484074 0.0186645 0.0120457
GO:0032526 response to retinoic acid 93 1.483506 0.0450431 0.0290700
GO:0035265 organ growth 138 1.482493 0.0306432 0.0197766
GO:0061458 reproductive system development 357 1.481139 0.0159016 0.0102626
GO:0072175 epithelial tube formation 117 1.480118 0.0447895 0.0289064
GO:0018212 peptidyl-tyrosine modification 300 1.480041 0.0185994 0.0120037
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 147 1.479343 0.0306432 0.0197766
GO:0010466 negative regulation of peptidase activity 152 1.479306 0.0350391 0.0226137
GO:0046328 regulation of JNK cascade 149 1.473598 0.0306432 0.0197766
GO:0032874 positive regulation of stress-activated MAPK cascade 129 1.472039 0.0493954 0.0318789
GO:0007389 pattern specification process 322 1.470523 0.0183551 0.0118461
GO:0046546 development of primary male sexual characteristics 113 1.469931 0.0493954 0.0318789
GO:0032872 regulation of stress-activated MAPK cascade 186 1.468648 0.0380555 0.0245604
GO:0031348 negative regulation of defense response 170 1.465406 0.0379636 0.0245011
GO:0051607 defense response to virus 189 1.465127 0.0286513 0.0184911
GO:0071407 cellular response to organic cyclic compound 489 1.464697 0.0159016 0.0102626
GO:0043087 regulation of GTPase activity 392 1.464144 0.0159016 0.0102626
GO:2001020 regulation of response to DNA damage stimulus 194 1.462309 0.0233030 0.0150394
GO:0061351 neural precursor cell proliferation 131 1.461875 0.0448487 0.0289446
GO:0033674 positive regulation of kinase activity 494 1.461655 0.0159016 0.0102626
GO:0007565 female pregnancy 159 1.459833 0.0297585 0.0192056
GO:0051897 positive regulation of protein kinase B signaling 133 1.459693 0.0406290 0.0262213
GO:0030168 platelet activation 131 1.459078 0.0448487 0.0289446
GO:0034332 adherens junction organization 129 1.458939 0.0493954 0.0318789
GO:0030879 mammary gland development 118 1.458833 0.0447454 0.0288779
GO:0043009 chordate embryonic development 496 1.458308 0.0159016 0.0102626
GO:0021915 neural tube development 141 1.454769 0.0306432 0.0197766
GO:0051028 mRNA transport 138 1.453037 0.0352673 0.0227609
GO:1902905 positive regulation of supramolecular fiber organization 169 1.451102 0.0431545 0.0278511
GO:0048562 embryonic organ morphogenesis 217 1.448161 0.0285672 0.0184368
GO:0110053 regulation of actin filament organization 208 1.447671 0.0286513 0.0184911
GO:1902806 regulation of cell cycle G1/S phase transition 152 1.443387 0.0350391 0.0226137
GO:0002009 morphogenesis of an epithelium 461 1.439933 0.0159016 0.0102626
GO:0031960 response to corticosteroid 135 1.438319 0.0451041 0.0291094
GO:0031349 positive regulation of defense response 415 1.436665 0.0180628 0.0116574
GO:0045936 negative regulation of phosphate metabolic process 498 1.435827 0.0159016 0.0102626
GO:0090596 sensory organ morphogenesis 207 1.434792 0.0329418 0.0212600
GO:0008154 actin polymerization or depolymerization 155 1.430854 0.0485015 0.0313020
GO:0071214 cellular response to abiotic stimulus 277 1.428203 0.0279137 0.0180150
GO:0104004 cellular response to environmental stimulus 277 1.428203 0.0279137 0.0180150
GO:0001701 in utero embryonic development 307 1.422623 0.0185164 0.0119502
GO:0000819 sister chromatid segregation 148 1.422302 0.0404532 0.0261078
GO:0016485 protein processing 184 1.422255 0.0472437 0.0304903
GO:0010563 negative regulation of phosphorus metabolic process 499 1.422064 0.0159016 0.0102626
GO:0043547 positive regulation of GTPase activity 322 1.418397 0.0223178 0.0144035
GO:0006302 double-strand break repair 200 1.417340 0.0427401 0.0275837
GO:2001233 regulation of apoptotic signaling pathway 360 1.414907 0.0268566 0.0173328
GO:0050851 antigen receptor-mediated signaling pathway 191 1.414319 0.0425678 0.0274725
GO:0002768 immune response-regulating cell surface receptor signaling pathway 312 1.413609 0.0185164 0.0119502
GO:2001242 regulation of intrinsic apoptotic signaling pathway 147 1.413431 0.0494462 0.0319117
GO:0051495 positive regulation of cytoskeleton organization 188 1.409979 0.0429443 0.0277155
GO:0002429 immune response-activating cell surface receptor signaling pathway 284 1.409151 0.0372315 0.0240286
GO:0003002 regionalization 248 1.387532 0.0374229 0.0241521
GO:0045089 positive regulation of innate immune response 311 1.376130 0.0226241 0.0146012
GO:0009615 response to virus 264 1.373906 0.0374799 0.0241889
GO:0051493 regulation of cytoskeleton organization 439 1.372295 0.0180490 0.0116485
GO:0008380 RNA splicing 386 1.368319 0.0220555 0.0142342
GO:1902903 regulation of supramolecular fiber organization 286 1.356384 0.0453344 0.0292581
Enriched terms for module #84AD00 (MTcor = -0.93)
ID Description setSize NES p.adjust qvalues
GO:0042773 ATP synthesis coupled electron transport 88 2.828241 0.0223578 0.0162795
GO:0042775 mitochondrial ATP synthesis coupled electron transport 87 2.817455 0.0223578 0.0162795
GO:0022904 respiratory electron transport chain 104 2.814443 0.0223578 0.0162795
GO:0045333 cellular respiration 171 2.775592 0.0223578 0.0162795
GO:0007269 neurotransmitter secretion 142 2.677088 0.0223578 0.0162795
GO:0099643 signal release from synapse 143 2.668203 0.0223578 0.0162795
GO:0006120 mitochondrial electron transport, NADH to ubiquinone 54 2.650402 0.0223578 0.0162795
GO:0006119 oxidative phosphorylation 128 2.646906 0.0223578 0.0162795
GO:0098693 regulation of synaptic vesicle cycle 105 2.623405 0.0223578 0.0162795
GO:0016079 synaptic vesicle exocytosis 99 2.593716 0.0223578 0.0162795
GO:0048489 synaptic vesicle transport 125 2.586872 0.0223578 0.0162795
GO:0097480 establishment of synaptic vesicle localization 125 2.586872 0.0223578 0.0162795
GO:0010257 NADH dehydrogenase complex assembly 64 2.584921 0.0223578 0.0162795
GO:0032981 mitochondrial respiratory chain complex I assembly 64 2.584921 0.0223578 0.0162795
GO:0097479 synaptic vesicle localization 135 2.570717 0.0223578 0.0162795
GO:0017156 calcium ion regulated exocytosis 124 2.566309 0.0223578 0.0162795
GO:0099003 vesicle-mediated transport in synapse 171 2.564606 0.0223578 0.0162795
GO:0099504 synaptic vesicle cycle 158 2.549670 0.0223578 0.0162795
GO:1902803 regulation of synaptic vesicle transport 75 2.547550 0.0223578 0.0162795
GO:0046928 regulation of neurotransmitter secretion 93 2.539251 0.0223578 0.0162795
GO:0006101 citrate metabolic process 28 2.524150 0.0223578 0.0162795
GO:0009060 aerobic respiration 66 2.510141 0.0223578 0.0162795
GO:0033108 mitochondrial respiratory chain complex assembly 87 2.503824 0.0223578 0.0162795
GO:1900449 regulation of glutamate receptor signaling pathway 54 2.497750 0.0223578 0.0162795
GO:0006099 tricarboxylic acid cycle 26 2.480137 0.0223578 0.0162795
GO:2000300 regulation of synaptic vesicle exocytosis 70 2.461367 0.0223578 0.0162795
GO:0015980 energy derivation by oxidation of organic compounds 251 2.446646 0.0223578 0.0162795
GO:0017158 regulation of calcium ion-dependent exocytosis 90 2.438766 0.0223578 0.0162795
GO:0072350 tricarboxylic acid metabolic process 31 2.428176 0.0223578 0.0162795
GO:0051588 regulation of neurotransmitter transport 124 2.406984 0.0223578 0.0162795
GO:0022900 electron transport chain 162 2.402303 0.0223578 0.0162795
GO:0006836 neurotransmitter transport 222 2.395609 0.0223578 0.0162795
GO:0007005 mitochondrion organization 452 2.363754 0.0223578 0.0162795
GO:2001257 regulation of cation channel activity 150 2.355495 0.0223578 0.0162795
GO:0048168 regulation of neuronal synaptic plasticity 46 2.347220 0.0223578 0.0162795
GO:0051648 vesicle localization 261 2.322752 0.0223578 0.0162795
GO:0051650 establishment of vesicle localization 245 2.317448 0.0223578 0.0162795
GO:0006335 DNA replication-dependent nucleosome assembly 32 2.315180 0.0223578 0.0162795
GO:0034723 DNA replication-dependent nucleosome organization 32 2.315180 0.0223578 0.0162795
GO:0099177 regulation of trans-synaptic signaling 375 2.288237 0.0223578 0.0162795
GO:0050804 modulation of chemical synaptic transmission 374 2.287089 0.0223578 0.0162795
GO:2000310 regulation of NMDA receptor activity 33 2.286404 0.0223578 0.0162795
GO:0032543 mitochondrial translation 124 2.280576 0.0223578 0.0162795
GO:1901524 regulation of mitophagy 17 2.273647 0.0223578 0.0162795
GO:0099601 regulation of neurotransmitter receptor activity 62 2.272499 0.0223578 0.0162795
GO:1902600 proton transmembrane transport 128 2.272480 0.0223578 0.0162795
GO:0006103 2-oxoglutarate metabolic process 14 2.256982 0.0223578 0.0162795
GO:0032412 regulation of ion transmembrane transporter activity 213 2.247505 0.0223578 0.0162795
GO:0036465 synaptic vesicle recycling 49 2.244697 0.0223578 0.0162795
GO:0006091 generation of precursor metabolites and energy 464 2.236065 0.0223578 0.0162795
GO:0070125 mitochondrial translational elongation 85 2.227963 0.0223578 0.0162795
GO:0022898 regulation of transmembrane transporter activity 220 2.223322 0.0223578 0.0162795
GO:0007007 inner mitochondrial membrane organization 37 2.221033 0.0223578 0.0162795
GO:0023061 signal release 380 2.215097 0.0223578 0.0162795
GO:0009126 purine nucleoside monophosphate metabolic process 304 2.211605 0.0223578 0.0162795
GO:0009167 purine ribonucleoside monophosphate metabolic process 303 2.205684 0.0223578 0.0162795
GO:0000422 autophagy of mitochondrion 55 2.204424 0.0223578 0.0162795
GO:0061726 mitochondrion disassembly 55 2.204424 0.0223578 0.0162795
GO:0015672 monovalent inorganic cation transport 407 2.197697 0.0223578 0.0162795
GO:0046034 ATP metabolic process 274 2.197151 0.0223578 0.0162795
GO:0070126 mitochondrial translational termination 87 2.197053 0.0223578 0.0162795
GO:0009161 ribonucleoside monophosphate metabolic process 316 2.182006 0.0223578 0.0162795
GO:0098877 neurotransmitter receptor transport to plasma membrane 12 2.177158 0.0223578 0.0162795
GO:0098969 neurotransmitter receptor transport to postsynaptic membrane 12 2.177158 0.0223578 0.0162795
GO:0009205 purine ribonucleoside triphosphate metabolic process 300 2.176266 0.0223578 0.0162795
GO:0035640 exploration behavior 23 2.172891 0.0223578 0.0162795
GO:0009199 ribonucleoside triphosphate metabolic process 305 2.171970 0.0223578 0.0162795
GO:1903540 establishment of protein localization to postsynaptic membrane 13 2.168906 0.0223578 0.0162795
GO:0032409 regulation of transporter activity 231 2.164542 0.0223578 0.0162795
GO:0000423 mitophagy 21 2.160674 0.0223578 0.0162795
GO:0009144 purine nucleoside triphosphate metabolic process 307 2.160562 0.0223578 0.0162795
GO:0009123 nucleoside monophosphate metabolic process 332 2.153721 0.0223578 0.0162795
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 67 2.150552 0.0223578 0.0162795
GO:0042407 cristae formation 30 2.146410 0.0223578 0.0162795
GO:1903533 regulation of protein targeting 79 2.143354 0.0223578 0.0162795
GO:0000266 mitochondrial fission 30 2.139862 0.0223578 0.0162795
GO:0045653 negative regulation of megakaryocyte differentiation 17 2.137809 0.0223578 0.0162795
GO:0006734 NADH metabolic process 34 2.132332 0.0223578 0.0162795
GO:0009141 nucleoside triphosphate metabolic process 323 2.128344 0.0223578 0.0162795
GO:0032594 protein transport within lipid bilayer 20 2.121697 0.0223578 0.0162795
GO:0006415 translational termination 99 2.117017 0.0223578 0.0162795
GO:1903008 organelle disassembly 78 2.116569 0.0223578 0.0162795
GO:1903146 regulation of autophagy of mitochondrion 41 2.111945 0.0223578 0.0162795
GO:0072384 organelle transport along microtubule 71 2.104751 0.0223578 0.0162795
GO:0070585 protein localization to mitochondrion 123 2.104079 0.0223578 0.0162795
GO:0035418 protein localization to synapse 55 2.099575 0.0223578 0.0162795
GO:0007006 mitochondrial membrane organization 115 2.098256 0.0223578 0.0162795
GO:0007215 glutamate receptor signaling pathway 81 2.098103 0.0223578 0.0162795
GO:0098930 axonal transport 50 2.093806 0.0223578 0.0162795
GO:0006839 mitochondrial transport 215 2.088816 0.0223578 0.0162795
GO:1903421 regulation of synaptic vesicle recycling 24 2.087482 0.0223578 0.0162795
GO:0006626 protein targeting to mitochondrion 84 2.087343 0.0223578 0.0162795
GO:0006007 glucose catabolic process 33 2.084569 0.0223578 0.0162795
GO:0006735 NADH regeneration 26 2.079659 0.0223578 0.0162795
GO:0061621 canonical glycolysis 26 2.079659 0.0223578 0.0162795
GO:0061718 glucose catabolic process to pyruvate 26 2.079659 0.0223578 0.0162795
GO:0032400 melanosome localization 23 2.073243 0.0223578 0.0162795
GO:0072655 establishment of protein localization to mitochondrion 120 2.071044 0.0223578 0.0162795
GO:0050905 neuromuscular process 87 2.070235 0.0223578 0.0162795
GO:0001505 regulation of neurotransmitter levels 289 2.069485 0.0223578 0.0162795
GO:0016241 regulation of macroautophagy 161 2.068810 0.0223578 0.0162795
GO:0000338 protein deneddylation 10 2.067647 0.0223578 0.0162795
GO:0033238 regulation of cellular amine metabolic process 74 2.066447 0.0223578 0.0162795
GO:0099632 protein transport within plasma membrane 13 2.065506 0.0223578 0.0162795
GO:0099637 neurotransmitter receptor transport 13 2.065506 0.0223578 0.0162795
GO:0048167 regulation of synaptic plasticity 163 2.064887 0.0223578 0.0162795
GO:0048488 synaptic vesicle endocytosis 37 2.060549 0.0223578 0.0162795
GO:0140238 presynaptic endocytosis 37 2.060549 0.0223578 0.0162795
GO:0140053 mitochondrial gene expression 147 2.059212 0.0223578 0.0162795
GO:1901021 positive regulation of calcium ion transmembrane transporter activity 37 2.055423 0.0223578 0.0162795
GO:0061615 glycolytic process through fructose-6-phosphate 27 2.039727 0.0223578 0.0162795
GO:0061620 glycolytic process through glucose-6-phosphate 27 2.039727 0.0223578 0.0162795
GO:1904062 regulation of cation transmembrane transport 283 2.033419 0.0223578 0.0162795
GO:0016082 synaptic vesicle priming 12 2.032477 0.0223578 0.0162795
GO:0051875 pigment granule localization 24 2.032323 0.0223578 0.0162795
GO:0006851 mitochondrial calcium ion transmembrane transport 25 2.032321 0.0223578 0.0162795
GO:2000311 regulation of AMPA receptor activity 18 2.031251 0.0223578 0.0162795
GO:0051705 multi-organism behavior 60 2.031153 0.0223578 0.0162795
GO:0010822 positive regulation of mitochondrion organization 113 2.021605 0.0223578 0.0162795
GO:0090140 regulation of mitochondrial fission 23 2.019707 0.0223578 0.0162795
GO:0009150 purine ribonucleotide metabolic process 471 2.013367 0.0223578 0.0162795
GO:0032402 melanosome transport 19 2.010979 0.0223578 0.0162795
GO:0035641 locomotory exploration behavior 12 2.010047 0.0223578 0.0162795
GO:0050884 neuromuscular process controlling posture 12 2.009172 0.0223578 0.0162795
GO:0034765 regulation of ion transmembrane transport 408 2.008212 0.0223578 0.0162795
GO:0009259 ribonucleotide metabolic process 485 2.008072 0.0223578 0.0162795
GO:2001259 positive regulation of cation channel activity 63 2.001511 0.0223578 0.0162795
GO:0048169 regulation of long-term neuronal synaptic plasticity 25 1.997028 0.0223578 0.0162795
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 17 1.996994 0.0322778 0.0235026
GO:0019646 aerobic electron transport chain 17 1.996994 0.0322778 0.0235026
GO:0006813 potassium ion transport 169 1.995549 0.0223578 0.0162795
GO:0016999 antibiotic metabolic process 106 1.987685 0.0223578 0.0162795
GO:0032401 establishment of melanosome localization 20 1.983706 0.0223578 0.0162795
GO:0047496 vesicle transport along microtubule 38 1.981060 0.0223578 0.0162795
GO:0048857 neural nucleus development 55 1.976708 0.0223578 0.0162795
GO:0051904 pigment granule transport 20 1.974316 0.0223578 0.0162795
GO:0051646 mitochondrion localization 41 1.968018 0.0223578 0.0162795
GO:0071333 cellular response to glucose stimulus 112 1.967897 0.0223578 0.0162795
GO:0006163 purine nucleotide metabolic process 493 1.966354 0.0223578 0.0162795
GO:0043039 tRNA aminoacylation 45 1.957513 0.0223578 0.0162795
GO:0070584 mitochondrion morphogenesis 20 1.955266 0.0223578 0.0162795
GO:0051932 synaptic transmission, GABAergic 36 1.953458 0.0223578 0.0162795
GO:0017157 regulation of exocytosis 181 1.951179 0.0223578 0.0162795
GO:0106027 neuron projection organization 83 1.947896 0.0223578 0.0162795
GO:1903861 positive regulation of dendrite extension 21 1.944171 0.0322778 0.0235026
GO:0008089 anterograde axonal transport 42 1.943317 0.0223578 0.0162795
GO:0071322 cellular response to carbohydrate stimulus 122 1.942160 0.0223578 0.0162795
GO:0010765 positive regulation of sodium ion transport 29 1.941056 0.0223578 0.0162795
GO:0010970 transport along microtubule 141 1.940548 0.0223578 0.0162795
GO:0099111 microtubule-based transport 141 1.940548 0.0223578 0.0162795
GO:0071326 cellular response to monosaccharide stimulus 114 1.939894 0.0223578 0.0162795
GO:0071331 cellular response to hexose stimulus 114 1.939894 0.0223578 0.0162795
GO:0051905 establishment of pigment granule localization 21 1.939555 0.0322778 0.0235026
GO:0043648 dicarboxylic acid metabolic process 81 1.939448 0.0223578 0.0162795
GO:1903859 regulation of dendrite extension 23 1.937957 0.0322778 0.0235026
GO:0099500 vesicle fusion to plasma membrane 10 1.936617 0.0223578 0.0162795
GO:0031111 negative regulation of microtubule polymerization or depolymerization 32 1.931813 0.0223578 0.0162795
GO:0016242 negative regulation of macroautophagy 32 1.929146 0.0223578 0.0162795
GO:0071804 cellular potassium ion transport 121 1.928829 0.0223578 0.0162795
GO:0071805 potassium ion transmembrane transport 121 1.928829 0.0223578 0.0162795
GO:0070129 regulation of mitochondrial translation 25 1.926568 0.0406563 0.0296032
GO:0060078 regulation of postsynaptic membrane potential 119 1.921361 0.0223578 0.0162795
GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 47 1.920872 0.0223578 0.0162795
GO:0072583 clathrin-dependent endocytosis 37 1.919903 0.0223578 0.0162795
GO:0099132 ATP hydrolysis coupled cation transmembrane transport 52 1.918763 0.0223578 0.0162795
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 12 1.918033 0.0223578 0.0162795
GO:1903305 regulation of regulated secretory pathway 134 1.916798 0.0223578 0.0162795
GO:0006521 regulation of cellular amino acid metabolic process 56 1.916787 0.0223578 0.0162795
GO:0097120 receptor localization to synapse 35 1.916778 0.0223578 0.0162795
GO:0010821 regulation of mitochondrion organization 170 1.914481 0.0223578 0.0162795
GO:0042551 neuron maturation 42 1.907931 0.0223578 0.0162795
GO:0008088 axo-dendritic transport 60 1.905457 0.0223578 0.0162795
GO:0030705 cytoskeleton-dependent intracellular transport 152 1.905058 0.0223578 0.0162795
GO:0099518 vesicle cytoskeletal trafficking 43 1.903245 0.0223578 0.0162795
GO:0016236 macroautophagy 267 1.902817 0.0223578 0.0162795
GO:1903539 protein localization to postsynaptic membrane 27 1.899904 0.0223578 0.0162795
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 17 1.898958 0.0322778 0.0235026
GO:0070131 positive regulation of mitochondrial translation 17 1.898371 0.0322778 0.0235026
GO:0043950 positive regulation of cAMP-mediated signaling 19 1.896103 0.0412231 0.0300159
GO:0043038 amino acid activation 46 1.892211 0.0223578 0.0162795
GO:0099188 postsynaptic cytoskeleton organization 10 1.890066 0.0322778 0.0235026
GO:0090313 regulation of protein targeting to membrane 34 1.889918 0.0223578 0.0162795
GO:0006418 tRNA aminoacylation for protein translation 42 1.889703 0.0223578 0.0162795
GO:0061003 positive regulation of dendritic spine morphogenesis 20 1.889239 0.0409811 0.0298397
GO:0051656 establishment of organelle localization 426 1.885636 0.0223578 0.0162795
GO:0034762 regulation of transmembrane transport 475 1.884657 0.0223578 0.0162795
GO:0043624 cellular protein complex disassembly 189 1.880512 0.0223578 0.0162795
GO:0032414 positive regulation of ion transmembrane transporter activity 94 1.877641 0.0223578 0.0162795
GO:0050432 catecholamine secretion 36 1.876824 0.0223578 0.0162795
GO:0001963 synaptic transmission, dopaminergic 24 1.873459 0.0488308 0.0355553
GO:2000785 regulation of autophagosome assembly 32 1.872715 0.0322778 0.0235026
GO:0071871 response to epinephrine 15 1.872703 0.0409811 0.0298397
GO:0006414 translational elongation 122 1.872548 0.0223578 0.0162795
GO:0140029 exocytic process 61 1.871625 0.0223578 0.0162795
GO:0035637 multicellular organismal signaling 176 1.865403 0.0223578 0.0162795
GO:0048311 mitochondrion distribution 13 1.865114 0.0322778 0.0235026
GO:0048813 dendrite morphogenesis 130 1.861945 0.0223578 0.0162795
GO:0008637 apoptotic mitochondrial changes 110 1.861401 0.0223578 0.0162795
GO:0035773 insulin secretion involved in cellular response to glucose stimulus 57 1.859820 0.0223578 0.0162795
GO:0014047 glutamate secretion 41 1.859517 0.0223578 0.0162795
GO:0097484 dendrite extension 32 1.858119 0.0322778 0.0235026
GO:0050808 synapse organization 378 1.857439 0.0223578 0.0162795
GO:0044106 cellular amine metabolic process 111 1.854721 0.0223578 0.0162795
GO:0060079 excitatory postsynaptic potential 88 1.853358 0.0223578 0.0162795
GO:0090314 positive regulation of protein targeting to membrane 29 1.852956 0.0322778 0.0235026
GO:0015991 ATP hydrolysis coupled proton transport 24 1.849629 0.0488308 0.0355553
GO:0060997 dendritic spine morphogenesis 55 1.848544 0.0223578 0.0162795
GO:0007612 learning 137 1.847873 0.0223578 0.0162795
GO:0042391 regulation of membrane potential 338 1.846104 0.0223578 0.0162795
GO:0008053 mitochondrial fusion 21 1.841318 0.0491806 0.0358101
GO:0099565 chemical synaptic transmission, postsynaptic 96 1.839139 0.0223578 0.0162795
GO:0021762 substantia nigra development 40 1.837172 0.0322778 0.0235026
GO:0001678 cellular glucose homeostasis 122 1.829115 0.0223578 0.0162795
GO:0051290 protein heterotetramerization 51 1.824872 0.0223578 0.0162795
GO:0038003 opioid receptor signaling pathway 11 1.823995 0.0223578 0.0162795
GO:0007416 synapse assembly 163 1.821593 0.0223578 0.0162795
GO:0090141 positive regulation of mitochondrial fission 14 1.820792 0.0486375 0.0354146
GO:0035864 response to potassium ion 12 1.820304 0.0493488 0.0359325
GO:0050433 regulation of catecholamine secretion 34 1.818383 0.0406563 0.0296032
GO:0006883 cellular sodium ion homeostasis 12 1.817844 0.0493488 0.0359325
GO:1901526 positive regulation of mitophagy 10 1.817454 0.0415419 0.0302480
GO:0030534 adult behavior 120 1.817174 0.0223578 0.0162795
GO:0018210 peptidyl-threonine modification 103 1.813500 0.0223578 0.0162795
GO:0061001 regulation of dendritic spine morphogenesis 42 1.811413 0.0223578 0.0162795
GO:0030072 peptide hormone secretion 204 1.808586 0.0223578 0.0162795
GO:0010644 cell communication by electrical coupling 29 1.806425 0.0483524 0.0352070
GO:0030073 insulin secretion 173 1.805960 0.0223578 0.0162795
GO:0035307 positive regulation of protein dephosphorylation 39 1.803262 0.0406563 0.0296032
GO:1990542 mitochondrial transmembrane transport 64 1.802349 0.0223578 0.0162795
GO:0051952 regulation of amine transport 63 1.801349 0.0223578 0.0162795
GO:0043524 negative regulation of neuron apoptotic process 129 1.799533 0.0322778 0.0235026
GO:0018107 peptidyl-threonine phosphorylation 95 1.793408 0.0223578 0.0162795
GO:1903214 regulation of protein targeting to mitochondrion 44 1.792350 0.0322778 0.0235026
GO:2000786 positive regulation of autophagosome assembly 11 1.792139 0.0322778 0.0235026
GO:0051937 catecholamine transport 48 1.790691 0.0223578 0.0162795
GO:0019320 hexose catabolic process 50 1.789735 0.0223578 0.0162795
GO:0050775 positive regulation of dendrite morphogenesis 35 1.786120 0.0322778 0.0235026
GO:0007611 learning or memory 229 1.781654 0.0223578 0.0162795
GO:0032411 positive regulation of transporter activity 102 1.778558 0.0223578 0.0162795
GO:0015800 acidic amino acid transport 60 1.773786 0.0223578 0.0162795
GO:1901019 regulation of calcium ion transmembrane transporter activity 80 1.772436 0.0223578 0.0162795
GO:0090199 regulation of release of cytochrome c from mitochondria 44 1.770651 0.0322778 0.0235026
GO:0008344 adult locomotory behavior 66 1.770444 0.0223578 0.0162795
GO:0061337 cardiac conduction 135 1.767448 0.0223578 0.0162795
GO:0097061 dendritic spine organization 75 1.766925 0.0223578 0.0162795
GO:0048667 cell morphogenesis involved in neuron differentiation 469 1.763595 0.0223578 0.0162795
GO:0019226 transmission of nerve impulse 46 1.756020 0.0223578 0.0162795
GO:0048814 regulation of dendrite morphogenesis 81 1.755244 0.0223578 0.0162795
GO:0000183 chromatin silencing at rDNA 39 1.752559 0.0406563 0.0296032
GO:0006006 glucose metabolic process 180 1.752368 0.0223578 0.0162795
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 90 1.752298 0.0223578 0.0162795
GO:0008306 associative learning 73 1.748468 0.0322778 0.0235026
GO:0046365 monosaccharide catabolic process 57 1.744426 0.0322778 0.0235026
GO:0009749 response to glucose 165 1.740851 0.0223578 0.0162795
GO:0016358 dendrite development 212 1.737918 0.0223578 0.0162795
GO:0007018 microtubule-based movement 215 1.733848 0.0223578 0.0162795
GO:0006520 cellular amino acid metabolic process 323 1.731993 0.0223578 0.0162795
GO:0009308 amine metabolic process 118 1.731877 0.0223578 0.0162795
GO:0060627 regulation of vesicle-mediated transport 443 1.728295 0.0223578 0.0162795
GO:0035306 positive regulation of dephosphorylation 51 1.726995 0.0322778 0.0235026
GO:0035304 regulation of protein dephosphorylation 125 1.722718 0.0322778 0.0235026
GO:0051963 regulation of synapse assembly 99 1.721303 0.0223578 0.0162795
GO:0050890 cognition 261 1.719962 0.0223578 0.0162795
GO:0035176 social behavior 46 1.719651 0.0223578 0.0162795
GO:0051703 intraspecies interaction between organisms 46 1.719651 0.0223578 0.0162795
GO:0001508 action potential 108 1.718387 0.0223578 0.0162795
GO:0015837 amine transport 66 1.709635 0.0406563 0.0296032
GO:1903747 regulation of establishment of protein localization to mitochondrion 70 1.706602 0.0322778 0.0235026
GO:0050885 neuromuscular process controlling balance 41 1.706275 0.0406563 0.0296032
GO:0032386 regulation of intracellular transport 384 1.698225 0.0223578 0.0162795
GO:0007626 locomotory behavior 171 1.697666 0.0223578 0.0162795
GO:0046717 acid secretion 91 1.694416 0.0223578 0.0162795
GO:1904427 positive regulation of calcium ion transmembrane transport 62 1.693830 0.0406563 0.0296032
GO:1901215 negative regulation of neuron death 181 1.688678 0.0223578 0.0162795
GO:0060999 positive regulation of dendritic spine development 41 1.687612 0.0406563 0.0296032
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 50 1.687056 0.0406563 0.0296032
GO:0099173 postsynapse organization 154 1.684717 0.0223578 0.0162795
GO:0051965 positive regulation of synapse assembly 62 1.683552 0.0481498 0.0350594
GO:0060996 dendritic spine development 93 1.682415 0.0406563 0.0296032
GO:1990138 neuron projection extension 141 1.681285 0.0322778 0.0235026
GO:0010975 regulation of neuron projection development 433 1.679506 0.0223578 0.0162795
GO:0032984 protein-containing complex disassembly 286 1.676087 0.0223578 0.0162795
GO:0007409 axonogenesis 364 1.674457 0.0223578 0.0162795
GO:0090276 regulation of peptide hormone secretion 167 1.674122 0.0223578 0.0162795
GO:0060359 response to ammonium ion 115 1.670481 0.0223578 0.0162795
GO:0043242 negative regulation of protein complex disassembly 58 1.669751 0.0406563 0.0296032
GO:0061564 axon development 403 1.669393 0.0223578 0.0162795
GO:0009746 response to hexose 170 1.667157 0.0223578 0.0162795
GO:0046390 ribose phosphate biosynthetic process 270 1.665120 0.0223578 0.0162795
GO:1905037 autophagosome organization 72 1.664485 0.0322778 0.0235026
GO:0050796 regulation of insulin secretion 147 1.663763 0.0223578 0.0162795
GO:0051261 protein depolymerization 88 1.663742 0.0322778 0.0235026
GO:1903779 regulation of cardiac conduction 65 1.662983 0.0406563 0.0296032
GO:0035249 synaptic transmission, glutamatergic 60 1.659985 0.0406563 0.0296032
GO:0009152 purine ribonucleotide biosynthetic process 253 1.658978 0.0223578 0.0162795
GO:0050806 positive regulation of synaptic transmission 138 1.654886 0.0322778 0.0235026
GO:0009260 ribonucleotide biosynthetic process 266 1.648019 0.0223578 0.0162795
GO:0009127 purine nucleoside monophosphate biosynthetic process 165 1.647936 0.0223578 0.0162795
GO:0009168 purine ribonucleoside monophosphate biosynthetic process 165 1.647936 0.0223578 0.0162795
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 78 1.647492 0.0322778 0.0235026
GO:0010823 negative regulation of mitochondrion organization 51 1.647404 0.0406563 0.0296032
GO:0009743 response to carbohydrate 196 1.646944 0.0223578 0.0162795
GO:0006914 autophagy 455 1.646826 0.0223578 0.0162795
GO:0061919 process utilizing autophagic mechanism 455 1.646826 0.0223578 0.0162795
GO:0006826 iron ion transport 50 1.645785 0.0481498 0.0350594
GO:0002478 antigen processing and presentation of exogenous peptide antigen 162 1.642622 0.0223578 0.0162795
GO:0019884 antigen processing and presentation of exogenous antigen 164 1.642118 0.0223578 0.0162795
GO:0009156 ribonucleoside monophosphate biosynthetic process 178 1.640985 0.0223578 0.0162795
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 93 1.639894 0.0406563 0.0296032
GO:0031145 anaphase-promoting complex-dependent catabolic process 76 1.639840 0.0223578 0.0162795
GO:0070588 calcium ion transmembrane transport 265 1.638377 0.0223578 0.0162795
GO:0006164 purine nucleotide biosynthetic process 263 1.636370 0.0223578 0.0162795
GO:0007032 endosome organization 70 1.635396 0.0406563 0.0296032
GO:0032456 endocytic recycling 42 1.635125 0.0482200 0.0351106
GO:0009145 purine nucleoside triphosphate biosynthetic process 151 1.628637 0.0223578 0.0162795
GO:0010976 positive regulation of neuron projection development 249 1.628464 0.0223578 0.0162795
GO:0010506 regulation of autophagy 301 1.624676 0.0223578 0.0162795
GO:0022411 cellular component disassembly 454 1.624089 0.0223578 0.0162795
GO:0001836 release of cytochrome c from mitochondria 55 1.623500 0.0406563 0.0296032
GO:0034284 response to monosaccharide 174 1.621427 0.0223578 0.0162795
GO:0008016 regulation of heart contraction 215 1.621068 0.0223578 0.0162795
GO:0006865 amino acid transport 122 1.618646 0.0322778 0.0235026
GO:0060998 regulation of dendritic spine development 70 1.617898 0.0406563 0.0296032
GO:0050803 regulation of synapse structure or activity 211 1.617753 0.0223578 0.0162795
GO:0032272 negative regulation of protein polymerization 54 1.617000 0.0483524 0.0352070
GO:0035725 sodium ion transmembrane transport 92 1.610313 0.0406563 0.0296032
GO:0009206 purine ribonucleoside triphosphate biosynthetic process 150 1.609436 0.0322778 0.0235026
GO:0043270 positive regulation of ion transport 237 1.608919 0.0223578 0.0162795
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 94 1.607915 0.0477472 0.0347664
GO:0048193 Golgi vesicle transport 290 1.607064 0.0223578 0.0162795
GO:0006814 sodium ion transport 160 1.605574 0.0223578 0.0162795
GO:0033157 regulation of intracellular protein transport 210 1.605225 0.0223578 0.0162795
GO:0042180 cellular ketone metabolic process 197 1.600646 0.0223578 0.0162795
GO:0043523 regulation of neuron apoptotic process 185 1.600244 0.0223578 0.0162795
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER 74 1.599848 0.0406563 0.0296032
GO:0048588 developmental cell growth 194 1.596777 0.0223578 0.0162795
GO:1901880 negative regulation of protein depolymerization 52 1.596148 0.0479719 0.0349300
GO:0045921 positive regulation of exocytosis 77 1.595622 0.0406563 0.0296032
GO:0043687 post-translational protein modification 335 1.593346 0.0223578 0.0162795
GO:0009201 ribonucleoside triphosphate biosynthetic process 155 1.592022 0.0223578 0.0162795
GO:0009124 nucleoside monophosphate biosynthetic process 185 1.591763 0.0223578 0.0162795
GO:0086065 cell communication involved in cardiac conduction 53 1.589545 0.0481936 0.0350913
GO:0006754 ATP biosynthetic process 142 1.588961 0.0322778 0.0235026
GO:0072522 purine-containing compound biosynthetic process 273 1.588010 0.0223578 0.0162795
GO:0050770 regulation of axonogenesis 143 1.585651 0.0322778 0.0235026
GO:1905477 positive regulation of protein localization to membrane 111 1.584776 0.0322778 0.0235026
GO:0038095 Fc-epsilon receptor signaling pathway 106 1.584156 0.0474974 0.0345845
GO:1904064 positive regulation of cation transmembrane transport 126 1.582798 0.0322778 0.0235026
GO:0031333 negative regulation of protein complex assembly 115 1.577292 0.0322778 0.0235026
GO:0051402 neuron apoptotic process 211 1.572632 0.0223578 0.0162795
GO:0060047 heart contraction 239 1.569107 0.0223578 0.0162795
GO:0000209 protein polyubiquitination 279 1.566710 0.0223578 0.0162795
GO:0000086 G2/M transition of mitotic cell cycle 227 1.561001 0.0223578 0.0162795
GO:0019318 hexose metabolic process 213 1.560866 0.0223578 0.0162795
GO:0009142 nucleoside triphosphate biosynthetic process 166 1.560120 0.0322778 0.0235026
GO:1903827 regulation of cellular protein localization 478 1.551928 0.0223578 0.0162795
GO:0031109 microtubule polymerization or depolymerization 92 1.551384 0.0476670 0.0347079
GO:0006399 tRNA metabolic process 157 1.550574 0.0467707 0.0340553
GO:0016482 cytosolic transport 136 1.548533 0.0322778 0.0235026
GO:0010389 regulation of G2/M transition of mitotic cell cycle 175 1.545398 0.0322778 0.0235026
GO:0046879 hormone secretion 254 1.540837 0.0223578 0.0162795
GO:0050807 regulation of synapse organization 207 1.538865 0.0223578 0.0162795
GO:0051668 localization within membrane 120 1.535453 0.0468065 0.0340813
GO:0008277 regulation of G protein-coupled receptor signaling pathway 135 1.526512 0.0322778 0.0235026
GO:0009165 nucleotide biosynthetic process 340 1.523839 0.0223578 0.0162795
GO:0010769 regulation of cell morphogenesis involved in differentiation 250 1.523596 0.0223578 0.0162795
GO:1901293 nucleoside phosphate biosynthetic process 343 1.522242 0.0223578 0.0162795
GO:0045666 positive regulation of neuron differentiation 321 1.515355 0.0223578 0.0162795
GO:0010498 proteasomal protein catabolic process 369 1.511369 0.0223578 0.0162795
GO:0034767 positive regulation of ion transmembrane transport 137 1.508585 0.0322778 0.0235026
GO:0009914 hormone transport 263 1.503732 0.0223578 0.0162795
GO:1903169 regulation of calcium ion transmembrane transport 131 1.502357 0.0474585 0.0345561
GO:0035303 regulation of dephosphorylation 189 1.501302 0.0223578 0.0162795
GO:0050773 regulation of dendrite development 137 1.500003 0.0322778 0.0235026
GO:0005996 monosaccharide metabolic process 234 1.498350 0.0223578 0.0162795
GO:0048639 positive regulation of developmental growth 148 1.496156 0.0466491 0.0339667
GO:0046883 regulation of hormone secretion 215 1.492888 0.0322778 0.0235026
GO:0003015 heart process 248 1.484907 0.0223578 0.0162795
GO:0048002 antigen processing and presentation of peptide antigen 174 1.482991 0.0322778 0.0235026
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 316 1.478598 0.0223578 0.0162795
GO:0051494 negative regulation of cytoskeleton organization 116 1.476216 0.0474585 0.0345561
GO:0051186 cofactor metabolic process 489 1.469441 0.0223578 0.0162795
GO:0044839 cell cycle G2/M phase transition 246 1.467143 0.0223578 0.0162795
GO:0010959 regulation of metal ion transport 321 1.459582 0.0223578 0.0162795
GO:0006090 pyruvate metabolic process 137 1.456922 0.0475367 0.0346130
GO:1903522 regulation of blood circulation 251 1.452451 0.0322778 0.0235026
GO:0051258 protein polymerization 212 1.448075 0.0322778 0.0235026
GO:1990778 protein localization to cell periphery 260 1.445071 0.0322778 0.0235026
GO:0140056 organelle localization by membrane tethering 138 1.441590 0.0474585 0.0345561
GO:1902749 regulation of cell cycle G2/M phase transition 192 1.440348 0.0456751 0.0332576
GO:1903829 positive regulation of cellular protein localization 297 1.430599 0.0223578 0.0162795
GO:0034764 positive regulation of transmembrane transport 173 1.428905 0.0461894 0.0336321
GO:0031346 positive regulation of cell projection organization 334 1.426292 0.0223578 0.0162795
GO:0033500 carbohydrate homeostasis 188 1.417367 0.0453990 0.0330565
GO:0070997 neuron death 311 1.414492 0.0223578 0.0162795
GO:0019882 antigen processing and presentation 202 1.412522 0.0457074 0.0332811
GO:0018209 peptidyl-serine modification 232 1.410053 0.0459884 0.0334857
GO:0010256 endomembrane system organization 344 1.400693 0.0223578 0.0162795
GO:0016311 dephosphorylation 418 1.391967 0.0322778 0.0235026
GO:0010817 regulation of hormone levels 412 1.388222 0.0223578 0.0162795
GO:0070838 divalent metal ion transport 401 1.383133 0.0322778 0.0235026
GO:0072511 divalent inorganic cation transport 403 1.380272 0.0322778 0.0235026
GO:0006816 calcium ion transport 364 1.379089 0.0322778 0.0235026
GO:0032535 regulation of cellular component size 292 1.377722 0.0453990 0.0330565
GO:1901214 regulation of neuron death 279 1.372852 0.0453368 0.0330113
GO:0019941 modification-dependent protein catabolic process 472 1.368516 0.0443827 0.0323165
GO:0006511 ubiquitin-dependent protein catabolic process 467 1.360809 0.0450364 0.0327925
GO:0044282 small molecule catabolic process 363 1.350433 0.0322778 0.0235026
GO:0022604 regulation of cell morphogenesis 411 1.345709 0.0453061 0.0329889
rm(df)


Disease Gene Network

for(module in top_modules){
  df = enrichment_DGN[[module]] %>% dplyr::select(ID, Description, setSize, NES, p.adjust, qvalues) %>% arrange(desc(NES)) %>% filter(NES>0)
  if(nrow(df)>0){
    print(kable(df, caption = paste0('Enriched terms for module ', module, ' (MTcor = ', round(dataset$MTcor[dataset$Module==module][1],2),')')))
    cat('\n') 
  } else cat(paste0('\nNo enrichment found for module ',module,'\n'))
}
Enriched terms for module #00B9E3 (MTcor = -0.93)
ID Description setSize NES p.adjust qvalues
umls:C0543888 Epileptic encephalopathy 51 2.517619 0.0466231 0.0349444
umls:C1838979 MITOCHONDRIAL COMPLEX I DEFICIENCY 29 2.409845 0.0466231 0.0349444
umls:C0751122 Infantile Severe Myoclonic Epilepsy 25 2.303187 0.0466231 0.0349444
umls:C0014547 Epilepsies, Partial 42 2.291802 0.0466231 0.0349444
umls:C0406810 Carney Complex 27 2.207425 0.0466231 0.0349444
umls:C0085292 Stiff-Person Syndrome 19 2.160874 0.0466231 0.0349444
umls:C0037769 West Syndrome 58 2.137014 0.0466231 0.0349444
umls:C0270850 Idiopathic generalized epilepsy 45 2.125396 0.0466231 0.0349444
umls:C0393706 Early infantile epileptic encephalopathy with suppression bursts 19 2.120049 0.0466231 0.0349444
umls:C2936907 NADH:Q(1) Oxidoreductase deficiency 20 2.097329 0.0466231 0.0349444
umls:C0014548 Epilepsy, Generalized 44 2.086088 0.0466231 0.0349444
umls:C0014550 Epilepsies, Myoclonic 36 2.079689 0.0466231 0.0349444
umls:C1955869 Malformations of Cortical Development 45 2.063900 0.0466231 0.0349444
umls:C2931919 X-linked infantile spasm syndrome 15 2.055925 0.0466231 0.0349444
umls:C0427086 Involuntary Movements 13 2.054965 0.0466231 0.0349444
umls:C0342776 Nicotinamide adenine dinucleotide coenzyme Q reductase deficiency 38 2.036608 0.0466231 0.0349444
umls:C0270736 Essential Tremor 49 2.033486 0.0466231 0.0349444
umls:C0238111 Lennox-Gastaut syndrome 11 2.028922 0.0466231 0.0349444
umls:C0026650 Movement Disorders 95 1.998762 0.0466231 0.0349444
umls:C0023264 Leigh Disease 77 1.985598 0.0466231 0.0349444
umls:C1838951 LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 14 1.968265 0.0466231 0.0349444
umls:C1096063 Drug Resistant Epilepsy 53 1.958415 0.0466231 0.0349444
umls:C0162635 Angelman Syndrome 53 1.956889 0.0466231 0.0349444
umls:C0376532 Epilepsy, Rolandic 15 1.950209 0.0466231 0.0349444
umls:C1849156 Spastic Ataxia 14 1.947152 0.0466231 0.0349444
umls:C0004134 Ataxia 221 1.944100 0.0466231 0.0349444
umls:C0751214 Hyperalgesia, Thermal 24 1.942523 0.0466231 0.0349444
umls:C0234166 Hyperexplexia 10 1.916174 0.0466231 0.0349444
umls:C0014553 Absence Epilepsy 49 1.888701 0.0466231 0.0349444
umls:C0391957 idiopathic epilepsy 17 1.883950 0.0466231 0.0349444
umls:C0014556 Epilepsy, Temporal Lobe 175 1.873512 0.0466231 0.0349444
umls:C1306341 Mental handicap 20 1.857124 0.0482247 0.0361448
umls:C0525045 Mood Disorders 238 1.850502 0.0466231 0.0349444
umls:C0751495 Seizures, Focal 18 1.836239 0.0482247 0.0361448
umls:C0035372 Rett Syndrome 111 1.834904 0.0466231 0.0349444
umls:C1142166 Brugada Syndrome (disorder) 46 1.828296 0.0466231 0.0349444
umls:C1510586 Autism Spectrum Disorders 216 1.824252 0.0466231 0.0349444
umls:C1720189 Episodic Ataxia 18 1.816075 0.0482247 0.0361448
umls:C0278864 Growth Hormone-Producing Pituitary Gland Neoplasm 10 1.807948 0.0482247 0.0361448
umls:C0432028 Split foot 10 1.807657 0.0482247 0.0361448
umls:C2911647 Weight Gain Adverse Event 138 1.803999 0.0466231 0.0349444
umls:C0037773 Spastic Paraplegia, Hereditary 62 1.782308 0.0466231 0.0349444
umls:C0162670 Mitochondrial Myopathies 48 1.748064 0.0471197 0.0353166
umls:C0085584 Encephalopathies 120 1.734605 0.0466231 0.0349444
umls:C0242422 Parkinsonian Disorders 173 1.710886 0.0466231 0.0349444
umls:C1263846 Attention deficit hyperactivity disorder 365 1.705684 0.0466231 0.0349444
umls:C0004936 Mental disorders 384 1.687791 0.0466231 0.0349444
umls:C0424551 Impaired exercise tolerance 27 1.685058 0.0481819 0.0361127
umls:C0009952 Febrile Convulsions 60 1.660894 0.0495553 0.0371421
umls:C0236736 Cocaine-Related Disorders 93 1.641811 0.0466231 0.0349444
umls:C0393593 Dystonia Disorders 119 1.637567 0.0466231 0.0349444
umls:C0424605 Developmental delay (disorder) 170 1.617865 0.0466231 0.0349444
umls:C0007758 Cerebellar Ataxia 94 1.611195 0.0484409 0.0363069
umls:C3714756 Intellectual Disability 422 1.609837 0.0466231 0.0349444
umls:C0041696 Unipolar Depression 366 1.606141 0.0466231 0.0349444
umls:C0018817 Atrial Septal Defects 231 1.584548 0.0466231 0.0349444
umls:C0025362 Mental Retardation 356 1.573522 0.0466231 0.0349444
umls:C0027765 nervous system disorder 388 1.567742 0.0466231 0.0349444
umls:C1269683 Major Depressive Disorder 426 1.564966 0.0466231 0.0349444
umls:C0751651 Mitochondrial Diseases 123 1.537339 0.0484409 0.0363069
umls:C0338656 Impaired cognition 343 1.514572 0.0466231 0.0349444
umls:C0043094 Weight Gain 217 1.473246 0.0482247 0.0361448
Enriched terms for module #73B000 (MTcor = 0.94)
ID Description setSize NES p.adjust qvalues
umls:C2986658 Diffuse Intrinsic Pontine Glioma 19 2.664576 0.0167243 0.0117021
umls:C0278504 Non-small cell lung cancer stage I 61 2.520511 0.0167243 0.0117021
umls:C0595936 Aqueous Humor Disorders 54 2.368952 0.0167243 0.0117021
umls:C0600518 Choroidal Neovascularization 43 2.332125 0.0167243 0.0117021
umls:C0016059 Fibrosis 163 2.305263 0.0167243 0.0117021
umls:C0034067 Pulmonary Emphysema 153 2.305145 0.0167243 0.0117021
umls:C1800706 Idiopathic Pulmonary Fibrosis 276 2.296737 0.0167243 0.0117021
umls:C3714514 Infection 464 2.287752 0.0167243 0.0117021
umls:C0240035 Interstitial fibrosis 82 2.270451 0.0167243 0.0117021
umls:C0151650 Renal fibrosis 143 2.268175 0.0167243 0.0117021
umls:C1306759 Eosinophilic disorder 96 2.258364 0.0167243 0.0117021
umls:C0152101 Hypoplastic Left Heart Syndrome 18 2.252855 0.0167243 0.0117021
umls:C0162871 Aortic Aneurysm, Abdominal 151 2.243151 0.0167243 0.0117021
umls:C1636667 Disorder characterized by eosinophilia 95 2.235024 0.0167243 0.0117021
umls:C0042798 Low Vision 19 2.233750 0.0167243 0.0117021
umls:C0041956 Ureteral obstruction 120 2.227728 0.0167243 0.0117021
umls:C0153676 Secondary malignant neoplasm of lung 490 2.218196 0.0167243 0.0117021
umls:C0002962 Angina Pectoris 31 2.217219 0.0167243 0.0117021
umls:C0340643 Dissection of aorta 31 2.201097 0.0167243 0.0117021
umls:C0019189 Hepatitis, Chronic 138 2.198963 0.0167243 0.0117021
umls:C0238288 Muscular Dystrophy, Facioscapulohumeral 60 2.196008 0.0167243 0.0117021
umls:C0025568 Metaplasia 62 2.193596 0.0167243 0.0117021
umls:C3495559 Juvenile arthritis 272 2.193496 0.0167243 0.0117021
umls:C0004623 Bacterial Infections 180 2.182155 0.0167243 0.0117021
umls:C3825567 Tumors in children 10 2.175738 0.0167243 0.0117021
umls:C0879615 Stromal Neoplasm 70 2.175153 0.0167243 0.0117021
umls:C0243038 Carcinoma, Lewis Lung 67 2.162927 0.0167243 0.0117021
umls:C1527311 Brain Edema 43 2.150425 0.0167243 0.0117021
umls:C0036421 Systemic Scleroderma 441 2.140162 0.0167243 0.0117021
umls:C1261287 Stenosis 26 2.136433 0.0167243 0.0117021
umls:C0008495 Chorioamnionitis 156 2.136288 0.0167243 0.0117021
umls:C0026654 Moyamoya Disease 34 2.133518 0.0167243 0.0117021
umls:C0015944 Fetal Membranes, Premature Rupture 155 2.129837 0.0167243 0.0117021
umls:C0027613 Neonatal hepatitis 12 2.110280 0.0167243 0.0117021
umls:C0029434 Osteogenesis Imperfecta 38 2.104095 0.0167243 0.0117021
umls:C0220810 Congenital defects 43 2.101958 0.0167243 0.0117021
umls:C0001339 Acute pancreatitis 70 2.099831 0.0167243 0.0117021
umls:C3665419 Intracranial glioma 34 2.098128 0.0167243 0.0117021
umls:C0003486 Aortic Aneurysm 167 2.097108 0.0167243 0.0117021
umls:C2919032 Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified 149 2.095887 0.0167243 0.0117021
umls:C0021345 Infectious Mononucleosis 22 2.091323 0.0167243 0.0117021
umls:C0032964 Pregnancy Complications, Hematologic 108 2.088528 0.0167243 0.0117021
umls:C0014457 Eosinophilia 102 2.085527 0.0167243 0.0117021
umls:C0019061 Hemolytic-Uremic Syndrome 49 2.084316 0.0167243 0.0117021
umls:C0019187 Hepatitis, Alcoholic 41 2.078615 0.0167243 0.0117021
umls:C0023893 Liver Cirrhosis, Experimental 149 2.077015 0.0167243 0.0117021
umls:C0206659 Embryonal Carcinoma 128 2.074546 0.0167243 0.0117021
umls:C0038395 Streptococcal Infections 35 2.071819 0.0167243 0.0117021
umls:C0032965 Pregnancy Complications, Infectious 24 2.065497 0.0167243 0.0117021
umls:C1292758 Precursor T-cell lymphoblastic lymphoma 12 2.060110 0.0167243 0.0117021
umls:C0022876 Premature Obstetric Labor 163 2.057221 0.0167243 0.0117021
umls:C0242488 Acute Lung Injury 57 2.056643 0.0167243 0.0117021
umls:C0011603 Dermatitis 126 2.055413 0.0167243 0.0117021
umls:C1719672 Severe Sepsis 66 2.054683 0.0167243 0.0117021
umls:C0008373 Cholesteatoma 33 2.053767 0.0167243 0.0117021
umls:C0162810 Cicatrix, Hypertrophic 51 2.052398 0.0167243 0.0117021
umls:C0026857 Musculoskeletal Diseases 107 2.051981 0.0167243 0.0117021
umls:C0032285 Pneumonia 312 2.051294 0.0167243 0.0117021
umls:C0034069 Pulmonary Fibrosis 290 2.045027 0.0167243 0.0117021
umls:C0024291 Lymphohistiocytosis, Hemophagocytic 69 2.044440 0.0167243 0.0117021
umls:C0220641 Lip and Oral Cavity Carcinoma 344 2.041983 0.0167243 0.0117021
umls:C0042345 Varicosity 39 2.039254 0.0167243 0.0117021
umls:C0403447 Chronic Kidney Insufficiency 149 2.037793 0.0167243 0.0117021
umls:C0149516 Chronic sinusitis 42 2.037077 0.0167243 0.0117021
umls:C0002940 Aneurysm 107 2.027965 0.0167243 0.0117021
umls:C0024236 Lymphedema 45 2.025914 0.0167243 0.0117021
umls:C0035369 Retroviridae Infections 54 2.025767 0.0167243 0.0117021
umls:C0026640 Mouth Neoplasms 173 2.021292 0.0167243 0.0117021
umls:C1519670 Tumor Angiogenesis 360 2.020365 0.0167243 0.0117021
umls:C0024115 Lung diseases 276 2.018978 0.0167243 0.0117021
umls:C0085390 Li-Fraumeni Syndrome 37 2.017408 0.0167243 0.0117021
umls:C0085437 Meningitis, Bacterial 32 2.016302 0.0167243 0.0117021
umls:C0151526 Premature Birth 235 2.015831 0.0167243 0.0117021
umls:C0856825 Acute GVH disease 90 2.015036 0.0167243 0.0117021
umls:C0867389 Chronic graft-versus-host disease 60 2.013438 0.0167243 0.0117021
umls:C0035455 Rhinitis 71 2.013250 0.0167243 0.0117021
umls:C0585362 Squamous cell carcinoma of mouth 42 2.012994 0.0167243 0.0117021
umls:C0035222 Respiratory Distress Syndrome, Adult 113 2.012097 0.0167243 0.0117021
umls:C0023484 Leukemia, Plasma Cell 35 2.011566 0.0167243 0.0117021
umls:C1334274 Invasive Carcinoma 134 2.010370 0.0167243 0.0117021
umls:C0340629 Aortic aneurysm without mention of rupture NOS 26 2.009482 0.0167243 0.0117021
umls:C0153381 Malignant neoplasm of mouth 344 2.008563 0.0167243 0.0117021
umls:C0036920 Sezary Syndrome 109 2.007829 0.0167243 0.0117021
umls:C0023646 Lichen Planus 16 2.007498 0.0167243 0.0117021
umls:C0007282 Carotid Stenosis 95 2.005633 0.0167243 0.0117021
umls:C0162872 Aortic Aneurysm, Thoracic 91 2.003847 0.0167243 0.0117021
umls:C1956391 Temporal Arteritis 13 2.001715 0.0167243 0.0117021
umls:C0019340 Herpes NOS 67 2.000683 0.0167243 0.0117021
umls:C0029172 Oral Submucous Fibrosis 45 1.998321 0.0167243 0.0117021
umls:C0339539 Familial Exudative Vitreoretinopathy 14 1.996388 0.0167243 0.0117021
umls:C0920646 Renal ischaemia 76 1.996294 0.0167243 0.0117021
umls:C0029118 Opportunistic Infections 25 1.996010 0.0167243 0.0117021
umls:C0014356 Enterocolitis 18 1.995200 0.0167243 0.0117021
umls:C0013537 Eclampsia 143 1.994462 0.0167243 0.0117021
umls:C1566590 Delayed Graft Function 13 1.993396 0.0167243 0.0117021
umls:C0033687 Proteinuria 67 1.991694 0.0167243 0.0117021
umls:C0009447 Common Variable Immunodeficiency 91 1.989739 0.0167243 0.0117021
umls:C0037928 Spinal Cord Diseases 32 1.988874 0.0167243 0.0117021
umls:C0374997 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site 246 1.988762 0.0167243 0.0117021
umls:C0042131 Uterine Diseases 16 1.986974 0.0167243 0.0117021
umls:C0235989 Renal interstitial fibrosis 29 1.984096 0.0167243 0.0117021
umls:C0003130 Anoxia 306 1.983164 0.0167243 0.0117021
umls:C0030481 Tropical Spastic Paraparesis 33 1.983160 0.0167243 0.0117021
umls:C0036117 Salmonella infections 23 1.982932 0.0167243 0.0117021
umls:C0034362 Q Fever 20 1.982387 0.0167243 0.0117021
umls:C0025295 Meningitis, Pneumococcal 28 1.981475 0.0167243 0.0117021
umls:C0971858 Arthritis, Collagen-Induced 133 1.979505 0.0167243 0.0117021
umls:C0085090 Lymphoma, AIDS-Related 27 1.977390 0.0167243 0.0117021
umls:C0042373 Vascular Diseases 328 1.976202 0.0167243 0.0117021
umls:C0035328 Retinal Vein Occlusion 24 1.974219 0.0167243 0.0117021
umls:C0079218 Fibromatosis, Aggressive 53 1.973459 0.0167243 0.0117021
umls:C0162820 Dermatitis, Allergic Contact 83 1.972440 0.0167243 0.0117021
umls:C0017658 Glomerulonephritis 161 1.972250 0.0167243 0.0117021
umls:C0887833 Carcinoma, Pancreatic Ductal 55 1.971403 0.0167243 0.0117021
umls:C0017411 Female Genital Diseases 14 1.970766 0.0167243 0.0117021
umls:C0947751 Vascular inflammations 99 1.970520 0.0167243 0.0117021
umls:C0014170 Endometrial Neoplasms 220 1.968924 0.0167243 0.0117021
umls:C1318485 Liver regeneration disorder 75 1.967044 0.0167243 0.0117021
umls:C0023895 Liver diseases 446 1.966124 0.0167243 0.0117021
umls:C0332853 Anastomosis 18 1.963422 0.0252770 0.0176865
umls:C0027626 Neoplasm Invasiveness 147 1.961754 0.0167243 0.0117021
umls:C0040053 Thrombosis 105 1.957679 0.0167243 0.0117021
umls:C0034040 Puerperal Disorders 27 1.956047 0.0167243 0.0117021
umls:C0206677 Adenomatous Polyps 58 1.953494 0.0167243 0.0117021
umls:C0036202 Sarcoidosis 195 1.953156 0.0167243 0.0117021
umls:C2931384 Moyamoya disease 1 25 1.953123 0.0167243 0.0117021
umls:C1176475 Ductal Carcinoma 185 1.951113 0.0167243 0.0117021
umls:C1512433 Cervical high grade squamous intraepithelial lesion 15 1.951104 0.0252770 0.0176865
umls:C1260959 Drusen 38 1.949270 0.0167243 0.0117021
umls:C0015929 Fetal Diseases 122 1.947972 0.0167243 0.0117021
umls:C1762616 Meningioma, benign, no ICD-O subtype 191 1.947949 0.0167243 0.0117021
umls:C0027697 Nephritis 117 1.942911 0.0167243 0.0117021
umls:C0032914 Pre-Eclampsia 275 1.942371 0.0167243 0.0117021
umls:C0701807 Acute anterior uveitis 33 1.941898 0.0167243 0.0117021
umls:C0007772 Intracranial Arteriovenous Malformation 10 1.941728 0.0167243 0.0117021
umls:C0022548 Keloid 146 1.941089 0.0167243 0.0117021
umls:C0006274 Bronchiolitis, Viral 139 1.938986 0.0167243 0.0117021
umls:C0017612 Glaucoma, Open-Angle 77 1.935449 0.0167243 0.0117021
umls:C0036420 Localized scleroderma 19 1.935438 0.0339424 0.0237497
umls:C0153690 Secondary malignant neoplasm of bone 233 1.934874 0.0167243 0.0117021
umls:C1368683 Epithelioma 225 1.932421 0.0167243 0.0117021
umls:C0278996 Cancer of Head and Neck 361 1.932031 0.0167243 0.0117021
umls:C1719495 Aggressive periodontitis, generalized 29 1.929658 0.0167243 0.0117021
umls:C0346429 Multiple malignancy 164 1.927884 0.0167243 0.0117021
umls:C0012236 DiGeorge Syndrome 64 1.927164 0.0167243 0.0117021
umls:C0013295 Duodenal Ulcer 60 1.925079 0.0167243 0.0117021
umls:C0149939 Obstructive nephropathy 33 1.924865 0.0167243 0.0117021
umls:C1851585 MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA 23 1.923578 0.0167243 0.0117021
umls:C0700613 Anxiety state 11 1.923350 0.0167243 0.0117021
umls:C0011615 Dermatitis, Atopic 333 1.919431 0.0167243 0.0117021
umls:C0333307 Superficial ulcer 98 1.918153 0.0167243 0.0117021
umls:C0031106 Periodontitis, Juvenile 69 1.916850 0.0167243 0.0117021
umls:C0020541 Hypertension, Portal 56 1.916834 0.0167243 0.0117021
umls:C0206708 Cervical Intraepithelial Neoplasia 179 1.916114 0.0167243 0.0117021
umls:C0014009 Empyema 11 1.915612 0.0167243 0.0117021
umls:C0023241 Legionnaires’ Disease 12 1.914343 0.0167243 0.0117021
umls:C0023267 Fibroid Tumor 270 1.914058 0.0167243 0.0117021
umls:C0003864 Arthritis 427 1.913413 0.0167243 0.0117021
umls:C0020473 Hyperlipidemia 174 1.912435 0.0167243 0.0117021
umls:C2004493 Leukemia, B-Cell 77 1.912346 0.0167243 0.0117021
umls:C0080233 Tooth Loss 14 1.912054 0.0252770 0.0176865
umls:C0018824 Heart valve disease 38 1.911223 0.0167243 0.0117021
umls:C0221204 Lytic lesion 11 1.910914 0.0167243 0.0117021
umls:C0032787 Postoperative Complications 48 1.910711 0.0167243 0.0117021
umls:C0034155 Purpura, Thrombotic Thrombocytopenic 32 1.910517 0.0167243 0.0117021
umls:C0236788 Bipolar II disorder 11 1.909844 0.0167243 0.0117021
umls:C0019080 Hemorrhage 54 1.909747 0.0167243 0.0117021
umls:C0013884 Filarial Elephantiases 16 1.909328 0.0252770 0.0176865
umls:C1444680 Posterior capsule opacification 12 1.907970 0.0252770 0.0176865
umls:C0004030 Aspergillosis 21 1.907854 0.0167243 0.0117021
umls:C0262985 Psoriasiform eczema 12 1.907710 0.0252770 0.0176865
umls:C0340543 Familial primary pulmonary hypertension 22 1.907194 0.0167243 0.0117021
umls:C0042164 Uveitis 100 1.907034 0.0167243 0.0117021
umls:C0032131 Plasmacytoma 63 1.906024 0.0167243 0.0117021
umls:C0003507 Aortic Valve Stenosis 72 1.905072 0.0167243 0.0117021
umls:C0035235 Respiratory Syncytial Virus Infections 217 1.903980 0.0167243 0.0117021
umls:C0024266 Lymphocytic Choriomeningitis 42 1.903168 0.0167243 0.0117021
umls:C0265004 Dilatation of aorta 14 1.902844 0.0339424 0.0237497
umls:C0263641 Epithelial hyperplasia of skin 33 1.901061 0.0167243 0.0117021
umls:C0278701 Gastric Adenocarcinoma 216 1.900705 0.0167243 0.0117021
umls:C0014072 Experimental Autoimmune Encephalomyelitis 305 1.895914 0.0167243 0.0117021
umls:C1621958 Glioblastoma Multiforme 370 1.892622 0.0167243 0.0117021
umls:C0079487 Helicobacter Infections 81 1.891091 0.0167243 0.0117021
umls:C0031154 Peritonitis 88 1.890533 0.0167243 0.0117021
umls:C0399440 Hereditary gingival fibromatosis 17 1.890429 0.0252770 0.0176865
umls:C0002448 Ameloblastoma 58 1.889633 0.0167243 0.0117021
umls:C0021831 Intestinal Diseases 54 1.889080 0.0167243 0.0117021
umls:C1306889 Peripheral arterial occlusive disease 14 1.886797 0.0339424 0.0237497
umls:C0011436 Dentinogenesis Imperfecta 11 1.885687 0.0167243 0.0117021
umls:C1861922 CAMPOMELIC DYSPLASIA 26 1.885473 0.0252770 0.0176865
umls:C0156181 Peritoneal adhesion 12 1.884784 0.0252770 0.0176865
umls:C3495801 Granulomatosis with polyangiitis 44 1.883371 0.0167243 0.0117021
umls:C0085083 Ovarian Hyperstimulation Syndrome 24 1.882728 0.0339424 0.0237497
umls:C0023055 Laryngeal neoplasm 89 1.880075 0.0167243 0.0117021
umls:C0742133 cervical cancer squamous cell 12 1.879654 0.0252770 0.0176865
umls:C0409959 Osteoarthritis, Knee 94 1.879294 0.0167243 0.0117021
umls:C0398686 Primary immune deficiency disorder 59 1.878575 0.0167243 0.0117021
umls:C0019158 Hepatitis 196 1.878264 0.0167243 0.0117021
umls:C1449563 Cardiomyopathy, Familial Idiopathic 159 1.877229 0.0167243 0.0117021
umls:C0265110 Cerebral Vasospasm 13 1.875252 0.0411477 0.0287912
umls:C0268731 Renal glomerular disease 81 1.874205 0.0167243 0.0117021
umls:C0019829 Hodgkin Disease 306 1.874098 0.0167243 0.0117021
umls:C0007766 Intracranial Aneurysm 96 1.873716 0.0167243 0.0117021
umls:C0543697 Mixed cryoglobulinemia 24 1.873631 0.0339424 0.0237497
umls:C0278484 Malignant neoplasm of colon stage IV 62 1.873243 0.0167243 0.0117021
umls:C0850666 Helicobacter pylori infection 225 1.872858 0.0167243 0.0117021
umls:C0345967 Malignant mesothelioma 227 1.872669 0.0167243 0.0117021
umls:C0036220 Kaposi Sarcoma 147 1.871938 0.0167243 0.0117021
umls:C0153349 Malignant neoplasm of tongue 41 1.871673 0.0167243 0.0117021
umls:C0153601 Malignant neoplasm of penis 22 1.871458 0.0252770 0.0176865
umls:C0009782 Connective Tissue Diseases 159 1.870142 0.0167243 0.0117021
umls:C0085786 Hamman-Rich syndrome 29 1.869605 0.0167243 0.0117021
umls:C0268363 Osteogenesis imperfecta type IV (disorder) 11 1.868969 0.0339424 0.0237497
umls:C0038358 Gastric ulcer 87 1.868234 0.0167243 0.0117021
umls:C0023281 Leishmaniasis 45 1.867381 0.0167243 0.0117021
umls:C0009319 Colitis 414 1.864835 0.0167243 0.0117021
umls:C0018378 Guillain-Barre Syndrome 39 1.864703 0.0167243 0.0117021
umls:C0042344 Varicose Ulcer 35 1.864204 0.0167243 0.0117021
umls:C0024143 Lupus Nephritis 161 1.863456 0.0167243 0.0117021
umls:C0031099 Periodontitis 198 1.862201 0.0167243 0.0117021
umls:C0035439 Rheumatic Heart Disease 41 1.861155 0.0167243 0.0117021
umls:C0349566 Squamous cell carcinoma of tongue 98 1.861022 0.0167243 0.0117021
umls:C0278488 Carcinoma breast stage IV 280 1.860954 0.0167243 0.0117021
umls:C2607914 Allergic rhinitis (disorder) 120 1.860865 0.0167243 0.0117021
umls:C0154084 Stage 0 Breast Carcinoma 13 1.860612 0.0411477 0.0287912
umls:C0178238 Intestinal infectious disease (disorder) 12 1.860562 0.0339424 0.0237497
umls:C0239946 Fibrosis, Liver 271 1.860536 0.0167243 0.0117021
umls:C0376620 Pouchitis 12 1.858472 0.0339424 0.0237497
umls:C0268351 Cutis Laxa, Autosomal Recessive, Type I 14 1.857879 0.0339424 0.0237497
umls:C0039445 Hereditary hemorrhagic telangiectasia 17 1.856179 0.0339424 0.0237497
umls:C0026277 Mixed Salivary Gland Tumor 92 1.854383 0.0167243 0.0117021
umls:C0017668 Focal glomerulosclerosis 85 1.852332 0.0167243 0.0117021
umls:C0018081 Gonorrhea 33 1.852291 0.0252770 0.0176865
umls:C0000786 Spontaneous abortion 191 1.850923 0.0167243 0.0117021
umls:C0006267 Bronchiectasis 33 1.849576 0.0252770 0.0176865
umls:C1367654 Marginal Zone B-Cell Lymphoma 38 1.849461 0.0167243 0.0117021
umls:C0334579 Anaplastic astrocytoma 125 1.847827 0.0167243 0.0117021
umls:C0022602 Actinic keratosis 69 1.847822 0.0167243 0.0117021
umls:C0028064 Niemann-Pick Diseases 10 1.846400 0.0252770 0.0176865
umls:C3272363 Ischemic Cerebrovascular Accident 271 1.845240 0.0167243 0.0117021
umls:C1290886 Chronic inflammatory disorder 59 1.845112 0.0167243 0.0117021
umls:C0263454 Chloracne 36 1.844147 0.0167243 0.0117021
umls:C1301355 Myelodysplastic-Myeloproliferative Diseases 17 1.842531 0.0339424 0.0237497
umls:C0409651 Seropositive rheumatoid arthritis 16 1.842431 0.0411477 0.0287912
umls:C0007873 Uterine Cervical Neoplasm 146 1.842088 0.0167243 0.0117021
umls:C0023343 Leprosy 105 1.841018 0.0167243 0.0117021
umls:C0020443 Hypercholesterolemia 150 1.840963 0.0167243 0.0117021
umls:C0162869 Aneurysm, Ruptured 22 1.840785 0.0339424 0.0237497
umls:C0162526 AIDS-Related Opportunistic Infections 10 1.839548 0.0339572 0.0237601
umls:C0008497 Choriocarcinoma 226 1.838158 0.0167243 0.0117021
umls:C0004626 Pneumonia, Bacterial 24 1.837186 0.0411477 0.0287912
umls:C0005411 Biliary Atresia 69 1.837120 0.0167243 0.0117021
umls:C0022354 Jaundice, Obstructive 12 1.836877 0.0339424 0.0237497
umls:C0019100 Severe Dengue 59 1.831721 0.0167243 0.0117021
umls:C0206694 Mucoepidermoid Carcinoma 59 1.830709 0.0167243 0.0117021
umls:C0042133 Uterine Fibroids 276 1.830595 0.0167243 0.0117021
umls:C0019069 Hemophilia A 73 1.830296 0.0167243 0.0117021
umls:C0558353 Tongue Carcinoma 44 1.829262 0.0252770 0.0176865
umls:C0282350 Sexual abuse 12 1.827923 0.0339424 0.0237497
umls:C0034065 Pulmonary Embolism 54 1.827452 0.0167243 0.0117021
umls:C0856053 Leukemia secondary 17 1.827178 0.0339424 0.0237497
umls:C0013720 Ehlers-Danlos Syndrome 52 1.824302 0.0167243 0.0117021
umls:C0079588 Ichthyosis, X-Linked 70 1.823989 0.0167243 0.0117021
umls:C1378703 Renal carcinoma 387 1.823203 0.0167243 0.0117021
umls:C1290884 Inflammatory disorder 183 1.822401 0.0167243 0.0117021
umls:C1876165 Copper-Overload Cirrhosis 11 1.819774 0.0411477 0.0287912
umls:C0149521 Pancreatitis, Chronic 214 1.819636 0.0167243 0.0117021
umls:C0333186 Restenosis 169 1.819625 0.0167243 0.0117021
umls:C0699949 airway disease 64 1.819065 0.0167243 0.0117021
umls:C0006663 Calcinosis 82 1.817570 0.0167243 0.0117021
umls:C0206180 Ki-1+ Anaplastic Large Cell Lymphoma 214 1.817324 0.0167243 0.0117021
umls:C0002793 Anaplasia 191 1.816733 0.0167243 0.0117021
umls:C0008384 Cholesterol Ester Storage Disease 11 1.816395 0.0411477 0.0287912
umls:C0015695 Fatty Liver 286 1.815854 0.0167243 0.0117021
umls:C0023465 Acute monocytic leukemia 64 1.814703 0.0167243 0.0117021
umls:C0035126 Reperfusion Injury 271 1.814696 0.0167243 0.0117021
umls:C0013595 Eczema 281 1.813419 0.0167243 0.0117021
umls:C0036205 Sarcoidosis, Pulmonary 41 1.813243 0.0167243 0.0117021
umls:C0038013 Ankylosing spondylitis 187 1.812473 0.0167243 0.0117021
umls:C0011616 Contact Dermatitis 62 1.811122 0.0167243 0.0117021
umls:C0013312 Dupuytren Contracture 16 1.810505 0.0471454 0.0329879
umls:C1333171 Primary Cutaneous Follicle Center Lymphoma 11 1.809953 0.0411477 0.0287912
umls:C0948089 Acute Coronary Syndrome 241 1.808814 0.0167243 0.0117021
umls:C0020507 Hyperplasia 122 1.808539 0.0167243 0.0117021
umls:C0334520 Teratoma, Malignant 17 1.808398 0.0471454 0.0329879
umls:C0521607 Peritoneal Fibrosis 29 1.807570 0.0339424 0.0237497
umls:C0010495 Cutis Laxa 26 1.804516 0.0411477 0.0287912
umls:C0017152 Gastritis 153 1.804121 0.0167243 0.0117021
umls:C0267375 Chronic colitis 24 1.802578 0.0471454 0.0329879
umls:C0008312 Primary biliary cirrhosis 201 1.802572 0.0167243 0.0117021
umls:C0024232 Lymphatic Metastasis 133 1.802518 0.0167243 0.0117021
umls:C0917804 Arteriovenous Malformations, Cerebral 15 1.802402 0.0471454 0.0329879
umls:C0235653 Malignant neoplasm of female breast 45 1.802396 0.0252770 0.0176865
umls:C0042487 Venous Thrombosis 75 1.802368 0.0167243 0.0117021
umls:C0042165 Anterior uveitis 28 1.802043 0.0471454 0.0329879
umls:C0021361 Female infertility 53 1.801870 0.0167243 0.0117021
umls:C0948008 Ischemic stroke 307 1.801617 0.0167243 0.0117021
umls:C0008149 Chlamydia Infections 61 1.801275 0.0167243 0.0117021
umls:C3642347 Basal-Like Breast Carcinoma 15 1.800277 0.0471454 0.0329879
umls:C0018915 Hemangioendothelioma 11 1.800217 0.0411477 0.0287912
umls:C0029458 Osteoporosis, Postmenopausal 74 1.799164 0.0167243 0.0117021
umls:C0152018 Esophageal carcinoma 445 1.798540 0.0167243 0.0117021
umls:C0033054 Prenatal Exposure Delayed Effects 44 1.797632 0.0252770 0.0176865
umls:C0085220 Cerebral Amyloid Angiopathy 35 1.797443 0.0167243 0.0117021
umls:C1336527 Carcinoma of urinary bladder, superficial 33 1.795379 0.0252770 0.0176865
umls:C0032927 Precancerous Conditions 351 1.794377 0.0167243 0.0117021
umls:C0022578 Keratoconus 66 1.794114 0.0167243 0.0117021
umls:C1561643 Chronic Kidney Diseases 229 1.793931 0.0167243 0.0117021
umls:C0853879 Invasive breast carcinoma 321 1.792351 0.0167243 0.0117021
umls:C0007104 Female Breast Carcinoma 48 1.792038 0.0339424 0.0237497
umls:C0037286 Skin Neoplasms 274 1.789932 0.0167243 0.0117021
umls:C0002351 Altitude Sickness 16 1.788366 0.0471454 0.0329879
umls:C0016034 Breast Fibrocystic Disease 55 1.788150 0.0167243 0.0117021
umls:C3494652 Severe dementia 11 1.784819 0.0471454 0.0329879
umls:C0376628 Chromosome Breakage 15 1.784685 0.0471454 0.0329879
umls:C0270726 Alexander Disease 16 1.784195 0.0471454 0.0329879
umls:C0031039 Pericardial effusion 22 1.783537 0.0471454 0.0329879
umls:C0015393 Eye Abnormalities 36 1.783211 0.0167243 0.0117021
umls:C0024282 Lymphocytosis 42 1.782982 0.0167243 0.0117021
umls:C3539878 Triple Negative Breast Neoplasms 388 1.782919 0.0167243 0.0117021
umls:C0001486 Adenovirus Infections 63 1.782503 0.0167243 0.0117021
umls:C0280803 Primary central nervous system lymphoma 39 1.782132 0.0253258 0.0177206
umls:C0032231 Pleurisy 22 1.780922 0.0471454 0.0329879
umls:C0007789 Cerebral Palsy 65 1.780762 0.0167243 0.0117021
umls:C0267941 Pancreatitis, Acute Necrotizing 30 1.780754 0.0411477 0.0287912
umls:C0009917 Contracture 35 1.780570 0.0252770 0.0176865
umls:C2609414 Acute kidney injury 96 1.776528 0.0167243 0.0117021
umls:C0033999 Pterygium 53 1.775969 0.0167243 0.0117021
umls:C0010606 Adenoid Cystic Carcinoma 185 1.775475 0.0167243 0.0117021
umls:C0265268 Adams Oliver syndrome 11 1.775360 0.0471454 0.0329879
umls:C0018798 Congenital Heart Defects 210 1.773590 0.0167243 0.0117021
umls:C0038354 Stomach Diseases 31 1.771818 0.0339424 0.0237497
umls:C0018133 Graft-vs-Host Disease 230 1.770887 0.0167243 0.0117021
umls:C0011644 Scleroderma 132 1.770086 0.0167243 0.0117021
umls:C1279420 Anxiety neurosis (finding) 10 1.769379 0.0411477 0.0287912
umls:C2986665 Early-Stage Breast Carcinoma 57 1.768873 0.0252770 0.0176865
umls:C0034063 Pulmonary Edema 66 1.768723 0.0167243 0.0117021
umls:C0278883 Metastatic melanoma 272 1.768577 0.0167243 0.0117021
umls:C1333762 Gastric Cardia Adenocarcinoma 31 1.766686 0.0339424 0.0237497
umls:C0037199 Sinusitis 29 1.766470 0.0471454 0.0329879
umls:C0007114 Malignant neoplasm of skin 192 1.765509 0.0167243 0.0117021
umls:C0008626 Congenital chromosomal disease 440 1.763545 0.0167243 0.0117021
umls:C0339543 Epiretinal Membrane 30 1.763514 0.0411477 0.0287912
umls:C0003838 Arterial Occlusive Diseases 37 1.762074 0.0167243 0.0117021
umls:C1096184 West Nile viral infection 64 1.761705 0.0252770 0.0176865
umls:C0149678 Epstein-Barr Virus Infections 174 1.761387 0.0167243 0.0117021
umls:C0024305 Lymphoma, Non-Hodgkin 426 1.761370 0.0167243 0.0117021
umls:C0013238 Dry Eye Syndromes 36 1.760131 0.0167243 0.0117021
umls:C0020217 Hydatidiform Mole 48 1.759795 0.0411477 0.0287912
umls:C0242706 Hyperoxia 42 1.759420 0.0252770 0.0176865
umls:C0013371 Shigella Infections 51 1.758149 0.0339424 0.0237497
umls:C0079772 T-Cell Lymphoma 239 1.758118 0.0167243 0.0117021
umls:C0008313 Cholangitis, Sclerosing 69 1.756650 0.0167243 0.0117021
umls:C0004610 Bacteremia 73 1.756270 0.0167243 0.0117021
umls:C0013182 Drug Allergy 52 1.753839 0.0252770 0.0176865
umls:C0007103 Malignant neoplasm of endometrium 413 1.751976 0.0167243 0.0117021
umls:C1883486 Uterine Corpus Cancer 413 1.751976 0.0167243 0.0117021
umls:C0079744 Diffuse Large B-Cell Lymphoma 459 1.751193 0.0167243 0.0117021
umls:C0279628 Adenocarcinoma Of Esophagus 229 1.751174 0.0167243 0.0117021
umls:C0006272 Bronchiolitis Obliterans 40 1.750466 0.0167243 0.0117021
umls:C0002965 Angina, Unstable 65 1.749311 0.0167243 0.0117021
umls:C1559271 Non-Malignant Ascites Adverse Event 146 1.748952 0.0167243 0.0117021
umls:C3714636 Pneumonitis 46 1.747471 0.0340331 0.0238131
umls:C0020474 Hyperlipidemia, Familial Combined 67 1.746435 0.0167243 0.0117021
umls:C0546837 Malignant neoplasm of esophagus 485 1.745507 0.0167243 0.0117021
umls:C0333997 Lymphoid hyperplasia 15 1.745000 0.0471454 0.0329879
umls:C0004997 Benign Ovarian Neoplasm 32 1.743089 0.0411477 0.0287912
umls:C0524910 Hepatitis C, Chronic 327 1.741859 0.0167243 0.0117021
umls:C0029445 Bone necrosis 40 1.741560 0.0167243 0.0117021
umls:C0949690 Spondylarthritis 47 1.740370 0.0411477 0.0287912
umls:C0751967 Multiple Sclerosis, Relapsing-Remitting 77 1.739242 0.0167243 0.0117021
umls:C1623038 Cirrhosis 307 1.738872 0.0167243 0.0117021
umls:C0206139 Lichen Planus, Oral 64 1.737950 0.0252770 0.0176865
umls:C0524909 Hepatitis B, Chronic 185 1.736431 0.0167243 0.0117021
umls:C1168327 High-Grade Prostatic Intraepithelial Neoplasia 80 1.734454 0.0167243 0.0117021
umls:C0600452 Hepatopulmonary Syndrome 81 1.733940 0.0167243 0.0117021
umls:C0042384 Vasculitis 105 1.733712 0.0167243 0.0117021
umls:C0040592 Trachoma 41 1.733263 0.0252770 0.0176865
umls:C0155862 Streptococcal pneumonia 25 1.733116 0.0471454 0.0329879
umls:C1335302 Pancreatic Ductal Adenocarcinoma 462 1.730426 0.0167243 0.0117021
umls:C0005779 Blood Coagulation Disorders 102 1.730172 0.0167243 0.0117021
umls:C0242647 Mucosa-Associated Lymphoid Tissue Lymphoma 142 1.727809 0.0167243 0.0117021
umls:C1840264 IMMUNE SUPPRESSION 61 1.726027 0.0252770 0.0176865
umls:C0024131 Lupus Vulgaris 238 1.725299 0.0167243 0.0117021
umls:C0007787 Transient Ischemic Attack 153 1.725171 0.0167243 0.0117021
umls:C0023290 Leishmaniasis, Visceral 58 1.725145 0.0252770 0.0176865
umls:C0026850 Muscular Dystrophy 182 1.725115 0.0167243 0.0117021
umls:C0206638 Giant Cell Tumor of Bone 58 1.724844 0.0252770 0.0176865
umls:C0238190 Inclusion Body Myositis (disorder) 58 1.723197 0.0252770 0.0176865
umls:C0206698 Cholangiocarcinoma 333 1.722673 0.0167243 0.0117021
umls:C0085110 Severe Combined Immunodeficiency 420 1.718085 0.0167243 0.0117021
umls:C1527390 Neoplasms, Intracranial 54 1.715787 0.0339471 0.0237530
umls:C0221757 alpha 1-Antitrypsin Deficiency 45 1.715674 0.0339626 0.0237638
umls:C0005695 Bladder Neoplasm 390 1.715393 0.0167243 0.0117021
umls:C0494165 Secondary malignant neoplasm of liver 349 1.714033 0.0167243 0.0117021
umls:C0206734 Hemangioblastoma 32 1.713130 0.0411477 0.0287912
umls:C1518171 Malignant Conversion 40 1.710506 0.0167243 0.0117021
umls:C0341439 Chronic liver disease 108 1.709358 0.0167243 0.0117021
umls:C3539909 Allergic disposition 149 1.708266 0.0167243 0.0117021
umls:C0025286 Meningioma 381 1.707166 0.0167243 0.0117021
umls:C1519346 Skin Carcinogenesis 95 1.706870 0.0339424 0.0237497
umls:C1511789 Desmoplastic 68 1.706768 0.0167243 0.0117021
umls:C0269102 Endometrioma 55 1.706713 0.0411477 0.0287912
umls:C0238394 Female Pseudohermaphroditism 43 1.706024 0.0339424 0.0237497
umls:C1134719 Invasive Ductal Breast Carcinoma 205 1.704863 0.0167243 0.0117021
umls:C0027726 Nephrotic Syndrome 144 1.704760 0.0167243 0.0117021
umls:C0403592 Chronic rejection of renal transplant 35 1.704078 0.0339424 0.0237497
umls:C1333064 Classical Hodgkin’s Lymphoma 100 1.702394 0.0167243 0.0117021
umls:C3714757 Juvenile rheumatoid arthritis 139 1.701053 0.0252770 0.0176865
umls:C0279702 Conventional (Clear Cell) Renal Cell Carcinoma 304 1.699252 0.0167243 0.0117021
umls:C0042029 Urinary tract infection 64 1.698838 0.0252770 0.0176865
umls:C2711227 Steatohepatitis 179 1.696872 0.0167243 0.0117021
umls:C0030524 Paratuberculosis 32 1.694411 0.0411477 0.0287912
umls:C0376545 Hematologic Neoplasms 399 1.692548 0.0167243 0.0117021
umls:C0020517 Hypersensitivity 121 1.692144 0.0252770 0.0176865
umls:C0851140 Carcinoma in situ of uterine cervix 48 1.689809 0.0471454 0.0329879
umls:C0266929 Chronic Periodontitis 127 1.689439 0.0252770 0.0176865
umls:C0011311 Dengue Fever 140 1.689382 0.0252770 0.0176865
umls:C0341858 Endometriosis of uterus 48 1.688473 0.0471454 0.0329879
umls:C0006413 Burkitt Lymphoma 167 1.687532 0.0167243 0.0117021
umls:C0007193 Cardiomyopathy, Dilated 328 1.687212 0.0167243 0.0117021
umls:C0019159 Hepatitis A 188 1.686011 0.0167243 0.0117021
umls:C0334590 Anaplastic Oligodendroglioma 121 1.684965 0.0252770 0.0176865
umls:C0392707 Atopy 42 1.684716 0.0341043 0.0238629
umls:C0007124 Noninfiltrating Intraductal Carcinoma 257 1.683990 0.0167243 0.0117021
umls:C0036983 Septic Shock 48 1.682822 0.0471454 0.0329879
umls:C0039103 Synovitis 76 1.682665 0.0167243 0.0117021
umls:C0278678 Metastatic Renal Cell Cancer 40 1.681762 0.0252770 0.0176865
umls:C0031090 Periodontal Diseases 94 1.681692 0.0339424 0.0237497
umls:C0027439 Nasopharyngeal Neoplasms 61 1.681166 0.0411477 0.0287912
umls:C0555198 Malignant Glioma 356 1.681136 0.0167243 0.0117021
umls:C0280785 Diffuse Astrocytoma 37 1.680705 0.0411477 0.0287912
umls:C0242852 Proliferative vitreoretinopathy 52 1.680549 0.0471454 0.0329879
umls:C2931852 Clear-cell metastatic renal cell carcinoma 92 1.680199 0.0252770 0.0176865
umls:C1292769 Precursor B-cell lymphoblastic leukemia 297 1.680059 0.0167243 0.0117021
umls:C0023892 Biliary cirrhosis 100 1.679717 0.0252770 0.0176865
umls:C0020542 Pulmonary Hypertension 283 1.679477 0.0167243 0.0117021
umls:C0023487 Acute Promyelocytic Leukemia 359 1.675116 0.0167243 0.0117021
umls:C0030809 Pemphigus Vulgaris 58 1.675058 0.0252770 0.0176865
umls:C0040038 Thromboembolism 87 1.674121 0.0252770 0.0176865
umls:C0007570 Celiac Disease 268 1.674037 0.0167243 0.0117021
umls:C0010674 Cystic Fibrosis 330 1.673220 0.0167243 0.0117021
umls:C0026946 Mycoses 193 1.673162 0.0167243 0.0117021
umls:C0339143 Thyroid associated opthalmopathies 71 1.672860 0.0167243 0.0117021
umls:C0026896 Myasthenia Gravis 139 1.672817 0.0252770 0.0176865
umls:C0029134 Optic Neuritis 32 1.672727 0.0411477 0.0287912
umls:C0005967 Bone neoplasms 84 1.672604 0.0252770 0.0176865
umls:C0746102 Chronic lung disease 47 1.672341 0.0411477 0.0287912
umls:C0860207 Drug-Induced Liver Injury 135 1.671859 0.0252770 0.0176865
umls:C0021051 Immunologic Deficiency Syndromes 349 1.671372 0.0167243 0.0117021
umls:C0001925 Albuminuria 111 1.671213 0.0167243 0.0117021
umls:C0940937 precancerous lesions 91 1.670272 0.0252770 0.0176865
umls:C0019621 Histiocytosis, Langerhans-Cell 48 1.669594 0.0471454 0.0329879
umls:C0024138 Lupus Erythematosus, Discoid 244 1.668026 0.0167243 0.0117021
umls:C0178664 Glomerulosclerosis (disorder) 63 1.667437 0.0411477 0.0287912
umls:C0025500 Mesothelioma 326 1.667059 0.0167243 0.0117021
umls:C0016781 Fuchs Endothelial Dystrophy 35 1.666732 0.0411477 0.0287912
umls:C0993582 Arthritis, Experimental 133 1.666548 0.0252770 0.0176865
umls:C0403416 Idiopathic crescentic glomerulonephritis 34 1.666285 0.0411477 0.0287912
umls:C0040028 Thrombocythemia, Essential 124 1.665844 0.0252770 0.0176865
umls:C0162557 Liver Failure, Acute 89 1.665768 0.0252770 0.0176865
umls:C1846064 Recurrent infections (sinusitis and bacterial pneumonia and meningitis) 43 1.665752 0.0339424 0.0237497
umls:C0024312 Lymphopenia 60 1.665304 0.0411477 0.0287912
umls:C0238463 Papillary thyroid carcinoma 379 1.665155 0.0167243 0.0117021
umls:C0345904 Malignant neoplasm of liver 481 1.664363 0.0167243 0.0117021
umls:C0745744 End Stage Liver Disease 32 1.661846 0.0471454 0.0329879
umls:C0001883 Airway Obstruction 37 1.660498 0.0411477 0.0287912
umls:C0011884 Diabetic Retinopathy 191 1.658249 0.0167243 0.0117021
umls:C0409974 Lupus Erythematosus 284 1.657680 0.0167243 0.0117021
umls:C1318544 M5b Acute differentiated monocytic leukemia 73 1.657522 0.0167243 0.0117021
umls:C0008925 Cleft Palate 216 1.656933 0.0167243 0.0117021
umls:C0033847 Pseudoxanthoma Elasticum 41 1.656699 0.0411477 0.0287912
umls:C0085129 Bronchial Hyperreactivity 128 1.656006 0.0252770 0.0176865
umls:C0037299 Skin Ulcer 32 1.654595 0.0471454 0.0329879
umls:C0410528 Skeletal dysplasia 66 1.653604 0.0252770 0.0176865
umls:C0238301 Cancer of Nasopharynx 80 1.651272 0.0252770 0.0176865
umls:C0339573 Glaucoma, Primary Open Angle 141 1.650596 0.0252770 0.0176865
umls:C0035412 Rhabdomyosarcoma 307 1.650114 0.0167243 0.0117021
umls:C1334177 Infiltrating Cervical Carcinoma 50 1.649179 0.0471454 0.0329879
umls:C0340288 Stable angina 66 1.648267 0.0252770 0.0176865
umls:C0741923 cardiac event 38 1.647709 0.0411477 0.0287912
umls:C0039483 Giant Cell Arteritis 97 1.646739 0.0339424 0.0237497
umls:C0023896 Alcoholic Liver Diseases 86 1.646518 0.0252770 0.0176865
umls:C0004238 Atrial Fibrillation 104 1.646495 0.0253254 0.0177203
umls:C1328840 Autoimmune Lymphoproliferative Syndrome 38 1.645828 0.0411477 0.0287912
umls:C0376544 Hematopoietic Neoplasms 140 1.645069 0.0252770 0.0176865
umls:C0001175 Acquired Immunodeficiency Syndrome 108 1.644807 0.0252770 0.0176865
umls:C0279000 Liver and Intrahepatic Biliary Tract Carcinoma 403 1.644307 0.0167243 0.0117021
umls:C3463897 HYDATIDIFORM MOLE, RECURRENT, 1 44 1.644252 0.0411477 0.0287912
umls:C0024796 Marfan Syndrome 47 1.644043 0.0471454 0.0329879
umls:C0577631 Carotid Atherosclerosis 88 1.643938 0.0252770 0.0176865
umls:C0023493 Adult T-Cell Lymphoma/Leukemia 366 1.641075 0.0167243 0.0117021
umls:C0376634 Craniofacial Abnormalities 175 1.640417 0.0167243 0.0117021
umls:C0006309 Brucellosis 36 1.639944 0.0471454 0.0329879
umls:C0018203 Chronic granulomatous disease 60 1.638802 0.0471454 0.0329879
umls:C0011303 Demyelinating Diseases 72 1.638019 0.0167243 0.0117021
umls:C0206685 Acinar Cell Carcinoma 32 1.636366 0.0471454 0.0329879
umls:C0018995 Hemochromatosis 76 1.634489 0.0252770 0.0176865
umls:C0030305 Pancreatitis 149 1.633939 0.0252770 0.0176865
umls:C0242383 Age related macular degeneration 331 1.632937 0.0167243 0.0117021
umls:C0022408 Arthropathy 95 1.632616 0.0339424 0.0237497
umls:C0852949 Arteriopathic disease 44 1.632289 0.0411477 0.0287912
umls:C0032962 Pregnancy Complications 94 1.630460 0.0339424 0.0237497
umls:C0280141 Acute Undifferentiated Leukemia 70 1.628983 0.0252770 0.0176865
umls:C0948192 Primary infection NOS 46 1.627992 0.0411613 0.0288007
umls:C0037274 Dermatologic disorders 363 1.627519 0.0167243 0.0117021
umls:C0027686 Pathologic Neovascularization 62 1.626941 0.0471454 0.0329879
umls:C0584960 Factor V Leiden mutation 40 1.625852 0.0411477 0.0287912
umls:C0025007 Measles 120 1.624298 0.0341106 0.0238674
umls:C0238790 bone destruction 66 1.623999 0.0339424 0.0237497
umls:C0004943 Behcet Syndrome 229 1.622649 0.0167243 0.0117021
umls:C0079745 Lymphoma, Large-Cell, Follicular 137 1.622214 0.0252770 0.0176865
umls:C0314719 Dryness of eye 32 1.621884 0.0471454 0.0329879
umls:C0011065 Cessation of life 117 1.619749 0.0341970 0.0239278
umls:C0008924 Cleft Lip 173 1.619444 0.0167243 0.0117021
umls:C0017525 Giant Cell Tumors 63 1.618874 0.0471454 0.0329879
umls:C0311375 Arsenic Poisoning 63 1.618215 0.0471454 0.0329879
umls:C0018213 Graves Disease 260 1.616571 0.0167243 0.0117021
umls:C0026691 Mucocutaneous Lymph Node Syndrome 145 1.615733 0.0339424 0.0237497
umls:C0006287 Bronchopulmonary Dysplasia 174 1.615642 0.0167243 0.0117021
umls:C0595921 Intraocular pressure disorder 84 1.615596 0.0252770 0.0176865
umls:C0878500 Intraepithelial Neoplasia 106 1.615096 0.0253263 0.0177209
umls:C0151546 Oral Cavity Carcinoma 73 1.614308 0.0252770 0.0176865
umls:C0027430 Nasal Polyps 141 1.613962 0.0252770 0.0176865
umls:C3665444 Neutrophilia (disorder) 40 1.613150 0.0471454 0.0329879
umls:C0598608 Hyperhomocysteinemia 98 1.610941 0.0411477 0.0287912
umls:C0740392 Infarction, Middle Cerebral Artery 77 1.610467 0.0252770 0.0176865
umls:C0022661 Kidney Failure, Chronic 483 1.610171 0.0167243 0.0117021
umls:C0152171 Idiopathic pulmonary hypertension 181 1.609855 0.0167243 0.0117021
umls:C0085096 Peripheral Vascular Diseases 94 1.609822 0.0411477 0.0287912
umls:C0085278 Antiphospholipid Syndrome 45 1.609807 0.0411477 0.0287912
umls:C0333875 High-Grade Squamous Intraepithelial Lesions 71 1.608227 0.0252770 0.0176865
umls:C0162309 Adrenoleukodystrophy 117 1.606103 0.0341970 0.0239278
umls:C0005940 Bone Diseases 137 1.605087 0.0252770 0.0176865
umls:C0220650 Metastatic malignant neoplasm to brain 105 1.604609 0.0253255 0.0177204
umls:C0024668 Mammary Neoplasms, Experimental 185 1.604462 0.0252770 0.0176865
umls:C0280324 Laryngeal Squamous Cell Carcinoma 110 1.603225 0.0339424 0.0237497
umls:C0740457 Malignant neoplasm of kidney 337 1.600983 0.0167243 0.0117021
umls:C0008625 Chromosome Aberrations 76 1.600004 0.0252770 0.0176865
umls:C0023904 Liver Neoplasms, Experimental 78 1.597632 0.0339424 0.0237497
umls:C0007138 Carcinoma, Transitional Cell 332 1.597320 0.0167243 0.0117021
umls:C0238198 Gastrointestinal Stromal Tumors 279 1.596899 0.0167243 0.0117021
umls:C0085655 Polymyositis 80 1.596428 0.0339424 0.0237497
umls:C0007133 Carcinoma, Papillary 211 1.595170 0.0167243 0.0117021
umls:C0024301 Lymphoma, Follicular 300 1.594771 0.0167243 0.0117021
umls:C0017563 Gingival Diseases 74 1.594420 0.0339424 0.0237497
umls:C0017601 Glaucoma 180 1.591954 0.0252770 0.0176865
umls:C0027059 Myocarditis 83 1.590910 0.0252770 0.0176865
umls:C0400966 Non-alcoholic Fatty Liver Disease 243 1.589232 0.0167243 0.0117021
umls:C0206681 Adenocarcinoma, Clear Cell 88 1.589081 0.0339424 0.0237497
umls:C0002874 Aplastic Anemia 111 1.584673 0.0339424 0.0237497
umls:C0553723 Squamous cell carcinoma of skin 126 1.580811 0.0411477 0.0287912
umls:C0035435 Rheumatism 86 1.580523 0.0411477 0.0287912
umls:C0027055 Myocardial Reperfusion Injury 132 1.580072 0.0252770 0.0176865
umls:C0007115 Malignant neoplasm of thyroid 393 1.580067 0.0167243 0.0117021
umls:C0023492 Leukemia, T-Cell 270 1.579952 0.0167243 0.0117021
umls:C0020459 Hyperinsulinism 211 1.577699 0.0167243 0.0117021
umls:C0014038 Encephalitis 106 1.575512 0.0341970 0.0239278
umls:C0019348 Herpes Simplex Infections 425 1.574852 0.0167243 0.0117021
umls:C0006012 Borderline Personality Disorder 146 1.573681 0.0339424 0.0237497
umls:C0024667 Animal Mammary Neoplasms 178 1.572727 0.0252770 0.0176865
umls:C0026846 Muscular Atrophy 157 1.570307 0.0252770 0.0176865
umls:C0346957 Disseminated Malignant Neoplasm 132 1.570126 0.0339572 0.0237601
umls:C0017185 Gastrointestinal Neoplasms 102 1.570089 0.0411477 0.0287912
umls:C0016057 Fibrosarcoma 224 1.567713 0.0167243 0.0117021
umls:C0041327 Tuberculosis, Pulmonary 170 1.566847 0.0252770 0.0176865
umls:C0021053 Immune System Diseases 142 1.563548 0.0411477 0.0287912
umls:C0278601 Inflammatory Breast Carcinoma 73 1.563244 0.0339424 0.0237497
umls:C0021655 Insulin Resistance 249 1.558897 0.0167243 0.0117021
umls:C0035372 Rett Syndrome 111 1.556926 0.0411477 0.0287912
umls:C0007117 Basal cell carcinoma 86 1.556102 0.0411477 0.0287912
umls:C0279671 Cervical Squamous Cell Carcinoma 110 1.553358 0.0411477 0.0287912
umls:C1512409 Hepatocarcinogenesis 399 1.553262 0.0167243 0.0117021
umls:C1527336 Sjogren’s Syndrome 88 1.550936 0.0471454 0.0329879
umls:C0022660 Kidney Failure, Acute 151 1.550136 0.0471454 0.0329879
umls:C1961099 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 287 1.548878 0.0167243 0.0117021
umls:C0338106 Adenocarcinoma of colon 193 1.546866 0.0252770 0.0176865
umls:C0151779 Cutaneous Melanoma 217 1.544101 0.0167243 0.0117021
umls:C0220633 Uveal melanoma 165 1.542561 0.0252770 0.0176865
umls:C0011633 Dermatomyositis 88 1.542280 0.0471454 0.0329879
umls:C0566602 Primary sclerosing cholangitis 81 1.539694 0.0471454 0.0329879
umls:C0007785 Cerebral Infarction 248 1.536002 0.0167243 0.0117021
umls:C0008479 Chondrosarcoma 194 1.535331 0.0252770 0.0176865
umls:C0281361 Adenocarcinoma of pancreas 252 1.534429 0.0167243 0.0117021
umls:C0020445 Hypercholesterolemia, Familial 132 1.534149 0.0471454 0.0329879
umls:C0005699 Blast Phase 183 1.533777 0.0252770 0.0176865
umls:C0030354 Papilloma 133 1.531579 0.0411477 0.0287912
umls:C0751396 Well Differentiated Oligodendroglioma 152 1.530093 0.0411477 0.0287912
umls:C0521158 Recurrent tumor 251 1.526603 0.0167243 0.0117021
umls:C0028945 oligodendroglioma 170 1.522911 0.0252770 0.0176865
umls:C1519680 Tumor Immunity 74 1.518855 0.0471454 0.0329879
umls:C0020456 Hyperglycemia 380 1.517361 0.0167243 0.0117021
umls:C3203102 Idiopathic pulmonary arterial hypertension 76 1.517151 0.0411477 0.0287912
umls:C0677932 Progressive Neoplastic Disease 124 1.516668 0.0471454 0.0329879
umls:C3539781 Progressive cGVHD 124 1.516668 0.0471454 0.0329879
umls:C0010823 Cytomegalovirus Infections 133 1.516011 0.0471454 0.0329879
umls:C0029456 Osteoporosis 368 1.515713 0.0167243 0.0117021
umls:C1861172 Venous Thromboembolism 108 1.514747 0.0471454 0.0329879
umls:C1519689 Tumor Promotion 79 1.513661 0.0471454 0.0329879
umls:C0023470 Myeloid Leukemia 430 1.511598 0.0167243 0.0117021
umls:C0242339 Dyslipidemias 187 1.511420 0.0252770 0.0176865
umls:C0033860 Psoriasis 481 1.510789 0.0167243 0.0117021
umls:C0007786 Brain Ischemia 357 1.509625 0.0167243 0.0117021
umls:C0333983 Hyperplastic Polyp 78 1.509326 0.0471454 0.0329879
umls:C0035078 Kidney Failure 268 1.509212 0.0167243 0.0117021
umls:C0151744 Myocardial Ischemia 412 1.507206 0.0167243 0.0117021
umls:C0243026 Sepsis 440 1.507135 0.0167243 0.0117021
umls:C0271650 Impaired glucose tolerance 235 1.505848 0.0167243 0.0117021
umls:C0023448 Lymphoid leukemia 195 1.505600 0.0252770 0.0176865
umls:C0086692 Benign Neoplasm 170 1.504205 0.0411477 0.0287912
umls:C0002871 Anemia 247 1.497204 0.0167243 0.0117021
umls:C1709246 Non-Neoplastic Disorder 374 1.491041 0.0167243 0.0117021
umls:C0856169 Endothelial dysfunction 182 1.487779 0.0471454 0.0329879
umls:C0029928 Ovarian Diseases 180 1.483842 0.0471454 0.0329879
umls:C0032580 Adenomatous Polyposis Coli 324 1.481725 0.0167243 0.0117021
umls:C0206624 Hepatoblastoma 178 1.478142 0.0471454 0.0329879
umls:C0685938 Malignant neoplasm of gastrointestinal tract 182 1.477487 0.0471454 0.0329879
umls:C1516170 Cancer Cell Growth 277 1.473205 0.0252770 0.0176865
umls:C0025149 Medulloblastoma 462 1.470612 0.0167243 0.0117021
umls:C0018671 Head and Neck Neoplasms 292 1.470018 0.0167243 0.0117021
umls:C0079773 Lymphoma, T-Cell, Cutaneous 185 1.463852 0.0471454 0.0329879
umls:C0812413 Malignant Pleural Mesothelioma 200 1.461323 0.0252770 0.0176865
umls:C0007113 Rectal Carcinoma 221 1.458939 0.0252770 0.0176865
umls:C0023452 Leukemia, Lymphocytic, Acute, L1 306 1.457041 0.0167243 0.0117021
umls:C0027022 Myeloproliferative disease 216 1.454890 0.0167243 0.0117021
umls:C0155626 Acute myocardial infarction 186 1.453952 0.0471454 0.0329879
umls:C1704272 Benign Prostatic Hyperplasia 301 1.452728 0.0167243 0.0117021
umls:C2145472 Urothelial Carcinoma 175 1.452684 0.0471454 0.0329879
umls:C0375023 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site 194 1.447951 0.0252770 0.0176865
umls:C0040136 Thyroid Neoplasm 397 1.446689 0.0252770 0.0176865
umls:C0027708 Nephroblastoma 265 1.444237 0.0167243 0.0117021
umls:C0334634 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse 261 1.441078 0.0167243 0.0117021
umls:C3469521 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) 189 1.438611 0.0471454 0.0329879
umls:C0032019 Pituitary Neoplasms 237 1.433424 0.0252770 0.0176865
umls:C0032584 polyps 206 1.429628 0.0252770 0.0176865
umls:C0035309 Retinal Diseases 289 1.423465 0.0167243 0.0117021
umls:C0022665 Kidney Neoplasm 258 1.420942 0.0167243 0.0117021
umls:C1520166 Xenograft Model 440 1.413595 0.0252770 0.0176865
umls:C1302401 Adenoma of large intestine 207 1.410496 0.0339297 0.0237407
umls:C0011853 Diabetes Mellitus, Experimental 422 1.403252 0.0252770 0.0176865
umls:C0085669 Acute leukemia 398 1.391983 0.0398840 0.0279070
umls:C2937358 Cerebral Hemorrhage 207 1.375771 0.0470951 0.0329527
umls:C0041296 Tuberculosis 427 1.372973 0.0252770 0.0176865
umls:C0036690 Septicemia 304 1.362101 0.0252770 0.0176865
umls:C0035335 Retinoblastoma 388 1.341589 0.0465136 0.0325458
Enriched terms for module #EE8045 (MTcor = 0.93)
ID Description setSize NES p.adjust qvalues
umls:C2986658 Diffuse Intrinsic Pontine Glioma 19 2.477416 0.0213829 0.0157834
umls:C3495559 Juvenile arthritis 272 2.378926 0.0213200 0.0157370
umls:C0595936 Aqueous Humor Disorders 54 2.334878 0.0213200 0.0157370
umls:C0006274 Bronchiolitis, Viral 139 2.289616 0.0213200 0.0157370
umls:C0004623 Bacterial Infections 180 2.272615 0.0213200 0.0157370
umls:C0151650 Renal fibrosis 143 2.231256 0.0213200 0.0157370
umls:C1527311 Brain Edema 43 2.191929 0.0213200 0.0157370
umls:C3714514 Infection 464 2.190516 0.0213200 0.0157370
umls:C0856825 Acute GVH disease 90 2.164842 0.0213200 0.0157370
umls:C0036202 Sarcoidosis 195 2.148506 0.0213200 0.0157370
umls:C0015944 Fetal Membranes, Premature Rupture 155 2.147448 0.0213200 0.0157370
umls:C0238288 Muscular Dystrophy, Facioscapulohumeral 60 2.143640 0.0213200 0.0157370
umls:C0240035 Interstitial fibrosis 82 2.132722 0.0213200 0.0157370
umls:C0008495 Chorioamnionitis 156 2.131669 0.0213200 0.0157370
umls:C0027697 Nephritis 117 2.126371 0.0213200 0.0157370
umls:C0085437 Meningitis, Bacterial 32 2.123222 0.0213200 0.0157370
umls:C0278504 Non-small cell lung cancer stage I 61 2.122751 0.0213200 0.0157370
umls:C2004493 Leukemia, B-Cell 77 2.122223 0.0213200 0.0157370
umls:C0041956 Ureteral obstruction 120 2.121561 0.0213200 0.0157370
umls:C0031099 Periodontitis 198 2.106942 0.0213200 0.0157370
umls:C0036421 Systemic Scleroderma 441 2.102414 0.0213200 0.0157370
umls:C2919032 Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified 149 2.101503 0.0213200 0.0157370
umls:C0032964 Pregnancy Complications, Hematologic 108 2.101098 0.0213200 0.0157370
umls:C0038395 Streptococcal Infections 35 2.095752 0.0213200 0.0157370
umls:C0036117 Salmonella infections 23 2.091344 0.0213200 0.0157370
umls:C0026857 Musculoskeletal Diseases 107 2.090082 0.0213200 0.0157370
umls:C0016059 Fibrosis 163 2.089532 0.0213200 0.0157370
umls:C0333307 Superficial ulcer 98 2.087237 0.0213200 0.0157370
umls:C0035235 Respiratory Syncytial Virus Infections 217 2.076661 0.0213200 0.0157370
umls:C0015929 Fetal Diseases 122 2.075651 0.0213200 0.0157370
umls:C1800706 Idiopathic Pulmonary Fibrosis 276 2.070348 0.0213200 0.0157370
umls:C0025568 Metaplasia 62 2.064722 0.0213200 0.0157370
umls:C0035455 Rhinitis 71 2.059612 0.0213200 0.0157370
umls:C0020517 Hypersensitivity 121 2.056660 0.0213200 0.0157370
umls:C0333186 Restenosis 169 2.056332 0.0213200 0.0157370
umls:C0039128 Syphilis 18 2.055331 0.0213200 0.0157370
umls:C0034067 Pulmonary Emphysema 153 2.048690 0.0213200 0.0157370
umls:C1636667 Disorder characterized by eosinophilia 95 2.048537 0.0213200 0.0157370
umls:C0014457 Eosinophilia 102 2.046762 0.0213200 0.0157370
umls:C0242488 Acute Lung Injury 57 2.043495 0.0311509 0.0229935
umls:C0162810 Cicatrix, Hypertrophic 51 2.041923 0.0213200 0.0157370
umls:C0850639 premalignant lesion 19 2.041144 0.0213829 0.0157834
umls:C0032285 Pneumonia 312 2.040063 0.0213200 0.0157370
umls:C0022876 Premature Obstetric Labor 163 2.039189 0.0213200 0.0157370
umls:C0332853 Anastomosis 18 2.037882 0.0213200 0.0157370
umls:C3714757 Juvenile rheumatoid arthritis 139 2.036202 0.0213200 0.0157370
umls:C1306759 Eosinophilic disorder 96 2.035730 0.0213200 0.0157370
umls:C0024291 Lymphohistiocytosis, Hemophagocytic 69 2.029287 0.0213200 0.0157370
umls:C0600518 Choroidal Neovascularization 43 2.027076 0.0213200 0.0157370
umls:C1292758 Precursor T-cell lymphoblastic lymphoma 12 2.021305 0.0216080 0.0159496
umls:C0009319 Colitis 414 2.019691 0.0213200 0.0157370
umls:C0023241 Legionnaires’ Disease 12 2.007745 0.0216080 0.0159496
umls:C0374997 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site 246 2.004850 0.0213200 0.0157370
umls:C0162871 Aortic Aneurysm, Abdominal 151 2.004158 0.0213200 0.0157370
umls:C0206659 Embryonal Carcinoma 128 2.004111 0.0213200 0.0157370
umls:C0024115 Lung diseases 276 2.000453 0.0213200 0.0157370
umls:C0001339 Acute pancreatitis 70 1.995536 0.0213200 0.0157370
umls:C1719672 Severe Sepsis 66 1.994544 0.0213200 0.0157370
umls:C0032914 Pre-Eclampsia 275 1.989170 0.0213200 0.0157370
umls:C0029410 Osteoarthritis of hip 53 1.988582 0.0213200 0.0157370
umls:C0085129 Bronchial Hyperreactivity 128 1.988006 0.0213200 0.0157370
umls:C0879615 Stromal Neoplasm 70 1.987804 0.0213200 0.0157370
umls:C0079218 Fibromatosis, Aggressive 53 1.987539 0.0213200 0.0157370
umls:C0153690 Secondary malignant neoplasm of bone 233 1.982889 0.0213200 0.0157370
umls:C0019829 Hodgkin Disease 306 1.982287 0.0213200 0.0157370
umls:C0079588 Ichthyosis, X-Linked 70 1.978848 0.0213200 0.0157370
umls:C0023343 Leprosy 105 1.978436 0.0213200 0.0157370
umls:C0235989 Renal interstitial fibrosis 29 1.976910 0.0311509 0.0229935
umls:C0151526 Premature Birth 235 1.972550 0.0213200 0.0157370
umls:C0011603 Dermatitis 126 1.968657 0.0213200 0.0157370
umls:C2607914 Allergic rhinitis (disorder) 120 1.966879 0.0213200 0.0157370
umls:C0149939 Obstructive nephropathy 33 1.964525 0.0213200 0.0157370
umls:C0018824 Heart valve disease 38 1.964080 0.0213200 0.0157370
umls:C0035222 Respiratory Distress Syndrome, Adult 113 1.963345 0.0213200 0.0157370
umls:C0263454 Chloracne 36 1.959919 0.0213200 0.0157370
umls:C0013537 Eclampsia 143 1.957980 0.0213200 0.0157370
umls:C0477474 Dermatitis and eczema 23 1.952579 0.0213200 0.0157370
umls:C0026654 Moyamoya Disease 34 1.952175 0.0311509 0.0229935
umls:C0042165 Anterior uveitis 28 1.951839 0.0213200 0.0157370
umls:C0032965 Pregnancy Complications, Infectious 24 1.950603 0.0213200 0.0157370
umls:C0494261 Combined immunodeficiency 22 1.948691 0.0213829 0.0157834
umls:C0398686 Primary immune deficiency disorder 59 1.948441 0.0311509 0.0229935
umls:C0043144 Wheezing 50 1.947701 0.0311509 0.0229935
umls:C0024143 Lupus Nephritis 161 1.939364 0.0213200 0.0157370
umls:C0017658 Glomerulonephritis 161 1.935815 0.0213200 0.0157370
umls:C0019189 Hepatitis, Chronic 138 1.935481 0.0213200 0.0157370
umls:C0340629 Aortic aneurysm without mention of rupture NOS 26 1.929815 0.0213200 0.0157370
umls:C1261287 Stenosis 26 1.928441 0.0213200 0.0157370
umls:C0003507 Aortic Valve Stenosis 72 1.927683 0.0213200 0.0157370
umls:C1333064 Classical Hodgkin’s Lymphoma 100 1.925577 0.0213200 0.0157370
umls:C0024305 Lymphoma, Non-Hodgkin 426 1.923015 0.0213200 0.0157370
umls:C1290884 Inflammatory disorder 183 1.922539 0.0213200 0.0157370
umls:C0003864 Arthritis 427 1.921011 0.0213200 0.0157370
umls:C0019340 Herpes NOS 67 1.920709 0.0213200 0.0157370
umls:C0034040 Puerperal Disorders 27 1.918742 0.0311509 0.0229935
umls:C0262655 Recurrent urinary tract infection 10 1.918535 0.0218867 0.0161553
umls:C0018133 Graft-vs-Host Disease 230 1.917069 0.0213200 0.0157370
umls:C0079487 Helicobacter Infections 81 1.916418 0.0213200 0.0157370
umls:C0030848 Peyronie Disease 14 1.913279 0.0214913 0.0158635
umls:C0042373 Vascular Diseases 328 1.910150 0.0213200 0.0157370
umls:C0206180 Ki-1+ Anaplastic Large Cell Lymphoma 214 1.909894 0.0213200 0.0157370
umls:C1290886 Chronic inflammatory disorder 59 1.906638 0.0311509 0.0229935
umls:C0034069 Pulmonary Fibrosis 290 1.904873 0.0213200 0.0157370
umls:C0014356 Enterocolitis 18 1.896437 0.0213200 0.0157370
umls:C0007282 Carotid Stenosis 95 1.895396 0.0213200 0.0157370
umls:C0004030 Aspergillosis 21 1.894287 0.0315451 0.0232845
umls:C0035457 Rhinitis, Allergic, Perennial 26 1.891891 0.0314450 0.0232106
umls:C0042487 Venous Thrombosis 75 1.891424 0.0213200 0.0157370
umls:C0392707 Atopy 42 1.891269 0.0311509 0.0229935
umls:C0085655 Polymyositis 80 1.888914 0.0213200 0.0157370
umls:C0009447 Common Variable Immunodeficiency 91 1.887062 0.0213200 0.0157370
umls:C1368683 Epithelioma 225 1.885352 0.0213200 0.0157370
umls:C0003486 Aortic Aneurysm 167 1.885293 0.0213200 0.0157370
umls:C0162820 Dermatitis, Allergic Contact 83 1.885115 0.0213200 0.0157370
umls:C0266929 Chronic Periodontitis 127 1.882263 0.0213200 0.0157370
umls:C0006272 Bronchiolitis Obliterans 40 1.881308 0.0311509 0.0229935
umls:C0751967 Multiple Sclerosis, Relapsing-Remitting 77 1.880040 0.0213200 0.0157370
umls:C0031090 Periodontal Diseases 94 1.879043 0.0213200 0.0157370
umls:C0019100 Severe Dengue 59 1.875929 0.0311509 0.0229935
umls:C1527336 Sjogren’s Syndrome 88 1.875917 0.0213200 0.0157370
umls:C0022548 Keloid 146 1.875774 0.0213200 0.0157370
umls:C0740903 allergic symptom 12 1.875239 0.0216080 0.0159496
umls:C0920646 Renal ischaemia 76 1.874924 0.0213200 0.0157370
umls:C0019061 Hemolytic-Uremic Syndrome 49 1.874393 0.0311509 0.0229935
umls:C0340288 Stable angina 66 1.873044 0.0213200 0.0157370
umls:C0011615 Dermatitis, Atopic 333 1.867401 0.0213200 0.0157370
umls:C0153252 Systemic candidiasis 33 1.866710 0.0405803 0.0299536
umls:C0019187 Hepatitis, Alcoholic 41 1.865726 0.0405803 0.0299536
umls:C3539909 Allergic disposition 149 1.865306 0.0213200 0.0157370
umls:C0014170 Endometrial Neoplasms 220 1.864897 0.0213200 0.0157370
umls:C0035369 Retroviridae Infections 54 1.864806 0.0405803 0.0299536
umls:C0021345 Infectious Mononucleosis 22 1.863938 0.0315692 0.0233023
umls:C0014072 Experimental Autoimmune Encephalomyelitis 305 1.862708 0.0213200 0.0157370
umls:C0206139 Lichen Planus, Oral 64 1.861166 0.0311509 0.0229935
umls:C0017411 Female Genital Diseases 14 1.859859 0.0318390 0.0235014
umls:C0004943 Behcet Syndrome 229 1.859711 0.0213200 0.0157370
umls:C1561535 Creatinine finding 74 1.858689 0.0311509 0.0229935
umls:C1801959 Histiocytic medullary reticulosis (disorder) 12 1.858365 0.0216080 0.0159496
umls:C0020523 Immediate hypersensitivity 87 1.857445 0.0213200 0.0157370
umls:C0079773 Lymphoma, T-Cell, Cutaneous 185 1.857153 0.0213200 0.0157370
umls:C0024232 Lymphatic Metastasis 133 1.853178 0.0213200 0.0157370
umls:C0993582 Arthritis, Experimental 133 1.852319 0.0213200 0.0157370
umls:C0007570 Celiac Disease 268 1.852155 0.0213200 0.0157370
umls:C0023465 Acute monocytic leukemia 64 1.851873 0.0311509 0.0229935
umls:C0042798 Low Vision 19 1.850846 0.0317037 0.0234016
umls:C0026946 Mycoses 193 1.849987 0.0213200 0.0157370
umls:C0376545 Hematologic Neoplasms 399 1.846868 0.0213200 0.0157370
umls:C0034065 Pulmonary Embolism 54 1.846421 0.0405803 0.0299536
umls:C0037199 Sinusitis 29 1.846386 0.0405803 0.0299536
umls:C0002382 Alveolar Bone Loss 26 1.845689 0.0314450 0.0232106
umls:C0020608 Hypodontia 18 1.845416 0.0315216 0.0232671
umls:C0153676 Secondary malignant neoplasm of lung 490 1.842982 0.0213200 0.0157370
umls:C0031106 Periodontitis, Juvenile 69 1.841787 0.0213200 0.0157370
umls:C0029883 Otitis Media with Effusion 17 1.841379 0.0413542 0.0305249
umls:C0085435 Arthritis, Reactive 38 1.841341 0.0405803 0.0299536
umls:C1096184 West Nile viral infection 64 1.841339 0.0405803 0.0299536
umls:C0242647 Mucosa-Associated Lymphoid Tissue Lymphoma 142 1.840017 0.0213200 0.0157370
umls:C0206677 Adenomatous Polyps 58 1.836225 0.0405803 0.0299536
umls:C1306889 Peripheral arterial occlusive disease 14 1.836155 0.0318390 0.0235014
umls:C0856053 Leukemia secondary 17 1.834491 0.0413542 0.0305249
umls:C0029899 Otosclerosis 15 1.834298 0.0214913 0.0158635
umls:C0701807 Acute anterior uveitis 33 1.832306 0.0405803 0.0299536
umls:C0019158 Hepatitis 196 1.831492 0.0213200 0.0157370
umls:C0175701 Aarskog syndrome 12 1.831353 0.0216080 0.0159496
umls:C0029172 Oral Submucous Fibrosis 45 1.831225 0.0311509 0.0229935
umls:C1318544 M5b Acute differentiated monocytic leukemia 73 1.830951 0.0213200 0.0157370
umls:C0079772 T-Cell Lymphoma 239 1.830325 0.0213200 0.0157370
umls:C0273115 Lung Injury 26 1.830009 0.0314450 0.0232106
umls:C0007766 Intracranial Aneurysm 96 1.829716 0.0213200 0.0157370
umls:C3714636 Pneumonitis 46 1.829014 0.0311509 0.0229935
umls:C0409959 Osteoarthritis, Knee 94 1.828574 0.0213200 0.0157370
umls:C0025229 Melioidosis 23 1.828572 0.0412888 0.0304767
umls:C1511789 Desmoplastic 68 1.827364 0.0213200 0.0157370
umls:C0398650 Immune thrombocytopenic purpura 68 1.825489 0.0311509 0.0229935
umls:C3272363 Ischemic Cerebrovascular Accident 271 1.824877 0.0213200 0.0157370
umls:C1332977 Childhood Leukemia 51 1.823810 0.0405803 0.0299536
umls:C0002351 Altitude Sickness 16 1.823373 0.0413542 0.0305249
umls:C0206694 Mucoepidermoid Carcinoma 59 1.822096 0.0405803 0.0299536
umls:C0085786 Hamman-Rich syndrome 29 1.816735 0.0405803 0.0299536
umls:C0023267 Fibroid Tumor 270 1.815043 0.0213200 0.0157370
umls:C0006840 Candidiasis 66 1.813852 0.0405803 0.0299536
umls:C0001925 Albuminuria 111 1.813335 0.0213200 0.0157370
umls:C0524702 Pulmonary Thromboembolisms 14 1.807108 0.0318390 0.0235014
umls:C0037274 Dermatologic disorders 363 1.806392 0.0213200 0.0157370
umls:C1519680 Tumor Immunity 74 1.805772 0.0311509 0.0229935
umls:C0877009 Muscle fibrosis 10 1.805284 0.0430706 0.0317919
umls:C0032787 Postoperative Complications 48 1.804926 0.0405803 0.0299536
umls:C0006413 Burkitt Lymphoma 167 1.802105 0.0213200 0.0157370
umls:C0340708 Deep vein thrombosis of lower limb 37 1.801789 0.0405803 0.0299536
umls:C1449563 Cardiomyopathy, Familial Idiopathic 159 1.800570 0.0213200 0.0157370
umls:C0019080 Hemorrhage 54 1.798345 0.0483787 0.0357099
umls:C0019069 Hemophilia A 73 1.798157 0.0311509 0.0229935
umls:C0009782 Connective Tissue Diseases 159 1.797990 0.0213200 0.0157370
umls:C1854310 Hypotrichosis simplex 15 1.797742 0.0416191 0.0307204
umls:C0431350 Primary microcephaly 17 1.797715 0.0489743 0.0361495
umls:C0020875 Ileal Diseases 16 1.797385 0.0489743 0.0361495
umls:C0023895 Liver diseases 446 1.797311 0.0213200 0.0157370
umls:C0524909 Hepatitis B, Chronic 185 1.797022 0.0213200 0.0157370
umls:C0206708 Cervical Intraepithelial Neoplasia 179 1.796918 0.0213200 0.0157370
umls:C0238394 Female Pseudohermaphroditism 43 1.796287 0.0482231 0.0355951
umls:C0036420 Localized scleroderma 19 1.795950 0.0414729 0.0306125
umls:C0035328 Retinal Vein Occlusion 24 1.795946 0.0314450 0.0232106
umls:C0013238 Dry Eye Syndromes 36 1.795804 0.0405803 0.0299536
umls:C0340643 Dissection of aorta 31 1.795056 0.0405803 0.0299536
umls:C0948008 Ischemic stroke 307 1.794768 0.0213200 0.0157370
umls:C0154084 Stage 0 Breast Carcinoma 13 1.794622 0.0418166 0.0308662
umls:C0008312 Primary biliary cirrhosis 201 1.794573 0.0213200 0.0157370
umls:C0030305 Pancreatitis 149 1.793622 0.0213200 0.0157370
umls:C0031154 Peritonitis 88 1.791978 0.0213200 0.0157370
umls:C0024312 Lymphopenia 60 1.791713 0.0405803 0.0299536
umls:C0178238 Intestinal infectious disease (disorder) 12 1.789844 0.0498646 0.0368067
umls:C0017152 Gastritis 153 1.789086 0.0213200 0.0157370
umls:C0376620 Pouchitis 12 1.788864 0.0498646 0.0368067
umls:C0242966 Systemic Inflammatory Response Syndrome 54 1.787890 0.0483787 0.0357099
umls:C0021051 Immunologic Deficiency Syndromes 349 1.787888 0.0213200 0.0157370
umls:C0029118 Opportunistic Infections 25 1.787602 0.0489743 0.0361495
umls:C0156181 Peritoneal adhesion 12 1.786238 0.0498646 0.0368067
umls:C0003872 Arthritis, Psoriatic 140 1.785486 0.0213200 0.0157370
umls:C0585362 Squamous cell carcinoma of mouth 42 1.784861 0.0405803 0.0299536
umls:C0013884 Filarial Elephantiases 16 1.784540 0.0489743 0.0361495
umls:C0162872 Aortic Aneurysm, Thoracic 91 1.784278 0.0213200 0.0157370
umls:C0023892 Biliary cirrhosis 100 1.782895 0.0213200 0.0157370
umls:C0017563 Gingival Diseases 74 1.782359 0.0311509 0.0229935
umls:C0029458 Osteoporosis, Postmenopausal 74 1.781473 0.0311509 0.0229935
umls:C1719495 Aggressive periodontitis, generalized 29 1.781152 0.0405803 0.0299536
umls:C0345967 Malignant mesothelioma 227 1.778173 0.0213200 0.0157370
umls:C0013312 Dupuytren Contracture 16 1.777424 0.0489743 0.0361495
umls:C0085390 Li-Fraumeni Syndrome 37 1.777215 0.0483787 0.0357099
umls:C0020217 Hydatidiform Mole 48 1.776973 0.0405803 0.0299536
umls:C0038013 Ankylosing spondylitis 187 1.776612 0.0213200 0.0157370
umls:C0007114 Malignant neoplasm of skin 192 1.776078 0.0213200 0.0157370
umls:C0850666 Helicobacter pylori infection 225 1.774730 0.0213200 0.0157370
umls:C0035126 Reperfusion Injury 271 1.774648 0.0213200 0.0157370
umls:C0040053 Thrombosis 105 1.773576 0.0213200 0.0157370
umls:C0010606 Adenoid Cystic Carcinoma 185 1.773300 0.0213200 0.0157370
umls:C0008149 Chlamydia Infections 61 1.772866 0.0405803 0.0299536
umls:C0080233 Tooth Loss 14 1.772439 0.0495858 0.0366009
umls:C3662483 Allergic sensitization 29 1.771174 0.0405803 0.0299536
umls:C1402294 Primary Lesion 30 1.771110 0.0405803 0.0299536
umls:C0699949 airway disease 64 1.769208 0.0405803 0.0299536
umls:C0278996 Cancer of Head and Neck 361 1.766759 0.0213200 0.0157370
umls:C0008497 Choriocarcinoma 226 1.764559 0.0213200 0.0157370
umls:C1848411 XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP E 13 1.764103 0.0495858 0.0366009
umls:C0149516 Chronic sinusitis 42 1.760737 0.0482231 0.0355951
umls:C3150911 GASTRIC CANCER, INTESTINAL 12 1.759898 0.0498646 0.0368067
umls:C0001486 Adenovirus Infections 63 1.759357 0.0405803 0.0299536
umls:C0079744 Diffuse Large B-Cell Lymphoma 459 1.757885 0.0213200 0.0157370
umls:C0971858 Arthritis, Collagen-Induced 133 1.756517 0.0213200 0.0157370
umls:C1559271 Non-Malignant Ascites Adverse Event 146 1.756292 0.0213200 0.0157370
umls:C1176475 Ductal Carcinoma 185 1.755945 0.0213200 0.0157370
umls:C1956391 Temporal Arteritis 13 1.755570 0.0495858 0.0366009
umls:C0011119 Decompression Sickness 13 1.755079 0.0495858 0.0366009
umls:C0694549 Community acquired pneumonia 29 1.753912 0.0482231 0.0355951
umls:C1292769 Precursor B-cell lymphoblastic leukemia 297 1.753829 0.0213200 0.0157370
umls:C0013595 Eczema 281 1.753064 0.0213200 0.0157370
umls:C0018213 Graves Disease 260 1.751967 0.0213200 0.0157370
umls:C0948089 Acute Coronary Syndrome 241 1.750868 0.0213200 0.0157370
umls:C0409651 Seropositive rheumatoid arthritis 16 1.749657 0.0489743 0.0361495
umls:C0149678 Epstein-Barr Virus Infections 174 1.749288 0.0213200 0.0157370
umls:C0278701 Gastric Adenocarcinoma 216 1.748453 0.0213200 0.0157370
umls:C0276680 Infection by Candida albicans 15 1.748193 0.0495578 0.0365803
umls:C0019159 Hepatitis A 188 1.747388 0.0213200 0.0157370
umls:C0017612 Glaucoma, Open-Angle 77 1.746690 0.0311509 0.0229935
umls:C0242706 Hyperoxia 42 1.746291 0.0482231 0.0355951
umls:C0399440 Hereditary gingival fibromatosis 17 1.745732 0.0489743 0.0361495
umls:C0024131 Lupus Vulgaris 238 1.744443 0.0213200 0.0157370
umls:C0033687 Proteinuria 67 1.744372 0.0482231 0.0355951
umls:C1519670 Tumor Angiogenesis 360 1.743868 0.0213200 0.0157370
umls:C0853879 Invasive breast carcinoma 321 1.742790 0.0213200 0.0157370
umls:C0023290 Leishmaniasis, Visceral 58 1.740428 0.0482231 0.0355951
umls:C1561643 Chronic Kidney Diseases 229 1.740151 0.0213200 0.0157370
umls:C0023470 Myeloid Leukemia 430 1.740125 0.0213200 0.0157370
umls:C0409974 Lupus Erythematosus 284 1.739497 0.0213200 0.0157370
umls:C0011616 Contact Dermatitis 62 1.739032 0.0405803 0.0299536
umls:C0023893 Liver Cirrhosis, Experimental 149 1.737959 0.0213200 0.0157370
umls:C0376544 Hematopoietic Neoplasms 140 1.735318 0.0213200 0.0157370
umls:C1621958 Glioblastoma Multiforme 370 1.734290 0.0213200 0.0157370
umls:C0220810 Congenital defects 43 1.733045 0.0482231 0.0355951
umls:C0149521 Pancreatitis, Chronic 214 1.732374 0.0213200 0.0157370
umls:C0027439 Nasopharyngeal Neoplasms 61 1.732158 0.0405803 0.0299536
umls:C0000786 Spontaneous abortion 191 1.730129 0.0213200 0.0157370
umls:C0079745 Lymphoma, Large-Cell, Follicular 137 1.729920 0.0213200 0.0157370
umls:C0011633 Dermatomyositis 88 1.728514 0.0213200 0.0157370
umls:C0002940 Aneurysm 107 1.728356 0.0213200 0.0157370
umls:C0005411 Biliary Atresia 69 1.725914 0.0482231 0.0355951
umls:C2945695 Limb ischemia 57 1.725085 0.0482231 0.0355951
umls:C0017185 Gastrointestinal Neoplasms 102 1.723935 0.0311509 0.0229935
umls:C0403447 Chronic Kidney Insufficiency 149 1.723352 0.0213200 0.0157370
umls:C1378703 Renal carcinoma 387 1.721292 0.0213200 0.0157370
umls:C0018273 Growth Disorders 64 1.720907 0.0405803 0.0299536
umls:C0027626 Neoplasm Invasiveness 147 1.719976 0.0213200 0.0157370
umls:C0006663 Calcinosis 82 1.719791 0.0311509 0.0229935
umls:C0036920 Sezary Syndrome 109 1.718321 0.0213200 0.0157370
umls:C0038358 Gastric ulcer 87 1.717007 0.0213200 0.0157370
umls:C0002793 Anaplasia 191 1.716325 0.0213200 0.0157370
umls:C0003130 Anoxia 306 1.716101 0.0213200 0.0157370
umls:C0026896 Myasthenia Gravis 139 1.714579 0.0213200 0.0157370
umls:C0346153 Breast Cancer, Familial 127 1.713297 0.0213200 0.0157370
umls:C0008313 Cholangitis, Sclerosing 69 1.711042 0.0482231 0.0355951
umls:C3542024 AORTIC VALVE DISEASE 2 52 1.710445 0.0482231 0.0355951
umls:C1334274 Invasive Carcinoma 134 1.709532 0.0213200 0.0157370
umls:C0023452 Leukemia, Lymphocytic, Acute, L1 306 1.709137 0.0213200 0.0157370
umls:C0029456 Osteoporosis 368 1.709073 0.0213200 0.0157370
umls:C0027430 Nasal Polyps 141 1.707847 0.0213200 0.0157370
umls:C0278883 Metastatic melanoma 272 1.707684 0.0213200 0.0157370
umls:C0042029 Urinary tract infection 64 1.707610 0.0482231 0.0355951
umls:C0021053 Immune System Diseases 142 1.706016 0.0213200 0.0157370
umls:C0023448 Lymphoid leukemia 195 1.705062 0.0213200 0.0157370
umls:C1861172 Venous Thromboembolism 108 1.703912 0.0213200 0.0157370
umls:C0220641 Lip and Oral Cavity Carcinoma 344 1.702619 0.0213200 0.0157370
umls:C0339573 Glaucoma, Primary Open Angle 141 1.701075 0.0213200 0.0157370
umls:C0153381 Malignant neoplasm of mouth 344 1.700469 0.0213200 0.0157370
umls:C0243038 Carcinoma, Lewis Lung 67 1.700457 0.0482231 0.0355951
umls:C0279628 Adenocarcinoma Of Esophagus 229 1.698785 0.0213200 0.0157370
umls:C0018203 Chronic granulomatous disease 60 1.697427 0.0482231 0.0355951
umls:C0349566 Squamous cell carcinoma of tongue 98 1.697011 0.0213200 0.0157370
umls:C0023485 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma 87 1.696231 0.0311509 0.0229935
umls:C0577631 Carotid Atherosclerosis 88 1.695058 0.0311509 0.0229935
umls:C0011644 Scleroderma 132 1.694061 0.0213200 0.0157370
umls:C0524910 Hepatitis C, Chronic 327 1.693594 0.0213200 0.0157370
umls:C0027726 Nephrotic Syndrome 144 1.690701 0.0213200 0.0157370
umls:C0023493 Adult T-Cell Lymphoma/Leukemia 366 1.689828 0.0213200 0.0157370
umls:C0039103 Synovitis 76 1.688400 0.0482231 0.0355951
umls:C0035435 Rheumatism 86 1.686457 0.0311509 0.0229935
umls:C0017525 Giant Cell Tumors 63 1.686411 0.0405803 0.0299536
umls:C0042384 Vasculitis 105 1.684148 0.0311509 0.0229935
umls:C0085110 Severe Combined Immunodeficiency 420 1.681789 0.0213200 0.0157370
umls:C0027055 Myocardial Reperfusion Injury 132 1.678653 0.0213200 0.0157370
umls:C1762616 Meningioma, benign, no ICD-O subtype 191 1.677007 0.0213200 0.0157370
umls:C0239946 Fibrosis, Liver 271 1.676727 0.0213200 0.0157370
umls:C0007124 Noninfiltrating Intraductal Carcinoma 257 1.676222 0.0213200 0.0157370
umls:C0042164 Uveitis 100 1.672861 0.0311509 0.0229935
umls:C0021841 Intestinal Neoplasms 121 1.670811 0.0213200 0.0157370
umls:C0025007 Measles 120 1.670755 0.0213200 0.0157370
umls:C1840264 IMMUNE SUPPRESSION 61 1.669468 0.0405803 0.0299536
umls:C0031069 Familial Mediterranean Fever 59 1.666993 0.0482231 0.0355951
umls:C0949691 Spondylarthropathies 65 1.664208 0.0482231 0.0355951
umls:C0024138 Lupus Erythematosus, Discoid 244 1.659966 0.0213200 0.0157370
umls:C0346429 Multiple malignancy 164 1.655313 0.0213200 0.0157370
umls:C0042133 Uterine Fibroids 276 1.652778 0.0213200 0.0157370
umls:C0027686 Pathologic Neovascularization 62 1.645218 0.0482231 0.0355951
umls:C0280324 Laryngeal Squamous Cell Carcinoma 110 1.643851 0.0311509 0.0229935
umls:C0940937 precancerous lesions 91 1.643798 0.0482231 0.0355951
umls:C0022578 Keratoconus 66 1.640926 0.0482231 0.0355951
umls:C0206698 Cholangiocarcinoma 333 1.637698 0.0213200 0.0157370
umls:C0034063 Pulmonary Edema 66 1.635592 0.0482231 0.0355951
umls:C0022680 Polycystic Kidney Diseases 100 1.635009 0.0405803 0.0299536
umls:C1333990 Hereditary Nonpolyposis Colorectal Cancer 100 1.632791 0.0405803 0.0299536
umls:C0020542 Pulmonary Hypertension 283 1.629915 0.0213200 0.0157370
umls:C0008924 Cleft Lip 173 1.629457 0.0213200 0.0157370
umls:C0005695 Bladder Neoplasm 390 1.628503 0.0213200 0.0157370
umls:C0341439 Chronic liver disease 108 1.624461 0.0311509 0.0229935
umls:C0035412 Rhabdomyosarcoma 307 1.623145 0.0213200 0.0157370
umls:C0019348 Herpes Simplex Infections 425 1.619254 0.0213200 0.0157370
umls:C0023524 Leukoencephalopathy, Progressive Multifocal 84 1.617181 0.0482231 0.0355951
umls:C0345904 Malignant neoplasm of liver 481 1.617168 0.0213200 0.0157370
umls:C0040028 Thrombocythemia, Essential 124 1.617080 0.0213200 0.0157370
umls:C0020473 Hyperlipidemia 174 1.616695 0.0213200 0.0157370
umls:C0024667 Animal Mammary Neoplasms 178 1.616187 0.0213200 0.0157370
umls:C0026691 Mucocutaneous Lymph Node Syndrome 145 1.614511 0.0213200 0.0157370
umls:C0151744 Myocardial Ischemia 412 1.612866 0.0213200 0.0157370
umls:C0376634 Craniofacial Abnormalities 175 1.606935 0.0213200 0.0157370
umls:C0008925 Cleft Palate 216 1.605817 0.0213200 0.0157370
umls:C0152018 Esophageal carcinoma 445 1.605376 0.0213200 0.0157370
umls:C0025286 Meningioma 381 1.604537 0.0213200 0.0157370
umls:C0041327 Tuberculosis, Pulmonary 170 1.604424 0.0213200 0.0157370
umls:C0020443 Hypercholesterolemia 150 1.602699 0.0213200 0.0157370
umls:C0008626 Congenital chromosomal disease 440 1.602318 0.0213200 0.0157370
umls:C0279000 Liver and Intrahepatic Biliary Tract Carcinoma 403 1.597942 0.0213200 0.0157370
umls:C1961099 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 287 1.597679 0.0213200 0.0157370
umls:C0007103 Malignant neoplasm of endometrium 413 1.595849 0.0213200 0.0157370
umls:C1883486 Uterine Corpus Cancer 413 1.595849 0.0213200 0.0157370
umls:C0011311 Dengue Fever 140 1.595500 0.0311509 0.0229935
umls:C0242596 Neoplasm, Residual 145 1.594286 0.0311509 0.0229935
umls:C0024314 Lymphoproliferative Disorders 167 1.594002 0.0213200 0.0157370
umls:C1623038 Cirrhosis 307 1.592983 0.0213200 0.0157370
umls:C0546837 Malignant neoplasm of esophagus 485 1.592897 0.0213200 0.0157370
umls:C0281361 Adenocarcinoma of pancreas 252 1.588880 0.0213200 0.0157370
umls:C0242383 Age related macular degeneration 331 1.588860 0.0213200 0.0157370
umls:C0022661 Kidney Failure, Chronic 483 1.588260 0.0213200 0.0157370
umls:C0026640 Mouth Neoplasms 173 1.588257 0.0213200 0.0157370
umls:C0334579 Anaplastic astrocytoma 125 1.588124 0.0311509 0.0229935
umls:C0005940 Bone Diseases 137 1.586987 0.0405803 0.0299536
umls:C0018798 Congenital Heart Defects 210 1.586787 0.0311509 0.0229935
umls:C0007621 Neoplastic Cell Transformation 109 1.584165 0.0405803 0.0299536
umls:C0023487 Acute Promyelocytic Leukemia 359 1.581779 0.0213200 0.0157370
umls:C0598608 Hyperhomocysteinemia 98 1.576703 0.0482231 0.0355951
umls:C0007873 Uterine Cervical Neoplasm 146 1.574003 0.0311509 0.0229935
umls:C0007786 Brain Ischemia 357 1.573395 0.0213200 0.0157370
umls:C0243026 Sepsis 440 1.571539 0.0213200 0.0157370
umls:C0375023 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site 194 1.568765 0.0311509 0.0229935
umls:C0036220 Kaposi Sarcoma 147 1.567461 0.0474230 0.0350045
umls:C0685938 Malignant neoplasm of gastrointestinal tract 182 1.567058 0.0311509 0.0229935
umls:C0085669 Acute leukemia 398 1.564294 0.0213200 0.0157370
umls:C0152171 Idiopathic pulmonary hypertension 181 1.564007 0.0311509 0.0229935
umls:C2316810 Chronic kidney disease stage 5 161 1.561765 0.0213200 0.0157370
umls:C0010674 Cystic Fibrosis 330 1.554634 0.0213200 0.0157370
umls:C0595989 Carcinoma of larynx 146 1.554064 0.0311509 0.0229935
umls:C1134719 Invasive Ductal Breast Carcinoma 205 1.549578 0.0402397 0.0297023
umls:C0338106 Adenocarcinoma of colon 193 1.547574 0.0311509 0.0229935
umls:C0238463 Papillary thyroid carcinoma 379 1.547233 0.0213200 0.0157370
umls:C3539878 Triple Negative Breast Neoplasms 388 1.542960 0.0213200 0.0157370
umls:C0007785 Cerebral Infarction 248 1.542908 0.0213200 0.0157370
umls:C0017601 Glaucoma 180 1.542728 0.0311509 0.0229935
umls:C0279702 Conventional (Clear Cell) Renal Cell Carcinoma 304 1.540463 0.0213200 0.0157370
umls:C0027708 Nephroblastoma 265 1.535806 0.0311509 0.0229935
umls:C1292778 Chronic myeloproliferative disorder 139 1.534717 0.0474230 0.0350045
umls:C0037286 Skin Neoplasms 274 1.534092 0.0213200 0.0157370
umls:C0024301 Lymphoma, Follicular 300 1.532711 0.0213200 0.0157370
umls:C0020445 Hypercholesterolemia, Familial 132 1.532093 0.0474230 0.0350045
umls:C1335302 Pancreatic Ductal Adenocarcinoma 462 1.528290 0.0213200 0.0157370
umls:C0149782 Squamous cell carcinoma of lung 163 1.527618 0.0311509 0.0229935
umls:C1384666 hearing impairment 134 1.524354 0.0475364 0.0350882
umls:C0400966 Non-alcoholic Fatty Liver Disease 243 1.524304 0.0311509 0.0229935
umls:C0917798 Cerebral Ischemia 163 1.519668 0.0311509 0.0229935
umls:C0151779 Cutaneous Melanoma 217 1.518516 0.0311509 0.0229935
umls:C0013336 Dwarfism 161 1.517249 0.0403029 0.0297489
umls:C0008479 Chondrosarcoma 194 1.514752 0.0402700 0.0297247
umls:C1336076 Sporadic Breast Carcinoma 126 1.514103 0.0479176 0.0353696
umls:C0008370 Cholestasis 127 1.513776 0.0475774 0.0351184
umls:C0278488 Carcinoma breast stage IV 280 1.508732 0.0213200 0.0157370
umls:C0023492 Leukemia, T-Cell 270 1.508727 0.0311509 0.0229935
umls:C0032927 Precancerous Conditions 351 1.508117 0.0213200 0.0157370
umls:C0033860 Psoriasis 481 1.498909 0.0213200 0.0157370
umls:C1272641 Systemic arterial pressure 380 1.498210 0.0213200 0.0157370
umls:C0011884 Diabetic Retinopathy 191 1.497532 0.0402546 0.0297132
umls:C0016057 Fibrosarcoma 224 1.495819 0.0213200 0.0157370
umls:C0740457 Malignant neoplasm of kidney 337 1.492967 0.0213200 0.0157370
umls:C0025500 Mesothelioma 326 1.492646 0.0213200 0.0157370
umls:C0007113 Rectal Carcinoma 221 1.492276 0.0311509 0.0229935
umls:C0024668 Mammary Neoplasms, Experimental 185 1.486728 0.0402861 0.0297365
umls:C1271104 Blood pressure finding 330 1.484275 0.0213200 0.0157370
umls:C0494165 Secondary malignant neoplasm of liver 349 1.480810 0.0213200 0.0157370
umls:C0027022 Myeloproliferative disease 216 1.467439 0.0465262 0.0343425
umls:C0007138 Carcinoma, Transitional Cell 332 1.461678 0.0213200 0.0157370
umls:C0032580 Adenomatous Polyposis Coli 324 1.456559 0.0213200 0.0157370
umls:C0032584 polyps 206 1.450466 0.0463533 0.0342149
umls:C0021400 Influenza 374 1.447931 0.0213200 0.0157370
umls:C0007193 Cardiomyopathy, Dilated 328 1.436125 0.0295915 0.0218425
umls:C0040136 Thyroid Neoplasm 397 1.435965 0.0213200 0.0157370
umls:C1704272 Benign Prostatic Hyperplasia 301 1.435475 0.0301940 0.0222872
umls:C0555198 Malignant Glioma 356 1.435058 0.0294219 0.0217173
umls:C1709246 Non-Neoplastic Disorder 374 1.429963 0.0213200 0.0157370
umls:C0015695 Fatty Liver 286 1.428683 0.0306953 0.0226572
umls:C1512409 Hepatocarcinogenesis 399 1.423309 0.0213200 0.0157370
umls:C0035309 Retinal Diseases 289 1.416967 0.0440414 0.0325084
umls:C1520166 Xenograft Model 440 1.408263 0.0213200 0.0157370
umls:C0035078 Kidney Failure 268 1.404060 0.0458797 0.0338653
umls:C0020456 Hyperglycemia 380 1.397997 0.0213200 0.0157370
umls:C0041296 Tuberculosis 427 1.394137 0.0213200 0.0157370
umls:C0036690 Septicemia 304 1.393012 0.0438335 0.0323550
umls:C0007115 Malignant neoplasm of thyroid 393 1.342035 0.0427786 0.0315763
umls:C0035335 Retinoblastoma 388 1.328727 0.0489743 0.0361495
Enriched terms for module #84AD00 (MTcor = -0.93)
ID Description setSize NES p.adjust qvalues
umls:C0543888 Epileptic encephalopathy 51 2.482362 0.0356247 0.0281029
umls:C0342776 Nicotinamide adenine dinucleotide coenzyme Q reductase deficiency 38 2.432047 0.0356247 0.0281029
umls:C1838979 MITOCHONDRIAL COMPLEX I DEFICIENCY 29 2.429053 0.0356247 0.0281029
umls:C0037769 West Syndrome 58 2.325541 0.0356247 0.0281029
umls:C2936907 NADH:Q(1) Oxidoreductase deficiency 20 2.180142 0.0356247 0.0281029
umls:C0014550 Epilepsies, Myoclonic 36 2.170404 0.0356247 0.0281029
umls:C0238111 Lennox-Gastaut syndrome 11 2.136084 0.0356247 0.0281029
umls:C0751122 Infantile Severe Myoclonic Epilepsy 25 2.113278 0.0356247 0.0281029
umls:C0393706 Early infantile epileptic encephalopathy with suppression bursts 19 2.092171 0.0356247 0.0281029
umls:C0017926 Glycogen Storage Disease Type VII 11 2.087134 0.0356247 0.0281029
umls:C1838951 LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 14 2.084908 0.0356247 0.0281029
umls:C0023264 Leigh Disease 77 2.058937 0.0356247 0.0281029
umls:C0085292 Stiff-Person Syndrome 19 2.057038 0.0356247 0.0281029
umls:C2931919 X-linked infantile spasm syndrome 15 2.048455 0.0356247 0.0281029
umls:C1849156 Spastic Ataxia 14 2.040328 0.0356247 0.0281029
umls:C0406810 Carney Complex 27 2.025996 0.0493656 0.0389425
umls:C0029124 Optic Atrophy 31 1.993882 0.0356247 0.0281029
umls:C0342492 Adrenal hypertrophy or hyperplasia 17 1.985649 0.0356247 0.0281029
umls:C1621895 Adrenal hyperplasia 17 1.985649 0.0356247 0.0281029
umls:C0162670 Mitochondrial Myopathies 48 1.982734 0.0356247 0.0281029
umls:C0014547 Epilepsies, Partial 42 1.967555 0.0356247 0.0281029
umls:C0026650 Movement Disorders 95 1.964739 0.0356247 0.0281029
umls:C1142166 Brugada Syndrome (disorder) 46 1.920346 0.0356247 0.0281029
umls:C0162674 Chronic progressive external ophthalmoplegia 19 1.911793 0.0493656 0.0389425
umls:C0004134 Ataxia 221 1.879095 0.0356247 0.0281029
umls:C0424551 Impaired exercise tolerance 27 1.854635 0.0493656 0.0389425
umls:C0014548 Epilepsy, Generalized 44 1.788307 0.0493656 0.0389425
umls:C0162666 Mitochondrial Encephalomyopathies 32 1.773487 0.0493656 0.0389425
umls:C0270850 Idiopathic generalized epilepsy 45 1.768474 0.0493656 0.0389425
umls:C1096063 Drug Resistant Epilepsy 53 1.758148 0.0356247 0.0281029
umls:C1955869 Malformations of Cortical Development 45 1.748752 0.0493656 0.0389425
umls:C0270736 Essential Tremor 49 1.746995 0.0493656 0.0389425
umls:C0278484 Malignant neoplasm of colon stage IV 62 1.732129 0.0493656 0.0389425
umls:C0035372 Rett Syndrome 111 1.687489 0.0493656 0.0389425
umls:C0026827 Muscle hypotonia 73 1.671249 0.0493656 0.0389425
umls:C0525045 Mood Disorders 238 1.632827 0.0356247 0.0281029
umls:C0027765 nervous system disorder 388 1.457565 0.0493656 0.0389425
rm(df)